Differential Network Analysis
... pval1=(logicalSum1+1)/(no.perms+1) pval1 pval2=(logicalSum2+1)/(no.perms+1) pval2 pval3=(logicalSum3+1)/(no.perms+1) pval3 pval4=(logicalSum4+1)/(no.perms+1) pval4 pval5=(logicalSum5+1)/(no.perms+1) pval5 pval6=(logicalSum6+1)/(no.perms+1) pval6 pval7=(logicalSum7+1)/(no.perms+1) pval7 pval8=(logica ...
... pval1=(logicalSum1+1)/(no.perms+1) pval1 pval2=(logicalSum2+1)/(no.perms+1) pval2 pval3=(logicalSum3+1)/(no.perms+1) pval3 pval4=(logicalSum4+1)/(no.perms+1) pval4 pval5=(logicalSum5+1)/(no.perms+1) pval5 pval6=(logicalSum6+1)/(no.perms+1) pval6 pval7=(logicalSum7+1)/(no.perms+1) pval7 pval8=(logica ...
Structure and evolution of plant disease resistance genes
... The NBS-LRR type of genes is abundant in plant species. For example, in Arabidopsis it is estimated that at least 150 different NBS-LRR genes exist comprising up to 1% of the genome (MEYERS et al. 1999). The homology between resistance proteins led to a suggestion that they may function in a conserv ...
... The NBS-LRR type of genes is abundant in plant species. For example, in Arabidopsis it is estimated that at least 150 different NBS-LRR genes exist comprising up to 1% of the genome (MEYERS et al. 1999). The homology between resistance proteins led to a suggestion that they may function in a conserv ...
The Compound-Heterozygous Filter
... lower the kinship of the parents the higher is the chance that two different mutant alleles of the disease-causing gene are present. Hence, this can be translated into a simple rule of thumb: If the parents are nonconsanguineous, compound heterozygosity is the likeliest explanation for a recessive d ...
... lower the kinship of the parents the higher is the chance that two different mutant alleles of the disease-causing gene are present. Hence, this can be translated into a simple rule of thumb: If the parents are nonconsanguineous, compound heterozygosity is the likeliest explanation for a recessive d ...
Genomic tools and Drug resistance dmedupe
... using the above mentioned methods. This achievement made it possible to study resistance at the molecular level because the genotypes of resistant and sensitive parasites can be compared to learn which mutations lead to resistance. It would be very costly and labor intensive to try to sequence the g ...
... using the above mentioned methods. This achievement made it possible to study resistance at the molecular level because the genotypes of resistant and sensitive parasites can be compared to learn which mutations lead to resistance. It would be very costly and labor intensive to try to sequence the g ...
Down Syndrome: From Understanding the Neurobiology to Therapy
... temporal areas and cerebellum. Lenticular nuclei as well as posterior parietal and occipital cortical gray matter are relatively preserved. For unknown reasons, the parahippocampal gyrus appears larger in DS than in the typical population. Recent evidence also points to a nonmotor contribution from ...
... temporal areas and cerebellum. Lenticular nuclei as well as posterior parietal and occipital cortical gray matter are relatively preserved. For unknown reasons, the parahippocampal gyrus appears larger in DS than in the typical population. Recent evidence also points to a nonmotor contribution from ...
Bioinfo primer - part 6/6
... • High throughput technologies give us long lists of the parts of systems (chromosomes, genomes, cells, etc). We can now analyse how they work together to produce the complexity of the organisms. • The function of the genome is – Metabolism: metabolic pathways convert chemical energy derived from fo ...
... • High throughput technologies give us long lists of the parts of systems (chromosomes, genomes, cells, etc). We can now analyse how they work together to produce the complexity of the organisms. • The function of the genome is – Metabolism: metabolic pathways convert chemical energy derived from fo ...
Phenotype association
... unrelated patients with DCM. One missense mutation (Arg975Trp) and one 3-bp deletion (Leu954del) were identified. These mutations involved conserved amino acids, were absent in 500 control individuals, and significantly altered metavinculin-mediated cross-linking of actin filaments in an in vitro as ...
... unrelated patients with DCM. One missense mutation (Arg975Trp) and one 3-bp deletion (Leu954del) were identified. These mutations involved conserved amino acids, were absent in 500 control individuals, and significantly altered metavinculin-mediated cross-linking of actin filaments in an in vitro as ...
Linkage, Recombination, and Crossing Over
... indistinguishable from non‐recombinant cells, there are not useful for mapping, but are nonetheless derived from a crossover event. ...
... indistinguishable from non‐recombinant cells, there are not useful for mapping, but are nonetheless derived from a crossover event. ...
Embryonic Development
... 2. Maternal Substances – located in the egg (mRNA, proteins, organelles) are unevenly distributed *Subsequent cells (after fertilization) will receive unequal amounts of these – this leads to cell differentiation ...
... 2. Maternal Substances – located in the egg (mRNA, proteins, organelles) are unevenly distributed *Subsequent cells (after fertilization) will receive unequal amounts of these – this leads to cell differentiation ...
Population Genetics:
... Here we have calculated frequencies for two "populations" as defined by political/geographic basis and we see large differences in the frequencies of the two alleles. Both populations have both alleles, the only thing that differs is the relative frequencies: this is the basis for differences among ...
... Here we have calculated frequencies for two "populations" as defined by political/geographic basis and we see large differences in the frequencies of the two alleles. Both populations have both alleles, the only thing that differs is the relative frequencies: this is the basis for differences among ...
Mitosis - Meiosis Lab
... spore coat color and the centromere. The probability of a crossover occurring between two particular genes on the same chromosome (linked genes) increases as the distance between those genes becomes larger. The frequency of crossover, therefore, appears to be directly proportional to the distance be ...
... spore coat color and the centromere. The probability of a crossover occurring between two particular genes on the same chromosome (linked genes) increases as the distance between those genes becomes larger. The frequency of crossover, therefore, appears to be directly proportional to the distance be ...
3.6 Genetics pp - 7th-grade-science-mississippi-2010
... If one parent has detached earlobes and the other parent has attached earlobes, and all of their children have detached earlobes, which trait is dominant? ...
... If one parent has detached earlobes and the other parent has attached earlobes, and all of their children have detached earlobes, which trait is dominant? ...
Practice exam (2012)
... 2. (10 pts) Describe the two essential components of the genetic module that translates a smooth gradient of BCD protein concentration into a sharp boundary of Hb expression in the fly embryo. Both components are associated with distinct structural features of the upstream regulatory sequences of th ...
... 2. (10 pts) Describe the two essential components of the genetic module that translates a smooth gradient of BCD protein concentration into a sharp boundary of Hb expression in the fly embryo. Both components are associated with distinct structural features of the upstream regulatory sequences of th ...
Gene Section CLTC (clathrin heavy polypeptide) Atlas of Genetics and Cytogenetics
... deregulated expression driven by its constitutively activated promoter and constitutive oligomerization of the chimeric protein via the CLTC multimerization domains normally used for clathrin coat assembly. Since ALK is a tyrosine kinase that is activated by cross-phosphorylation following ligand bi ...
... deregulated expression driven by its constitutively activated promoter and constitutive oligomerization of the chimeric protein via the CLTC multimerization domains normally used for clathrin coat assembly. Since ALK is a tyrosine kinase that is activated by cross-phosphorylation following ligand bi ...
TPJ_4378_sm_FigS1-7
... 40 adult apterous aphids were released at the center of a pot containing one WT and one mutant or transgenic plant, equidistant from the two plants. The number of the released insects that had settled on each plant was determined 24, 48 and 72 h after release. Values are the average of adult aphid n ...
... 40 adult apterous aphids were released at the center of a pot containing one WT and one mutant or transgenic plant, equidistant from the two plants. The number of the released insects that had settled on each plant was determined 24, 48 and 72 h after release. Values are the average of adult aphid n ...
genetics - cloudfront.net
... Mendel discovered that each trait is controlled by two factors (alleles) Alleles – different versions of a gene ( represented by letters: T or t) Genes – factors that determine your traits Genes are located on chromosomes ...
... Mendel discovered that each trait is controlled by two factors (alleles) Alleles – different versions of a gene ( represented by letters: T or t) Genes – factors that determine your traits Genes are located on chromosomes ...
Document
... Consider a cross between a pea plant that is heterozygous for round seeds and a pea plant that has wrinkled seed. The allele for round seeds is dominant (R) over that for wrinkled seeds (r). Determine the genotypes of the offspring and indicate both the ...
... Consider a cross between a pea plant that is heterozygous for round seeds and a pea plant that has wrinkled seed. The allele for round seeds is dominant (R) over that for wrinkled seeds (r). Determine the genotypes of the offspring and indicate both the ...
DMD Reviews 85 - Action Duchenne
... major hurdle for the creation of AAV-vector based therapy for the treatment of Duchenne Muscular Dystrophy (DMD). This is the great size of the Dystrophin gene, whose coding sequence is about 11.2kb (kilobases), while the packaging capacity of the AAV is only 5kb. While there have been some studies ...
... major hurdle for the creation of AAV-vector based therapy for the treatment of Duchenne Muscular Dystrophy (DMD). This is the great size of the Dystrophin gene, whose coding sequence is about 11.2kb (kilobases), while the packaging capacity of the AAV is only 5kb. While there have been some studies ...
MSWord
... of microarray gene expression datasets (Culhane et al., 2003). CIA is a multivariate method that identifies trends or co-relationships in multiple datasets which contain the same samples. That is either the rows or the columns of a matrix must be "matchable". CIA can be applied to datasets where the ...
... of microarray gene expression datasets (Culhane et al., 2003). CIA is a multivariate method that identifies trends or co-relationships in multiple datasets which contain the same samples. That is either the rows or the columns of a matrix must be "matchable". CIA can be applied to datasets where the ...
Hepatic Model Comparison For the scope of studying multi
... charge balanced, improving upon Recon 1 transporters. Currently, two hepatic metabolic reconstructions are available [1,2]. The Jerby network is an automated reconstruction, derived from Recon 1. The Gille network was manually reconstructed including components from Recon 1 and additional hepatic me ...
... charge balanced, improving upon Recon 1 transporters. Currently, two hepatic metabolic reconstructions are available [1,2]. The Jerby network is an automated reconstruction, derived from Recon 1. The Gille network was manually reconstructed including components from Recon 1 and additional hepatic me ...
Human Gene Therapy
... for the first time opening the real possibility of using intact human genes for the treatment of gene diseases. These resources have already proved extremely popular for gene mapping, isolation and sequencing. Similarly, the use of fully sequenced genomic fragments from PAC/BAC libraries for function ...
... for the first time opening the real possibility of using intact human genes for the treatment of gene diseases. These resources have already proved extremely popular for gene mapping, isolation and sequencing. Similarly, the use of fully sequenced genomic fragments from PAC/BAC libraries for function ...
view pdf - University of Arizona
... genes) cell types, usually with one cell type showing a higher level of expression. The expression of a subset of these genes was also analysed during megagametogenesis and early seed development. For example, 12 genes were transcriptionally active in the developing embryo and/or endosperm. These re ...
... genes) cell types, usually with one cell type showing a higher level of expression. The expression of a subset of these genes was also analysed during megagametogenesis and early seed development. For example, 12 genes were transcriptionally active in the developing embryo and/or endosperm. These re ...
Gene expression profiling
In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment. Many experiments of this sort measure an entire genome simultaneously, that is, every gene present in a particular cell.DNA microarray technology measures the relative activity of previously identified target genes. Sequence based techniques, like serial analysis of gene expression (SAGE, SuperSAGE) are also used for gene expression profiling. SuperSAGE is especially accurate and can measure any active gene, not just a predefined set. The advent of next-generation sequencing has made sequence based expression analysis an increasingly popular, ""digital"" alternative to microarrays called RNA-Seq. However, microarrays are far more common, accounting for 17,000 PubMed articles by 2006.