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pistilata
pistilata

... •AP3/PI hetero-dimer binds to the sequence in the AP3 promoter that are necessary for AP3t expression and can activate transcription in absence of protein synthesis *study was carried out by combination of class A and C genes *Phenotypic analysis of AP3/PI over-expression lines indicated their addit ...
splice sites at the termini generating a novel intron from a dSpm
splice sites at the termini generating a novel intron from a dSpm

... As a result of mRNA processing, seven new amino acids are inserted into the A2 protein. The functionality of this modified protein was directly confirmed by transient expression studies. The evolutionary implications of these findings are discussed. ...
Modulation of base excision repair of 8
Modulation of base excision repair of 8

... first is false pairing of 8-oxoG (in syn-conformation) with adenine, resulting in increased frequency of replication errors (4–6). This lesion-templated misincorporation of dATP by DNA polymerases leads to mutations and cancer, particularly in individuals with mutated MUTYH gene whose product removes ...
Mining medical data using multiple corpora
Mining medical data using multiple corpora

... each textual field become a tagged field. Records coming from Medline or from formats based on ISO2709 (UNIMARC, USMARC, Inist standard), which are organized with fields and subfields, can then be converted. 1.1.2. Clusterization and information retrieval tools. Another part of DILIB workbench consi ...
14lctout - Evergreen Archives
14lctout - Evergreen Archives

... C. Identifying the Loci Involved in Lactose Metabolism 1. Jacob and Monod search for E. coli mutants incapable of lactose utilization, but how can cells that do not grow be isolated? Two methods: a. Replica Plating (Fig. 14.3) (1) Cells are exposed to mutagens and grown on glucose medium. (2) Each c ...
PDF - Oxford Academic - Oxford University Press
PDF - Oxford Academic - Oxford University Press

... Although the previous studies examined different (nonfunctional) polymorphisms, it is likely that they would not provide evidence for the MAOA-uVNTR either, as these polymorphisms are in strong disequilibrium with each other. Therefore it appears more likely that different alleles at the MAO genes d ...
Temperature-sensitive control of protein activity by conditionally
Temperature-sensitive control of protein activity by conditionally

... expressed by the ptc-Gal4 driver, a striking loss of both wg and sen at the intersection of the a/p and d/v boundaries (arrows in Fig. 3f–h,j–l) is observed at both 29 °C and 18 °C. Mild temperature sensitivity of ptc-Gal4 decreased the activity of dnN at the lower temperature (compare Fig. 3f with ...
Genotypes and phenotypes Review Proteomics and 2-DE
Genotypes and phenotypes Review Proteomics and 2-DE

... The structural and quantitative heterogeneity that the proteins create to fulfill their functions is the central subject of functional proteomics. At present, many laboratories perform studies using 2-DE protein patterns to detect proteins that may be involved in a biological or pathological process ...
Inferring Ancestral Chloroplast Genomes with Inverted
Inferring Ancestral Chloroplast Genomes with Inverted

... Since the gene contents are reduced to equal after the simplification step, it is feasible to use GRAPPA to infer an inversion phylogeny. That’s to say, if inversions are allowed to cross the boundaries of predetermined IR and single copy regions, we can use the original GRAPPA to compute the ancest ...
final_report_columns
final_report_columns

... score signifies higher conservation. ‘‘C’’ means that the prediction is conserved, otherwise, the prediction is ‘‘N” for non-conserved. For details see: http://annovar.openbioinformatics.org/en/latest/user-guide/filter/#-phylop-and-siphy-annotation and http://compgen.cshl.edu/phast/help-pages/phyloP ...
Genotypes and Phenotypes
Genotypes and Phenotypes

... putting aside some time late next week to work on it.  It will require you to get some information ...
revised Elements of Genetics
revised Elements of Genetics

... and the inheritance of acquired traits (pangenesis). Blending inheritance would lead to uniformity across populations in only a few generations and thus would remove variation from a population on which natural selection could act. Darwin's initial model of heredity was adopted by, and then heavily ...
Extending Mendelian Genetics
Extending Mendelian Genetics

... texture—curly hair or straight hair—are autosomal genes. Many human genetic disorders are also caused by autosomal genes. The chance of a person having one of these disorders can be predicted, just as Mendel could predict the phenotypes that would appear in his pea plants. Why? Because there are t ...
Key Terms
Key Terms

... green seeds? Yellow seeds? Draw a Punnett square to support your answer. ...
Module 6: Enzymatic Function
Module 6: Enzymatic Function

... Pointers to the Swiss-Prot protein sequence entries that correspond to the enzyme (if any) ...
Identification and quantification of mycotoxigenic fungi
Identification and quantification of mycotoxigenic fungi

... metabolites are being considered [47]. The levels of detection for mycotoxins are extremely sensitive and now concentrations of as low as 1015 (106 is the mg kg1 level) can be conceived of with NMR and mass spectroscopy. Furthermore, it is possible to determine if all the genes of a pathway can b ...
Regulation of phenylalanine biosynthesis in Escherichia coli K
Regulation of phenylalanine biosynthesis in Escherichia coli K

... chromosome; pheR mutants acquired the wild-type phenotype when either F117 (which covers the 93-min region) or F116 (which covers min 59 to 65) was introduced into the cell. A rifampin resistance mutation, rpoB366, was found to derepress transcription of the pheA operon. pheR and rpoB366 affected tw ...
Leukaemia Section t(5;9)(q14.1;p24) SSBP2/JAK2 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Leukaemia Section t(5;9)(q14.1;p24) SSBP2/JAK2 Atlas of Genetics and Cytogenetics in Oncology and Haematology

Probing the evolution of appendage specialization by
Probing the evolution of appendage specialization by

... associated with secondary phenotypes, most notably abnormal morphogenesis of the gut (Fig. S1). To overcome this problem, we generated genetic mosaics in which only part of the developing embryo is transformed (22) (Fig. 2 G and H). These mosaic embryos can express near wild-type levels of PhUbx in ...
Natural genetic transformation: prevalence, mechanisms
Natural genetic transformation: prevalence, mechanisms

NQO1 Pro187Ser polymorphism confers to the susceptibility of
NQO1 Pro187Ser polymorphism confers to the susceptibility of

... NQO1 is foremostly supposed to be an essential defense against cancers, and the mechanisms were described from various aspects. In-vitro study revealed that NQO1 specifically got rid of the generation of benzo(a)pyrene quinone-DNA adducts produced by CYP1A1 and P450 reductase [4]. In addition, NQO1 ...
MEDICAL BIOLOGY
MEDICAL BIOLOGY

... 3. Whether is possible to consider as alternative the following traits: а) normal coagulation of blood and sickle-cell anemia; b) normal metabolism of phenylalanine and phenylketonuria; c) presence of dark pigment in a skin and its absence(albinism); d) brown eyes and light hear; e) short fingers on ...
The dual nature of homologous recombination in plants
The dual nature of homologous recombination in plants

... salinity, frequently has to be introduced into inbred lines. Apart from classical breeding, which is limited to the same or closely related species at best, transgenesis-aided breeding could be the option for the future in many cases. Already this is common practice for the introduction of genes fro ...
Chromosome-encoded gene cluster for the
Chromosome-encoded gene cluster for the

... One such strain, named AD9, was selected from these isolates for further detailed analyses owing to its ability to grow rapidly on this medium. The morphological, physiological and biochemical characteristics of AD9 are summarized in Supplementary Table S1 available with the online version of this p ...
Congenital Adrenal Hyperplasia (CAH)
Congenital Adrenal Hyperplasia (CAH)

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Nutriepigenomics

Nutriepigenomics is the study of food nutrients and their effects on human health through epigenetic modifications. There is now considerable evidence that nutritional imbalances during gestation and lactation are linked to non-communicable diseases, such as obesity, cardiovascular disease, diabetes, hypertension, and cancer. If metabolic disturbances occur during critical time windows of development, the resulting epigenetic alterations can lead to permanent changes in tissue and organ structure or function and predispose individuals to disease.
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