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Contents - World Health Organization
Contents - World Health Organization

... information with the following: 'Precautions/Neuropsychiatric Events: There have been postmarketing reports (mostly from Japan) of self-injury and delirium with the use of oseltamivir (Tamiflu) in patients with influenza. The reports were primarily among paediatric patients. The relative ...
FORCED OXIDATIVE DEGRADATION STUDY OF DORIPENEM BY UV SPECTROPHOTOMETRIC METHOD  Research Article
FORCED OXIDATIVE DEGRADATION STUDY OF DORIPENEM BY UV SPECTROPHOTOMETRIC METHOD Research Article

Please click here to view commentary
Please click here to view commentary

... description of the evidence, the vast preponderance of evidence comes from cross-sectional studies, a study design known to be open to confounding and bias. As the ADA assessment of effectiveness gives little information concerning the relative quality of the studies, it may be useful to look toward ...
Document 8: Zebrafish
Document 8: Zebrafish

... Light triggers zebrafish to breed, so periods of darkness are important for allowing animals to rest. Francis (2008) states that one of the fastest ways to ensure fish will not lay eggs, is to leave the lights on all the time. Zebrafish larvae reared in constant light have been observed to show sev ...
Public Assessment Report Scientific discussion AlendroSteo Kit 70
Public Assessment Report Scientific discussion AlendroSteo Kit 70

... tablets have been shown to have comparable quality and the same composition as Alendromed. Therefore, the view was that, as for Alendromed, the benefit outweighs the identified risk. What measures are being taken to ensure the safe and effective use of this medicine? A risk management plan has been ...
Reviewer 1 - WHO archives
Reviewer 1 - WHO archives

... palpitations or other cardiovascular effects; some also developed headache and nausea.  J Allergy Clin Immunol;109(1):171‐5, 2002 Jan. EpiPen Jr versus EpiPen in young children  weighing 15 to 30 kg at risk for anaphylaxis.  Martindale 33 ed., P.829  ...
11_Bioequivalence
11_Bioequivalence

... another product if it contains the same active substance or therapeutic moiety and, clinically, shows the same efficacy and safety as that product, whose efficacy and safety has been established. • In practice, demonstration of bioequivalence is generally the most appropriate method of substantiatin ...
DEVELOPMENT AND VALIDATION OF METHODS FOR ESTIMATION OF ADRENOCHROME Research Article
DEVELOPMENT AND VALIDATION OF METHODS FOR ESTIMATION OF ADRENOCHROME Research Article

... intra-day variation studies. In the intra-day studies, three repeated injections of standard and sample solutions were made and the response factor of drug peaks and percentage RSD were calculated. In the inter-day variation studies, three repeated injections of standard and sample solutions were ma ...
Unit IV Insects Aquatic Insects
Unit IV Insects Aquatic Insects

Ampicillin - IARC Monographs on the Evaluation of Carcinogenic
Ampicillin - IARC Monographs on the Evaluation of Carcinogenic

Syllabus
Syllabus

... Note: Examiner to set eight questions and the candidates are required to attempt any five. 1. Introduction: Definition, history, scope and development of Pharmacognosy. (2) 2. Sources of drugs: Biological, marine, geographical and plant tissue cultures. (4) 3. Classification of drugs: Alphabetical, ...
Chemotherapeutic Agents in the Treatment of
Chemotherapeutic Agents in the Treatment of

... •After an oral dosage of 500 mg once daily for three consecutive days, significant levels of azithromycin can be detected in most tissues for 7 to 10 days. •Therapeutic use requires a single dose of 250 mg per day for 5 days after an initial loading dose of 500. ...
ICH Q8 & Q9 - Presentation for IPA
ICH Q8 & Q9 - Presentation for IPA

... Q9: Benefits of Quality Risk Management Approach • Enhancement of patient confidence worldwide in decision making on the quality of pharmaceuticals • Promotion of more effective use of regulatory and industry resources • Establishment of a systematic, well-informed and thorough method of decision m ...
SYLLABUS FOR B. PHARM. - All India Council For Technical
SYLLABUS FOR B. PHARM. - All India Council For Technical

... The AICTE in fulfillment of its responsibility has prepared a model course curriculum/syllabus for B.Pharm. after taking suggestions inputs from various eminent academicians and industry with a view to cater the existing, as well as, growing needs of the industry profession and to help in producing ...
prialt - Who we are
prialt - Who we are

... For poorly water soluble compounds, Elan's proprietary NanoCrystal technology can enable formulation and improve compound activity and final product characteristics. The NanoCrystal technology can be incorporated into all dosage forms both parenteral and oral, including solid, liquid, fast-melt, pul ...
sulfonamides-part-1
sulfonamides-part-1

63rd FIP Congress Sydney, Australia
63rd FIP Congress Sydney, Australia

... particular responsibility to educate consumers and patients on how best to use these medicines, including the crucial importance of sticking with their treatment regimen,” stated Jean Parrot, President of the International Pharmaceutical Federation (FIP). “Equally so, pharmacists should be engaged i ...
View the article - Jefferson Digital Commons
View the article - Jefferson Digital Commons

... the malformed pig's cloudy cornea.' More recently, the situation has been reversed and the responsibility for reproductive problems such as congenital malformations, infertility, abortions, and hereditary diseases is often blamed on others, for ...
6 Synergy and polyvalence: paradigms to explain the activity of herbal products
6 Synergy and polyvalence: paradigms to explain the activity of herbal products

... when their extracts were tested pharmacologically. These extracts consisted of complex mixtures of many different compounds and were either dismissed as inactive, with anecdotal reports of activity being explained by the placebo effect, or they declined in use because of difficulties in analysis, st ...
Intermolecular Forces Round Robin
Intermolecular Forces Round Robin

IOSR Journal of Pharmacy and Biological Sciences (IOSRJPBS)
IOSR Journal of Pharmacy and Biological Sciences (IOSRJPBS)

... induce some degree of cytotoxicity. It is also apparent that excessive toxicity often does not allow a proper evaluation of the relevant genetic endpoint. Indeed, at very low survival levels in mammalian cells, mechanisms other than direct genotoxicity per se can lead to ``positive'' results that ar ...
TECHNICAL PROFILE OF BROMO
TECHNICAL PROFILE OF BROMO

Revised: April 2016 AN: 01395/2014 SUMMARY OF PRODUCT
Revised: April 2016 AN: 01395/2014 SUMMARY OF PRODUCT

... Whenever possible, fluoroquinolones should only be used based on susceptibility testing. Use of the product deviating from the instructions given in the SPC may increase the prevalence of bacteria resistant to fluoroquinolones and may decrease the effectiveness of treatment with other quinolones due ...
manuscript_rajeev k singla
manuscript_rajeev k singla

Revised: April 2016 AN: 01396/2014 SUMMARY OF PRODUCT
Revised: April 2016 AN: 01396/2014 SUMMARY OF PRODUCT

... Whenever possible, fluoroquinolones should only be used based on susceptibility testing. Use of the product deviating from the instructions given in the SPC may increase the prevalence of bacteria resistant to fluoroquinolones and may decrease the effectiveness of treatment with other quinolones due ...
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Environmental persistent pharmaceutical pollutant



The term Environmental persistent pharmaceutical pollutants (EPPP) was first suggested in the nomination in 2010 of pharmaceuticals and environment as an emerging issue in a Strategic Approach to International Chemicals Management (SAICM) by the International Society of Doctors for the Environment (ISDE). The occurring problems from EPPPs are in parallel explained under environmental impact of pharmaceuticals and personal care products (PPCP). The European Union summarizes pharmaceutical residues with the potential of contamination of water and soil together with other micropollutants under “priority substances”.
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