Prep1.1 has essential genetic functions in hindbrain development
... form a subgroup of Meinox proteins that share ~80% overall amino acid sequence identity. By contrast, the Meis and Prep proteins share high amino acid sequence conservation only in specific domains (Fognani et al., 2002). An additional difference between Prep and Meis might lie in Hox proteins bindi ...
... form a subgroup of Meinox proteins that share ~80% overall amino acid sequence identity. By contrast, the Meis and Prep proteins share high amino acid sequence conservation only in specific domains (Fognani et al., 2002). An additional difference between Prep and Meis might lie in Hox proteins bindi ...
PDF + SI - Development - The Company of Biologists
... This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. ...
... This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. ...
Prep1.1 has essential genetic functions in hindbrain development
... form a subgroup of Meinox proteins that share ~80% overall amino acid sequence identity. By contrast, the Meis and Prep proteins share high amino acid sequence conservation only in specific domains (Fognani et al., 2002). An additional difference between Prep and Meis might lie in Hox proteins bindi ...
... form a subgroup of Meinox proteins that share ~80% overall amino acid sequence identity. By contrast, the Meis and Prep proteins share high amino acid sequence conservation only in specific domains (Fognani et al., 2002). An additional difference between Prep and Meis might lie in Hox proteins bindi ...
channel 1 gene dosage
... Prosser, Steinmeyer, Jentsch & Jockusch, 1994), and ClClCadr, K (missense mutation; Gronemeier et al. 1994). Using an antibody against a ClC-1 peptide that reacts with the ClC-1 protein in frozen sections, Gurnett, Kahl, Anderson & Campbell (1995) showed the ClC-1 channel to be present on the sarcol ...
... Prosser, Steinmeyer, Jentsch & Jockusch, 1994), and ClClCadr, K (missense mutation; Gronemeier et al. 1994). Using an antibody against a ClC-1 peptide that reacts with the ClC-1 protein in frozen sections, Gurnett, Kahl, Anderson & Campbell (1995) showed the ClC-1 channel to be present on the sarcol ...
Mapping of the Recessive White Locus and
... PRISM 3730 DNA Sequencer and Sequencing Analysis 3.4 (Applied Biosystems). A primer set designed for exon 5 failed to detect the PCR products in the White Plymouth Rock. Therefore, a new 5′ primer was designed to cover a 30-bp region upstream of exon 5. An attempt was made to investigate the sequenc ...
... PRISM 3730 DNA Sequencer and Sequencing Analysis 3.4 (Applied Biosystems). A primer set designed for exon 5 failed to detect the PCR products in the White Plymouth Rock. Therefore, a new 5′ primer was designed to cover a 30-bp region upstream of exon 5. An attempt was made to investigate the sequenc ...
Mendelian inheritance - Center of Statistical Genetics
... with an explicit model of inheritance. In other words, it is the analysis of the ratios of offspring from a particular parental cross to test for conformity with the Mendelian theory. The starting point of segregation analysis is the collection of as may as possible families with the trait under con ...
... with an explicit model of inheritance. In other words, it is the analysis of the ratios of offspring from a particular parental cross to test for conformity with the Mendelian theory. The starting point of segregation analysis is the collection of as may as possible families with the trait under con ...
1 Genetic constitution of a population
... Several agencies affect gene and genotype frequencies in the process of transmission of genes from one generation to the next. To understand quantitative genetic variation fully we need to know how these factors, separately and together, influence genetic variation in populations over time, and what ...
... Several agencies affect gene and genotype frequencies in the process of transmission of genes from one generation to the next. To understand quantitative genetic variation fully we need to know how these factors, separately and together, influence genetic variation in populations over time, and what ...
20Sexual Reproduction, Meiosis, and Genetic Recombination
... the environment changes, a population that reproduces asexually may not be able to adapt to the new conditions. Under such conditions, organisms that reproduce sexually ...
... the environment changes, a population that reproduces asexually may not be able to adapt to the new conditions. Under such conditions, organisms that reproduce sexually ...
Genetic Predisposition to Breast and/or Ovarian Cancer – Focus on
... 3) gene cluster was correlated with an increased breast cancer risk ([OR] = 1.31 95% CI = 1.21 to 1.42 for one copy deletion) (Long et al., 2013). In consonance with the polygenic model, the aggregation of breast and/or ovarian cases within a family, not attributed to mutations in BRCA1 and BRCA2, c ...
... 3) gene cluster was correlated with an increased breast cancer risk ([OR] = 1.31 95% CI = 1.21 to 1.42 for one copy deletion) (Long et al., 2013). In consonance with the polygenic model, the aggregation of breast and/or ovarian cases within a family, not attributed to mutations in BRCA1 and BRCA2, c ...
SUSCEPTIBILITY TO TRANSMITTED
... stock. They will be spoken of collectively as Ak-type leukemias. If the results with the hybrid leukemias are considered alone, the number of successful inoculations falls short of numerical agreement with the predicted values for a single dominant gene. Conspicuously higher values were obtained onl ...
... stock. They will be spoken of collectively as Ak-type leukemias. If the results with the hybrid leukemias are considered alone, the number of successful inoculations falls short of numerical agreement with the predicted values for a single dominant gene. Conspicuously higher values were obtained onl ...
Functional cooperation between the non-paralogous
... lumbar region than at the cervical and the thoracic level (Barone, 1986), (ii) all lumbar vertebrae are very similar to each other, lateral and spinous processes (the more useful features for vertebral rank identification) having a smooth gradient of size and shape from the first lumbar vertebra to ...
... lumbar region than at the cervical and the thoracic level (Barone, 1986), (ii) all lumbar vertebrae are very similar to each other, lateral and spinous processes (the more useful features for vertebral rank identification) having a smooth gradient of size and shape from the first lumbar vertebra to ...
foreign
... Law of Independent Assortment , = ½ It states that when two pairs of traits are combined in a hybrid segregation of one pair of character is independent of other pair of characters = ½ In law of segregation two alleles of same trait (gene) get segregated , while in law of independent assortment two ...
... Law of Independent Assortment , = ½ It states that when two pairs of traits are combined in a hybrid segregation of one pair of character is independent of other pair of characters = ½ In law of segregation two alleles of same trait (gene) get segregated , while in law of independent assortment two ...
Are common disease susceptibility alleles the same in outbred and
... shown in supplementary Table 1. To test for association, we used two approaches that take into account the relatedness between all pairs of individuals in our sample.15,22 The first test, called the general two-allele model (GTAM), allows for a quantitative trait to follow any twoallele model (inclu ...
... shown in supplementary Table 1. To test for association, we used two approaches that take into account the relatedness between all pairs of individuals in our sample.15,22 The first test, called the general two-allele model (GTAM), allows for a quantitative trait to follow any twoallele model (inclu ...
RESISTANCE AS A RESPONSE TO STRESS
... altered to yield resistance, then susceptible and resistant strains will have quantitatively different amounts of that P450. Three P450s have been demonstrated to be over-expressed by resistant insect strains: P450Lpr (Wheelock & Scott 1992), CYP6A1 (Cariño et al. 1994), and CYP6A2 (Waters et al. 19 ...
... altered to yield resistance, then susceptible and resistant strains will have quantitatively different amounts of that P450. Three P450s have been demonstrated to be over-expressed by resistant insect strains: P450Lpr (Wheelock & Scott 1992), CYP6A1 (Cariño et al. 1994), and CYP6A2 (Waters et al. 19 ...
Hd6, a rice quantitative trait locus involved in photoperiod
... quantitative trait loci (QTLs), because of their biological and agronomic importance. The development of a high-density linkage map based on DNA markers made it possible to map QTLs with high resolution (1). However, it has been difficult to identify genes underlying QTLs, because their individual e ...
... quantitative trait loci (QTLs), because of their biological and agronomic importance. The development of a high-density linkage map based on DNA markers made it possible to map QTLs with high resolution (1). However, it has been difficult to identify genes underlying QTLs, because their individual e ...
MAGMA manual (version 1.06)
... MAGMA detects a header in the file it will look for SNP IDs and p-values in the SNP and P column respectively. If no header is found it will use the first column for SNP IDs and the second column for p-values. If you want to use different columns instead, you can add the use modifier (with two value ...
... MAGMA detects a header in the file it will look for SNP IDs and p-values in the SNP and P column respectively. If no header is found it will use the first column for SNP IDs and the second column for p-values. If you want to use different columns instead, you can add the use modifier (with two value ...
Annotation mapping functions
... org.“XX”.“yy”.db - organism annotation packages containing all the gene data for en entire organism, where “XX” is the abbreviation for Genus and species. “yy” is the central ID that binds the data together, such as Entrez gene (eg). KEGG.db and GO.db containing systems biology data / pathways. ...
... org.“XX”.“yy”.db - organism annotation packages containing all the gene data for en entire organism, where “XX” is the abbreviation for Genus and species. “yy” is the central ID that binds the data together, such as Entrez gene (eg). KEGG.db and GO.db containing systems biology data / pathways. ...
RNA Interference and Small Interfering RNAs
... RNase III cleaves both strands of the dsRNA and generates dsRNA fragments of about 15 bp in length with a 2-nt 3' overhang.[44] Consistent with an RNase III-like cleavage reaction, it was observed that 21- and 22-nt siRNA duplexes with 3' overhangs were more efficient in degrading target RNA than si ...
... RNase III cleaves both strands of the dsRNA and generates dsRNA fragments of about 15 bp in length with a 2-nt 3' overhang.[44] Consistent with an RNase III-like cleavage reaction, it was observed that 21- and 22-nt siRNA duplexes with 3' overhangs were more efficient in degrading target RNA than si ...
A Comparative Genomic Analysis of Two Distant Diptera, the Fruit
... Modern genomics have revolutionized genetics and, consequently, biology. The enormous acceleration of data acquisition, in fields such as whole genome sequence determination and genome-wide gene expression profiling, has opened novel possibilities for the study of model organisms and organisms for w ...
... Modern genomics have revolutionized genetics and, consequently, biology. The enormous acceleration of data acquisition, in fields such as whole genome sequence determination and genome-wide gene expression profiling, has opened novel possibilities for the study of model organisms and organisms for w ...
Tufts` Canine and Feline Breeding and Genetics Conference
... Genetic diseases are caused by chromosomal alterations or gene mutations. Disease-causing mutations are heritable changes in the sequence of genomic DNA that alter the expression, structure, and function of the coded protein. The genotype refers to the animal’s genetic makeup, reflected by its DNA s ...
... Genetic diseases are caused by chromosomal alterations or gene mutations. Disease-causing mutations are heritable changes in the sequence of genomic DNA that alter the expression, structure, and function of the coded protein. The genotype refers to the animal’s genetic makeup, reflected by its DNA s ...
Edwards syndrome
... Failure to identify characteristic symptoms and signs of Edwards syndrome and refer to a geneticist for evaluation and genetic counseling Failure to request chromosome analysis with clinical diagnosis of Edwards syndrome Failure to offer prenatal screening for pregnant ...
... Failure to identify characteristic symptoms and signs of Edwards syndrome and refer to a geneticist for evaluation and genetic counseling Failure to request chromosome analysis with clinical diagnosis of Edwards syndrome Failure to offer prenatal screening for pregnant ...
Gbx2 is required for the morphogenesis of the mouse inner ear
... posterior semicircular canals are also missing but the lateral canal is present (n=3). The cochlear ducts of Type III specimens are more malformed than those of Type I and Type II, and have less than one coil. Inner ears categorized as Type IV are the most severe; they are cystic without any discern ...
... posterior semicircular canals are also missing but the lateral canal is present (n=3). The cochlear ducts of Type III specimens are more malformed than those of Type I and Type II, and have less than one coil. Inner ears categorized as Type IV are the most severe; they are cystic without any discern ...
Fitness landscapes of gene regulation in variable - UvA-DARE
... ll living organisms are equipped with mechanisms that enable them to sense their environment and respond to it. In many cases the response consists of regulating gene expression. For bacteria the link between sensing and response is often formed by a small network of interacting proteins and regulat ...
... ll living organisms are equipped with mechanisms that enable them to sense their environment and respond to it. In many cases the response consists of regulating gene expression. For bacteria the link between sensing and response is often formed by a small network of interacting proteins and regulat ...