JB-D - Pharmaceutical Press
... Most drugs are taken orally and typical measures for the dose are then mg/kg or µmol/kg body weight (or per cm2 body surface area for interspecies comparisons). The same measures are used for intravenous injections and any other type of bolus dose. For inhalation experiments using sprays, it is not ...
... Most drugs are taken orally and typical measures for the dose are then mg/kg or µmol/kg body weight (or per cm2 body surface area for interspecies comparisons). The same measures are used for intravenous injections and any other type of bolus dose. For inhalation experiments using sprays, it is not ...
The Ophthalmology Market
... valued at US$ 8,037.9 million for ophthalmology devices followed by the European market at US $ 7,647.70 million 1. The major device companies with 2013 sales and projected sales in 2020 are provided in the graphic below :Worldwide top 10 companies based on ophthalmic medical technology revenues in ...
... valued at US$ 8,037.9 million for ophthalmology devices followed by the European market at US $ 7,647.70 million 1. The major device companies with 2013 sales and projected sales in 2020 are provided in the graphic below :Worldwide top 10 companies based on ophthalmic medical technology revenues in ...
... The K. vesicatoria extract was tested against two different drug-resistant strains of M. tuberculosis, which resulted in an MIC of 50.00 μg/mL on both strains. The combination of K. vesicatoria with INH exhibited the best synergistic antimycobacterial activity with a fractional inhibitory concentrati ...
Pharmaceutical Marketing: A Comparison of Different
... Patient Information Leaflet is a document provided along with a prescription medication to provide additional information about that drug. The first information that‟s listed is usually the brand name, the quantities of the drug available and generic name of the product. The other sections are as fo ...
... Patient Information Leaflet is a document provided along with a prescription medication to provide additional information about that drug. The first information that‟s listed is usually the brand name, the quantities of the drug available and generic name of the product. The other sections are as fo ...
Hepatotoxicity by Acetaminophen and Amiodarone in
... liver toxicity is one of the major causes for the withdrawal of newly discovered molecules. Characteristics viz. high fecundity rate, transparent eggs, less maintenance cost, livelihood in E3 medium without external feeding make Zebrafish (Danio rerio) suitable vertebral model for the hepatotoxicity ...
... liver toxicity is one of the major causes for the withdrawal of newly discovered molecules. Characteristics viz. high fecundity rate, transparent eggs, less maintenance cost, livelihood in E3 medium without external feeding make Zebrafish (Danio rerio) suitable vertebral model for the hepatotoxicity ...
CAS no.: 056-23-5 Molecular formula: CCl4 Melting point
... the extent depending upon the administration vehicle (11-13). It appears to be distributed to all major organs following absorption (2), with highest concentrations being in fat. Carbon tetrachloride is thought to be metabolized by the hepatic cytochrome P-450 enzymes with the production of the high ...
... the extent depending upon the administration vehicle (11-13). It appears to be distributed to all major organs following absorption (2), with highest concentrations being in fat. Carbon tetrachloride is thought to be metabolized by the hepatic cytochrome P-450 enzymes with the production of the high ...
... Orally administered doses of 100, 200 and 400mg/kg of methanol of stem heart wood of Glycosmis pentaphylla produced significant decrease in SGOT, SGPT, SALKP and total bilirubin levels. The activity of the extracts is found to be dose dependant. In CCl4 induced toxic hepatitis, toxicity begins with ...
Therapeutic uses of Loop Diuretics
... • a decreased lumen-positive potential which normally drives divalent cation reabsorption. • a decreased hypertonicity of the medulla and therefore a decreased ability of the kidney to concentrate the urine. • an inhibition of macula densa sensitivity (by inhibiting Na+ and Cl- transport into macula ...
... • a decreased lumen-positive potential which normally drives divalent cation reabsorption. • a decreased hypertonicity of the medulla and therefore a decreased ability of the kidney to concentrate the urine. • an inhibition of macula densa sensitivity (by inhibiting Na+ and Cl- transport into macula ...
Psilocybin and Consciousness
... humans via a serotonin-2 agonist action” Vollenweider et al. 1998 – Administered psilocybin to three groups who were pre-treated with 5-HT2 antagonist ketanserin, 5-HT/ D2 antagonist risperidone, or D2 ...
... humans via a serotonin-2 agonist action” Vollenweider et al. 1998 – Administered psilocybin to three groups who were pre-treated with 5-HT2 antagonist ketanserin, 5-HT/ D2 antagonist risperidone, or D2 ...
What is an optimal dosage regimen - Physiologie et Thérapeutique
... • Disadvantages – "local information" (response at a given dose does not provide any information about another dose) – no information about the distribution of the individual patient's dose response. ...
... • Disadvantages – "local information" (response at a given dose does not provide any information about another dose) – no information about the distribution of the individual patient's dose response. ...
Determination and validation of hydrazine content by
... A simple and sensitive spectrophotometric method was developed, optimized and validated for the determination of hydrazine in various drug substances. Which is the process genotoxic impurity. The validation of analytical method was realized trough specificity, linearity, Limit of detection, Limit of ...
... A simple and sensitive spectrophotometric method was developed, optimized and validated for the determination of hydrazine in various drug substances. Which is the process genotoxic impurity. The validation of analytical method was realized trough specificity, linearity, Limit of detection, Limit of ...
First Dose in Humans
... Applies to situations usually encountered during the conventional development of pharmaceuticals Recognises that it does not apply to novel therapeutic agents Recognises an abbreviated approach may be relevant for some products Does not consider clinical trial design or dose Focuses on toxicity ...
... Applies to situations usually encountered during the conventional development of pharmaceuticals Recognises that it does not apply to novel therapeutic agents Recognises an abbreviated approach may be relevant for some products Does not consider clinical trial design or dose Focuses on toxicity ...
Quality indicators and quantity metrics of antibiotic use
... administration and duration of therapy. OQI-24 OPAT (Outpatient Antibiotic Parenteral Treatment) antibiotics should be correctly stored, prepared, reconstituted, dispensed and administrated. OQI-25 Administered doses of OPAT (Outpatient Antibiotic Parenteral Treatment) intravenous therapy should be ...
... administration and duration of therapy. OQI-24 OPAT (Outpatient Antibiotic Parenteral Treatment) antibiotics should be correctly stored, prepared, reconstituted, dispensed and administrated. OQI-25 Administered doses of OPAT (Outpatient Antibiotic Parenteral Treatment) intravenous therapy should be ...
Effects of Enoyl-Acyl Protein Carrier Reductase Mutations on
... acid hydrazide; INH) is an essential compound of global TB management program [3]. However, the continuing rise in the incidence of multi drug resistant TB (resistant to ≥ 1 anti-TB drug including INH) [4], extensively drug resistant TB (resistant to INH and rifampicin, and in addition to ≥ 3 classe ...
... acid hydrazide; INH) is an essential compound of global TB management program [3]. However, the continuing rise in the incidence of multi drug resistant TB (resistant to ≥ 1 anti-TB drug including INH) [4], extensively drug resistant TB (resistant to INH and rifampicin, and in addition to ≥ 3 classe ...
Supramolecular organization of model liquid crystalline
... Sir: N-Acetylcysteine (NAC) is an antioxidant agent used as a mucolytic and to prevent acute hepatic failure following paracetamol poisoning [1]. NAC has also been thought to prevent radiocontrast nephrotoxicity [2]. Potential analytical interferences between NAC and creatinine measurement have been ...
... Sir: N-Acetylcysteine (NAC) is an antioxidant agent used as a mucolytic and to prevent acute hepatic failure following paracetamol poisoning [1]. NAC has also been thought to prevent radiocontrast nephrotoxicity [2]. Potential analytical interferences between NAC and creatinine measurement have been ...
Background: This experiment involves analysis of a hypothetical
... Acetaminophen has fewer side effects, and has largely replaced acetanilide and phenacetin. (Ironically, Bayer first prepared phenacetin from acetaminophen on the assumption that the phenolic OH group would irritate the stomach, so they wanted to "mask" the -OH as -OCH2CH3.) Bayer's next addition to ...
... Acetaminophen has fewer side effects, and has largely replaced acetanilide and phenacetin. (Ironically, Bayer first prepared phenacetin from acetaminophen on the assumption that the phenolic OH group would irritate the stomach, so they wanted to "mask" the -OH as -OCH2CH3.) Bayer's next addition to ...
Environmental persistent pharmaceutical pollutant
The term Environmental persistent pharmaceutical pollutants (EPPP) was first suggested in the nomination in 2010 of pharmaceuticals and environment as an emerging issue in a Strategic Approach to International Chemicals Management (SAICM) by the International Society of Doctors for the Environment (ISDE). The occurring problems from EPPPs are in parallel explained under environmental impact of pharmaceuticals and personal care products (PPCP). The European Union summarizes pharmaceutical residues with the potential of contamination of water and soil together with other micropollutants under “priority substances”.