- Endotec
... Textured implants use polymethylmethacrylate for primary fixation of the femoral, tibial and patellar components, while the porous coated components can be used without cement, relying on tissue ingrowth stabilization into the micro-porous coated (325 micron pore size) fixation surface of each compo ...
... Textured implants use polymethylmethacrylate for primary fixation of the femoral, tibial and patellar components, while the porous coated components can be used without cement, relying on tissue ingrowth stabilization into the micro-porous coated (325 micron pore size) fixation surface of each compo ...
Regulation of the Intermediate Filament Protein Nestin at Rodent
... why 4E2 recognizes a nestin fragment but not the native protein or other large fragments that contain the N terminus is unclear but suggests that some special epitope is present on the prominent fragment it does recognize. The labeling observed with 4E2 in muscles as well as in cultured myotubes (da ...
... why 4E2 recognizes a nestin fragment but not the native protein or other large fragments that contain the N terminus is unclear but suggests that some special epitope is present on the prominent fragment it does recognize. The labeling observed with 4E2 in muscles as well as in cultured myotubes (da ...
Slow Ventricular Conduction in Mice Heterozygous for a
... (8) in their original report of the Cx43 2/2 mouse. Conduction studies. Conduction velocity was measured on the ventricular epicardial surface in superfused neonatal hearts and perfused adult hearts. Hearts of neonatal and adult mice were rapidly excised and placed in oxygenated cardioplegic solutio ...
... (8) in their original report of the Cx43 2/2 mouse. Conduction studies. Conduction velocity was measured on the ventricular epicardial surface in superfused neonatal hearts and perfused adult hearts. Hearts of neonatal and adult mice were rapidly excised and placed in oxygenated cardioplegic solutio ...
Aprotinin Preserves Cellular Junctions and Reduces
... Background—Cardiac surgery with cardiopulmonary bypass (CPB) and cardioplegic arrest has been associated with myocardial edema attributable to vascular permeability, which is regulated in part by thrombin-induced alterations in cellular junctions. Aprotinin has been demonstrated to prevent activatio ...
... Background—Cardiac surgery with cardiopulmonary bypass (CPB) and cardioplegic arrest has been associated with myocardial edema attributable to vascular permeability, which is regulated in part by thrombin-induced alterations in cellular junctions. Aprotinin has been demonstrated to prevent activatio ...
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... examined; Pten2 and Pten3, which are identical to one another except that Pten2 possesses a short C-terminal extension that mediates binding to Baz (von Stein et al., 2005). As Pten3 lacks this extension, it is unable to bind to Baz (von Stein et al., 2005). Previous work has suggested that Pten2 is ...
... examined; Pten2 and Pten3, which are identical to one another except that Pten2 possesses a short C-terminal extension that mediates binding to Baz (von Stein et al., 2005). As Pten3 lacks this extension, it is unable to bind to Baz (von Stein et al., 2005). Previous work has suggested that Pten2 is ...
The Relationships between Asterion, the Transverse
... of the lateral transverse sinus and was found to lie at least 1.0 cm medially to the transverse-sigmoid junction. Thus, it is not a useful landmark to identify the transverse-sigmoid junction(8). Day et al(3) reported that asterion was located at the transverse-sigmoid junction complex in 61% on the ...
... of the lateral transverse sinus and was found to lie at least 1.0 cm medially to the transverse-sigmoid junction. Thus, it is not a useful landmark to identify the transverse-sigmoid junction(8). Day et al(3) reported that asterion was located at the transverse-sigmoid junction complex in 61% on the ...
Lens Major Intrinsic Protein (MIP)
... turbidity assay. The absorbance time course at 350 nm was monitored when PC-Mbs vesicles (-) and PC vesicles (A)were mixed with 25 pM PS vesicles. Vesicles were incubated in the same solution described for Figure 1. After 3 min of preincubation, 25 r M PS vesicles was added to the cuvette (arrow). e ...
... turbidity assay. The absorbance time course at 350 nm was monitored when PC-Mbs vesicles (-) and PC vesicles (A)were mixed with 25 pM PS vesicles. Vesicles were incubated in the same solution described for Figure 1. After 3 min of preincubation, 25 r M PS vesicles was added to the cuvette (arrow). e ...
The intercalated disc-associated Xin family of proteins in cardiac
... Intercalated discs (ICDs) are cardiac-specific structures located at the longitudinal termini of cardiomyocytes. Classically, the functions assigned to ICDs include mechanical and electrical communication among adjacent cardiomyocytes. More recently, it has been increasingly realized that ICDs also ...
... Intercalated discs (ICDs) are cardiac-specific structures located at the longitudinal termini of cardiomyocytes. Classically, the functions assigned to ICDs include mechanical and electrical communication among adjacent cardiomyocytes. More recently, it has been increasingly realized that ICDs also ...
2. introduction
... across 11 myocytes (separated by horizontal white lines) during a pause following pacing at a basic cycle length of 240msec. The 6th cell from the top of the image developed a spontaneous Ca2+ wave that cascaded to the top 5 cells in succession and to one additional cell below where it was extinguis ...
... across 11 myocytes (separated by horizontal white lines) during a pause following pacing at a basic cycle length of 240msec. The 6th cell from the top of the image developed a spontaneous Ca2+ wave that cascaded to the top 5 cells in succession and to one additional cell below where it was extinguis ...
CASK (LIN2) interacts with Cx43 in wounded skin and their
... three proteins, at different sites in the plasma membrane, primarily 2–3 cell diameters from the edge of the scratch. Similarly, suprabasal cells relatively near the wound margin in foreskin showed extensive CADM1 and Cx43 overlap and frequent colocalization of all three proteins (Fig. 7). Increased ...
... three proteins, at different sites in the plasma membrane, primarily 2–3 cell diameters from the edge of the scratch. Similarly, suprabasal cells relatively near the wound margin in foreskin showed extensive CADM1 and Cx43 overlap and frequent colocalization of all three proteins (Fig. 7). Increased ...
... specific neurons. These links include chemical synapses that utilize neurotransmitters to evoke postsynaptic responses and gap junctions that regulate ion flow between coupled neurons. Although some progress has been made towards understanding the molecular basis of chemical synaptic specificity (Sa ...
Vertebrobasilar junction aneurysm: surgical treatment via far lateral
... angle of exposure, the working space at the level of the foramen magnum, and visualization of both the ventral and ventrolateral aspects of the craniovertebral junction and the contralateral aspects of the inferior clivus (10,17-24). For intradural lesions, resection of a third to half of the condyl ...
... angle of exposure, the working space at the level of the foramen magnum, and visualization of both the ventral and ventrolateral aspects of the craniovertebral junction and the contralateral aspects of the inferior clivus (10,17-24). For intradural lesions, resection of a third to half of the condyl ...
Anatomical study of endoscope assisted far lateral keyhole
... that drilling the occipital condyle can cause atlanto-occipital joint instability and significantly increased in range of motion sometimes requiring atlanto-occipital joint arthrodesis[17]. Spektor et al reported that drilling of the jugular tubercle and occipital condyle increased the risk of injur ...
... that drilling the occipital condyle can cause atlanto-occipital joint instability and significantly increased in range of motion sometimes requiring atlanto-occipital joint arthrodesis[17]. Spektor et al reported that drilling of the jugular tubercle and occipital condyle increased the risk of injur ...
Analysis of Connexin43 phosphorylated at S325, S328 and S330 in
... diseases (Bergoffen et al., 1993; Gong et al., 1997; Kelsell et al., 1997) including oculodentodigital dysplasia, a disease linked to Connexin43 (Cx43) mutations that can cause atrioseptal defects and arrhythmias (Paznekas et al., 2003). Twenty-one connexin genes have been identified in humans (Sohl ...
... diseases (Bergoffen et al., 1993; Gong et al., 1997; Kelsell et al., 1997) including oculodentodigital dysplasia, a disease linked to Connexin43 (Cx43) mutations that can cause atrioseptal defects and arrhythmias (Paznekas et al., 2003). Twenty-one connexin genes have been identified in humans (Sohl ...
Chapter 05: Synaptic Transmission
... together by clusters of connexins Connexon A channel formed by six connexins Two connexons combine to from a gap junction channel Allows ions to pass from one cell to the other 1-2 nm wide : large enough for all the major cellular ions and many small organic molecules to pass ...
... together by clusters of connexins Connexon A channel formed by six connexins Two connexons combine to from a gap junction channel Allows ions to pass from one cell to the other 1-2 nm wide : large enough for all the major cellular ions and many small organic molecules to pass ...
Innexin7a forms junctions that stabilize the basal
... canal (Fig. 3E). We conclude that furrow canals are also present in Tribolium. However, in contrast to Drosophila, the furrow canals are not heavily enriched with actin. Neither phalloidin nor an actin antibody could detect conspicuous actin enrichment at the bases of the ingressing membrane (Fig. 3 ...
... canal (Fig. 3E). We conclude that furrow canals are also present in Tribolium. However, in contrast to Drosophila, the furrow canals are not heavily enriched with actin. Neither phalloidin nor an actin antibody could detect conspicuous actin enrichment at the bases of the ingressing membrane (Fig. 3 ...
Document
... Add cytoplasmic factor to in vitro > 200 fold difference Trahey and McCormick Science Oct 1987 ...
... Add cytoplasmic factor to in vitro > 200 fold difference Trahey and McCormick Science Oct 1987 ...
Understanding Activity in Electrically Coupled Networks Using PRCs
... As described in the introductory Chap. 1, the PRC, or the phase resetting curve describes whether a perturbation advances or delays the phase of a periodically firing neuron.1 PRCs have been used to predict phase-locking behaviors for periodic, pulsatile stimuli (Glass & Mackey 1988; Rinzel & Erment ...
... As described in the introductory Chap. 1, the PRC, or the phase resetting curve describes whether a perturbation advances or delays the phase of a periodically firing neuron.1 PRCs have been used to predict phase-locking behaviors for periodic, pulsatile stimuli (Glass & Mackey 1988; Rinzel & Erment ...
An EMMPRIN–c-catenin–Nm23 complex drives ATP production and
... Confocal analysis confirmed that EMMPRIN is also located at junctions formed by human umbilical vein endothelial cells (HUVECs), where it partially colocalizes with the junction components VE-cadherin (48% colocalization), PECAM-1 (95%) and JAM-A (also known as F11R; 81%) (data not shown). We next i ...
... Confocal analysis confirmed that EMMPRIN is also located at junctions formed by human umbilical vein endothelial cells (HUVECs), where it partially colocalizes with the junction components VE-cadherin (48% colocalization), PECAM-1 (95%) and JAM-A (also known as F11R; 81%) (data not shown). We next i ...
Cadherins constitute a superfamily of transmembrane - HAL
... local concentration of cadherin molecules at the cell surface, the recruitment of both cytoskeleton binding proteins and regulating proteins and the reorganization of cytoskeleton network. All these processes are intimately interrelated and their individual contribution to the modulation of cell-cel ...
... local concentration of cadherin molecules at the cell surface, the recruitment of both cytoskeleton binding proteins and regulating proteins and the reorganization of cytoskeleton network. All these processes are intimately interrelated and their individual contribution to the modulation of cell-cel ...
Cell crawling mediates collective cell migration to
... 7, 23). Surprisingly, the presence of lamellipodia was observed for all gap sizes tested from 15 up to 150 μm (Movies S1 and S2). The formation of lamellipodia started shortly after the release of the PDMS pillar (during the first 10 min) and were present until there was no more available space, at w ...
... 7, 23). Surprisingly, the presence of lamellipodia was observed for all gap sizes tested from 15 up to 150 μm (Movies S1 and S2). The formation of lamellipodia started shortly after the release of the PDMS pillar (during the first 10 min) and were present until there was no more available space, at w ...
Viscoelastic dissipation stabilizes cell shape changes
... case of biological systems might cause fracture or loss of cellular integrity (9). On the other hand, viscous materials do not store elastic energy and thus have no reference configuration. As a result, deformation keeps increasing as long as a force is applied, and no recoil is observed upon releas ...
... case of biological systems might cause fracture or loss of cellular integrity (9). On the other hand, viscous materials do not store elastic energy and thus have no reference configuration. As a result, deformation keeps increasing as long as a force is applied, and no recoil is observed upon releas ...
Transfected Connexin45 Alters Gap Junction Permeability in Cells
... Many cells express more than one connexin. Differential ...
... Many cells express more than one connexin. Differential ...
Epithelia and integration in sponges
... implies being constructed of fewer parts with less hierarchical organization. In fact, sponges are usually described as lacking organs, tissues, nerves, muscle, and even epithelia. However, not only is this view not very useful for understanding what characteristics the animals have, there is also m ...
... implies being constructed of fewer parts with less hierarchical organization. In fact, sponges are usually described as lacking organs, tissues, nerves, muscle, and even epithelia. However, not only is this view not very useful for understanding what characteristics the animals have, there is also m ...
Gap junction
A gap junction may also be called a nexus or macula communicans. When found in nerves they are also referred to as an electrical synapse. While an ephapse has some similarities to a gap junction, by modern definition these two entities are different. Gap junctions are a specialized intercellular connection between a multitude of animal cell-types. They directly connect the cytoplasm of two cells, which allows various molecules, ions and electrical impulses to directly pass through a regulated gate between cells.One gap junction channel is composed of two connexons(or hemichannels), which connect across the intercellular space. Gap junctions are analogous to the plasmodesmata that join plant cells.Gap junctions are expressed in virtually all tissues of the body, with the exception of adult fully developed skeletal muscle and mobile cell types such as sperm or erythrocytes. Gap Junctions, however, are not found in simpler organisms such as sponges and slime molds.