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Orientation of the transcription factor binding
Orientation of the transcription factor binding

... challenge is to expand the known repertoire of TF-target pairs by identifying novel Transcription Factor Binding Sites (TFBS) based on sequence data. One main difficulty in such computational predictions is the large number of false positives they generate. Here we examine the association of five fe ...
1 mec-15 Encodes an F-box Protein Required for Touch
1 mec-15 Encodes an F-box Protein Required for Touch

... ubiquitin ligase (NAKATA et al. 2005). Thus, modulation of protein levels by proteosome pathways plays a critical role in regulating the development of neurons in C. elegans. In this paper we describe the molecular and phenotypic characterization of mec15, which defines an additional ubiquitin ligas ...
Identification and quantification of mycotoxigenic fungi
Identification and quantification of mycotoxigenic fungi

... This is an elegant, and well-known, technique that has brought previously inconceivable areas of research into reach. There is a large literature on the subject. However, the basic process involves denaturing (separating the individual strands) DNA by heat applied for specific lengths of time. A sma ...
Characterization of two rice DNA methyltransferases
Characterization of two rice DNA methyltransferases

... function. The Dnmt1/ MET1 class has maintenance methylation activity in vivo (Finnegan et al. 1996;Li et al. 1992;Ronemus et al. 1996) . Dnmt2 MTases contain only a methyltransferase domain and lack significant activity both in vivo and in vitro (Okano et al. 1998) . Whereas the Dnmt3 class contains ...
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File

... reappeared from nowhere! *A dominant trait appears in every generation of the offspring. A recessive trait does not. ...
Identification of R-Gene Homologous DNA Fragments Genetically
Identification of R-Gene Homologous DNA Fragments Genetically

... the CK1 and L3 probes had many bands in common, suggesting that the CK1 and L3 fragments detected different parts of the same genes. The DNA copy number per locus detected by the CK1 probe was similar as detected by the L3 probe, except for the L3C locus, which contained one additional copy in both ...
Gene Section SIX1 (sine oculis homeobox homolog 1) (mammalian)
Gene Section SIX1 (sine oculis homeobox homolog 1) (mammalian)

... Six1 is a transcription factor that is known to play a role in the proliferation and survival of precursor cells during normal development in numerous tissues including, amongst others, the kidney, inner ear, and muscle. It is also demonstrated to play a role in the proliferation of cancer cells and ...
rolduc meeting. feel connected!
rolduc meeting. feel connected!

... ncing: discovering genetic causes of mitochondrial disorders ic and pathophysiological basis of mitochondrial disorders althy individuals affects multiple protein-coding genes and can result in severe congenital abnormalities in offspring teasomal activity as a marker of myogenic dysfunction ...
The Incompatible Desiderata of Gene Cluster Properties
The Incompatible Desiderata of Gene Cluster Properties

... easily controlled by the parameter g for max-gap clusters but there is no way to constrain the local density of r-window clusters without also further constraining the maximum cluster length. This trade-off between global and local density gives a simple illustration of how it can be difficult to de ...
Genetics
Genetics

... Chromosomes are found in each of our cells. We have 23 pairs of them. That means each cell has 46 in all. Chromosomes are made up of alleles. Each one has more than two thousand alleles along its length. Alleles are instructions for cells. Because chromosomes come in pairs, alleles come in pairs, to ...
Ribosomal Protein RPL27a Promotes Female
Ribosomal Protein RPL27a Promotes Female

... synthesis and sufficient ribosome levels to support morphogenesis of the gametophyte. Here, we show that mutations in a number of different ribosomal protein genes lead to reduced seed set and an increase in the number of defective ovules in siliques. This is particularly apparent in mutants affectin ...
Homology - a persona..
Homology - a persona..

... can lead to a tree that has the correct phylogeny for the sequences but not for the taxa from which they derive; a gene tree is not necessarily a species tree. Xenology is defined as that condition (horizontal transfer) where the history of the gene involves an interspecies transfer of genetic mater ...
Chromosome-encoded gene cluster for the
Chromosome-encoded gene cluster for the

... this paper. Based on these characteristics, the Institute of Microbiology (Chinese Academy of Sciences, Beijing) tentatively identified AD9 as Delftia acidovorans. To confirm this identification at the genetic level, the partial 16S rDNA of AD9 was sequenced and compared with other sequences in DNA ...
Defects in Protein Glycosylation Cause SHO1-Dependent
Defects in Protein Glycosylation Cause SHO1-Dependent

... PAK family, and Ste5, a scaffolding protein for the MAP kinase cascade. The cascade itself is composed of Ste11 (an MAPKKK), Ste7 (an MAPKK), and Fus3 or Kss1 (two MAPKs). Either MAPK is capable of functioning in the pheromone pathway, but it is likely that Fus3 does so in vivo (Madhani and Fink 199 ...
Current Microbiology
Current Microbiology

... of unknown function (hoxE), is separated by at least 16 kb from the residual structural genes hoxUYH in an unusual way. With respect to the accessory genes, hoxW, hypA, B, and F are contiguous downstream of hoxH in A. nidulans [4], whereas they are scattered throughout the genome of Synechocystis [1 ...
Effects of increased concentrations of chloride on the expression of
Effects of increased concentrations of chloride on the expression of

... significantly different effects on gene behavior and impacts on the expression of many different proteins. Since, the first line of defense against reactive oxygen species are the superoxide dismutase (SOD), increasing the amount of SOD under stress can be considered as an indicator for the formatio ...
3.1 Intro to Genetics
3.1 Intro to Genetics

... your mother has blue eyes and your father has brown eyes, can you predict if their child will have blue or brown eyes? Can you calculate it? ...
The Structure and Function of the DNA from Bacteriophage Lambda
The Structure and Function of the DNA from Bacteriophage Lambda

24. Genetics - WordPress.com
24. Genetics - WordPress.com

... F1 plants: one gene dominant phenotype one gene recessive phenotype ...
Arabidopsis brassinosteroid biosynthetic mutantdwarf7
Arabidopsis brassinosteroid biosynthetic mutantdwarf7

... BRI1-EMS-SUPPRESSOR1 (BES1) [40,41] in Arabidopsis. Although BES1 and BZR1 share 88% identity at their amino acid sequences, the two transcription factors regulate their target genes differently; BES1 is involved in transcriptional activation [40], and BZR1 both activates and represses transcription ...
Chapter 10
Chapter 10

... hedgehog, shrew, opposum, horse, elephant, pangolin, sloth, llama, and dolphin. Also sequenced are the genomes of many species of fruit flies, worms, and fungi, hundreds of bacteria, mitochondria, and chloroplasts, and thousands of viruses. Together these genomes represent a colossal amount of seque ...
The Gene Ontology
The Gene Ontology

... operations or sets of molecular events with a defined beginning and end ...
About the origin and development of hereditary
About the origin and development of hereditary

... which suggests that, previous to this loss, another hit should occur to initiate the transformation of normal into tumoral cells. (2) All known mechanisms of inactivation of the candidate von Hippel-Lindau (VHL) gene have been studied in the tumors, detecting alterations in 65% of them. This confirm ...
Proprietary Databases
Proprietary Databases

... The Personalis Regulatory Regions Database contains several hundred thousand putative transcription factor binding sites/regulatory regions. These regulatory annotations enable us to interpret intergenic and other non-coding variants that may have a significant impact on gene expression and function ...
Compound leaves: equal to the sum of their parts?
Compound leaves: equal to the sum of their parts?

... information from completed genome projects. The current challenge is to explore whether the regulatory mechanisms that control leaf development in model species have been conserved in non-model species and how these regulatory mechanisms have evolved to produce various leaf forms. The leaves of seed ...
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Epigenetics of human development

Development before birth, including gametogenesis, embryogenesis, and fetal development, is the process of body development from the gametes are formed to eventually combine into a zygote to when the fully developed organism exits the uterus. Epigenetic processes are vital to fetal development due to the need to differentiate from a single cell to a variety of cell types that are arranged in such a way to produce cohesive tissues, organs, and systems.Epigenetic modifications such as methylation of CpGs (a dinucleotide composed of a 2'-deoxycytosine and a 2' deoxyguanosine) and histone tail modifications allow activation or repression of certain genes within a cell, in order to create cell memory either in favor of using a gene or not using a gene. These modifications can either originate from the parental DNA, or can be added to the gene by various proteins and can contribute to differentiation. Processes that alter the epigenetic profile of a gene include production of activating or repressing protein complexes, usage of non-coding RNAs to guide proteins capable of modification, and the proliferation of a signal by having protein complexes attract either another protein complex or more DNA in order to modify other locations in the gene.
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