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Biochemical and genetic characterization of the
Biochemical and genetic characterization of the

... DNA ligase, was initially identified in a screen for conditional lethal cell division cycle mutants (15). Subsequently, it was demonstrated that cdc9 mutants exhibit hypersensitivity to a wide range of DNA damaging agents and hyper-recombination (16–19). Based on amino acid sequence homology, the po ...
Updated map of duplicated regions in the yeast genome
Updated map of duplicated regions in the yeast genome

... pairs that may have been formed by the same genome duplication event, but for which the evidence is weaker. The aim of the present paper is to try to maximize the amount of the yeast genome that is mapped into sister chromosomal regions, working under the assumption that the hypothesis of simultaneo ...
Cover Page In-silico study of Neural Tube Defect in relation to
Cover Page In-silico study of Neural Tube Defect in relation to

... the FGCP activity, thereby block the intestinal absorption of folate (Halsted et al, 1998). This prompted us to focus on the systematic analysis of GCPII gene and its involvement in Neural tube defect using ...
PDF
PDF

... on both the X and Y chromosomes (i.e. 16 X-Y gene pairs, henceforth gametologs)8 that are distinguished from other sex-linked genes by (i) their selective preservation in multiple species across ~300 million years of sex chromosome evolution to prevent male-female dosage disparity, (ii) the breadth ...
Chapter 8 DNA Fingerprinting and Forensic Analysis
Chapter 8 DNA Fingerprinting and Forensic Analysis

... – The gene encoding this protein has lots of sequence variability across the human population. – Since this gene is not present in other life forms, it reduces the interference that could otherwise be contributed by bacteria, fungi, dog, or cat DNA picked up in the sample at crime scene. ...
Sex Chromosome Dosage Effects On Gene Expression In
Sex Chromosome Dosage Effects On Gene Expression In

... on both the X and Y chromosomes (i.e. 16 X-Y gene pairs, henceforth gametologs)8 that are distinguished from other sex-linked genes by (i) their selective preservation in multiple species across ~300 million years of sex chromosome evolution to prevent male-female dosage disparity, (ii) the breadth ...
Gene expression in Plasmodium: from gametocytes to sporozoites
Gene expression in Plasmodium: from gametocytes to sporozoites

... identified a single putative gene, PfSR. SRCR domains have been implicated in immune recognition/activation and lipid/protein adhesion. PCR analysis of the P. berghei homolog (PbSR) showed that its transcript is detected in asexual and sexual stages of parasite differentiation. However, the protein ...
Cluster analysis for microaray data
Cluster analysis for microaray data

... Example: green/ red data points were generated from two different normal distributions ...
bYTEBoss bly-217-transgenic-crops
bYTEBoss bly-217-transgenic-crops

... understand how the gene is regulated, what other effects it might have on the plant, and how it interacts with other genes. Scientists today still know very little on which genes are responsible for enhancing yield potential, improving stress tolerance, modifying chemical processes of the harvested ...
emboj201385-sup
emboj201385-sup

... by crossing to the FlpE mouse line. (E) KO allele after Cre-mediated recombination. Deletion of Exon 2 results in loss of function of the Hmx1 gene by deleting the homeobox domain and the 3’ untranslated region. (F) Hmx1fl/fl genotyping strategy. (G) Genotyping results from Hmx1fl/fl, wild-type and ...
5` Flanking Sequences of the Rat Tyrosine Hydroxylase Gene Target
5` Flanking Sequences of the Rat Tyrosine Hydroxylase Gene Target

... is very difficult due to the time and expense involved in maintaining transgenic lines. Although limited in number, previous experiments in which TH regulatory regions were used in transgenic mice have failed to demonstrate correct tissue-specific expression, although some TH cell groups were approp ...
studies on human x-chromosomal disorder
studies on human x-chromosomal disorder

... Conditions caused by a change in the number or structure of chromosomes are known as chromosomal disorders. There are over 3000 chromosomal disorders which make a major contribution to human morbidity and mortality. A very high number of both Mendelian and other diseases (some of which are incurable ...
Cluster analysis for microaray data
Cluster analysis for microaray data

... Example: green/ red data points were generated from two different normal distributions ...
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DNA

... • Carries amino acids to ribosomes to pair with mRNA ...
AP Biology: Evolution
AP Biology: Evolution

... Big Idea 3: Living systems store, retrieve, transmit and respond to information essential to life processes. Enduring Understandings  1C3: Populations of organisms continue to evolve.  3A1: DNA, and in some cases RNA, is the primary source of heritable information.  3A3: The chromosomal basis of ...
power point
power point

... 2 from your father, you will amplify 2 different sized pieces of DNA – one larger than the other • In STR PCR, several different STR primers amplifying several areas of interest simultaneously ...
Grade 7 Model Science Unit 6: Inheritance and Variation
Grade 7 Model Science Unit 6: Inheritance and Variation

... Each chromosome consists of a single, very long DNA molecule, and each gene on the chromosome is a particular segment of that DNA. The instructions for forming species’ characteristics are carried in DNA. All cells in an organism have the same genetic content, but the genes used (expressed) by the c ...
Part 2 - Laboratory of Aquaculture & Artemia Reference Center
Part 2 - Laboratory of Aquaculture & Artemia Reference Center

... crustacean Artemia. Apart from serving as livefeed in aquaulture industries, Artemia seems to be the ultimate model for several genomic puzzles. Genomic research on Artemia at the molecular level is still in its infancy and a complete genomic analysis is needed. Artemia has proved to be a potential ...
12-Transcription-The Relationship Between Genes and Proteins
12-Transcription-The Relationship Between Genes and Proteins

... exon of a gene, the 5′ end of the nascent RNA is capped with 7-methylguanylate. Transcription by RNA polymerase II terminates at any one of multiple termination sites downstream from the poly(A) site, which is located at the 3′ end of the final exon. After the primary transcript is cleaved at the po ...
Comprehensive Genetic Testing
Comprehensive Genetic Testing

... clinical genomics These powerful testing options have the goal of efficiently finding the underlying cause to explain a constellation of medical concerns. Many genetic disorders involve multiple body systems. Clinical genomics testing can identify a cause that explains all medical symptoms, across t ...
Basic Concepts in the Study of Diseases with Complex Genetics
Basic Concepts in the Study of Diseases with Complex Genetics

... mutated, e.g., to GAATTT, which is no longer cleaved by EcoRI. Most RFLPs only have two alleles, one with the restriction site, which is cleavable by the restriction enzyme, and one allele without the site. When following such alleles in families, an individual will often have the same allele on bot ...
chapter 15 - Scranton Prep Biology
chapter 15 - Scranton Prep Biology

... bod/ color and wing size are on the same chromosome and are usually thus inherited together. produce genetic D. Independent assortment of chromosomes and crossing over recombinants of traits Genetic recombination : The production of offspring with new combinations of events the from results differen ...
Supplementary Table 2 (doc 106K)
Supplementary Table 2 (doc 106K)

... Legendre A, Miao X-X, Da Lage J-L, Wicker-Thomas C (2008). Evolution of a desaturase involved in female pheromonal cuticular hydrocarbon biosynthesis and courtship behavior in Drosophila. Insect Biochem Mol Biol 38(2): 244-255. Rice AH, Duffy JB (2001). Characterization of baldspot, a putative gene ...
#1
#1

... gene is located (Bernardi 2000). GC3 varies from a typical 40% in low-GC-content regions to 80% and more in high-GC-content regions. GC content is correlated with various genomic features, including repeat element distribution, methylation pattern (Jabbari and Bernardi 1998), and, most remarkably, g ...
Document
Document

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Nutriepigenomics

Nutriepigenomics is the study of food nutrients and their effects on human health through epigenetic modifications. There is now considerable evidence that nutritional imbalances during gestation and lactation are linked to non-communicable diseases, such as obesity, cardiovascular disease, diabetes, hypertension, and cancer. If metabolic disturbances occur during critical time windows of development, the resulting epigenetic alterations can lead to permanent changes in tissue and organ structure or function and predispose individuals to disease.
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