Evolutionary dynamics of CRISPR gene drives
... Though originally proposed over a decade ago (1), the chief technical difficulty of this approach—inducing easily programmable cutting at arbitrary target sites—has only recently been overcome by the discovery and development of the CRISPR/Cas9 genome editing system (23– 27). Briefly, Cas9 is an end ...
... Though originally proposed over a decade ago (1), the chief technical difficulty of this approach—inducing easily programmable cutting at arbitrary target sites—has only recently been overcome by the discovery and development of the CRISPR/Cas9 genome editing system (23– 27). Briefly, Cas9 is an end ...
hermann joseph muller 1890—1967
... Edgar Altenburg to share the teaching while they carried out research on mutation rates and the mutation process. Muller also continued with Altenburg a long-term project started in 1912 that was not published until 1920: a study of what Muller called the gene-character problem. On theoretical groun ...
... Edgar Altenburg to share the teaching while they carried out research on mutation rates and the mutation process. Muller also continued with Altenburg a long-term project started in 1912 that was not published until 1920: a study of what Muller called the gene-character problem. On theoretical groun ...
Hermann Joseph Muller - National Academy of Sciences
... Edgar Altenburg to share the teaching while they carried out research on mutation rates and the mutation process. Muller also continued with Altenburg a long-term project started in 1912 that was not published until 1920: a study of what Muller called the gene-character problem. On theoretical groun ...
... Edgar Altenburg to share the teaching while they carried out research on mutation rates and the mutation process. Muller also continued with Altenburg a long-term project started in 1912 that was not published until 1920: a study of what Muller called the gene-character problem. On theoretical groun ...
View our poster (1.1 MB PDF)
... Figure 1. RNA interference (RNAi) is a highly evolutionarily conserved mechanism of gene regulation. RNAi occurs at the post-transcriptional level and is triggered by short double-stranded RNA (dsRNA), known as short interfering RNA (siRNA), which is endogenously processed from long dsRNA by the RNa ...
... Figure 1. RNA interference (RNAi) is a highly evolutionarily conserved mechanism of gene regulation. RNAi occurs at the post-transcriptional level and is triggered by short double-stranded RNA (dsRNA), known as short interfering RNA (siRNA), which is endogenously processed from long dsRNA by the RNa ...
glo-3, a novel Caenorhabditis elegans gene, is required for lysosome
... was coinjected into glo-3(zu446) at 4.5ng/μl with pRF4[Rol-6D] at 100ng/μl. glo3(zu446); kxEx41[glo-3::gfp; rol-6(su1006)D] was used in the analysis presented here, and 6/6 other independently derived lines showed a similar subcellular distribution of GFP. 7/7 lines were Glo(+), showing wild-type pa ...
... was coinjected into glo-3(zu446) at 4.5ng/μl with pRF4[Rol-6D] at 100ng/μl. glo3(zu446); kxEx41[glo-3::gfp; rol-6(su1006)D] was used in the analysis presented here, and 6/6 other independently derived lines showed a similar subcellular distribution of GFP. 7/7 lines were Glo(+), showing wild-type pa ...
Dysfunction of Wild-Type Huntingtin in Huntington
... factors (2). Various authors demonstrated that transcription factors such as CBP [cAMP-response element binding protein (CREB) binding protein], TATA binding protein, and Sin3A can be recruited into the intranuclear aggregates, thus reinforcing the hypothesis of a role for transcriptional dysregulat ...
... factors (2). Various authors demonstrated that transcription factors such as CBP [cAMP-response element binding protein (CREB) binding protein], TATA binding protein, and Sin3A can be recruited into the intranuclear aggregates, thus reinforcing the hypothesis of a role for transcriptional dysregulat ...
zChap07_140901 - Online Open Genetics
... occurs during meiosis (mitotic recombination may also occur in some species, but it is relatively rare). If meiosis results in recombination, the products are said to have a recombinant genotype. On the other hand, if no recombination occurs during meiosis, the products have their original combinati ...
... occurs during meiosis (mitotic recombination may also occur in some species, but it is relatively rare). If meiosis results in recombination, the products are said to have a recombinant genotype. On the other hand, if no recombination occurs during meiosis, the products have their original combinati ...
Design-O-Saur - Beyond Benign
... Decode provided information to build a genetically unique dinosaur. Understand that this is a model that could be used to look at human genetics Understand gene sequences and the results of these sequences Materials: Clay – model magic works very well Student sheets Time needed: 1 x 45-60 ...
... Decode provided information to build a genetically unique dinosaur. Understand that this is a model that could be used to look at human genetics Understand gene sequences and the results of these sequences Materials: Clay – model magic works very well Student sheets Time needed: 1 x 45-60 ...
Asymmetries in Retrieval of Gene Function Information
... The SI field identifies secondary source databanks and accession numbers of outside resources discussed in MEDLINE articles. The field is composed of the source followed by a slash followed by an accession number and can be searched with one or both components, e.g., genbank [si], AF001892 ...
... The SI field identifies secondary source databanks and accession numbers of outside resources discussed in MEDLINE articles. The field is composed of the source followed by a slash followed by an accession number and can be searched with one or both components, e.g., genbank [si], AF001892 ...
Integrated mapping and characterization of the gene underlying the
... as normal or palmate with from three to five rather shallow sinuses, but other leaf shapes such as subokra, okra and superokra with variable depth of indentations also exist. The leaf shape of G. barbadense is defined as Sea Island-type, and is similar to subokra observed in G. hirsutum, having mode ...
... as normal or palmate with from three to five rather shallow sinuses, but other leaf shapes such as subokra, okra and superokra with variable depth of indentations also exist. The leaf shape of G. barbadense is defined as Sea Island-type, and is similar to subokra observed in G. hirsutum, having mode ...
Genetic balancers
... A drawback of these methods is that they are not easily adapted for the isolation of large numbers of lethal mutations over large genetic regions. They may require many different sets of appropriate marker mutations, which either may be too difficult to score or may not exist. A more sophisticated a ...
... A drawback of these methods is that they are not easily adapted for the isolation of large numbers of lethal mutations over large genetic regions. They may require many different sets of appropriate marker mutations, which either may be too difficult to score or may not exist. A more sophisticated a ...
DOCX format - 129 KB - Office of the Gene Technology Regulator
... ‘Plant Material’ means any part of the GM or non-GM Wheat plants grown at a Planting Area, whether viable or not, including, but not limited to, seed, stubble and pollen, whether from the plant itself or derived from or produced by the plant. ‘Planting Area’ means an area of land where the GM and no ...
... ‘Plant Material’ means any part of the GM or non-GM Wheat plants grown at a Planting Area, whether viable or not, including, but not limited to, seed, stubble and pollen, whether from the plant itself or derived from or produced by the plant. ‘Planting Area’ means an area of land where the GM and no ...
Causes that Make a Difference - Philsci
... actually made the difference, such as Mary’s striking the match. This distinction is elusive, and it is tempting to dismiss it as illusory. On this view, there is an ontological difference between causes and non-causes, but there is no ontological difference among causes. This was the position taken ...
... actually made the difference, such as Mary’s striking the match. This distinction is elusive, and it is tempting to dismiss it as illusory. On this view, there is an ontological difference between causes and non-causes, but there is no ontological difference among causes. This was the position taken ...
Imprinting of the Y Chromosome Influences Dosage Compensation
... produces an intermediate level of male survival. Males with both maternal and paternal Y chromosomes have very low survival, suggesting that the effect of the paternal Y chromosome is dominant. In spite of the widely held view that the Y chromosome has little genetic information or importance, Y chr ...
... produces an intermediate level of male survival. Males with both maternal and paternal Y chromosomes have very low survival, suggesting that the effect of the paternal Y chromosome is dominant. In spite of the widely held view that the Y chromosome has little genetic information or importance, Y chr ...
Gene interactions in the evolution of genomic imprinting
... of tuning expression of the gene copies inherited from one parent or another for dosage-sensitive phenotypes, especially those related to demands for maternal resources (Haig, 2002). Here, we examine an alternative set of recently proposed ‘interaction’ models in which genomic imprinting is favoured ...
... of tuning expression of the gene copies inherited from one parent or another for dosage-sensitive phenotypes, especially those related to demands for maternal resources (Haig, 2002). Here, we examine an alternative set of recently proposed ‘interaction’ models in which genomic imprinting is favoured ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... GSTP1 -105 Ile/Ile (AA) genotype (31.1% Vs 68% in controls ; OR=0.457 with 95%CI (0.241 - 0.866); p =0.0164). The frequency of GSTP1 -105 Ile/Val (AG) genotypes was higher in preeclamptic patients than control (45.9% Vs 26%; OR= 1.767 with 95% CI (0.849 - 3.678); p=0.0251). GSTP1 -105 homozygous Val ...
... GSTP1 -105 Ile/Ile (AA) genotype (31.1% Vs 68% in controls ; OR=0.457 with 95%CI (0.241 - 0.866); p =0.0164). The frequency of GSTP1 -105 Ile/Val (AG) genotypes was higher in preeclamptic patients than control (45.9% Vs 26%; OR= 1.767 with 95% CI (0.849 - 3.678); p=0.0251). GSTP1 -105 homozygous Val ...
The Parasexual Cycle in Candida albicans Provides an
... a strains to generate an a/a tetraploid strain. Mating occurs both under laboratory conditions and in different in vivo niches in a mammalian host [9–12]. Population studies of clinical isolates are also consistent with C. albicans strains undergoing genetic exchange in their natural environment, al ...
... a strains to generate an a/a tetraploid strain. Mating occurs both under laboratory conditions and in different in vivo niches in a mammalian host [9–12]. Population studies of clinical isolates are also consistent with C. albicans strains undergoing genetic exchange in their natural environment, al ...
Forche et al. 2008 PLoS Biology
... a strains to generate an a/a tetraploid strain. Mating occurs both under laboratory conditions and in different in vivo niches in a mammalian host [9–12]. Population studies of clinical isolates are also consistent with C. albicans strains undergoing genetic exchange in their natural environment, al ...
... a strains to generate an a/a tetraploid strain. Mating occurs both under laboratory conditions and in different in vivo niches in a mammalian host [9–12]. Population studies of clinical isolates are also consistent with C. albicans strains undergoing genetic exchange in their natural environment, al ...
How to recognize and diagnose chromosome rearrangements. David D. Perkins Background
... with phenotypes that are characteristically different for each het gene (Mylyk 1975. See How to identify and score genes that confer vegetative incompatibility). At least a few ascospores can be obtained from heterozygous crosses of most duplications. As expected, these produce black ascospores, som ...
... with phenotypes that are characteristically different for each het gene (Mylyk 1975. See How to identify and score genes that confer vegetative incompatibility). At least a few ascospores can be obtained from heterozygous crosses of most duplications. As expected, these produce black ascospores, som ...
What determines a leaf`s shape? | SpringerLink
... The independent origin and evolution of leaves as small, simple microphylls or larger, more complex megaphylls in plants has shaped and influenced the natural composition of the environment. Significant contributions have come from megaphyllous leaves, characterized usually as flat, thin lamina entr ...
... The independent origin and evolution of leaves as small, simple microphylls or larger, more complex megaphylls in plants has shaped and influenced the natural composition of the environment. Significant contributions have come from megaphyllous leaves, characterized usually as flat, thin lamina entr ...
Depolarization of the actin cytoskeleton is a specific phenotype in
... (Waddle et al., 1996). We also prepared a strain carrying CAP2-GFP and the sac6∆ mutation to serve as a positive control in this screen. This strain, YJC1435, was obtained by inserting GFP (S65T) and HIS3 at the C terminus of CAP1 in AAY1046, sac6∆ (Adams et al., 1993). The cassette with GFP (S65T) ...
... (Waddle et al., 1996). We also prepared a strain carrying CAP2-GFP and the sac6∆ mutation to serve as a positive control in this screen. This strain, YJC1435, was obtained by inserting GFP (S65T) and HIS3 at the C terminus of CAP1 in AAY1046, sac6∆ (Adams et al., 1993). The cassette with GFP (S65T) ...
Are sperm-binding proteins among two closely related frog species
... addition of sperm in vitro. However, if the cause of infertility is due to the inability of sperm to bind to the egg, IVF will not be able to facilitate fertilization since sperm will never be able to bind and subsequently fuse with the egg. In this case, couples may have to try other artificial rep ...
... addition of sperm in vitro. However, if the cause of infertility is due to the inability of sperm to bind to the egg, IVF will not be able to facilitate fertilization since sperm will never be able to bind and subsequently fuse with the egg. In this case, couples may have to try other artificial rep ...
Y11 Revision material - Biology - Whitworth Community High School
... consist of. □ Describe t he factors that increase and decrease blood pressure. □ Explain the difference between fitness and health □ Explain how smoking increases blood pressure. □ Explain how diet can reduce the risk of heart disease. □ Recall what carbohydrates, fats, and proteins are made of ...
... consist of. □ Describe t he factors that increase and decrease blood pressure. □ Explain the difference between fitness and health □ Explain how smoking increases blood pressure. □ Explain how diet can reduce the risk of heart disease. □ Recall what carbohydrates, fats, and proteins are made of ...