Pyrethroids
... Figure 4: Interaction of Pyrethrum with its receptors occurs at 3 points of the structure. Toxicity Pyrethroids, like OPs and carbamates, are neurotoxins when administered systemically. And, like all other insecticides, they affect nerve cell function. They do not kill cells. Unlike OPs and carbamat ...
... Figure 4: Interaction of Pyrethrum with its receptors occurs at 3 points of the structure. Toxicity Pyrethroids, like OPs and carbamates, are neurotoxins when administered systemically. And, like all other insecticides, they affect nerve cell function. They do not kill cells. Unlike OPs and carbamat ...
Invertebrate Alternatives for Toxicity Testing: Hydra Stakes its
... In vitro assays are fast, cheap, and ethically more acceptable alternatives to animal tests. Miniature in vitro systems are used to generate quantitative data for the dose that produces a certain biological effect, but their use in predicting in vivo effects is still limited. The exact concentration ...
... In vitro assays are fast, cheap, and ethically more acceptable alternatives to animal tests. Miniature in vitro systems are used to generate quantitative data for the dose that produces a certain biological effect, but their use in predicting in vivo effects is still limited. The exact concentration ...
Appendix G3
... The BCOP assay was performed following the methods of Sina et al. (1995). Bovine eyes were obtained from a local abattoir as a by-product from freshly slaughtered animals. The eyes were grossly examined for damage and those exhibiting defects were discarded. The corneas were excised such that a 2 to ...
... The BCOP assay was performed following the methods of Sina et al. (1995). Bovine eyes were obtained from a local abattoir as a by-product from freshly slaughtered animals. The eyes were grossly examined for damage and those exhibiting defects were discarded. The corneas were excised such that a 2 to ...
CNSToxicity
... disturbances and intellectual impairment Histology: gliosis and loss of neurons in basal ganglia ...
... disturbances and intellectual impairment Histology: gliosis and loss of neurons in basal ganglia ...
CNS Toxicity
... disturbances and intellectual impairment Histology: gliosis and loss of neurons in basal ganglia ...
... disturbances and intellectual impairment Histology: gliosis and loss of neurons in basal ganglia ...
Effect of different cyanobacterial biomasses and their fractions with
... While numerous studies focused on the effects of microcystins, the role of other components of complex cyanobacterial water blooms in toxicity is poorly understood. In this study we have evaluated effects of various fractions of cyanobacterial biomass with different composition and microcystin conte ...
... While numerous studies focused on the effects of microcystins, the role of other components of complex cyanobacterial water blooms in toxicity is poorly understood. In this study we have evaluated effects of various fractions of cyanobacterial biomass with different composition and microcystin conte ...
Study of toxic metals (Cd, Pb, Hg and Ni) in rabbits and broiler
... 50 mg/kg of Ni damaged the liver parenchyma induces pathological focal fatty infiltration in broilers and rabbits. The toxic elements (especially the Pb and Hg) reduced the activity of pancreatic amylase, trypsin and total protease, and lipase. A large number of syncytial giant cells and degenerated ...
... 50 mg/kg of Ni damaged the liver parenchyma induces pathological focal fatty infiltration in broilers and rabbits. The toxic elements (especially the Pb and Hg) reduced the activity of pancreatic amylase, trypsin and total protease, and lipase. A large number of syncytial giant cells and degenerated ...
TOX/2013/02 - Committee on Toxicity
... ingestion, aspartame is fully hydrolysed within the gastro-intestinal tract. The products resulting from these reactions are methanol and the amino acids aspartic acid and phenylalanine, which are absorbed and enter normal endogenous metabolic pathways. Hydrolysis of aspartame releases a correspondi ...
... ingestion, aspartame is fully hydrolysed within the gastro-intestinal tract. The products resulting from these reactions are methanol and the amino acids aspartic acid and phenylalanine, which are absorbed and enter normal endogenous metabolic pathways. Hydrolysis of aspartame releases a correspondi ...
TOXICOLOGY I :
... changes not realized until months or years later. They may occur at various levels within the body, such as an organ, a type of cell, or a specific biochemical. Knowledge of how toxic agents damage the body has progressed along with medical knowledge. It is now known that various observable changes ...
... changes not realized until months or years later. They may occur at various levels within the body, such as an organ, a type of cell, or a specific biochemical. Knowledge of how toxic agents damage the body has progressed along with medical knowledge. It is now known that various observable changes ...
Zhongzhou Ointment
... 5, 6. Animal test of acute percutaneous toxicity of each single drug in Zhongzhou Ointment Reported conclusion: actual non-toxic grade Materials of animal acute toxicity tests and references are as follows: Acute Oral Toxicity Test I. Objective: mainly to investigate the acute toxic reaction of Zhon ...
... 5, 6. Animal test of acute percutaneous toxicity of each single drug in Zhongzhou Ointment Reported conclusion: actual non-toxic grade Materials of animal acute toxicity tests and references are as follows: Acute Oral Toxicity Test I. Objective: mainly to investigate the acute toxic reaction of Zhon ...
Assignment on Literature review Submitted by, Ms. Bini
... lipid peroxidation (LPO). Oxidative stress was manifested by induction of LPO as determined by higher malondialdehyde levels. This was accompanied by elevation of Tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) activities. They also found the protective measures of ...
... lipid peroxidation (LPO). Oxidative stress was manifested by induction of LPO as determined by higher malondialdehyde levels. This was accompanied by elevation of Tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) activities. They also found the protective measures of ...
N-(n-butyl) thiophosphoric triamide (NBPT)—secondary
... This assessment report has been prepared by the Director of NICNAS, in accordance with the secondary notification provisions of the Act. Under the Act manufacturers/importers of the chemical are required to notify the Director of new information and apply for assessment. New information can include ...
... This assessment report has been prepared by the Director of NICNAS, in accordance with the secondary notification provisions of the Act. Under the Act manufacturers/importers of the chemical are required to notify the Director of new information and apply for assessment. New information can include ...
Pyrethroid-Induced Reproductive Toxico-Pathology in Non
... liver and testes (Jin et al., 2011). The male infertility and pyrethroid pesticide exposure have been closely associated in various studies (Perry, 2008). Reduced sperm counts in semen or testicular/epididymal tissues of pyrethroid treated rats (Elbetieha et al., 2001), humans (Tan et al., 2002), mi ...
... liver and testes (Jin et al., 2011). The male infertility and pyrethroid pesticide exposure have been closely associated in various studies (Perry, 2008). Reduced sperm counts in semen or testicular/epididymal tissues of pyrethroid treated rats (Elbetieha et al., 2001), humans (Tan et al., 2002), mi ...
Phenol and Its Toxicity: A Case Report
... shock was observed which can be ascribed to the combined effect of gastrointestinal bleeding and dehydration. Phenol is depressant of the nervous system, especially the respiratory centre. Respiratory effects are often characterized by an initial increase in respiratory rate followed by a decrease i ...
... shock was observed which can be ascribed to the combined effect of gastrointestinal bleeding and dehydration. Phenol is depressant of the nervous system, especially the respiratory centre. Respiratory effects are often characterized by an initial increase in respiratory rate followed by a decrease i ...
Zebrafish models for assessing developmental and reproductive
... European Agency for the Evaluation of Medicinal Products (EMEA) have also accepted zebrafish toxicity and safety assessment data for investigative new drug (IND) approval, and more than a dozen of new drugs discovered primarily based on zebrafish models are now in clinical trials (Chakraborty et al., ...
... European Agency for the Evaluation of Medicinal Products (EMEA) have also accepted zebrafish toxicity and safety assessment data for investigative new drug (IND) approval, and more than a dozen of new drugs discovered primarily based on zebrafish models are now in clinical trials (Chakraborty et al., ...
Imported food risk statement Peanuts/pistachios and aflatoxins
... through liver cirrhosis. Long-term sublethal doses have nutritional and immunologic consequences while all doses have a cumulative effect on the risk of liver cancer. Although the incidence of aflatoxin-contaminated foods is higher in developing countries, it has been estimated that aflatoxin may be ...
... through liver cirrhosis. Long-term sublethal doses have nutritional and immunologic consequences while all doses have a cumulative effect on the risk of liver cancer. Although the incidence of aflatoxin-contaminated foods is higher in developing countries, it has been estimated that aflatoxin may be ...
Meeting Agenda - Kubiak Research Group
... AFOSR MURI Novel Catalytic Mechanisms for the Chemical Reduction of Carbon Dioxide to Energy-Dense Liquids Monday, December 9, 2013 NSB Auditorium ...
... AFOSR MURI Novel Catalytic Mechanisms for the Chemical Reduction of Carbon Dioxide to Energy-Dense Liquids Monday, December 9, 2013 NSB Auditorium ...
Toxicity, mechanism and health effects of some heavy metals
... many adverse health effects and last for a long period of time, heavy metal exposure continues and is increasing in many parts of the world. Heavy metals are significant environmental pollutants and their toxicity is a problem of increasing significance for ecological, evolutionary, nutritional and en ...
... many adverse health effects and last for a long period of time, heavy metal exposure continues and is increasing in many parts of the world. Heavy metals are significant environmental pollutants and their toxicity is a problem of increasing significance for ecological, evolutionary, nutritional and en ...
Effects of Marine Toxins on the Reproduction and Early
... 1. Main Marine Toxins Produced by Bacteria and Phytoplankton Many species of marine microorganisms produce toxins that have significant impact in other species such as invertebrates, vertebrates and in many cases, human populations. Among other groups, Bacteria, Cyanobacteria, Diatoms, Crysophytes a ...
... 1. Main Marine Toxins Produced by Bacteria and Phytoplankton Many species of marine microorganisms produce toxins that have significant impact in other species such as invertebrates, vertebrates and in many cases, human populations. Among other groups, Bacteria, Cyanobacteria, Diatoms, Crysophytes a ...
vomitoxin contaminated food intake as an environmental risk factor
... and other studies reported differences in neurotransmitter concentrations in the brain of exposed swine (Prelusky 1992; Prelusky 1993). Furthermore, certain specific serotonin receptor antagonists were able to block DON induced vomiting in swine, as well as intravenous administration of chlorpromazi ...
... and other studies reported differences in neurotransmitter concentrations in the brain of exposed swine (Prelusky 1992; Prelusky 1993). Furthermore, certain specific serotonin receptor antagonists were able to block DON induced vomiting in swine, as well as intravenous administration of chlorpromazi ...
i m. pharm. - Rajiv Gandhi University of Health Sciences
... 6.0 Brief resume of the intended work: 6.1 Need of the study: The asymmetric reduction of ketones is one of the most important, Fundamental and practical reactions for producing non-racemic chiral alcohols, which can be transformed into various functionalities, without racemization, to synthesize i ...
... 6.0 Brief resume of the intended work: 6.1 Need of the study: The asymmetric reduction of ketones is one of the most important, Fundamental and practical reactions for producing non-racemic chiral alcohols, which can be transformed into various functionalities, without racemization, to synthesize i ...
Effect-Based Tools for Monitoring and Predicting
... dangerous levels of carbon monoxide and methane. Standardized biological test methods to measure water quality developed quickly after the US Environmental Protection Agency (US EPA) initiated a national policy in 1984 to control toxic substances based on a water quality approach aimed at the protec ...
... dangerous levels of carbon monoxide and methane. Standardized biological test methods to measure water quality developed quickly after the US Environmental Protection Agency (US EPA) initiated a national policy in 1984 to control toxic substances based on a water quality approach aimed at the protec ...
NELUMBO NUCIFERA
... p.o. Furosimide (20 mg/kg) was used as positive control in study. The diuretic effect of the extract was evaluated by measuring urine volume, sodium, potassium and chloride content. Results: In the normal rats diuresis began with low volumes of urine excreted until completing 24hrs. The level of Na+ ...
... p.o. Furosimide (20 mg/kg) was used as positive control in study. The diuretic effect of the extract was evaluated by measuring urine volume, sodium, potassium and chloride content. Results: In the normal rats diuresis began with low volumes of urine excreted until completing 24hrs. The level of Na+ ...
Exam Study Guide
... Describe the sources of mercury release into the environment. Describe the effect of methylation of mercury on toxicity. In general terms, what species are impacted by methylmercury? ...
... Describe the sources of mercury release into the environment. Describe the effect of methylation of mercury on toxicity. In general terms, what species are impacted by methylmercury? ...
Citrinin
Citrinin is a mycotoxin originally isolated in 1931 by Hetherington and Raistrick from a culture of Penicillium citrinum. It has since been found to be produced by a variety of other fungi that are found or used in the production of human foods, such as grain, cheese, sake, and red pigments. Citrinin has also been found in commercial red yeast rice supplements.