Recent advances in bioinformatics and computational biology
... find the optimal alignment of a group of nucleotide or protein sequences is a combinatorial optimization problem. Metaheuristics are approaches that guide local heuristic search procedure to explore the solution space beyond local optimality. Examples of metaheuristics include genetic algorithm, sim ...
... find the optimal alignment of a group of nucleotide or protein sequences is a combinatorial optimization problem. Metaheuristics are approaches that guide local heuristic search procedure to explore the solution space beyond local optimality. Examples of metaheuristics include genetic algorithm, sim ...
HRB/MRCG 2011/7 Genome-wide DNA methylation analysis of
... Unique methylation changes were found in the brain of patients with TLE as well as according to pathology. An analysis of what the genes do found many to be involved in brain development and structure, neurotransmission, cell death and DNA transcription. We also identified methylation changes to wha ...
... Unique methylation changes were found in the brain of patients with TLE as well as according to pathology. An analysis of what the genes do found many to be involved in brain development and structure, neurotransmission, cell death and DNA transcription. We also identified methylation changes to wha ...
EOC Review Unit 7_Genetics
... B-4.6 Predict inherited traits by using the principles of Mendelian genetics (including segregation, independent assortment, and dominance). What you should know: - Genes control each trait of a living thing by controlling the formation of an organism’s proteins. - diploid - pair of chromosomes - on ...
... B-4.6 Predict inherited traits by using the principles of Mendelian genetics (including segregation, independent assortment, and dominance). What you should know: - Genes control each trait of a living thing by controlling the formation of an organism’s proteins. - diploid - pair of chromosomes - on ...
Epigenetic correlations with adult phenotype: Implications for
... programming. The intent of developmental programming is to match the growing fetus to its predicted post natal environment but it can become maladaptive when the ‘fit’ between the predicted and later environments is mismatched. Where adverse programming occurs a “metabolic phenotype” may result char ...
... programming. The intent of developmental programming is to match the growing fetus to its predicted post natal environment but it can become maladaptive when the ‘fit’ between the predicted and later environments is mismatched. Where adverse programming occurs a “metabolic phenotype” may result char ...
Bio 135 Ch. 11 Rev Guide
... 25. Know what crossing over is, what it looks like, and how it changes the chromosomes. (see text p. 277, fig 11-‐16) ...
... 25. Know what crossing over is, what it looks like, and how it changes the chromosomes. (see text p. 277, fig 11-‐16) ...
Review handout A
... What can you say about the inheritance of this trait (dominant/recessive, sex-linked/autosomal)? Autosomal recessive. Recessive because there is an affected offspring without an affected parent. It is autosomal because an X-linked trait cannot be passed to a daughter unless the father is affected (r ...
... What can you say about the inheritance of this trait (dominant/recessive, sex-linked/autosomal)? Autosomal recessive. Recessive because there is an affected offspring without an affected parent. It is autosomal because an X-linked trait cannot be passed to a daughter unless the father is affected (r ...
Dr. Hieter`s Lecture
... that displayed cell-cycle dependent fluctuations in transcript levels. • 40% were of unknown function. • 30% are located next to other cell-cycle transcribed genes (possible enhancer effect). • Correlation with known and unknown promoter elements. ...
... that displayed cell-cycle dependent fluctuations in transcript levels. • 40% were of unknown function. • 30% are located next to other cell-cycle transcribed genes (possible enhancer effect). • Correlation with known and unknown promoter elements. ...
Using High-Throughput Sequencing to Investigate the Transgenerational
... levels [25-26]. Modifications to the histone tails, particularly the addition of methyl groups or acetyl groups to key lysine residues, is known to either activate or repress gene transcription by altering interactions of the transcription factors with the DNA. Information about DNA-protein interact ...
... levels [25-26]. Modifications to the histone tails, particularly the addition of methyl groups or acetyl groups to key lysine residues, is known to either activate or repress gene transcription by altering interactions of the transcription factors with the DNA. Information about DNA-protein interact ...
Downstream analysis of transcriptomic data
... • Dimensionality reduc3on techniques are a common approach for dealing with noisy, high-‐dimensional data. • These unsupervised methods can help uncover interes3ng structure in complex datasets. • However they ...
... • Dimensionality reduc3on techniques are a common approach for dealing with noisy, high-‐dimensional data. • These unsupervised methods can help uncover interes3ng structure in complex datasets. • However they ...
Using Statistical Design and Analysis to Detect
... There are some random effects that are unknown: slide effects other effects introduced in the experiment (such as biological replicate effects) residual random effects that include any sources of variation unaccounted for by other terms ...
... There are some random effects that are unknown: slide effects other effects introduced in the experiment (such as biological replicate effects) residual random effects that include any sources of variation unaccounted for by other terms ...
Zebrafish as a model organism for the study of functional genomics
... In order to investigate the functional roles of novel genes in vertebrates, the generation of transgenic or gene knock-out mice has been wildly established. However, it is an expensive and time-consuming process that cannot be applicable to other vertebrate species. Zebrafish is a good model organis ...
... In order to investigate the functional roles of novel genes in vertebrates, the generation of transgenic or gene knock-out mice has been wildly established. However, it is an expensive and time-consuming process that cannot be applicable to other vertebrate species. Zebrafish is a good model organis ...
15C-ErorsExcptionChromoInh
... mammalian genes depend on whether they were inherited from the mother or the father (imprinting) • For most genes it is a reasonable assumption that a specific allele will have the same effect regardless of whether it was inherited from the mother or father. • However, for some traits in mammals, it ...
... mammalian genes depend on whether they were inherited from the mother or the father (imprinting) • For most genes it is a reasonable assumption that a specific allele will have the same effect regardless of whether it was inherited from the mother or father. • However, for some traits in mammals, it ...
GENETICS
... The offspring of many generations that have the same trait Purebred short pea plants always come from short parent plants Purebred German Sheppard dogs always come from German Sheppard parents ...
... The offspring of many generations that have the same trait Purebred short pea plants always come from short parent plants Purebred German Sheppard dogs always come from German Sheppard parents ...
BIO 5099: Molecular Biology for Computer Scientists
... I missed by a factor of 1000x the number of extant species in the world. (Thanks, Dan) http://www.all-species.org: “~1.7 million species have been identified and described. Estimates of undiscovered species on Earth range from 10 million to 100 million” ...
... I missed by a factor of 1000x the number of extant species in the world. (Thanks, Dan) http://www.all-species.org: “~1.7 million species have been identified and described. Estimates of undiscovered species on Earth range from 10 million to 100 million” ...
CHAPTER 15 THE CHROMOSOMAL BASIS OF INHERITANCE
... mammalian genes depend on whether they were inherited from the mother or the father (imprinting) • For most genes it is a reasonable assumption that a specific allele will have the same effect regardless of whether it was inherited from the mother or father. • However, for some traits in mammals, it ...
... mammalian genes depend on whether they were inherited from the mother or the father (imprinting) • For most genes it is a reasonable assumption that a specific allele will have the same effect regardless of whether it was inherited from the mother or father. • However, for some traits in mammals, it ...
Slide - Smith Lab
... resulting in the formation of the optic vesicle • Inductive interaction between neural ectoderm and surface ectoderm results in formation of the lens placode, defined by the expression of Pax6 and Sox2 • Lens and cornea share many transcriptional networks, consistent with their origin from the surfa ...
... resulting in the formation of the optic vesicle • Inductive interaction between neural ectoderm and surface ectoderm results in formation of the lens placode, defined by the expression of Pax6 and Sox2 • Lens and cornea share many transcriptional networks, consistent with their origin from the surfa ...
Automate Function Prediction
... • Score GO classes using a score that takes the frequency of GO class in seq. DB into account • Method is used to predict: – GO Classes ...
... • Score GO classes using a score that takes the frequency of GO class in seq. DB into account • Method is used to predict: – GO Classes ...
Control of reproduction by Polycomb Group complexes in animals
... to triploid endosperm. The fertilised egg cell gives rise to the embryo. As the two male gametes of a given pollen tube originate from a single mitosis, they are genetically identical and their zygotic fusion products are also genetically identical. In spite of their unique genetic identity, the emb ...
... to triploid endosperm. The fertilised egg cell gives rise to the embryo. As the two male gametes of a given pollen tube originate from a single mitosis, they are genetically identical and their zygotic fusion products are also genetically identical. In spite of their unique genetic identity, the emb ...
Human and murine PTX1/Ptx1 gene maps to the region for Treacher
... typed for all loci are shown at the top of the figure. For individual pairs of loci, more than 112 animals were typed (see text). Each column represents the chromosome identified in the backcross progeny that was inherited from the (C57BL/6J × M. spretus) F1 parent. The shaded boxes represent the pr ...
... typed for all loci are shown at the top of the figure. For individual pairs of loci, more than 112 animals were typed (see text). Each column represents the chromosome identified in the backcross progeny that was inherited from the (C57BL/6J × M. spretus) F1 parent. The shaded boxes represent the pr ...
Conference title
... read Illumina data for the de novo assembly of a non-model snail species transcriptome (Radix balthica, Basommatophora, Pulmonata), and a comparison of assembler performance. BMC Genomics, 12:317. Wheat, C. W., and H. Vogel (2011) Transcriptome sequencing goals, assembly and assessment in V. Orgogoz ...
... read Illumina data for the de novo assembly of a non-model snail species transcriptome (Radix balthica, Basommatophora, Pulmonata), and a comparison of assembler performance. BMC Genomics, 12:317. Wheat, C. W., and H. Vogel (2011) Transcriptome sequencing goals, assembly and assessment in V. Orgogoz ...
Dr. Wade Berrettini`s Powerpoint presentation
... to obtain a genotype at 1 SNP every ~ 3000 base pairs in the genome, allowing determination of most common SNPs. Allele-specific fluorescently-tagged DNA fragments (known as oligonucleotides) are mounted on the slide. The oligonucleotides are sequence-specific for one of the two alleles of a given S ...
... to obtain a genotype at 1 SNP every ~ 3000 base pairs in the genome, allowing determination of most common SNPs. Allele-specific fluorescently-tagged DNA fragments (known as oligonucleotides) are mounted on the slide. The oligonucleotides are sequence-specific for one of the two alleles of a given S ...
PDF
... (Graham, 1974). Subsequent studies, however, proved that neither of these explanations was correct (see below). Our first series of experiments was designed to test if gross cytoplasmic differences existed between fertilized and activated eggs and especially if extragenetic components from spermatoz ...
... (Graham, 1974). Subsequent studies, however, proved that neither of these explanations was correct (see below). Our first series of experiments was designed to test if gross cytoplasmic differences existed between fertilized and activated eggs and especially if extragenetic components from spermatoz ...
Solving Linkage Problems
... Solving Linkage Problems Tip: The most important part is to determine which progeny resulted from parental type gametes, and which from recombinant types. In a plant, leaf color and leaf shape are controlled by two linked genes. Leaves of the wild-type plant are red. A recessive mutation in this gen ...
... Solving Linkage Problems Tip: The most important part is to determine which progeny resulted from parental type gametes, and which from recombinant types. In a plant, leaf color and leaf shape are controlled by two linked genes. Leaves of the wild-type plant are red. A recessive mutation in this gen ...
File
... Punnet Square - A tool we use for predicting the traits of an offspring – Letters are used as symbols to designate genes – Capital letters are used for dominant genes – Lower case letters are used for recessive genes – Genes always exist in pairs – Alleles are different forms of a gene, like having ...
... Punnet Square - A tool we use for predicting the traits of an offspring – Letters are used as symbols to designate genes – Capital letters are used for dominant genes – Lower case letters are used for recessive genes – Genes always exist in pairs – Alleles are different forms of a gene, like having ...
chapter 15 - Course Notes
... produce a 1:1:1:1 phenotypic ratio. If completely linked, we should expect to see a 1:1:0:0 ratio with only parental phenotypes among offspring. Most of the offspring had parental phenotypes, suggesting linkage between the genes. However, 17% of the flies were recombinants, suggesting incomple ...
... produce a 1:1:1:1 phenotypic ratio. If completely linked, we should expect to see a 1:1:0:0 ratio with only parental phenotypes among offspring. Most of the offspring had parental phenotypes, suggesting linkage between the genes. However, 17% of the flies were recombinants, suggesting incomple ...