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Retinoic Acid - Wesleyan College Faculty
Retinoic Acid - Wesleyan College Faculty

... Treating Neurula Embryos with Retinoic Acid? To study global changes in gene expression patterns we use DNA microarrays Large numbers of genes (from 5-10K) represented on small coated glass slides (chips) Assess changes in gene expression patterns in normal vs treated embryos (work in progress) ...
Three dimensional analysis of the Golgi apparatus
Three dimensional analysis of the Golgi apparatus

... organelle. It rapidly responds to changes of its environment. Depletion of the cellular adenosintriphosphate (ATP) pool leads to massive but reversible Golgi apparatus alterations [1]. By examination of thin sections in the electron microscope, a dissociation of the Golgi apparatus stacks is visible ...
Benefits of Simple Exchange Transfusion in Sickle Cell Disease
Benefits of Simple Exchange Transfusion in Sickle Cell Disease

... altered surface charge that promotes the formation of lengthy polymeric chains (gelation) when in the deoxygenated state. The oxygen affinity of dilute, unpolymerized HbS is similar to that of normal hemoglobin. However, the oxygen affinity of concentrated HbS solutions is decreased [1], thereby rep ...
Hydrogen peroxide in the human body
Hydrogen peroxide in the human body

... Living organisms have evolved mechanisms to sequester transition metal ions into protein-bound forms that cannot catalyze OH formation and other free radical reactions in vivo. These mechanisms are especially important in such extracellular £uids as the blood plasma [1,16,17]. Nevertheless, H2 O2 c ...
Inside the Crawling T Cell - The Journal of Immunology
Inside the Crawling T Cell - The Journal of Immunology

... Broad spectrum kinase inhibitor staurosporine and selective PKC-a and -b inhibitor Go6976 used in functional studies were purchased from Calbiochem (Nottingham, U.K.). After 4 h of incubation in culture medium or under specific experimental conditions as described in the figure legends, unattached c ...
Chapter 16 - Respiratory System
Chapter 16 - Respiratory System

...  Cystic fibrosis- a recessive genetic disorder that causes thick, sticky mucus to build up in the lungs and digestive tract.  Emphysema – a progressive degenerative disease that destroys alveolar walls; this decreases the surface area of the respiratory membrane and reduces the volume of gases th ...
CELL: THE UNIT OF LIFE
CELL: THE UNIT OF LIFE

... of molecules across the plasma membrane takes place by diffusion, osmosis, active transport, phagocytosis (cell eating) and pinocytosis (cell drinking). ii) PROTOPLASM: It is a living substance of the cell that possesses all vital products made up of inorganic and organic molecules. It includes cyto ...
Drug analysis - WordPress.com
Drug analysis - WordPress.com

... Amoxicillin, was designed this time by changing the benzene to a phenol. The addition of the hydroxyl group (-OH) now increases the bioavailability of Amoxicillin to 95% and allow it to be taken orally. Cephalosporins are more stable (due to a double bond) to the action of beta-lactamase that destro ...
Bystin in human cancer cells: intracellular localization and function
Bystin in human cancer cells: intracellular localization and function

... between embryo implantation and metastasis and invasion of malignant tumors [3]. For example, a family of cell adhesion molecules, integrins, functions in the angiogenesis of implantation and metastasis [4]. ...
CHAPTER 2
CHAPTER 2

... islands of proliferation at the orifices of these glands grow and coalesce to cover the surface. Deeper burns that destroy the skin appendages require new epidermis to be grafted. Burned skin that is not replaced by a graft heals with dense scarring. Since this scar tissue lacks the elasticity of no ...
Training Effects of Aerobic exercise on the Cardiovascular
Training Effects of Aerobic exercise on the Cardiovascular

... Increase in heart size is one of the benefits that may arise as a result of endurance training. 1. Larger atria and ventricles allow for a greater volume of blood to be pumped each time the heart beats. 2. Increased thickness of the walls of the heart (cardiac muscle) allows for increased contractil ...
Respiratory System[1] - missdannocksyear11biologyclass
Respiratory System[1] - missdannocksyear11biologyclass

... With air entering and leaving the lungs, they increase and decrease in size on a regular basis. When organs in the body increase in size, they will touch other organs because of the lack of space. This is a danger because living tissue is very delicate and when tissues rub against each other, fricti ...
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... Suppressed myosin ...
Nigerian National Diagnostic Histopathology EQA
Nigerian National Diagnostic Histopathology EQA

... duration, and vomiting of blood and loss of consciousness of 5 hours’ duration. Fever has been occurring on and off for some time (the exact duration was not stated) and he has been receiving treatment at the Navy Reference Hospital. Fever was said to be high grade and associated with chills. The pa ...
General Chordate Characteristics
General Chordate Characteristics

... Gills and gill slits – directly secrete from gills into water using simple diffusion Kidneys - Ammonia is changed into urea in liver and eliminated in urine filtered through kidney ...
Пособие для самостоятельной работы студентов
Пособие для самостоятельной работы студентов

... constituent of nucleic acid lodged within an outer ...
Dia 1
Dia 1

... Novel Technologies to assess Gut Health Claims for Carbohydrates Subthema 1: Synthesis and structural analysis of functional oligosaccharides Name: Prof. Dr. Lubbert Dijkhuizen Affiliation: University of Groningen/ Microbiology Contact: [email protected] ...
AMBER PARTICLES AS LIVING PLANT CELL MARKERS IN FLOW
AMBER PARTICLES AS LIVING PLANT CELL MARKERS IN FLOW

... components. The presence of amber components (alcohol soluble amber fraction and sodium succinate) in cultivation media mostly had no influence on cellular fluorescence. This indicates that the increase of cell fluorescence is not directly associated with the effect of succinic acid, a wellknown phy ...
Open full article
Open full article

... Discussion This study is the first one in the area and in this particular biotope that describes in detail local cyanoprocaryote populations. Even though the results concern only the most representative morphotypes found on the pneumatophores, results obtained show a considerable number of new recor ...
Molecular imaging of homodimeric protein–protein interactions in
Molecular imaging of homodimeric protein–protein interactions in

... TK molecule. The double N-hRLUC chimera was combined with the chimera containing C-hRLUC downstream of TK in cotransfection strategies. The double C-hRLUC chimera was combined with that containing N-hRLUC upstream of TK. The first combination represented our tail-to-head TK homodimer with the additi ...
Nerve activates contraction - Holly H. Nash
Nerve activates contraction - Holly H. Nash

... debris in the lymphatic stream; houses white blood cells involved in immunity. © 2015 Pearson Education, Inc. ...
Ras Part II
Ras Part II

... Drosophila melanogaster ...
Welcome to BISC 220 Cell Physiology Lab
Welcome to BISC 220 Cell Physiology Lab

... II. pET-14 = plasmid in this E. coli strain T7 promoter ...
Chemical biology: Chromatin chemistry goes cellular
Chemical biology: Chromatin chemistry goes cellular

... out that they have found a temperature range (67–80 K) where the molecular building blocks have sufficient mobility on the surface to examine many different binding sites, but also note that the cooling rate of the sample is critical in optimizing the ST structures. A cooling rate of only 0.02 K per ...
Weak pairwise correlations imply strongly correlated network states in a neural population
Weak pairwise correlations imply strongly correlated network states in a neural population

... Much of what we know about biological networks has been learned by studying one element at a time—recording the electrical activity of single neurons, the expression levels of single genes or the concentrations of individual metabolites. On the other hand, important aspects of biological function mu ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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