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Literome: PubMed-scale genomic knowledge base in the cloud
Literome: PubMed-scale genomic knowledge base in the cloud

... to interpret such data for identifying disease genes and drug targets. There has been increasing interest in adopting a systems approach that incorporates prior knowledge such as gene networks and genotype–phenotype associations. The majority of such knowledge resides in text such as journal publica ...
Preface to the special issue: ecological and evolutionary genomics
Preface to the special issue: ecological and evolutionary genomics

... is inherently difficult, as specific traits are controlled by relatively tiny regions within vast genomes. In addition, adaptation might actually involve selection at the genome© 2006 Blackwell Publishing Ltd ...
Proximal promoter
Proximal promoter

... • How much is a binding site used – Observed expression of all promoters over time – Predicted site count ...
What is really out there?
What is really out there?

... either mutagenesis or transgenesis, may cause stress and thus lead to an altered expression of untargeted genes. In all of the cases studied, the observed alteration was more extensive in mutagenized than in transgenic plants.” 11,267 (51) genes vs. 2,318 (25) genes ...
IIE 366
IIE 366

... Syndrome) are caused by missing or extra sex chromosomes ...
Slides
Slides

... Changing Large Groups of Genes • One type of protein can affect many genes – CAP has a binding site on many genes – So several genes are switched on when it is activated ...
biotechnology: tools and applications
biotechnology: tools and applications

... • Cotton resistant to boll weevil • Soybeans resistant to herbicide (Roundup) • Corn resistant to European corn borer • Rapeseed with healthier vegetable oil ...
aging
aging

... changes in insulin/IGF-1 pathways. KO mice lacking fat-specific insulin receptor (FIRKO) have reduced fat mass; do not show signs of age-related obesity. Food intake is normal. Mean life-span increased 18% (about 134 days). Reducing fat mass, without caloric restriction, increases longevity through ...
Questions - Humble ISD
Questions - Humble ISD

... Did you memorize or learn about DNA 1. What is the shape of DNA? Who determined this shape? 2. What biomolecule does DNA belong to? 3. What is the monomer of DNA. 4. What are the 3 parts of the monomer? 5. A single-ringed N-base is called _____ & includes ________ & _______ 6. A double-ringed N-base ...
x2-2 genetics F12
x2-2 genetics F12

... Most traits are determined by a combination of genes & the environment Even sex can be altered by environment! (ex. exposure to certain hormones/chemicals) ...
pres2_odell - Harlem Children Society
pres2_odell - Harlem Children Society

... a PAX6 gene mutation in humans may lead to a defect of the endocrine pancreas. Whereas, we investigated the possibility of heterozygous mutations in islet-cell transcription factors such as IPF1/IDX-1/STF-1/PDX-1 and NEUROD1/BETA2 serve as a genetic cause of diabetes or glucose intolerance PAX6 gene ...
Standard Grade Biology – Investigating Cells
Standard Grade Biology – Investigating Cells

... Examples of proteins include: ______________________________________ Sequence of DNA bases The sequence (order) of bases (A, T, C, G) is like a biological book that can be read. This sequence contains the genetic instructions that control an organism’s inherited characteristics, e.g. ...
a5_1_1-1_done
a5_1_1-1_done

... 20. Tumor-suppressing genes code for proteins with what function? Preventing uncontrolled cell division. Cancer can be caused by a mutation in a tumor-suppressing gene that causes there to be too little or too much of the tumor-suppressing protein made? Too little. 21. Explain how mutations that occ ...
Steubenstraβe 4 Horne Tistrup Dyrlaeger ApS DE
Steubenstraβe 4 Horne Tistrup Dyrlaeger ApS DE

... gene. The dog is genetically clear and will not be affected by Neonatal Encephalopathy. The dog can pass only the normal gene on to all its offspring. The currently known mutation has been analysed. The result is only valid for the submitted sample and for the breed Standard Poodle. The current resu ...
Chapter 5 Mutation and genetic variation
Chapter 5 Mutation and genetic variation

... These rates are underestimates as they are based on loss-of-function mutations. Direct estimate of number of mutations of all kinds made for ...
human accelerated region - School of Life Sciences
human accelerated region - School of Life Sciences

... 10. Another set of genes is involved in amino acid catabolism. Here their interpretation is that some of these genes/proteins might be important in metabolism of muscle proteins derived from a diet richer in meat than chimpanzees, and especially gorillas, eat. 11. They list several other genes impl ...
Biology 6 Practice Genetics Problems (chapter 15)
Biology 6 Practice Genetics Problems (chapter 15)

... chromosomes in gametes and 50% parental chromosomes (as revealed by a test cross). This would be the case only if the genetic loci are at opposite ends of a chromosome, which produces the same basic outcome as with unlinked genes (50% parental genotypes, 50% recombinant genotypes). If recombination ...
Unit 7: Heredity and Biotechnology
Unit 7: Heredity and Biotechnology

... Cystic Fibrosis is an autosomal (not sex-linked) recessive disorder caused by a defect in the CFTR gene. This gene codes for a transport protein called a chloride ion channel that is important for producing sweat, digestive juices, and mucus in our bodies. Defective CFTR proteins cause the body to p ...
CH 20 DNA TECHNOLOGY - Ed W. Clark High School
CH 20 DNA TECHNOLOGY - Ed W. Clark High School

... 1. Medical applications for diagnosis of diseases by analyzing the RFLPs (restriction fragment length polymorphisms using Southern Blotting) 2. Gene Therapy can be used to alter an individual’s genes to help treat diseases by inserting a normal allele of a defective gene . Retroviruses have been use ...
Unit B2, B2.7 Mark scheme
Unit B2, B2.7 Mark scheme

... (formed from) different sperm / 2 sperm ...
Haematology Essentials - International Society of Obstetric Medicine
Haematology Essentials - International Society of Obstetric Medicine

... – No past history of thrombocytopenia (except previous pregnancy) – Occurrence during late gestation – No association with fetal thrombocytopenia – Spontaneous resolution after delivery ...
Genomics: A Mapping Analogy - University of Wisconsin
Genomics: A Mapping Analogy - University of Wisconsin

... With this map, can you know the function of all the buildings on campus? Is it possible to know the names and locations of all the buildings without knowing their functions? Likewise, is it possible to know the names and locations of all the genes of an organism without knowing their function? In m ...
Study guideCh8
Study guideCh8

... What happens to the DNA during each of these types of mutation (i.e. is it frame-shifted, does the codon change, are large pieces of DNA moved)? Can you explain the process by which the mutation may have occurred (for example, if I tell you a mutant has a frame-shift mutation, can you explain to me ...
Genetics_PWRPOINT
Genetics_PWRPOINT

... Stands for: Deoxyribonucleic acid  It is where genetic information is stored.  It determines every inherited physical characteristics of every living thing.  It controls how the cell replicates and functions. ...
Controlling the Ir Genes - The Journal of Immunology
Controlling the Ir Genes - The Journal of Immunology

... identification and sequence determination of these genes in the class II region of the human and murine MHCs occurred in the early and mid-1980s (3). By the mid-1980s, it was found that expression of the MHC class II (MHC-II)2 genes was regulated during the development of B lymphocytes and could be ...
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Nutriepigenomics

Nutriepigenomics is the study of food nutrients and their effects on human health through epigenetic modifications. There is now considerable evidence that nutritional imbalances during gestation and lactation are linked to non-communicable diseases, such as obesity, cardiovascular disease, diabetes, hypertension, and cancer. If metabolic disturbances occur during critical time windows of development, the resulting epigenetic alterations can lead to permanent changes in tissue and organ structure or function and predispose individuals to disease.
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