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Adriane Fugh-Berman MD PharmedOut.org Georgetown University
Adriane Fugh-Berman MD PharmedOut.org Georgetown University

... • The majority of these sales were for expensive atypicals • Many sales are for off-label uses *IMS Health Top line industry data ( imshealth.com) ...
4th Quarter 2011 - University Hospital
4th Quarter 2011 - University Hospital

... From the time when Mary first joined The University Hospital in 2008, she has always been a great asset to the Pharmacy Department. While exceeding all expectations at work, Mary has also focused on working toward reaching her biggest dreams of becoming a Clinical Pharmacist, and with such passion f ...
PHANTOM CORPS POWERLIFTING TEAM
PHANTOM CORPS POWERLIFTING TEAM

... In consideration of the acceptance of my entry in this Powerlifting competition I intend to be legally bound, for not only myself but also for my heirs, my executors, and my administrators. I signing this release from liability I waive and release everyone connected with competition from any and all ...
Post marketing surveillance
Post marketing surveillance

... Often, the Benefit/Risk balance of a medicinal product cannot be fully identified until after a drug is on the market and has been used by a large, diverse group of patients over time. Clinical trials conducted before approval may be too small, too short, based on surrogate endpoints….. to detect al ...
Individualizing Antidepressant Therapy Individualizing
Individualizing Antidepressant Therapy Individualizing

... persons aged 5 years and olderaccording to the World Health Organization ...
Full Topic List
Full Topic List

... Byetta, a drug used to treat diabetes, has been linked to acute pancreatitis, a sometimes fatal inflammation of the pancreas. Symptoms of acute pancreatitis include severe abdominal pain. Byetta has also been linked to kidney failure. ...
Eleventh Specialty Pharma Newsletter (December 2009)
Eleventh Specialty Pharma Newsletter (December 2009)

... corrosion, degraded tablet material and hydrocarbon oil with trace amounts of iron were found in tablets. Jan 29 FDA approves new orphan drug Kynamro to treat inherited cholesterol disorder. The U.S. Food and Drug Administration today approved Kynamro (mipomersen sodium) injection as an addition to ...
FORM – Initial Review - UIC Office of the Vice Chancellor for Research
FORM – Initial Review - UIC Office of the Vice Chancellor for Research

... the agent is “investigational (experimental)” and that “an investigational drug is one that is not approved by the Food and Drug Administration (FDA) for the use being studied.” ...
The First Amendment And Off-Label Promotion
The First Amendment And Off-Label Promotion

... including off-label uses not set forth in the approved NDA.8 For some conditions, an off-label use of a medication may reflect the standard of care.9 Therefore, in many cases health insurers, including the federal government, will pay for off-label treatments.10 However, under FDA regulations, if t ...


... “The approval of Periostat tablets by the FDA is an important milestone in the development of our regulatory and commercial strategies,” said Brian Gallagher, PhD, chairman, president and chief executive officer of CollaGenex. “This is our second NDA approval and was achieved less than one year from ...
4941 MD Advisor
4941 MD Advisor

... of prescription drugs and oversee the information provided to physicians, there continues to be much information about drug studies that goes undisclosed. While often too complex for patients to understand, clinical trial results are useful to doctors and academic scientists, who use them to compare ...
The Food and Drug Administration (FDA) - Overview
The Food and Drug Administration (FDA) - Overview

... contaminants. FDA also ensures the purity and effectiveness of biologicals (medical preparations made from living organisms and their products), such as insulin and vaccines. ...
pre-IND status inhaled INV102
pre-IND status inhaled INV102

... Pre-IND meeting confirms company’s regulatory and clinical strategy for inhaled INV102 (nadolol) 3M formulation and device accepted Proposed toxicology program confirmed and underway Proposal for Phase 1 studies accepted Regulatory targets include COPD, severe asthma and cystic fibrosis ...
Dietary Supplements
Dietary Supplements

... extract or combination of above listed ingredients ...
LACHMAN CONSULTANT SERVICES, INC.
LACHMAN CONSULTANT SERVICES, INC.

... B. Statement of Grounds The Federal Food, Drug and Cosmetic Act provides for the submission of an Abbreviated New Drug Application for a drug product that differs in dosage strength from that of the listed drug provided the FDA has approved a petition that proposed filing such an application . The R ...
Slide 1
Slide 1

... word would be spread that physicians were being "systematically forced" to decide who would live and who would die.” $1.8 million unrestricted educational grant for Task Force on “Values, Ethics and Rationing in Critical Care” Support for ‘Surviving Sepsis’ Campaign Funding of treatment guidelines f ...
False negative for hydrocodone
False negative for hydrocodone

... days after last use, but hair samples contain hydrocodone for up to 3 months. More on Over-the-counter cold and allergy remedies that contain ephedrine, pseudoephedrine, propylephedrine. Siemens Rail Automation Siemens Rail Automation purchases additional Kinesix software for their work in train con ...
PV Gaps and FDAAA
PV Gaps and FDAAA

... “[T]he Secretary shall report to the Congress on the ways in which the Secretary has used the active postmarket risk identification and analysis system…to identify specific drug safety signals and to better understand the outcomes associated with drugs marketed in the United States” (FDAAA, section ...
FDA Regulatory Authority
FDA Regulatory Authority

... health by assuring the safety, efficacy and security of human and veterinary drugs, biological products, medical devices, our nations' food supply, cosmetics, and products that emit radiation. The FDA is also responsible for advancing the public health by helping to speed innovations that make medic ...
Grapefruit to Glaucoma
Grapefruit to Glaucoma

... associated with a genetic predisposition toward simvastatinrelated myopathy. The most serious form of myopathy, called rhabdomyolysis, can damage the kidneys and lead to kidney failure which can be fatal. FDA is requiring changes to the simvastatin label to add new contraindications (should not be u ...
Still AwAiting the ‘BioSimilArS’ revolution
Still AwAiting the ‘BioSimilArS’ revolution

... ■■“The FDA process for biosimilars must include product-specific safety monitoring” because “pharmaceutical companies will make manufacturing-related changes to biologics periodically throughout their lifecycles, and even small changes could affect safety or efficacy.” The bottom line is that clinic ...
Antibiotics court order based on what happened, and didn`t happen
Antibiotics court order based on what happened, and didn`t happen

... “In response to the findings of the task force, the FDA (in this article we use “FDA” to designate the Food and Drug Administration or any of its units), in 1973, issued a regulation providing that the agency would propose to withdraw approval of all subtherapeutic uses of antibiotics in animal feed ...
Agenus` (AGEN) IND for AGEN1884 Cleared by FDA
Agenus` (AGEN) IND for AGEN1884 Cleared by FDA

... Agenus Inc. (Nasdaq: AGEN) announced that the U.S. Food and Drug Administration (FDA) cleared the company's investigational new drug (IND) application for AGEN1884, an immune checkpoint modulator (CPM) antibody that binds to cytotoxic T-lymphocyte antigen-4 (CTLA-4). Clearance was also received for ...
Updated Synagis® Guidelines for RSV Prophylaxis
Updated Synagis® Guidelines for RSV Prophylaxis

... prevention of serious lower respiratory tract disease due to RSV in children at high risk of RSV disease. The goal of this update is to provide more specific guidance for identifying those infants and children who are at increased risk for hospitalization due to RSV. The AAP found chronologic age to ...
Pharmacogenetics and the Promise of Individualized Medical Care
Pharmacogenetics and the Promise of Individualized Medical Care

... Roche expected sales this year: $6.5 billion expected sales by 2010: $12 billion ...
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List of off-label promotion pharmaceutical settlements

The following are settlements reached against pharmaceutical companies to resolve allegations of off-label promotion of drugs. Under the Federal Food, Drug, and Cosmetic Act, it is illegal for pharmaceutical companies to promote their products for uses not approved by the Food and Drug Administration (FDA), and corporations that market drugs for off-label indications may be subject to civil liability under the False Claims Act as well as criminal penalties.
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