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Cell Division, Genetics, Molecular Biology
Cell Division, Genetics, Molecular Biology

... - proteins produced by cell determine structure, function & development of cell  Proteins responsible for inherited traits  Sequence of base pairs in DNA makes up genetic code of organism  Genetic code determines how amino acids strung together (how proteins are made) ...
Mutation of Rice BC12/GDD1, Which Encodes a Kinesin
Mutation of Rice BC12/GDD1, Which Encodes a Kinesin

... Showed the same results in “PTCH1” Cell seeding and cell count after 48h. Cell number increase 2 times in patental, control shRNA transfection cell. But, cell proliferation decrease in Gli1-shRNA compare to patental, control shRNA cell. ...
How hair can reveal a history
How hair can reveal a history

... a “short tandem repeat,” a bit of DNA that is repeated multiple times. The exact number of repeats at each locus varies from person to person and can range anywhere between the low single digits to the mid-50s. Because we get one copy of each chromosome from our mother and one from our father, there ...
The Map-based Sequence of the Rice Genome
The Map-based Sequence of the Rice Genome

11. Conceptual Change and Conceptual Diversity Contribute to
11. Conceptual Change and Conceptual Diversity Contribute to

... genetic code and of the basic processes of transcription and translation in the 1960s, the two identities of the gene in classical genetics—the Mendelian and the hypothetical material—converged on a single identity, the molecular gene. Looked at more closely, however, the causal role of the gene had ...
lecture23_AnnotatePr..
lecture23_AnnotatePr..

... transcripts with both manual review and experimental testing procedures PET A short sequence that contains both the 5' and 3' ends of a transcript RACE Rapid amplification of cDNA ends: a technique for amplifying cDNA sequences between a known internal position in a transcript and its 5' end RxFrag ...
reviews - Docentes
reviews - Docentes

... thermophilus LMG 18311, red) and for the extremely thermophilic bacterium Thermotoga maritima (blue). For each encoded protein, BLAST searches were carried out against the proteins in five archaeal genomes (Pyrococcus abyssi, Pyrococcus furiosus, Archaeoglobus fulgidus, Methanocaldococcus jannaschii ...
Consortium for Educational Communication Summary
Consortium for Educational Communication Summary

... (now called gene). For each character there is always a pair of factors involved one each contributed by male and female parents during reproduction. The law of independent assortment states that the distribution of alleles to gametes during meiosis is random. If one particular allele goes to one ga ...
What is the probability that an offspring will have black fur?
What is the probability that an offspring will have black fur?

... law of segregation the two factors for each trait segregate or separate from each other during meiosis when gametes form law of independent assortment the factors for one trait separate independently of how factors for other traits separate allele each form of a gene with different information pheno ...
Document
Document

... In eukaryotes, nuclear chromosomes are packaged by proteins into a condensed structure called chromatin. This allows the very long DNA molecules to fit into the cell nucleus. The structure of chromosomes and chromatin varies through the cell cycle. Chromosomes are the essential unit for cellular div ...
Genetic engineering - Dr. Salah A. Martin
Genetic engineering - Dr. Salah A. Martin

... In medicine genetic engineering has been used to mass produce insulin, human growth hormones, follistim (for treating infertility), human albumin, monoclonal antibodies, antihemophilic factors, vaccines and many other drugs. Vaccination generally involves injecting weak live, killed or inactivated f ...
Appendix S1.
Appendix S1.

... At the same time, using 14 genes (LUM, HGF, MET, MYOC, PAX6, COL1A1, COL2A1, TGFB1, TGIF, UMODL1, MMP1, MMP3, MMP9 & NYX) [1-22] reported to be associated with myopia as a training set for in silico prioritization tool Endeavour [23,24], all genes identified from the MYP6 locus were prioritized comp ...
video slide
video slide

... expression by blocking the binding of activators to their control elements or to components of the transcription machinery or by turning off transcription even in the presence of activators. ...
HIGH FREQUENCY GENE TARGETING USING INSERTIONAL
HIGH FREQUENCY GENE TARGETING USING INSERTIONAL

http://www.med.wisc.edu/news/item.php?id=3922 Lifestyle Choices
http://www.med.wisc.edu/news/item.php?id=3922 Lifestyle Choices

... Rakel cites a 2007 review by Dr. Steven Schroeder of the University of California-San Francisco. Schroeder‟s study concluded that the largest influence on the risk of death in America is attributed to personal behavior, such as smoking, obesity, and stress. The paper adds that, even if top-notch hea ...
Review of BASIC transmission genetics
Review of BASIC transmission genetics

... These “non-Mendelian” ratios indicate linkage between these two genes. Linkage means these genes are on the same chromosome. How close are they? We measure the GENETIC distance between 2 genes using % recombination (= “map units” = centiMorgans= cM). Genetic distance is solely based on recombination ...
Genes
Genes

... maternal traits is unique for each individual child ...
Supplementary Figure legends
Supplementary Figure legends

... JAK/STAT reporter assay (4×socsLuc) employed to exclude reporter-specific artefacts. Data analysis and representation were performed using R and Bioconductor11. ...
Variations to Mendelian Genetics
Variations to Mendelian Genetics

... • Females get sex linked diseases less often than males because statistically it is harder to inherit two “bad/lethal genes” than it is to inherit one. ...
Exam 1 Name Mcbio 316 - Page 1- Q1. Mutants defective for the
Exam 1 Name Mcbio 316 - Page 1- Q1. Mutants defective for the

... Because they are unable to proofread errors that occur during DNA replication, such strains accumulate mutations at a high frequency. The resulting large number of "lethal mutations" that arise during cell division slows the growth of the colonies. The mutation frequency is highest when the cells ar ...
Chapter 2 lesson 2
Chapter 2 lesson 2

... • Last week Craig Venter, the lead scientist at Celera Corporation in Maryland, announced that his team had cracked the chemical code for every human gene. • This breakthrough is likely to lead to great medical advances. Knowing detailed information about human genes could help millions of people wh ...
Inheritance - CCRI Faculty Web
Inheritance - CCRI Faculty Web

... Monohybrid Cross • Cross between parent plants that differ in only one characteristic – Mendel developed four hypotheses from the monohybrid cross: • There are alternative forms of genes – Alleles ...
1 Incomplete Dominance: A type of intermediate inheritance
1 Incomplete Dominance: A type of intermediate inheritance

... • Two or more genes (Poly) affect one characteristic of an organism. • Ex: There are multiple genes for height in humans. – Humans inherit three alleles for height from three separate height genes from each parent. – Someone inherits only tall alleles from their father and only short alleles from th ...
goals - s3.amazonaws.com
goals - s3.amazonaws.com

... • This sequence is referred to as an Alu sequence after a restriction enzyme site that is located within this 300 base pair length of DNA. ...
HW10 Answer Key
HW10 Answer Key

... proteins that act in several different ways to either remove nucleosomes from DNA, alter the location of nucleosomes (on or off of promoters), or alter the structure of nucleosomes (making promoter sequences more or less available) 10 points if inhibitory function and ability to be regulated are des ...
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Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
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