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Combination therapy: Synergism between natural plant extracts and
Combination therapy: Synergism between natural plant extracts and

... Stanojevic et al. [29] investigated in vitro synergistic antibacterial activity of aqueous extract of Salvia officinalis L. and its synergistic action with the preservatives sodium nitrite, sodium benzoate and potassium sorbate against selected food spoiling bacteria. Synergism was assessed by the C ...
Advanced Toxicology Lecture 3: Excretion
Advanced Toxicology Lecture 3: Excretion

... • Kidneys receive about 25% of first pass cardiac output, and ~20% is filtered through the glomeruli (25 g /day of urea is filtered and excreted). • The glomerular capillaries have very large pores (70 nm) and allow compounds up to a molecular weight of 60 kDa (
Cutek CD33 Naked Paint Stripper
Cutek CD33 Naked Paint Stripper

... controls can be highly effective in protecting workers and will typically be independent of worker interactions to provide this high level of protection. The basic types of engineering controls are: Process controls which involve changing the way a job activity or process is done to reduce the risk. ...
The Technique of Distillation
The Technique of Distillation

... example, extraction of a marine sponge with an organic solvent can yield a complex mixture of organic compounds, which can then be tested for biological activity or are “bioassayed”. If the mixture shows promising biological activity, the components of the complex mixture may be separated and purifi ...
Herbal Medication Pitfalls Question “Natural Product” or Drug
Herbal Medication Pitfalls Question “Natural Product” or Drug

... medicines available. However, one must be aware of the power of herbs to heal and, if misused, to cause imbalance. Herbs produce no side effects when used in the amounts required to effect a cure. Negative effects occur only when one fails to observe the cautions that herbalists have recognized afte ...
Hydroxypropyl Methyl Cellulose (HPMC)
Hydroxypropyl Methyl Cellulose (HPMC)

... properties is not available in any other water-soluble polymer. Hydroxypropyl methylcellulose Ethers are highly efficient, often yielding optimum performance at a lower concentration than that required with other water-soluble polymers.The broad range of Hydroxypropyl methylcellulose is certainly on ...
Elastin-like Polypeptide (ELP) Platform: Creation of Differentiated
Elastin-like Polypeptide (ELP) Platform: Creation of Differentiated

... PE0139 is a fusion of fully native insulin to an ELP in order to form a super-long-acting basal insulin product. The fusion protein is produced in E. coli and does not form inclusion bodies, but is recovered as a soluble protein with correct disulphide bridging between the A and B chains of the insu ...
Antimicrobial tissue concentrations. Infect Dis Clin N Am 17
Antimicrobial tissue concentrations. Infect Dis Clin N Am 17

Syllabi of Master of Pharmaceutical Sciences in SEMESTER-I (M
Syllabi of Master of Pharmaceutical Sciences in SEMESTER-I (M

... OPTIMIZATION:- Definition ,need ,advantages ,Meaning of general terms involved in optimization process .Classification of optimization methods. Brief description and importance of experimental design with special reference to designs adequate for large number of variables. Introduction of correlatio ...
cephalosporins
cephalosporins

Top Children`s Vitamin Brand Chock
Top Children`s Vitamin Brand Chock

... Many of the 'vitamins' used in Flintstones are considered hazardous substances in Europe Interestingly, many of the ingredients promoted in Flintstones vitamins as helping children get their daily intake of nutrients are actually listed as hazardous or outright banned in places like the European Un ...
B-8 - New Psychiatric Medications
B-8 - New Psychiatric Medications

An In VitroAlternative For Predicting Systemic Toxicity - In
An In VitroAlternative For Predicting Systemic Toxicity - In

... Developing the Hypothesis and Testing it When the in vivo Cmax for toxicity is identified at steady state for the lowest dose that results in toxicity, and compared to in vitro concentration response curves for toxicity, a relationship can be identified that enables the prediction of the in vivo pl ...
New (and emerging) Psychoactive Substances (NPS)
New (and emerging) Psychoactive Substances (NPS)

... of Psychotropic Substances. Examples of phenethylamine new or emerging substances in Australia include the 2C and NBOMe series. The 2C series are a group of psychedelic phenethylamines, with 2C-B being the most frequently reported new phenethylamine. 2C-B has been described as a cross between LSD an ...
New Psychoactive Substances-High index of suspicion needed in
New Psychoactive Substances-High index of suspicion needed in

... with the synthetic cathinones. Hallucinations due to 5HT2A agonism however are more prominent in this group of compounds. Biochemical abnormalities reported include elevated creatine kinase, deranged liver enzymes, renal impairment with consequent increased creatinine and serum potassium.11 Hence on ...
ATOPICA 10 mg soft capsules for dogs
ATOPICA 10 mg soft capsules for dogs

... Amounts to be administered and administration route The mean recommended dose of ciclosporin is 5 mg/kg body weight according to the following scheme. For a dog weighing 2 to < 3 kg one capsule of the veterinary medicinal product For a dog weighing 3 to < 4 kg two capsules of the veterinary medicina ...
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pdf

... Glucocorticoids are often used for the treatment of ketosis and Isoflupredone acetate and dexamethasone is commonly used for this purpose. In this study, 20 male lambs 12 -15 months that their weight and nutritional status were similar divided in 2 groups (10 cows), and for all of the 10 sheep in ex ...
pharmacological review of chemicals used for the capture of animals
pharmacological review of chemicals used for the capture of animals

... other chemicals, such as phencyclidine. Morphine potentiates the analgesic activity of phencyclidine and renders an animal more tractable. Effective immobilization of an animal by morphine and phencyclidine can be partially antagonized by administering nalorphine (Harthoorn, 1962; 1963). M99-Etorph ...
IOSR Journal of Applied Chemistry (IOSR-JAC)
IOSR Journal of Applied Chemistry (IOSR-JAC)

... generation, 8-methoxyquinolone derivative of fluoroquinolone antibacterial agent, synthetic, active against a broad spectrum of pathogens, encompassing Gram-negative and Gram-positive bacteria. However, most of fluoroquinolones show miner side effect one of these is skin reaction including photosens ...
Homemade Ginger Ale
Homemade Ginger Ale

... antidote for stomach upset. Feeling a little motion sickness or queasy? Ginger was shown to be far superior to Dramamine, a commonly used over-the-counter and prescription drug for motion sickness. Ginger reduces all symptoms associated with motion sickness including dizziness, nausea, vomiting, and ...
GATE 2009 Pharmaceutical Sciences Question Paper
GATE 2009 Pharmaceutical Sciences Question Paper

... Quaternary structure in protein molecules refers to the (A) Arrangement of multiple domains in a single polypeptide chain (B) Specific arrangement of multiple subunits in multi-subunit proteins (C) Formation of molten globules (D) Protein folding in single subunit prot eins ...
tetrahydrogestrinone (THG)
tetrahydrogestrinone (THG)

... THG did neither display (Anti-)estrogenic nor (Anti-)glucocorticoid activity in our classical preclinical test systems. THG did not inhibit androgen receptors activation by testosterone or progesterone receptors activation by progesterone, nor did THG have endogen receptor agonist or antagonist acti ...
Guideline on Repeated Dose Toxicity Corr - EMA
Guideline on Repeated Dose Toxicity Corr - EMA

... (CPMP/ICH/136/95; ICH S5B(M)) Further histopathological examination may be necessary depending on the medicinal product tested. Bone marrow smear should be prepared from all animals, but only examined if treatment-related changes are suspected in tissues/organs or in peripheral blood. The smears wil ...
DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD OF
DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD OF

... The standard solution of acenocoumarol, when scanned in UV range, showed the λmax at 283 nm. Linear relationships between drug concentrations were obtained over the range of 3-18µg/ml. The regression equation was y = 0.064 χ + 0.013 with value of R2 as 0.996. Assay of Acenocoumarol tablet formulatio ...
Issued December 2013 AN: 01018/2012 SUMMARY OF PRODUCT
Issued December 2013 AN: 01018/2012 SUMMARY OF PRODUCT

... Teratogenic effects attributed to high doses of febantel have been reported in sheep and rats. No studies have been performed in dogs during early pregnancy. Use of the product during pregnancy should be in accordance with a benefit risk assessment by the responsible veterinarian. Use of the product ...
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Environmental persistent pharmaceutical pollutant



The term Environmental persistent pharmaceutical pollutants (EPPP) was first suggested in the nomination in 2010 of pharmaceuticals and environment as an emerging issue in a Strategic Approach to International Chemicals Management (SAICM) by the International Society of Doctors for the Environment (ISDE). The occurring problems from EPPPs are in parallel explained under environmental impact of pharmaceuticals and personal care products (PPCP). The European Union summarizes pharmaceutical residues with the potential of contamination of water and soil together with other micropollutants under “priority substances”.
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