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... their encoded proteins are now very different  For example the lysozyme gene was duplicated and evolved into the gene that encodes -lactalbumin in mammals  Lysozyme is an enzyme that helps protect animals ...
Chromatin, DNA methylation and neuron gene regulation — the
Chromatin, DNA methylation and neuron gene regulation — the

... Molecular links between DNA methylation and chromatin remodelling Activation or repression of gene transcription is correlated with the acetylation status of nucleosomal histone proteins, especially those in the vicinity of gene promoters. The enzymes that perform histone acetylation (histone acetyl ...
Document
Document

... their encoded proteins are now very different  For example the lysozyme gene was duplicated and evolved into the gene that encodes -lactalbumin in mammals  Lysozyme is an enzyme that helps protect animals ...
Analyses of human–chimpanzee orthologous gene
Analyses of human–chimpanzee orthologous gene

... mouse, and rat orthologs. The orthology of these gene alignments is considered unambiguous. Ka/Ks ratios for each alignment were previously calculated by the Chimpanzee Sequencing and Analysis Consortium (2005) as well as estimates of lineage-specific protein changes. Given the similarity between hu ...
The causes and molecular consequences of polyploidy
The causes and molecular consequences of polyploidy

... percentage of viable X, 2X, or 3X gametes. These gametes can then hybridize with other X, 2X, or 3X gametes to generate plants of higher ploidy levels (Fig. 1E). Hence, triploid plants are regarded as a bridge toward polyploidy (triploid bridge), rather than a dead end (triploid block).12 Currently, ...


... Central Dogma of Biology The information for making proteins is stored in DNA. There is a process (transcription and translation) by which DNA is converted to protein. By understanding this process and how it is regulated we can make predictions and models of cells. Assembly ...
uncorrected page proofs
uncorrected page proofs

... the X chromosome? Refer to the box on page xxx to read about the crosses involving an X-linked gene that were carried out by TH Morgan. Morgan was the first to demonstrate that one particular gene was located on one particular chromosome (refer to figure 14.1). People normally have three colour rece ...
Influence of industrial contamination on mobile genetic elements
Influence of industrial contamination on mobile genetic elements

... The acquisition of new genetic material via horizontal gene transfer allows bacteria to rapidly evolve. One key to estimating the contribution of horizontal gene transfer to bacterial evolution is to quantify the abundance of mobile genetic elements (MGEs) in bacterial communities under varying degr ...
Chapter 9, 10, and 11
Chapter 9, 10, and 11

Dogs for trait mapping activity
Dogs for trait mapping activity

... We are a group of scientists trying to find the gene responsible for an orange spot in dogs. Dogs are diploid just like humans, which means that they have two copies (alleles) of each gene. For this exercise, the dominant allele is indicated by “A” and the recessive allele is indicated by “a”. Prete ...
Three Point Linkage Problems
Three Point Linkage Problems

... The piglets grow up, and someone is foolish enough to let them breed. 80 offspring are produced. What gametes are made and in what frequency? (in other words, work backwards. You are filling numbers into the data chart that we usually give you!) Remember distances between loci represent recombinatio ...
DISPERSAL, GENE FLOW, AND ISOLATION
DISPERSAL, GENE FLOW, AND ISOLATION

... conclusion. Different estimators of FST (e.g., Nei 1973; Weir & Cockerham 1984) perform about equally well for moderate to low levels of gene flow. Genealogical Methods More on this in the PowerPoint presentation given during lecture. Genealogical methods also exist for estimating Nm and isolation b ...
p53
p53

... lower number of genes at any given time. – Differences between cell types are NOT due to different genes but to different gene expression by cells with the same genome. ...
Gene Section FHIT (fragile histidine triad) Atlas of Genetics and Cytogenetics
Gene Section FHIT (fragile histidine triad) Atlas of Genetics and Cytogenetics

Gene - CS273a
Gene - CS273a

Pr-P-105
Pr-P-105

... alcoholic volatiles were linaloxide I, u-Terpineol, cis-linaloloxide, 1,6-octadien-3-01 and 3,7-dimethyl. Levels of these volatiles increased after UV-B treatment for 10 min and then decreased. The same tendency was also found in other alcoholic volatiles such as phenylethyl alcohol, benzyl alcohol ...
Evolutionary Genomics of Fast Evolving Tunicates
Evolutionary Genomics of Fast Evolving Tunicates

... species. In the species from the genus Ciona, which also have undergone a similar, yet less extreme, process of genome compaction, gene density is between three (C. intestinalis) and four (C. savignyi) times lower than O. dioica (see table 1 for details on genome sizes and gene numbers). In turn, in ...
Practical Platy Genetics
Practical Platy Genetics

... America, where he collected many different species for his personal collection and possibly for sale to exotic animal collectors. It is very reasonable to assume he was the first European collector of platys! Fifty years later, Dr. Myron Gordon was an early researcher of platys and swordtails. Both ...
ppt - Chair of Computational Biology
ppt - Chair of Computational Biology

... disequilibrium (LD) with one another, and the numbers on the bottom indicate each of the 12 SNPs. SNP 9 is the causal variant, which in this simple example determines drug response: allele C results in a therapeutic response, whereas allele G results in an adverse reaction. In this example, the sele ...
LOTUS-DB: an integrative and interactive database for
LOTUS-DB: an integrative and interactive database for

... (3). Sacred lotus seed is one of the world’s longest living seeds (1300 years) (1). These facts led scientists to believe that sacred lotus might hold the key to the secret of aging. In addition, its nanoscopic closely packed protuberances of petals and leaves could repel grime and water, which is t ...
Grapes are Divine - Michigan Agriculture in the Classroom
Grapes are Divine - Michigan Agriculture in the Classroom

... Tell the students that each of them has genes that determine traits like their eye-color, hair color, height, and the ability to curl their tongues. Explain that plants, like grapes have genes too. When scientists find a trait they like, they use genetics to find out how to produce that trait. ...
Document
Document

... • Transcription = transcribe DNA code into RNA (uses same ‘language’ of nucleic acids) • Translation = translate nucleic acid code into a sequence of amino acids (the primary structure of polypeptides) • Post-translational modification = chemical modification to activate a protein so it can function ...
Chapter 20
Chapter 20

... The use of cultured eukaryotic cells as host cells and yeast artificial chromosomes (YACs) as vectors helps avoid gene expression problems YACs behave normally in mitosis and can carry more DNA than a plasmid Eukaryotic hosts can provide the posttranslational modifications that many proteins ...
Bioinformatics - University of Colorado Denver
Bioinformatics - University of Colorado Denver

... (Created in part by: April Bednarski Advised by: Professor Himadri Pakrasi, Funded by a grant from: Howard Hughes Medical Institute to Washington University) First, briefly read through the glossary; you may need it during this exercise. I expect you to look through the glossary in more detail when ...
PubMed Advanced: Linking PubMed to NCBI Genetics Databases
PubMed Advanced: Linking PubMed to NCBI Genetics Databases

... Not the same as keyword searching! Ex: SOD1 becomes “superoxide dismutase 1[substance name]” ...
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Gene expression profiling



In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment. Many experiments of this sort measure an entire genome simultaneously, that is, every gene present in a particular cell.DNA microarray technology measures the relative activity of previously identified target genes. Sequence based techniques, like serial analysis of gene expression (SAGE, SuperSAGE) are also used for gene expression profiling. SuperSAGE is especially accurate and can measure any active gene, not just a predefined set. The advent of next-generation sequencing has made sequence based expression analysis an increasingly popular, ""digital"" alternative to microarrays called RNA-Seq. However, microarrays are far more common, accounting for 17,000 PubMed articles by 2006.
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