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- ZytoVision GmbH
- ZytoVision GmbH

... CBFA/CBFB transcription factor complex involved in myeloid differentiation. The chromosomal aberrations inv(16) (p13.1q22.1) and the related translocation t(16;16)(p13.1;q22.1), which have been detected in about 10% of patients with AML (acute myeloblastic leukemia), lead to the fusion of the CBFB g ...
Protein Synthesis Lab
Protein Synthesis Lab

... Step 1: Transcription • Transcription is the first step of protein synthesis. This step takes place in the nucleus of eukaryotic cells. Segments of DNA called genes store the information on the proper order of amino acids to construct the cells proteins. Click on one of the chromosomes to see what ...
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.

... another ORF. All have a low codon adaptation index (CAI) of not greater than 0.18, are short (with an average length of 132 codons), and have no known homology with other proteins or are associated with no known phenotype. For four of these ORFs in two pairs (YPL034c and YPL035c, and YPR038w and YPR ...
Jeopardy - Herrin High School
Jeopardy - Herrin High School

... Question: What conditions CANNOT be made from two DNA fingerprints that show identical patterns of bands? a. The DNA from the two DNA fingerprints almost certainly came from the same person. b. The DNA from the two DNA fingerprints definitely came from two different people. c. The DNA from the two D ...
ch 11 notes
ch 11 notes

An Overview of Mutation Detection Methods in Genetic Disorders
An Overview of Mutation Detection Methods in Genetic Disorders

... called mitosis while germ cells are produced through meiosis division. Meiosis involves a reductional division followed by an equational division, Meiosis I and II, respectively. Oogenesis begins in the female fetus at 12 weeks, but it is stopped in a stage of meiosis I (when the homologous chromoso ...
100-Question
100-Question

... 20. Which of the following statements does not apply to members of Class Aves? A. They have feathers. B. They have compact, hollow bones. C. They are homeothermic. D. They excrete urea. E. They use song in mating behavior. 21. Darwin’s theory of natural selection includes all of the following stipul ...
Bickering Genes Shape Evolution
Bickering Genes Shape Evolution

... Although studies such as these follow have two fewer chromosomes than chimps. formation or one that codes for a normal the effects of meiotic drive on the natural And it might help explain why in some Eu- protein. Spores containing the prionhistory of organisms, geneticists Fernando ropean mice, as ...
Autosomal Dominance and Recessive Genetic Diseases
Autosomal Dominance and Recessive Genetic Diseases

... • A genetic disease that occurs when neither parent has any genetic defect. • These cases arise via random genetic mutations in the DNA. • A sporadic genetic mutation is more likely for a dominant disease than for a recessive genetic disease. ...
Chapter 1 (6 questions)
Chapter 1 (6 questions)

... Where do photosynthesis and respiration take place? Understand the general formulas for photosynthesis and respiration. What happens to high energy electrons during photosynthesis? How can you increase the rate of photosynthesis? (3) Review BRIEFLY!!! Calvin Cycle Glycolysis Krebs Cycle Chapter 6 (1 ...
Laws of Heredity -Single Gene Disorders
Laws of Heredity -Single Gene Disorders

... Carrier of X-linked recessive trait ...
chapter11
chapter11

... Cells that produce telomerase continue to divide indefinitely beyond the point at which cell division would normally cease. Active telomerase is found in germ cells that give rise to sperm and eggs in animals, but it is absent in somatic cells. The absence of telomerase activity in animal cells may ...
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...  Rungs of the ladder are different in their composition ...
Mendel`s experiments: Mendel`s conclusions
Mendel`s experiments: Mendel`s conclusions

... Carrier of X-linked recessive trait ...
Investigation 9: Genetic Variation
Investigation 9: Genetic Variation

... genetics code. The alleles for legs are aa, the alleles for eye color are Ee, the alleles for fur pattern are FF, and the alleles for tail shape are tt. • The combination of alleles in an organism’s chromosomes is the organism’s genotype. The genotype lists the paired alleles that are particular to ...
Introduction - Cedar Crest College
Introduction - Cedar Crest College

... By convention, the capital letter represents the dominant and the lowercase letter represents the recessive. ...
Comprehensive analysis of CpG islands in human
Comprehensive analysis of CpG islands in human

... CpG islands are important for gene expression; studies show that methylation of CpG islands plays a significant role in gene silencing. In 1987, Gardiner-Garden and Frommer set the standard definition of what a CpG island is: a 200 base pair stretch of DNA with 50% G + C content and an observed CpG/ ...
Slide 1
Slide 1

... Institute after glowing recommendations from Thomas Hunt Morgan, Edmund Wilson and M. Carey Thomas, the president of Bryn Mawr. Her work on sex determination was published as a Carnegie Institute report in 1905. ...
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... A huge amount of money is spent on space research by many countries. There is debate in society about the benefit of spending such large amounts of money where it could be used to fight poverty, or education or support for the elderly. Describe TWO spin-offs from the space program and explain how th ...
DNA PPT - Lyndhurst School District
DNA PPT - Lyndhurst School District

... (http://creativecommons.org/licenses/by/3.0)], via Wikimedia Commons DNA, chromosomes and genes 7. By Mediran (Own work) [CC-BY-SA-3.0 (http://creativecommons.org/licenses/by-sa/3.0)], via Wikimedia Commons cell 8. By OpenStax College [CC-BY-3.0 (http://creativecommons.org/licenses/by/3.0)], via Wik ...
The GC-content is very variable in different geneome regions
The GC-content is very variable in different geneome regions

... consequence this can be the main difference between species: the variability of genes more than the protein characteristics. Moreover we know that euchromatic regions undergo crossing over with an high probability [20]. It is known that CENP-A, a centromere protein, is able to identify centromeres b ...
Chapter 11: Complex Inheritance and Human Heredity
Chapter 11: Complex Inheritance and Human Heredity

... In organisms such as peas and fruit flies, scientists can perform crosses to study genetic relationships. In the case of humans, a scientist studies a family history using a pedigree, a diagram that traces the inheritance of a particular trait through several generations. A pedigree uses symbols to ...
Genetic mapping and manipulation: Chapter 6
Genetic mapping and manipulation: Chapter 6

... autonomous pieces of DNA derived from normal chromosomes. They are usually relatively small as compared with full-length chromosomes and exhibit segregation properties that are independent of other chromosomes, including the chromosome from which they were derived. In many ways they most resemble ex ...
Keratosis pilaris and ulerythema ophryogenes associated with an
Keratosis pilaris and ulerythema ophryogenes associated with an

... keratosis pilaris affecting shoulders, upper back, upper arms, and thighs. Our patient has a very similar clinical picture of widespread keratosis pilaris. Recently, Horsley et al. [1998] described a 37-year-old woman with del(18p) which was in fact a cryptic 2;18 translocation and keratosis pilaris ...
f`O~ ~"`7~~JC<r{~ c.~v{ (~~~1
f`O~ ~"`7~~JC

... (Bemstein et al., 1988). Mutation alters a DNA molecule into another DNA molecule differing in sequence from the original. Damage alters a DNA molecule into something that is not DNA: it may affect both strands, or only one strand. A mutation, once it has occurred, cannot be recognized as such (exce ...
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Chromosome



A chromosome (chromo- + -some) is a packaged and organized structure containing most of the DNA of a living organism. It is not usually found on its own, but rather is complexed with many structural proteins called histones as well as associated transcription (copying of genetic sequences) factors and several other macromolecules. Two ""sister"" chromatids (half a chromosome) join together at a protein junction called a centromere. Chromosomes are normally visible under a light microscope only when the cell is undergoing mitosis. Even then, the full chromosome containing both joined sister chromatids becomes visible only during a sequence of mitosis known as metaphase (when chromosomes align together, attached to the mitotic spindle and prepare to divide). This DNA and its associated proteins and macromolecules is collectively known as chromatin, which is further packaged along with its associated molecules into a discrete structure called a nucleosome. Chromatin is present in most cells, with a few exceptions - erythrocytes for example. Occurring only in the nucleus of eukaryotic cells, chromatin composes the vast majority of all DNA, except for a small amount inherited maternally which is found in mitochondria. In prokaryotic cells, chromatin occurs free-floating in cytoplasm, as these cells lack organelles and a defined nucleus. The main information-carrying macromolecule is a single piece of coiled double-stranded DNA, containing many genes, regulatory elements and other noncoding DNA. The DNA-bound macromolecules are proteins, which serve to package the DNA and control its functions. Chromosomes vary widely between different organisms. Some species such as certain bacteria also contain plasmids or other extrachromosomal DNA. These are circular structures in the cytoplasm which contain cellular DNA and play a role in horizontal gene transfer.Compaction of the duplicated chromosomes during cell division (mitosis or meiosis) results either in a four-arm structure (pictured to the right) if the centromere is located in the middle of the chromosome or a two-arm structure if the centromere is located near one of the ends. Chromosomal recombination during meiosis and subsequent sexual reproduction plays a vital role in genetic diversity. If these structures are manipulated incorrectly, through processes known as chromosomal instability and translocation, the cell may undergo mitotic catastrophe and die, or it may unexpectedly evade apoptosis leading to the progression of cancer.In prokaryotes (see nucleoids) and viruses, the DNA is often densely packed and organized. In the case of archaea by homologs to eukaryotic histones, in the case of bacteria by histone-like proteins. Small circular genomes called plasmids are often found in bacteria and also in mitochondria and chloroplasts, reflecting their bacterial origins.
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