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The α-globin gene cluster: genetics and disorders
The α-globin gene cluster: genetics and disorders

... Hemoglobin (Hb) is the oxygen-carrying protein packaged within circulating erythrocytes. It has been extensively studied in terms of its structure–function relationship, genetics and hereditary disorders. In 1949, Pauling and colleagues1 described sickle cell anemia as the first molecular disease. G ...
Gene Ontology
Gene Ontology

... Term definitions § Biological process terms ................... § Molecular function terms ................... § Cellular component terms ................ § Obsolete terms ................................ ...
Study and engineering of gene function: mutagenesis
Study and engineering of gene function: mutagenesis

... • Make changes in amino acid sequence based on rational decisions • Structure known? Mutate amino acids in any part of protein thought to influence activity/stability/solubility etc. • Protein with multiple family members? Mutate desired protein in positions that bring it closer to another family me ...
7 Grade Science Sample Assessment Items S7L3a.
7 Grade Science Sample Assessment Items S7L3a.

... Each form of a gene is called an allele. The alleles for human blood type are A, B, and O. Both the allele for type A blood and type B blood are dominant. The allele for type O blood is recessive. What blood type will a person have if he inherits an allele for type A and an allele for type O? A. A* ...
Chapter 12 Patterns of Inheritance
Chapter 12 Patterns of Inheritance

... • One allele of each gene / homologous chromosome 2) Alleles of a gene segregate from one another during meiosis • Law of Segregation • Which allele enters which gamete occurs by chance 3) Differing alleles can mask one another if occupying same cell • Dominant Allele: Allele expressed (observed) • ...
Distinguishing endogenous versus exogenous DNA
Distinguishing endogenous versus exogenous DNA

... during their maturation and development. More specifically, the genes encoding their surface receptors undergo rearrangement and splicing. DNA rearrangement is unique to lymphocytes and represents the molecular basis for the generation of the huge diversity of immune receptors that exist for virtual ...
- Wiley Online Library
- Wiley Online Library

Welcome to the Gene and Allele Database Tutorial
Welcome to the Gene and Allele Database Tutorial

SEX LINKAGE
SEX LINKAGE

... Is it possible for the female to express the same way that the male does? Yes, of course, but there is a stipulation  The female must contain two damaged alleles (chromosomes) in order to express ...
CACAO_remote_training
CACAO_remote_training

... In different environments In different tissues In disease states ...
Genetics
Genetics

...  Using cardboard cutouts representing the four bases Watson and Crick shifted molecules around on their desktops, as though putting together a puzzle. ...
Genetics - Humble ISD
Genetics - Humble ISD

... • Pea plants are good for genetic research o Relatively simple genetically  Most characters are controlled by a single gene  Each gene has only 2 alleles, one of which is completely dominant to the other Mendel’s Law of Heredity (#1) • Law of Segregation o When gametes (eggs & sperm) are produced ...
2002-09_GO_annotation_JL
2002-09_GO_annotation_JL

... FlyBase (database for the fruitfly Drosophila melanogaster), Berkeley Drosophila Genome Project (Drosophila informatics; GO database & software), Saccharomyces Genome Database (SGD) (database for the budding yeast Saccharomyces cerevisiae), Mouse Genome Database (MGD) & Gene Expression Database (GXD ...
4.1 Single Gene Effects in Limousin
4.1 Single Gene Effects in Limousin

... same). For example, for polledness, the animals carrying two polled genes (PP) or two horned genes (pp) are both homozygous. However, if the genes are different (Pp) the animal is heterozygous (hetero means different). While we can be confident that all horned animals are homozygous for the horned g ...
Mendel and Genetics
Mendel and Genetics

... • When the two alleles for a trait are not the same as each other. Example Ee, Ww, Rr, Tt ...
Population Genetics
Population Genetics

... 1st figure out where the phenotype fits - ( TT is homozygous dominant or p2 ) - ( Tt is heterozygous dominant or 2pq ) - ( tt is homozygous recessive or q2 ) 2nd figure out what the percentage of the total number of alleles the selected phenotype represents –18 white cats = 36 t alleles, 9 black = 1 ...


... normal variant or a pathological condition) that has revolutionized human genetics. And more is to come, for within the next few years the human genome will be sequenced in its entirety, leading to further advances in understanding of gene organization and expression. It is still unclear how much of ...
Megatask 2 : Clustering of an unspecified set of gene lists
Megatask 2 : Clustering of an unspecified set of gene lists

... Fig.5 : cluster-size for clusters with three large clusters of genes that coincide 100%. 100% proximity-threshold in genesets Much more processing could be done and also the biological function of these genelists could be investigated with enrichr but unfortunately my time is up for this megatask. T ...
Non-Mendelian Inheritance PPT
Non-Mendelian Inheritance PPT

... • X-linked recessive traits are traits resulting from a recessive allele on the X chromosome. • There are over 100 different human conditions that are caused by recessive alleles found on the X chromosomes. • X-linked recessive alleles are represented by a X , superscript lower case letter ...
Mendelian Genetics PPT - Madison County Schools
Mendelian Genetics PPT - Madison County Schools

... not get her eye color (or vice versa). The two traits are inherited INDEPENDENTLY of one another. ...
Genetics Review - Biology Junction
Genetics Review - Biology Junction

... (many genes), they can not be traced to a single parent Many genes have been discovered through the study of genetic disorders - they can be dominant or recessive ...
BioPHP - Minitools Chaos Game Representation of DNAGraphical
BioPHP - Minitools Chaos Game Representation of DNAGraphical

... This program translates the input DNA sequence into protein sequence. Translation can be carried out in 1, 3 or all the six frames. DNA sequence may be added as shown in the example input or in any other format (number, spaces and line feeds are removed). Also, there are options to remove extra spac ...
Bioethics Topics BioEthics
Bioethics Topics BioEthics

... egg'sand development (from a single cell to around 250 "But altering the so-called in this manner long been considered cells)," the institute says.germline The researchers will usehas donated, surplus embryosoff-limits. from IVF That's because such changes can be passed down to future generations. M ...
Bacterial Transformation - Pitt
Bacterial Transformation - Pitt

... phenomenon. This association was strengthened by the one gene-one enzyme hypothesis proposed by George Beadle and Edward Tatum in 1940; according to this hypothesis, the transforming principle involved one or more genes that produced enzymes needed to synthesize the polysaccharide coat. In 1944 a te ...
12-Transcription-The Relationship Between Genes and Proteins
12-Transcription-The Relationship Between Genes and Proteins

... • RNA polymerase binds to different promoters with different strengths; binding strength relates to the level of gene expression • There are some common consensus sequences for promoters: ...
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Gene



A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term ""having a gene"" (e.g., ""good genes,"" ""hair colour gene"") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.The concept of a gene continues to be refined as new phenomena are discovered. For example, regulatory regions of a gene can be far removed from its coding regions, and coding regions can be split into several exons. Some viruses store their genome in RNA instead of DNA and some gene products are functional non-coding RNAs. Therefore, a broad, modern working definition of a gene is any discrete locus of heritable, genomic sequence which affect an organism's traits by being expressed as a functional product or by regulation of gene expression.
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