SB2_1_Balakrishnan
... • Aim 2. From Interactions to Function – Drug Discovery – HIV-1 targets human hubs – HIV-1 targets many interaction partners of functionally relevant ...
... • Aim 2. From Interactions to Function – Drug Discovery – HIV-1 targets human hubs – HIV-1 targets many interaction partners of functionally relevant ...
DRiPs and other sources of peptide ligands for MHC class I molecules
... of proteasome inhibitors is indisputable, the secondary effects of blocking proteasomes on cell physiology can seriously confound experimental analysis. These effects include rapid depletion of the pool of free Ub available for conjugation, induction of molecular chaperones, and a general inhibition ...
... of proteasome inhibitors is indisputable, the secondary effects of blocking proteasomes on cell physiology can seriously confound experimental analysis. These effects include rapid depletion of the pool of free Ub available for conjugation, induction of molecular chaperones, and a general inhibition ...
Antigen design and administration
... hydrophilic and flexible. This is because most proteins have their hydrophobic residues buried in the interior of the molecule. Consequently, peptide antibodies directed against the N- or C-terminal of a protein are often a good choice because being at the ends they are both flexible and charged (be ...
... hydrophilic and flexible. This is because most proteins have their hydrophobic residues buried in the interior of the molecule. Consequently, peptide antibodies directed against the N- or C-terminal of a protein are often a good choice because being at the ends they are both flexible and charged (be ...
Establishing Mechanisms of Vitamin D Signaling Pathways
... Project Advisor: Dr. Adrian F. Gombart Department of Biochemistry and Biophysics Linus Pauling Institute HHMI ...
... Project Advisor: Dr. Adrian F. Gombart Department of Biochemistry and Biophysics Linus Pauling Institute HHMI ...
Mate choice inside an egg cell.
... envelope, thus, the newly formed pronucleus is a mosaic. Sperm retain part of their original nuclear membrane, with variation between sperm being a function of the amount and/or composition of nuclear membrane retained (Yanagimachi and Noda 1970, Longo 1976). There is a noticeable gap in the literat ...
... envelope, thus, the newly formed pronucleus is a mosaic. Sperm retain part of their original nuclear membrane, with variation between sperm being a function of the amount and/or composition of nuclear membrane retained (Yanagimachi and Noda 1970, Longo 1976). There is a noticeable gap in the literat ...
Gender differences in cancer susceptibility
... The sex differential in primary cancer susceptibility can be quantified by comparison of incidence rates in males and females. The latest analysis of the National Cancer Institute Surveillance Epidemiology and End Results (SEER) database showed that incidence rates per 100,000 people and age-adjuste ...
... The sex differential in primary cancer susceptibility can be quantified by comparison of incidence rates in males and females. The latest analysis of the National Cancer Institute Surveillance Epidemiology and End Results (SEER) database showed that incidence rates per 100,000 people and age-adjuste ...
Male Infertility
... • Empiric medical therapy • clomiphene citrate: antiestrogen, increase secretion of GNRH, FSH, and LH. Low sperm count • antioxidant therapy: vit E • growth hormone ...
... • Empiric medical therapy • clomiphene citrate: antiestrogen, increase secretion of GNRH, FSH, and LH. Low sperm count • antioxidant therapy: vit E • growth hormone ...
Protein - World Initiative for Soy in Human Health
... Cardiovacular disease (#1 cause of death – 17 million/year) Diabetes: deaths projected to increase by 50%/10 years Childhood = premature death and disability in adulthood ...
... Cardiovacular disease (#1 cause of death – 17 million/year) Diabetes: deaths projected to increase by 50%/10 years Childhood = premature death and disability in adulthood ...
Male Infertility
... • Empiric medical therapy • clomiphene citrate: antiestrogen, increase secretion of GNRH, FSH, and LH. Low sperm count • antioxidant therapy: vit E • growth hormone ...
... • Empiric medical therapy • clomiphene citrate: antiestrogen, increase secretion of GNRH, FSH, and LH. Low sperm count • antioxidant therapy: vit E • growth hormone ...
Daily energy expenditure and cell
... conflict in resource allocation between two processes demanding energy and nutrients (Murphy 1996; Hemborg and Lundberg 1998). There is also a tendency for males of several species to initiate moult earlier than females, and thus increase the period of moult-breeding overlap (Dhondt 1981; Hemborg 19 ...
... conflict in resource allocation between two processes demanding energy and nutrients (Murphy 1996; Hemborg and Lundberg 1998). There is also a tendency for males of several species to initiate moult earlier than females, and thus increase the period of moult-breeding overlap (Dhondt 1981; Hemborg 19 ...
Serpent regulates Drosophila immunity genes in the larval fat body
... of antimicrobial peptide genes (Ip et al., 1993; Lemaitre et al., 1995, 1996; Corbo and Levine, 1996; Williams et al., 1997; Wu and Anderson, 1998). It was proposed that one pathway is responsible for the induction of the antibacterial peptides, the other for the induction of the antifungal peptides ...
... of antimicrobial peptide genes (Ip et al., 1993; Lemaitre et al., 1995, 1996; Corbo and Levine, 1996; Williams et al., 1997; Wu and Anderson, 1998). It was proposed that one pathway is responsible for the induction of the antibacterial peptides, the other for the induction of the antifungal peptides ...
A Quantitative Cell-Based High
... MAPK-catalyzed phosphorylation of substrate proteins functions as a switch to turn on or off the activity of the substrate protein. Substrates include: other protein kinases, phospholipases, transcription factors, cytoskeletal proteins. Protein phosphatases remove the phosphates that were transferre ...
... MAPK-catalyzed phosphorylation of substrate proteins functions as a switch to turn on or off the activity of the substrate protein. Substrates include: other protein kinases, phospholipases, transcription factors, cytoskeletal proteins. Protein phosphatases remove the phosphates that were transferre ...
Studying MAP kinase signaling with a small
... progression to relapse in some patients. They show that such mutations are common in ALL and in its recurrence. Furthermore, lymphoblasts from patients with mutations that were associated with upregulation of ERK showed increased cytotoxicity over wild-type controls when treated with MEK Inhibitor U ...
... progression to relapse in some patients. They show that such mutations are common in ALL and in its recurrence. Furthermore, lymphoblasts from patients with mutations that were associated with upregulation of ERK showed increased cytotoxicity over wild-type controls when treated with MEK Inhibitor U ...
mab-3 is required for male development and behavior
... Male-specific expression of mab-3 reporters in the intestine and nervous system mab-3 mutations cause defects in V ray formation and male intestinal differentiation, but, like dsx, mab-3 might play other sex-specific roles not yet identified. For example, mab-3 expression in the nervous system might ...
... Male-specific expression of mab-3 reporters in the intestine and nervous system mab-3 mutations cause defects in V ray formation and male intestinal differentiation, but, like dsx, mab-3 might play other sex-specific roles not yet identified. For example, mab-3 expression in the nervous system might ...
Regulators and signalling in insect haemocyte immunity
... Phagocytosis of a microbe by a phagocytic cell is an extremely complex and diverse process which requires multiple successive interactions between the phagocyte and the pathogen as well as sequential signal transduction events. Phagocytosis is induced when phagocyte surface receptors, are activated ...
... Phagocytosis of a microbe by a phagocytic cell is an extremely complex and diverse process which requires multiple successive interactions between the phagocyte and the pathogen as well as sequential signal transduction events. Phagocytosis is induced when phagocyte surface receptors, are activated ...
No Slide Title
... Each of these KIR proteins can also have dimorphic cytoplasmic tails. In nomenclature KIR2D or KIR3D is followed by a letter “L” or “S” indicating the presence of a “Long” or “Short” cytoplasmic tail. *Pseudogenes have a “P” instead of an “L” or “S” (KIR2DP1 & KIR3DP1) ...
... Each of these KIR proteins can also have dimorphic cytoplasmic tails. In nomenclature KIR2D or KIR3D is followed by a letter “L” or “S” indicating the presence of a “Long” or “Short” cytoplasmic tail. *Pseudogenes have a “P” instead of an “L” or “S” (KIR2DP1 & KIR3DP1) ...
Immunity and the Invertebrates
... that accomplished by the phagocytic cells found in humans. In animals ranging from starfish to humans, phagocytic cells travel through a circulatory system or (in the case of starfish) through a fluid-filled body cavity, or coelom. In multicellular animals that lack a body cavity and a circulatory s ...
... that accomplished by the phagocytic cells found in humans. In animals ranging from starfish to humans, phagocytic cells travel through a circulatory system or (in the case of starfish) through a fluid-filled body cavity, or coelom. In multicellular animals that lack a body cavity and a circulatory s ...
BIOGRAPHICAL SKETCH NAME: Mary K. Baylies eRA COMMONS
... The goal of the Baylies lab is to characterize the genes and mechanisms that are essential for the specification, morphogenesis, and homeostasis of skeletal muscle. Our past work has lead to the identification of signal transduction pathways (i.e. RTK, Notch, Wnt and BMP) and transcription factors ( ...
... The goal of the Baylies lab is to characterize the genes and mechanisms that are essential for the specification, morphogenesis, and homeostasis of skeletal muscle. Our past work has lead to the identification of signal transduction pathways (i.e. RTK, Notch, Wnt and BMP) and transcription factors ( ...
Session 4 â Student Presentation 6, Amy Booth
... TH17 cells CD8+ classical dendritic cells Class-switch recombination in B cells ...
... TH17 cells CD8+ classical dendritic cells Class-switch recombination in B cells ...
Nov26_07
... adaptive). • Can you think of a way to test the idea that regeneration is adaptive? ...
... adaptive). • Can you think of a way to test the idea that regeneration is adaptive? ...
lecture_27_Mar_19_invert_immunity
... Innate immunity refers to a nonspecific defense mechanisms that a host uses immediately or within several hours after exposure to a stimulus. This is the immunity one is born with and is the initial response by the body to eliminate microbes and prevent infection. Unlike adaptive immunity, innate im ...
... Innate immunity refers to a nonspecific defense mechanisms that a host uses immediately or within several hours after exposure to a stimulus. This is the immunity one is born with and is the initial response by the body to eliminate microbes and prevent infection. Unlike adaptive immunity, innate im ...
T Cell Antigen Receptors and the lmmunoglobulin Supergene
... are used by most T cells. Because the p gene family also has twelve functional J, gene segments, six in each cluster, and at least two Dg gene segments (Figure l), combinatorial use of even a moderately sized V, gene segment repertoire with the D, and J, gene segments would permit substantial Vg reg ...
... are used by most T cells. Because the p gene family also has twelve functional J, gene segments, six in each cluster, and at least two Dg gene segments (Figure l), combinatorial use of even a moderately sized V, gene segment repertoire with the D, and J, gene segments would permit substantial Vg reg ...
The Gene Ontology and Immune System Processes
... Gene Ontology Background • GO ontology development is focused on “normal” aspects of an organism’s biology. – Includes defense and immune responses. – Includes processes of symbiosis, encompassing mutualism through parasitism, in which processes originating from one organism affect another organism ...
... Gene Ontology Background • GO ontology development is focused on “normal” aspects of an organism’s biology. – Includes defense and immune responses. – Includes processes of symbiosis, encompassing mutualism through parasitism, in which processes originating from one organism affect another organism ...
Leaf Miners - WSU Extension
... For garden plants, infected leaves can be picked off and disposed of in the garbage; they should not be composted. You can squeeze the leaf to kill the larva before disposing of it. If you are diligent with this effort, you can wipe out the next generation of leaf miners or at least limit its size. ...
... For garden plants, infected leaves can be picked off and disposed of in the garbage; they should not be composted. You can squeeze the leaf to kill the larva before disposing of it. If you are diligent with this effort, you can wipe out the next generation of leaf miners or at least limit its size. ...
Drosophila melanogaster
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Drosophila melanogaster is a species of fly (the taxonomic order Diptera) in the family Drosophilidae. The species is known generally as the common fruit fly or vinegar fly. Starting with Charles W. Woodworth's proposal of the use of this species as a model organism, D. melanogaster continues to be widely used for biological research in studies of genetics, physiology, microbial pathogenesis, and life history evolution. It is typically used because it is an animal species that is easy to care for, has four pairs of chromosomes, breeds quickly, and lays many eggs. D. melanogaster is a common pest in homes, restaurants, and other occupied places where food is served.Flies belonging to the family Tephritidae are also called ""fruit flies"". This can cause confusion, especially in Australia and South Africa, where the Mediterranean fruit fly Ceratitis capitata is an economic pest.