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Bioinformatics - Sequences and Computers
Bioinformatics - Sequences and Computers

... contain information that is realized by readers, the sequence of nucleotides in DNA contains information that is realized by the gene expression machinery of cells. Just as documents may provide information that stimulates readers to act on something (like adopting a new life style), genes contain t ...
A hierarchical unsupervised growing neural network for
A hierarchical unsupervised growing neural network for

... networks have a series of properties that make them suitable for the analysis of gene expression patterns. They can deal with real-world data sets containing noisy, illdefined items with irrelevant variables and outliers, and whose statistical distributions do not need to be parametric ones. SOM are ...
GAlibLecture
GAlibLecture

... (GA1DArrayAlleleGenome &)ga.statistics().bestIndividual(); cout << "The GA found:\n" << ga.statistics().bestIndividual() << " "; cout<< "Its sum is:"; int s=0; ...
Genetic analysis of acidocin B, a novel bacteriocin
Genetic analysis of acidocin B, a novel bacteriocin

... transformants cultivated in MRS broth containing erythromycin was assayed for the presence of acidocin B using C. sporogenes as indicator strain in a plate assay. T h e results (Fig. 1) show that the smallest fragment that confers the capacity to produce acidocin B is contained within a 4 kb XbaI-Ba ...
Sex-Linked Genes - Doctor Jade Main
Sex-Linked Genes - Doctor Jade Main

... • for each inherited characteristic an organism must have 2 genes – one from each parent • maybe the same or different • two of same allelehomozygous • two different allelesheterozygous ...
DNA Structure - StudyTime NZ
DNA Structure - StudyTime NZ

... Mutations are the only way of creating totally new alleles in a species ...
What is a Gene?
What is a Gene?

... genes of Avar. You generalized SEQUENCE-OF over all genes before, you will recall. This time, however, confine your attention to those genes that encode proteins. To do this, note that by mousing over the GENOME button and then the GENOME-ELEMENTS sub-menu, you’ll see a provocative function called C ...
Antisense derivatives of U7 small nuclear RNA as
Antisense derivatives of U7 small nuclear RNA as

... particular of U7 snRNA, have been widely used for this purpose [1]. Apart from the advantage that the antisense RNA accumulates as part of a stable small nuclear ribonucleoprotein (snRNP), U7 snRNA expression cassettes, with their small size, will fit into all types of gene therapy vectors so that t ...
LP7 - Inheritance and Genetic Diseases
LP7 - Inheritance and Genetic Diseases

...  Hemochromatosis (iron overload) indicates accumulation of iron in the body from any cause. The most important causes are hereditary hemochromatosis (HHC), a genetic disorder. The gene responsible for hereditary hemochromatosis (known as HFE gene) is located on chromosome 6; the majority of heredit ...
Why does the giraffe have such a long neck? Analysis zeroes in on
Why does the giraffe have such a long neck? Analysis zeroes in on

... at the genomes of possible subspecies of giraffe. A subspecies is another group within a species with shared qualities. The scientists will try to learn whether the possible giraffe subspecies are actually different from one another. If the subspecies are distinct from one another, then some of the ...
Gregor Mendel Garden Pea Monohybrid Cross
Gregor Mendel Garden Pea Monohybrid Cross

... • Each individual can only have 2 alleles • Number of alleles possible for any gene is constrained, but usually more than two alleles exist for any gene in an ...
Extremophiles - University of Arizona
Extremophiles - University of Arizona

... will be about 150 degrees C. Above this various diseases, including specific forms much of the year. These communities include photosynthetic eukarya, notably temperature, probably no life-forms of cancer. could prevent dissolution of the chemiIn PCR, an enzyme known as a DNA algae and diatoms, as w ...
1548 Tn Gene Is Borne by Composite Transposon Aminoglycoside
1548 Tn Gene Is Borne by Composite Transposon Aminoglycoside

... 17); (ii) enzymatic modification of the drug (21), primarily through N-acetylation, O-nucleotidylation, or O-phosphorylation, which is the most common mechanism; (iii) modification of the target by mutation in ribosomal proteins or in 16S rRNA (18); and (iv) trapping of the drug (13, 14). Microorgan ...
breeding an alpaca industry
breeding an alpaca industry

... Why is it a beginning? Because then we can start to use the results to influence genetic selection with some certainty . How long will it take? Many years, possibly between 5 and 10. ...
Prenatal diagnosis of phenylketonuria
Prenatal diagnosis of phenylketonuria

... 172,369 newborns in Bangalore, detected six cases of PKU (1 in 28728 screened). PKU induced mental retardation can be prevented by a phenylalanine restricted diet, the special diet is difficult to obtain in India, and is expensive. It is not surprising therefore, that in India, most parents having a ...
chapter_16
chapter_16

... Nullisomy = loss of one homologous chromosome pair. Monosomy = loss of a single chromosome. Trisomy = one extra chromosome. ...
Characterization of the soil microbial community associated with the
Characterization of the soil microbial community associated with the

...  ð1 mol bp DNA=660 g DNAÞ ...
Chapter 6 - VU Research Portal
Chapter 6 - VU Research Portal

... and deletions. Mutations in intron 2 occur in 94% of the patients. All patients are compound heterozygous, with the exception of four patients from two families 57,58 for which homozygosity was described. The severity of the disease differs substantially between these patients with homozygous mutati ...
(Part 1) Eolution and Development
(Part 1) Eolution and Development

... Homeotic genes and evolution 2. Each gene has distinctive 180 bp homeobox domain • the homeobox is a DNA binding motif. 3. Perfect correlation between 3’-5’ order of genes and their embryonic expression/targets • genes at 3’ end of cluster expressed in head. • genes at 5’ end expressed in most post ...
Genetics Review for USMLE (Part 2) Single Gene Disorders Some
Genetics Review for USMLE (Part 2) Single Gene Disorders Some

Chromosomes and Genes - hrsbstaff.ednet.ns.ca
Chromosomes and Genes - hrsbstaff.ednet.ns.ca

... The remaining pair of human chromosomes consists of the sex chromosomes, X and Y. Females have two X chromosomes, and males have one X and one Y chromosome. In females, one of the X chromosomes in each cell is inactivated and known as a Barr body. This ensures that females, like males, have only one ...
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DNA Testing Procedures - American Hereford Association
DNA Testing Procedures - American Hereford Association

... inherits two alleles of each gene, one from its sire and one from its dam. These two alleles can be identical (making the animal homozygous), or different (making the animal heterozygous) for any given gene. DNA: Deoxyribonucleic acid (DNA) is a nucleic acid present in the cells of all living organi ...
Lessons from genetics: interpreting complex phenotypes in RNAi
Lessons from genetics: interpreting complex phenotypes in RNAi

... The process of endocytosis has a crucial role in the maintenance of cell physiology and homeostasis [4,5]. Endocytosis regulates a broad spectrum of signaling processes, ranging from cell migration and cell adhesion to anchorage-dependent cell growth, cell proliferation, and polarity of the cell [6– ...
View/print full test page
View/print full test page

... This panel includes both sequencing and high resolution deletion/duplication analysis of the genes specified. o Sequencing is performed using a customized next generation sequencing library. Analysis includes the coding exons of all genes in the panel plus ten bases into the introns and untranslated ...
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Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
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