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Penicillin the Drug of War
Penicillin the Drug of War

... stunned by the number of its fatalities. More than 15 million people were killed, making  it  one  of  the  deadliest  conflicts  in  history.  The  true  causes  of  death were not only related to the numbers and sizes of the nations involved, but the inability to treat war causalities, wounds, inf ...
A survey of volumes of antimicrobials used in food animals
A survey of volumes of antimicrobials used in food animals

... these practices in combination have the potential to accelerate the emergence of resistant bacteria in these animals that can then be passed through contact or via the food chain to infect humans via antibiotics structurally similar to antibiotics used in animal health:  USA, estimated that 70% of ...
Ch11_Outline
Ch11_Outline

... On completing this chapter, you should be able to: • Summarize factors that influence the effectiveness of agents used for microbial control • Explain some of the physical methods of control used to achieve sterilization and destroy all forms of microbes • Compare the chemical methods of microbial c ...
Coagulase-negative Staphylococcus Species Information Sheet
Coagulase-negative Staphylococcus Species Information Sheet

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Aerobic and anaerobic microbiology of suppurative sialadenitis
Aerobic and anaerobic microbiology of suppurative sialadenitis

... These data demonstrate the isolation of 29 (35% of all isolates) -lactamase-producing organisms from 24 of 47 (51.1%) individuals with suppurative sialadenitis. These organisms can survive penicillin therapy and may also protect penicillin-susceptible bacteria from penicillin by releasing the enzym ...
Symposium3_1
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Central Nervous System Infections
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Gentamicin Sulfate Cream USP, 0.1%
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Crisis point: the Rise and Fall of Penicillin
Crisis point: the Rise and Fall of Penicillin

... years before it existed in purified form. In 1930, crude penicillin was tested at Sheffield Royal Infirmary in England by a young doctor named Cecil Paine. He had studied under Fleming in London, and wrote to him to obtain a culture of the Penicillium fungus. Paine was concerned about sycosis barbae ...
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Use of Germicides in the Home and the Healthcare Setting: Is There

... is associated with constitutive degradative enzymes but is more commonly linked to cellular impermeability. Both mechanisms limit the concentration of the germicide to reach the target site(s) in microbes. Prions, the agents most resistant to germicides, are not inactivated by any of the commonly us ...
Infectious Folliculitis and Dermatophytosis
Infectious Folliculitis and Dermatophytosis

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Antibiotic usage and resistance — trends in Estonian University
Antibiotic usage and resistance — trends in Estonian University

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IOSR Journal of Agriculture and Veterinary Science (IOSR-JAVS)
IOSR Journal of Agriculture and Veterinary Science (IOSR-JAVS)

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antibiotic prophylaxis - Stark County Dental Society
antibiotic prophylaxis - Stark County Dental Society

... and brushing teeth. The microbiology of PJI being predominantly staph and the oral flora being largely strep with very few strains of staph explains the lack of association between oral-induced bacteremia and PJI. The overuse of antibiotics has become a real concern due to the increase in resistant ...
Impetigo - Boston Health Care for the Homeless Program
Impetigo - Boston Health Care for the Homeless Program

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BONE AND JOINT INFECTIONS
BONE AND JOINT INFECTIONS

... pathogen (75% of cases) among younger sexually active individuals ...
`METICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA
`METICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA

... Bacteria are present in the nose and on the skin of healthy individuals, they are said to colonise these sites and are referred to as normal flora. The bacteria present are mainly beneficial, but in certain circumstances they may be associated with infection. In about one third of healthy people, the ...
Comparative genomics of non-pseudomonal bacterial species
Comparative genomics of non-pseudomonal bacterial species

... the same species, as this will help determine their relevance in the clinical context. As a chronic condition requiring long-term antibiotic use, CF is further complicated by microvariation seen in persisting species that both adapts them to the host environment and can lead to the emergence of anti ...
Antibacterial Honey (Medihoney™)
Antibacterial Honey (Medihoney™)

... Surprisingly, inhibitory concentrations in the order of 12%–14% v/v for P aeruginosa with antibacterial honey were found. This contrasts with the earlier work of George et al13 where Australian and New Zealand Leptospermum honeys were shown to effectively inhibit the growth of more than 100 clinical ...
Treatment of infectious disease: Beyond antibiotics
Treatment of infectious disease: Beyond antibiotics

... YejABEF, TonB) of Gram negative bacteria (Cotter et al., 2013) subsequently bringing to cell death. Although Gram negative bacteria are not susceptible to bacteriocin, but removal of LPS make them sensitive towards bacteriocins (Stevens et al., 1991). The exact mode of action of bacteriocin over cel ...
Beta-Lactam Antibiotics - Southern Methodist University
Beta-Lactam Antibiotics - Southern Methodist University

... The amide of the β-lactam ring is unusually reactive due to ring strain and a conformational arrangement which does not allow the lone pair of the nitrogen to interact with the double bond of the carbonyl. β-Lactams acylate the hydroxyl group on the serine residue of PBP active site in an irreversib ...
Unknown template for Lab
Unknown template for Lab

... also observed that the initial tube given of the organisms had changed from a yellow color to a red pigment that looked similar to an organism used in a previous lab. I confirmed this by looking back to lab #39 on epidemiology finding that we did use the M. luteus organism in that lab. S. aureus is ...
Focus on antimicrobial resistance - Canadian Pharmacists Association
Focus on antimicrobial resistance - Canadian Pharmacists Association

... §  Therapeutics, environmental hygiene, sanitary condition §  Infectious diseases now only related to five per cent of deaths ...
Topical treatment with fresh human milk versus emollient on atopic
Topical treatment with fresh human milk versus emollient on atopic

... locally on eczema spots in children with AE. Methods: This was a split body, controlled, randomized and physician blinded pilot study, of children with AE with two similar contralateral eczema spots having a mother breastfeeding the child or a sibling. Fresh expressed milk and emollient was applied ...
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Staphylococcus aureus



Staphylococcus aureus is a gram-positive coccal bacterium that is a member of the Firmicutes, and is frequently found in the respiratory tract and on the skin. It is often positive for catalase and nitrate reduction. Although S. aureus is not always pathogenic, it is a common cause of skin infections such as abscesses, respiratory infections such as sinusitis, and food poisoning. Pathogenic strains often promote infections by producing potent protein toxins, and expressing cell-surface proteins that bind and inactivate antibodies. The emergence of antibiotic-resistant forms of S. aureus such as MRSA is a worldwide problem in clinical medicine.Staphylococcus was first identified in 1880 in Aberdeen, Scotland, by the surgeon Sir Alexander Ogston in pus from a surgical abscess in a knee joint. This name was later appended to Staphylococcus aureus by Friedrich Julius Rosenbach, who was credited by the official system of nomenclature at the time. An estimated 20% of the human population are long-term carriers of S. aureus which can be found as part of the normal skin flora and in the nostrils. S. aureus is the most common species of Staphylococcus to cause Staph infections and is a successful pathogen due to a combination of nasal carriage and bacterial immunoevasive strategies.S. aureus can cause a range of illnesses, from minor skin infections, such as pimples, impetigo, boils, cellulitis, folliculitis, carbuncles, scalded skin syndrome, and abscesses, to life-threatening diseases such as pneumonia, meningitis, osteomyelitis, endocarditis, toxic shock syndrome, bacteremia, and sepsis. Its incidence ranges from skin, soft tissue, respiratory, bone, joint, endovascular to wound infections. It is still one of the five most common causes of hospital-acquired infections and is often the cause of postsurgical wound infections. Each year, around 500,000 patients in United States' hospitals contract a staphylococcal infection.
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