Editorial - Ontario Association on Developmental Disabilities
... John Langdon Down was the first to formally describe this condition in 1866, when he distinguished it from cretinism (which now is known to be caused by a severe deficiency of iodine), although the characteristic physical features of Down syndrome have been depicted for centuries in classical art. I ...
... John Langdon Down was the first to formally describe this condition in 1866, when he distinguished it from cretinism (which now is known to be caused by a severe deficiency of iodine), although the characteristic physical features of Down syndrome have been depicted for centuries in classical art. I ...
Polymorphism of the CTNNB1 and FOXL2 Genes is not
... Polymorphism of the CTNNB1 and FOXL2 Genes is not Associated with Canine XX Testicular/Ovotesticular Disorder of Sex Development* Sylwia SALAMON, Joanna NOWACKA-WOSZUK, and Marek SWITONSKI ...
... Polymorphism of the CTNNB1 and FOXL2 Genes is not Associated with Canine XX Testicular/Ovotesticular Disorder of Sex Development* Sylwia SALAMON, Joanna NOWACKA-WOSZUK, and Marek SWITONSKI ...
View Poster - Technology Networks
... Micro (mi)RNAs are short (mostly 21-23nt) RNAs with the ability to regulate target genes post-transcriptionally. Many known miRNAs are involved in tissue development and maintenance and, until now, miRNAs appeared to be absent altogether from unicellular organisms. This has often led to the speculat ...
... Micro (mi)RNAs are short (mostly 21-23nt) RNAs with the ability to regulate target genes post-transcriptionally. Many known miRNAs are involved in tissue development and maintenance and, until now, miRNAs appeared to be absent altogether from unicellular organisms. This has often led to the speculat ...
Punnett Squares and Binomials
... D, Recognize that mathematical facts, procedures, and claims must be justified. Anticipation of Questions: I expect students to have difficulty remembering the pattern of a squared binomial. Some of the questions I anticipate the students asking are as follows: 1. Why can’t you just distribute the p ...
... D, Recognize that mathematical facts, procedures, and claims must be justified. Anticipation of Questions: I expect students to have difficulty remembering the pattern of a squared binomial. Some of the questions I anticipate the students asking are as follows: 1. Why can’t you just distribute the p ...
In hemoglobin Tocucci there was a replacement of the amino acid
... What process can lead to break of genes linkage? A. mitosis B. pleiotropy C. meiosis D. mutation E. crossing-over ANSWER: E All of the following aneuploids are resulted of female nondisjunction except A. triplo-X. B. Jacobs syndrome. C. Down syndrome. D. Patau syndrome. E. Klinefelter syndrome. ANSW ...
... What process can lead to break of genes linkage? A. mitosis B. pleiotropy C. meiosis D. mutation E. crossing-over ANSWER: E All of the following aneuploids are resulted of female nondisjunction except A. triplo-X. B. Jacobs syndrome. C. Down syndrome. D. Patau syndrome. E. Klinefelter syndrome. ANSW ...
The Plant Cell
... overexpressed in Arabidopsis. miR172 normally is expressed in a temporal manner, consistent with its proposed role in flowering time control. The regulatory target of miR172 is a subfamily of APETALA2 (AP2) transcription factor genes. We present evidence that miR172 downregulates these target genes ...
... overexpressed in Arabidopsis. miR172 normally is expressed in a temporal manner, consistent with its proposed role in flowering time control. The regulatory target of miR172 is a subfamily of APETALA2 (AP2) transcription factor genes. We present evidence that miR172 downregulates these target genes ...
Flowering-Time Genes Modulate the Response to
... However, only LFY is expressed also during the vegetative phase, when its RNA is found in young leaf primordia, which arise in positions on the shoot meristem that are homologous to those of the later-arising flowers (Blázquez et al. 1997; Hempel et al. 1997). LFY RNA expression increases upon flor ...
... However, only LFY is expressed also during the vegetative phase, when its RNA is found in young leaf primordia, which arise in positions on the shoot meristem that are homologous to those of the later-arising flowers (Blázquez et al. 1997; Hempel et al. 1997). LFY RNA expression increases upon flor ...
Induction of XIST expression from the human active
... The XIST gene is the only gene known to be expressed exclusively from the inactive X chromosome (8) and is localised to the smallest interval of the X chromosome required in cis for inactivation to occur (9,10). The XIST RNA, which is not translated, remains in the nucleus where it is associated wit ...
... The XIST gene is the only gene known to be expressed exclusively from the inactive X chromosome (8) and is localised to the smallest interval of the X chromosome required in cis for inactivation to occur (9,10). The XIST RNA, which is not translated, remains in the nucleus where it is associated wit ...
Complete genome sequence of the rifamycin SV
... Amycolatopsis mediterranei is used for industry-scale production of rifamycin, which plays a vital role in antimycobacterial therapy. As the first sequenced genome of the genus Amycolatopsis, the chromosome of strain U32 comprising 10 236 715 base pairs, is one of the largest prokaryotic genomes eve ...
... Amycolatopsis mediterranei is used for industry-scale production of rifamycin, which plays a vital role in antimycobacterial therapy. As the first sequenced genome of the genus Amycolatopsis, the chromosome of strain U32 comprising 10 236 715 base pairs, is one of the largest prokaryotic genomes eve ...
An Arabidopsis Mutant with a Reduced Leve1 of cabl40 RNA 1s a
... occurrence of cosuppression are: (1) the unexpected production of antisense RNA, (2) methylation of the cosuppressed' promoters, and (3) ectopic pairing of the repeated sequences of the genome (reviewed in Jorgensen, 1991). An antisense transcript could suppress gene expression post-transcriptionall ...
... occurrence of cosuppression are: (1) the unexpected production of antisense RNA, (2) methylation of the cosuppressed' promoters, and (3) ectopic pairing of the repeated sequences of the genome (reviewed in Jorgensen, 1991). An antisense transcript could suppress gene expression post-transcriptionall ...
Leapfrogging: primordial germ cell transplantation
... 3′ UTRs to drive Cas9 mRNA into germ cells has not been demonstrated in Xenopus, but has been used in zebrafish (MorenoMateos et al., 2015). However, we speculate that the use of highly efficient doses of Cas9-sgRNA complexes or efficient doses of Cas9 mRNA plus sgRNA (see Nakayama et al., 2014) mig ...
... 3′ UTRs to drive Cas9 mRNA into germ cells has not been demonstrated in Xenopus, but has been used in zebrafish (MorenoMateos et al., 2015). However, we speculate that the use of highly efficient doses of Cas9-sgRNA complexes or efficient doses of Cas9 mRNA plus sgRNA (see Nakayama et al., 2014) mig ...
Gene Regulation in Development and Evolution
... not only true for comparatively simple creatures such as nematode worms, but also pertains to the “crown and summit” of animal evolution, the human genome. Differential gene expression can be defined as the synthesis of a protein (or RNA in the case of non-coding genes) in a subset of the cells comp ...
... not only true for comparatively simple creatures such as nematode worms, but also pertains to the “crown and summit” of animal evolution, the human genome. Differential gene expression can be defined as the synthesis of a protein (or RNA in the case of non-coding genes) in a subset of the cells comp ...
Trans-HHS Workshop: Diet, DNA Methylation
... The roles of nutrients in DNA methylation, especially in genome-wide methylation, have also been described. Zinc deficiency can reduce the utilization of methyl groups from S-adenosylmethionine (SAM) in rat liver and results in genomic DNA hypomethylation as well as histone hypomethylation (20,21). ...
... The roles of nutrients in DNA methylation, especially in genome-wide methylation, have also been described. Zinc deficiency can reduce the utilization of methyl groups from S-adenosylmethionine (SAM) in rat liver and results in genomic DNA hypomethylation as well as histone hypomethylation (20,21). ...
Transgenic Tobacco Plants with Bacillus thuringiensis 8
... which leads to osmotic imbalance and cell lysis (Hofmann et ai., 1988; Slatin et ai., 1990; English et al., 1991; English and Slatin, 1992). Among insecticidal protein genes, lepidopteran specific genes, cryJA class, are mostly well characterized (Adang et al., 1985; Thorne et al., 1986; Schnepf et ...
... which leads to osmotic imbalance and cell lysis (Hofmann et ai., 1988; Slatin et ai., 1990; English et al., 1991; English and Slatin, 1992). Among insecticidal protein genes, lepidopteran specific genes, cryJA class, are mostly well characterized (Adang et al., 1985; Thorne et al., 1986; Schnepf et ...
On epistasis: why it is unimportant in polygenic directional selection References
... Recent years have seen an increased emphasis on epistasis (e.g. Wolf et al. 2000; Carlborg & Haley 2004). Students of development and evo-devo, as well as some human geneticists, have paid particular interest to interactions. For those in these fields, epistasis is an interesting phenomenon on its o ...
... Recent years have seen an increased emphasis on epistasis (e.g. Wolf et al. 2000; Carlborg & Haley 2004). Students of development and evo-devo, as well as some human geneticists, have paid particular interest to interactions. For those in these fields, epistasis is an interesting phenomenon on its o ...
Chromosome Mutations - Circle
... a mechanism for choosing some variants over others resulting in survival of the fittest and gradual changes in populations of organisms. Without a mechanism for generation of new variation, populations would be selected into a corner where only one variation would survive and new species could never ...
... a mechanism for choosing some variants over others resulting in survival of the fittest and gradual changes in populations of organisms. Without a mechanism for generation of new variation, populations would be selected into a corner where only one variation would survive and new species could never ...
BIOLOGY 181 Lab # 10 Mendelian Genetics in Corn INTRODUCTION
... produces the endosperm phenotype smooth. Smooth kernels appear hard and starchy. The recessive phenotype produces wrinkled kernels, which are shrunken in appearance. In this lab, we will examine the mode of inheritance of these two genes by looking at the progeny of a fertilization event between a m ...
... produces the endosperm phenotype smooth. Smooth kernels appear hard and starchy. The recessive phenotype produces wrinkled kernels, which are shrunken in appearance. In this lab, we will examine the mode of inheritance of these two genes by looking at the progeny of a fertilization event between a m ...
Do the Time-Warp: Continuous Alignment ... Expression Time-Series Data Georg Kurt Gerber UC
... In this thesis, a probabilistic framework is presented for making gene expression timeseries data from different experiments directly comparable. This method addresses the issues of DNA microarray data noise, missing values, different sampling rates between experiments, and variability in the timing ...
... In this thesis, a probabilistic framework is presented for making gene expression timeseries data from different experiments directly comparable. This method addresses the issues of DNA microarray data noise, missing values, different sampling rates between experiments, and variability in the timing ...
Linkage Mapping
... A testcross lets us “count” the number of recombinant and nonrecombinant gametes The phenotype of the testcross progeny is determined by the gametes from the heterozygous parent Each phenotype in a testcross has a unique genotype (unlike in the F2 of dihybrid cross) ...
... A testcross lets us “count” the number of recombinant and nonrecombinant gametes The phenotype of the testcross progeny is determined by the gametes from the heterozygous parent Each phenotype in a testcross has a unique genotype (unlike in the F2 of dihybrid cross) ...
Genome browsers and other resources
... Genome browsers and other resources Some from this years issue: 6. Genomic variation, diseases and drugs – highlights from 29 papers OMIM.org: Online Mendelian Ineritance in Man (OMIM*), an online catalog of human genes and genetic disorders GRASP v2.0: an update on the Genome-Wide Repository o ...
... Genome browsers and other resources Some from this years issue: 6. Genomic variation, diseases and drugs – highlights from 29 papers OMIM.org: Online Mendelian Ineritance in Man (OMIM*), an online catalog of human genes and genetic disorders GRASP v2.0: an update on the Genome-Wide Repository o ...
Introduction to Mendelian Genetics
... Important terms to know: • Gene: – A segment of DNA that codes for a specific protein/trait. • Allele: – A specific form of a gene • Dominant: – The overpowering form of a gene – Occurs most often in a population – Represented by a capital letter ...
... Important terms to know: • Gene: – A segment of DNA that codes for a specific protein/trait. • Allele: – A specific form of a gene • Dominant: – The overpowering form of a gene – Occurs most often in a population – Represented by a capital letter ...
Genomic overview of serine proteases
... model of evolution. In the near future, the full sequencing of the genomes of other species will allow for a more precise analysis of the evolutionary history or serine proteases among different species. Recently, Olsson and Lundwall [21] reported the presence of mouse orthologues to human kallikrei ...
... model of evolution. In the near future, the full sequencing of the genomes of other species will allow for a more precise analysis of the evolutionary history or serine proteases among different species. Recently, Olsson and Lundwall [21] reported the presence of mouse orthologues to human kallikrei ...
Simplified Insertion of Transgenes Onto Balancer Chromosomes via
... inserted onto balancers using a random and inefficient process. Here we describe balancer chromosomes that can be directly targeted with transgenes of interest via recombinase-mediated cassette exchange (RMCE). ...
... inserted onto balancers using a random and inefficient process. Here we describe balancer chromosomes that can be directly targeted with transgenes of interest via recombinase-mediated cassette exchange (RMCE). ...
Nucleic Acids Research
... In fact, if pCC9 is taken as a standard, the only difference in the 3 maps is the additional EcoRI site in pCC1, and the additional HindIII site in pCC10. Sequence Analysis of the Three Putative Chicken Cytochrome c Genes Nucleotide Sequence Differences. Sequence analysis of pCC1, pCC9 and pCC10 wer ...
... In fact, if pCC9 is taken as a standard, the only difference in the 3 maps is the additional EcoRI site in pCC1, and the additional HindIII site in pCC10. Sequence Analysis of the Three Putative Chicken Cytochrome c Genes Nucleotide Sequence Differences. Sequence analysis of pCC1, pCC9 and pCC10 wer ...