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Replication timing as an epigenetic mark
Replication timing as an epigenetic mark

... Developmental regulation is a key hallmark of an epigenetic mark.7 While the aforementioned observations make a strong case for the mitotic inheritance of replication timing profiles in a given cell type, evidence for developmental regulation has been primarily anecdotal.12 As described, the first a ...
Polyploidy Enhances F Pollen Sterility Loci
Polyploidy Enhances F Pollen Sterility Loci

... microarray analysis was used to detect numerous subtle differences in gene expression between diploid (2x) and tetraploid (4x) Rangpur lime (Citrus limonia; Allario et al., 2011). Our laboratory carried out microarray analysis to assess genetic variation between autotetraploid (Taichung65-4x) and di ...
Chromosomal breakpoint positions suggest a direct role for radiation
Chromosomal breakpoint positions suggest a direct role for radiation

... particle tracks, that (by direct ionization and through the agency of chemical radicals) cause damage to the chromatin structure manifesting as single-strand DNA breaks, double-strand DNA breaks, base damage and DNA-protein crosslinks (Ward, 1988; Kovacs et al., 1994; Grosovsky et al., 1988). DNA st ...
RASPBERRY3 Gene Encodes a Novel Protein Important for Embryo
RASPBERRY3 Gene Encodes a Novel Protein Important for Embryo

... protein may be localized in the chloroplast. Complementation analysis supports the possibility that the RASPBERRY3 protein may be involved in chloroplast development. Our experiments demonstrate the important role of the chloroplast, directly or indirectly, in embryo morphogenesis and development. ...
PDF - 2.6 MB
PDF - 2.6 MB

... Your classmate discovers an X-linked male-sterile mutant that arose spontaneously in her mouse colony. Having heard about your studies of the human SPG gene, she points out that most genes on the human X chromosome have counterparts on the mouse X chromosome, and that her male-sterile mice might be ...
Guidance on the Use of Biochemical and Molecular Markers
Guidance on the Use of Biochemical and Molecular Markers

... The molecular distance component is computed on the differences observed on a set of markers. Different types of molecular markers and distances can be used. In the case of the study done in France on maize, 60 SSR markers and Roger’s distance have been used. It is important that sufficient markers, ...
The 2R hypothesis and the human genome sequence
The 2R hypothesis and the human genome sequence

... loci until disomic inheritance is established (Ohno, 1970). This is important for our interpretation of what a paleopolyploid genome should look like because one of the properties we test in assessing genome duplication is the synchronicity of divergence of duplicated loci. Depending on the manner a ...
CHAPTER 14 MENDEL AND THE GENE IDEA
CHAPTER 14 MENDEL AND THE GENE IDEA

... ° Therefore, the probability of all three being present (ppyyRr) in one offspring is 1/4 × 1/2 ...
APOE distribution in World populations
APOE distribution in World populations

... Spatial autocorrelation analysis depicts that the variation at this locus is influenced by ‘isolation by distance’ with a strong positive correlation for lower distances up to 1313 (distance class 2) kilometres. Correspondence analysis plot assigns most populations according to major ethnic grouping ...
(reversed and/or heterotaxic) phenotype in SWV mice
(reversed and/or heterotaxic) phenotype in SWV mice

... the IV phenotype. Test matings of these phenodcviants, corroborated by PCR, have confirmed them to be + I + . Although the phenotypes of the affected SWV + I + and ivl + mice resembled those found in iviiu mice, the occurrence of situs inversus and heterotaxia were not independent of each other, and ...
Invagination centers within the Drosophila stomatogastric nervous
Invagination centers within the Drosophila stomatogastric nervous

... of six fascicles within each longitudinal connective can be observed (Grenningloh et al., 1991; not shown). A dorsal fascicle and the most ventral one fasciculate together (arrowhead) at the subesophageal ganglion; they split again anteriorly to contribute to the brain neuropile (bn) and the fcn, re ...
Genetics - Michael
Genetics - Michael

... produce more food could also sustain larger armies. The cultural influence of these civilizations expanded over time, and with their success spread their knowledge of selecting for favorable traits in agriculture. Thus, indirectly these early geneticists established the foundations for modern societ ...
JunctionSeq Package User Manual
JunctionSeq Package User Manual

... Under the default parameterization, JunctionSeq also builds upon and expands the basic design put forth by DEXSeq, providing (among other things) the ability to test for both differential exon usage and differential splice junction usage. These two types of analyses are complementary: Exons represen ...
Prothrombin Gene Mutation - Hamilton Health Sciences
Prothrombin Gene Mutation - Hamilton Health Sciences

... the body will make too much of the prothrombin protein. This makes the blood more likely to clot. • One or both parents can pass on the prothrombin gene mutation to their child. ...
Parents AUTOSOMAL RECESSIVE: one parent affected
Parents AUTOSOMAL RECESSIVE: one parent affected

... Brother with deafness Parents with normal hearing ...
1 - bioRxiv
1 - bioRxiv

... between tissues. The same is observed in patients with mutations in the creatine transporter SLC6A8, causing mental retardation and constipation, where also different skewing ratios in different tissues have been found 66. The most frequent X-linked mental retardation syndrome is fragile X syndrome ...
Identification of Quantitative Trait Loci That Affect Aggressive
Identification of Quantitative Trait Loci That Affect Aggressive

... The male was removed from the cage before the birth of the pups. Litters were culled to no more than five pups during the first 3 postnatal days. Pups were weaned at 27–30 d of age. Male pups were individually housed immediately after weaning and remained individually housed through the end of behav ...
Supplementary Table 1 Entrez Gene (http://www.ncbi.nlm.nih.gov
Supplementary Table 1 Entrez Gene (http://www.ncbi.nlm.nih.gov

... (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple al ...
Molecular Genetic Improvement of Protein Quality in Maize
Molecular Genetic Improvement of Protein Quality in Maize

... bioavailability of zinc. Zinc deficiency is a widespread nutritional disorder that can lead to growth failure, pregnancy complications, low birth weight and impaired immune function (see Global Importance of Zinc Deficiency in Humans: its Relation to Malnutrition and Strategies for its Prevention). ...
genes is conserved among species related to
genes is conserved among species related to

... 1996). Variation in expression of surface-exposed proteins is known as antigenic variation and is often found for (a)fimbrial adhesins of pathogenic or opportunistic bacteria that are able to adhere to the epithelial cell layer of the gastro-intestinal tract of the host. In this study we have determ ...
Using comparative genomic hybridization to
Using comparative genomic hybridization to

... (10-15 MY diverged relative to D. melanogaster)[28] provides us with a unique opportunity to demonstrate the degree to which hybridization ratio reflects underlying sequence divergence. It is not our goal to devise an explicit model to explain variation in hybridization due to other sequence charact ...
Expression of p53 Target Genes in the Early Phase of Long
Expression of p53 Target Genes in the Early Phase of Long

... activation of p53 have? The control of the transcriptional activity of p53 is considered crucial for determining which p53 response is activated [5]. In this paper, we describe the expression of p53-related genes in the rat hippocampal CA1 area in the early phase of long-term potentiation (30 min af ...
Mutations
Mutations

... • Recombination analysis located mutations in four distinct regions of genome. • Complementation tests showed each of four regions correlated with different complementation group (each was a different ...
Heterochromia iridis - a case study
Heterochromia iridis - a case study

... Heterochromia iridis can either be congenital or may be acquired later during the life time due to certain diseases or injuries. It may be familial and is inherited as an autosomal dominant trait. Environmental or acquired factors can alter these inherited traits. Congenital heterochromia may also o ...
Anticoagulant resistance in the Norway rat and Guidelines for the
Anticoagulant resistance in the Norway rat and Guidelines for the

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Nutriepigenomics

Nutriepigenomics is the study of food nutrients and their effects on human health through epigenetic modifications. There is now considerable evidence that nutritional imbalances during gestation and lactation are linked to non-communicable diseases, such as obesity, cardiovascular disease, diabetes, hypertension, and cancer. If metabolic disturbances occur during critical time windows of development, the resulting epigenetic alterations can lead to permanent changes in tissue and organ structure or function and predispose individuals to disease.
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