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2016 Research projects booklet - School of Population Health
2016 Research projects booklet - School of Population Health

... opportunities of the highest calibre. You’ll work closely with an expert supervisor on a specific research topic to produce a thesis of significant academic scholarship and originality. Research training at the School of Population Health can lead to the award of undergraduate Honours or a postgradu ...
Tumour necrosis factor and lymphotoxin A progression? EDITORIAL
Tumour necrosis factor and lymphotoxin A progression? EDITORIAL

... smoked in their life but who have developed COPD. It is possible that within this type of subject, genes other than those that are important for the development of COPD in smokers play a role. Therefore, we advocate additional studies on the genetics of COPD in these subjects, probably in relation t ...
Rapid divergence and diversification of mammalian duplicate gene
Rapid divergence and diversification of mammalian duplicate gene

... While small Ne is also thought to result in a higher prevalence of subfunctionalization [34], this process does not appear to play a major role in the retention of duplicate genes in either lineage. One possible reason for this observation is that subfunctionalization may be more common in duplicate ...
Bacterial Contamination of Platelets: Summary for Clinicians
Bacterial Contamination of Platelets: Summary for Clinicians

... diagnosis of posttransfusion illness because signs and symptoms (including fever, rigors, and change in blood pressure) resemble those expected from either an immunologicallymediated transfusion reaction or from sepsis associated with underlying diseases and therapies. Gram-positive organisms (eg, S ...
Characterization of Two ENU-Induced Mutations Affecting Mouse
Characterization of Two ENU-Induced Mutations Affecting Mouse

... phenotype (Moffatt et al. 2007). Together, these data suggest that an accumulation of NPR-C ligands in the Skm1 mice may contribute to the skeletal phenotype. More recently, using a genome-wide analysis, NPR3 was shown to be associated with overall body height and trunk length in humans (Soranzo et ...
Evolutionary divergence and functions of the ADAM and ADAMTS
Evolutionary divergence and functions of the ADAM and ADAMTS

... motifs’ (ADAMTS) genes make up two similar, yet distinct, gene families. The human and mouse genomes contain 21 and 24 putatively functional protein-coding ADAM genes, respectively, and 24 versus 32 putatively functional protein-coding ADAMTS genes, respectively. Analysis of evolutionary divergence ...
Barriers to Weight Loss in Patients with Primary
Barriers to Weight Loss in Patients with Primary

... their health (benefit) and/or alleviate the severity of their chronic diseases (benefit) in order for them to adopt new measures for weight loss. They must be willing to overcome barriers (e.g. hunger, going to classes, changes buying habits, etc.) to do this. Perceived Self-efficacy Self-efficacy r ...
Section of Neuro-Infectious Disease Strategic Plan
Section of Neuro-Infectious Disease Strategic Plan

... neurology have provided a pathway for neurology residents to pursue interests in NID. A NID Fellowship has recently been established at Johns Hopkins University. The NIH budget situation and potential cuts to Medicare reimbursement have challenged scientists and clinicians, including NID subspeciali ...
Health Related Quality of Life in Children with Osteoporosis: By
Health Related Quality of Life in Children with Osteoporosis: By

... Clinical care providers today are more aware and have a better understanding of how osteoporosis affects a child’s quality of life and their ability to function. Fractures result in pain and suffering for children with this chronic illness and there is often a further reduction in mobility, independ ...
Integrating Genetic and Network Analysis to Characterize Genes
Integrating Genetic and Network Analysis to Characterize Genes

... "Gene Connectivity, Function, and Sequence Conservation: Predictions from Modular Yeast Co-Expression Networks" (2006) by Carlson MRJ, Zhang B, Fang Z, Mischel PS, Horvath S, and Nelson SF, BMC Genomics 2006, 7:40 How to integrate SNP markers into weighted gene co-expression network analysis? The fo ...
Rhodococcus - case study IJTLD
Rhodococcus - case study IJTLD

Ensembl Introduction
Ensembl Introduction

... the UCSC and NCBI Browsers? • The gene set. Automatic annotation based on mRNA and protein information. ...
It`s all about the patient: bringing new cystic fibrosis treatments to life
It`s all about the patient: bringing new cystic fibrosis treatments to life

... use lung function as an inclusion or exclusion criterion can (perhaps unintentionally) dictate the age of the population that can access the study. For example, older patients will have been exposed to more infections, so are more likely to have reduced lung function compared with younger patients. ...
Tracking the evolution of 3D gene organization demonstrates its
Tracking the evolution of 3D gene organization demonstrates its

... (6,7,11) and TF binding sites (8,12). In addition, genes encoding interacting proteins, that form protein complexes and genes along the same pathway have been shown to be co-localized in 3D in human (10). Chromosomes’ 3D conformation has been shown to be related to tissue-specific regulation (13,14) ...
Thyroid Disease: The Hidden Epidemic Michael Cheikin MD Holistic
Thyroid Disease: The Hidden Epidemic Michael Cheikin MD Holistic

... toward thyroid and auto-immune disease. However, as discussed in prior articles, these genes are like switches that can be turned on or off by factors under our control. Most authors agree (and is evidenced by studies of identical twins raised in different environments) that only 20% of our illness ...
Maine Medical Center Research Institute
Maine Medical Center Research Institute

... distress; and the possibility of insurance and job discrimination. A possible risk of not knowing includes being unaware of the need for treatment. These risks can change depending on the results of the research and whether there is a treatment or cure for a particular disease. Sometimes patients ha ...
The Principles Prevention in Dentistry
The Principles Prevention in Dentistry

... Many oral health professionals may feel very uncertain and anxious about how they can become involved in this health practice, which seems so far removed from prevention and clinical dentistry. The behavior of oral health providers and their attitudes towards their own oral health reflect their unde ...
Genetic analysis of metabolites in apple fruits indicates an mQTL
Genetic analysis of metabolites in apple fruits indicates an mQTL

... peel, the taste, and the browning of the seeds. For each progeny, >10 fruits from each of the two trees were harvested separately, while for the two parents ‘Prima’ and ‘Fiesta’ fruits from five trees (five replicates) were harvested. The fruits were harvested randomly from different sides of each i ...
Sarcoidosis and MIF gene polymorphism:
Sarcoidosis and MIF gene polymorphism:

... concept has emerged that sarcoidosis results from the exposure of genetically susceptible individuals to specific environmental agents that are as yet unknown [1, 2]. Genetic susceptibility to sarcoidosis is supported by familial clustering [3] and a higher prevalence of disease in firstdegree relat ...
32 Fungal Genetics Newsletter Ursula Kües , Michaela J. Klaus
32 Fungal Genetics Newsletter Ursula Kües , Michaela J. Klaus

... General conclusions. When wanting to study interactions between different heterologous genes in C. cinereus, one might choose to sequentially transform a strain with the genes of interest. However, every single transformation procedure does need its own selection marker and there are only a few avai ...
Infection Prevention and Control (IPC) & Workplace Health and Safety (WHS)
Infection Prevention and Control (IPC) & Workplace Health and Safety (WHS)

... Although Ebola is rare, it has the potential for person-to-person transmission, including HCWs not wearing personal protective equipment (PPE), family members or others who provide care and/or have direct contact with an infected person. Personnel must take appropriate measures to decrease the risk ...
single nucleotide polymorphisms and suicidal behaviour
single nucleotide polymorphisms and suicidal behaviour

... polymorphisms. It seems that especially genes regulating serotoninergic system and neuronal systems involved in stress response are associated with suicidal behaviour. Most genetic studies on suicidal behaviour have considered a small set of functional polymorphisms relevant mostly to monoaminergic ...
About Scleroderma.doc
About Scleroderma.doc

... Factors other than sex such as race and ethnicity may influence the risk of getting scleroderma, the age of onset and the pattern or severity of internal organ involvement. The reasons for this are unclear. Although scleroderma is not directly inherited, some scientists believe there is a slight pre ...
Pathway and Gene Set Analysis of Microarray Data
Pathway and Gene Set Analysis of Microarray Data

... Bioinformatics Workshop, Brno ...
A program for annotating and predicting the effects of single
A program for annotating and predicting the effects of single

... genome sequences. Once a genome is sequenced, the SnpEff program can be used to annotate and classify genetic polymorphisms based on their effects on annotated genes, such as synonymous or non-synonymous SNPs, start codon gains or losses, stop codon gains or losses; or based on their genomic locatio ...
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Public health genomics

Public Health Genomics is the use of genomics information to benefit public health. This is visualized as more effective personalized preventive care and disease treatments with better specificity, targeted to the genetic makeup of each patient. According to the CDC, Public Health genomics is an emerging field of study that assesses the impact of genes and their interaction with behavior, diet and the environment on the population’s health.This field of public health genomics is less than a decade old. A number of think tanks, universities, and governments (including the U.S., UK, and Australia) have started public health genomics projects. Research on the human genome is generating new knowledge that is changing public health programs and policies. Advances in genomic sciences are increasingly being used to improve health, prevent disease, educate and train the public health workforce, other healthcare providers, and citizens.
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