Vaccination with recombinant fusion proteins incorporating Toll
... by SDS-PAGE (Fig. 1B) and Western blot analysis using antibody to the C-terminal poly-histidine tag (Fig. 1C). The purity of the recombinant fusion proteins was >95% with endotoxin levels of <0.03 EU/g, as determined by Limulus amebocyte lysate assay (data not shown). TLR-mediated signaling induces ...
... by SDS-PAGE (Fig. 1B) and Western blot analysis using antibody to the C-terminal poly-histidine tag (Fig. 1C). The purity of the recombinant fusion proteins was >95% with endotoxin levels of <0.03 EU/g, as determined by Limulus amebocyte lysate assay (data not shown). TLR-mediated signaling induces ...
Licentiate thesis from the Department of Immunology,
... Tuberculosis (TB) remains one of the world’s most serious infectious diseases. It is estimated that a third of the world’s population is latently infected and 8 million new cases are recorded each year. Although BCG vaccination triggers protective immune responses in the neonates, it confers protect ...
... Tuberculosis (TB) remains one of the world’s most serious infectious diseases. It is estimated that a third of the world’s population is latently infected and 8 million new cases are recorded each year. Although BCG vaccination triggers protective immune responses in the neonates, it confers protect ...
Cervarix-H-C-721-P46-0088: EPAR - EMA
... Use of concomitant medication (e.g. prophylactic use of antibiotics or antipyretics) throughout the study period (from Day 0 up to Month 36) in all groups. ...
... Use of concomitant medication (e.g. prophylactic use of antibiotics or antipyretics) throughout the study period (from Day 0 up to Month 36) in all groups. ...
Canada Communicable Disease Report
... available for pertussis serology that perform adequately. Whole bacterial antigens have the advantage of being less costly to prepare but are less well-standardized and suffer from cross reaction with other Bordetella species and other organisms (such as H. influenzae). One such whole bacterial EIA ...
... available for pertussis serology that perform adequately. Whole bacterial antigens have the advantage of being less costly to prepare but are less well-standardized and suffer from cross reaction with other Bordetella species and other organisms (such as H. influenzae). One such whole bacterial EIA ...
Combining Human and Rat Sequences in Her
... by self pE2TM (124 ± 4, P < 0.001). Therefore, heterologous Her2 or neu DNA is superior in overcoming T-cell tolerance. All ELISPOT assays were performed with pooled PBL except in NeuT mice whose splenocytes were used because neu-reactive T cells were not detectable in their PBL. Induction of Her-2 ...
... by self pE2TM (124 ± 4, P < 0.001). Therefore, heterologous Her2 or neu DNA is superior in overcoming T-cell tolerance. All ELISPOT assays were performed with pooled PBL except in NeuT mice whose splenocytes were used because neu-reactive T cells were not detectable in their PBL. Induction of Her-2 ...
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... of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The NIDDK is part of the National Institutes of Health of the U.S. Department of Health and Human Services. Established in 1980, the Clearinghouse provides information about digestive diseases to people with digestive d ...
... of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The NIDDK is part of the National Institutes of Health of the U.S. Department of Health and Human Services. Established in 1980, the Clearinghouse provides information about digestive diseases to people with digestive d ...
The Amoebiasis module is available here.
... however response was small. Vaccine moderately inhibited trophozoite adherence in vitro via anti-body action. Production of DNA gal-lectin DNA vaccine in murine model. ...
... however response was small. Vaccine moderately inhibited trophozoite adherence in vitro via anti-body action. Production of DNA gal-lectin DNA vaccine in murine model. ...
The Immune Response to Helicobacter pylori
... vaccinated with a control protein (FlaA) or negative control. Antibody titers remained high even 8 months after the last immunization. Antibodies were able to bind native flagellin from H. pylori lysate. Vaccination with chimeric flagellin provided mice with significant protection against H. pylori. ...
... vaccinated with a control protein (FlaA) or negative control. Antibody titers remained high even 8 months after the last immunization. Antibodies were able to bind native flagellin from H. pylori lysate. Vaccination with chimeric flagellin provided mice with significant protection against H. pylori. ...
Alternative therapies in Staphylococcus aureus diseases
... these preparations could find use in the treatment of topic infections, particularly because bacteriocins do not affect the host tissues (Kokai-Kun et al., 2003; Oh et al., 2006; Kokai-Kun et al., 2003; De et al., 2009). In vivo experiments conducted by De et al. (2009) concerned animal model infect ...
... these preparations could find use in the treatment of topic infections, particularly because bacteriocins do not affect the host tissues (Kokai-Kun et al., 2003; Oh et al., 2006; Kokai-Kun et al., 2003; De et al., 2009). In vivo experiments conducted by De et al. (2009) concerned animal model infect ...
Hepatitis AE - Jacobi Medical Center
... Reported Cases Of Hepatitis A, United States, 1952-2002 ...
... Reported Cases Of Hepatitis A, United States, 1952-2002 ...
Varicella
... one dose of varicella vaccine for all children < 13, and for susceptible adolescents from 13-18 • In 1996 ACIP recommended vaccination for all children < 13 years of age; for susceptible adolescents and adults vaccination recommended for those at high risk of infection or complications. Vaccination ...
... one dose of varicella vaccine for all children < 13, and for susceptible adolescents from 13-18 • In 1996 ACIP recommended vaccination for all children < 13 years of age; for susceptible adolescents and adults vaccination recommended for those at high risk of infection or complications. Vaccination ...
Immunization Competencies for Health Professionals
... Directorate (BGTD) of Health Canada. Like all medicines, vaccines must undergo rigorous review and testing before they are approved for use. Health Canada also supervises all aspects of vaccine production by the manufacturers to ensure safety, sterility, and quality. Before a new vaccine can be subm ...
... Directorate (BGTD) of Health Canada. Like all medicines, vaccines must undergo rigorous review and testing before they are approved for use. Health Canada also supervises all aspects of vaccine production by the manufacturers to ensure safety, sterility, and quality. Before a new vaccine can be subm ...
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... then passes into the cerebrospinal fluid and hence into the perilymphatic zone 6). It is clear that deafness is generally not associated with mumps meningitis since none among more than 50 children suffering from proven mumps meningitis were found to have hearing loss7). A therapeutic regimen for se ...
... then passes into the cerebrospinal fluid and hence into the perilymphatic zone 6). It is clear that deafness is generally not associated with mumps meningitis since none among more than 50 children suffering from proven mumps meningitis were found to have hearing loss7). A therapeutic regimen for se ...
Thesis - doktori
... natural infection facilitates repeated infections that may exacerbate pathology and chronic diseases. The association of C. pneumoniae with chronic human diseases was first shown in seroepidemiological studies, which demonstrated the association of antibodies to C. pneumoniae with acute myocardial i ...
... natural infection facilitates repeated infections that may exacerbate pathology and chronic diseases. The association of C. pneumoniae with chronic human diseases was first shown in seroepidemiological studies, which demonstrated the association of antibodies to C. pneumoniae with acute myocardial i ...
View Full Text-PDF
... able to form spores. Various forms of acute enteric diseases, generically called enterotoxemias, in sheep, goats, and other animals have been attributed to C. perfringens. In humans, it can cause gangrene and gastrointestinal diseases. C. perfringens strains are classified into five toxinotypes, A, ...
... able to form spores. Various forms of acute enteric diseases, generically called enterotoxemias, in sheep, goats, and other animals have been attributed to C. perfringens. In humans, it can cause gangrene and gastrointestinal diseases. C. perfringens strains are classified into five toxinotypes, A, ...
Developing a vaccine for tick paralysis
... placed . Five months after immunization, the rabbits were unaffected by normally lethal doses of injected tOxi n. Although the toxoid presents a promising basis for a vaccine. the scientists' next prob· le on is to develop a meth od of producing the para lysis a nt igen (tox in) o n a large scale. T ...
... placed . Five months after immunization, the rabbits were unaffected by normally lethal doses of injected tOxi n. Although the toxoid presents a promising basis for a vaccine. the scientists' next prob· le on is to develop a meth od of producing the para lysis a nt igen (tox in) o n a large scale. T ...
Polysaccharide-protein conjugate vaccines
... [0005] Attachment to the protein yields a number of T cell epitopes. These T cell epitopes interact With CD4 helper T cells, greatly facilitating an antibody response to the attached polysaccharide. The T helper cell-dependent response to a conjugate results in both serum IgG antibodies and immune m ...
... [0005] Attachment to the protein yields a number of T cell epitopes. These T cell epitopes interact With CD4 helper T cells, greatly facilitating an antibody response to the attached polysaccharide. The T helper cell-dependent response to a conjugate results in both serum IgG antibodies and immune m ...
PDF - Journal of Veterinary Science
... using OMP and DNT of B. bronchiseptica as antigens. Generally, antibody titers peaked at 4 and 6 weeks in sera and egg yolks, respectively, after the first injection (Fig. 1 and 2). The titers of the vaccinated groups were three times higher than those of the control group. Antibody profiles against ...
... using OMP and DNT of B. bronchiseptica as antigens. Generally, antibody titers peaked at 4 and 6 weeks in sera and egg yolks, respectively, after the first injection (Fig. 1 and 2). The titers of the vaccinated groups were three times higher than those of the control group. Antibody profiles against ...
The Immune System
... attacks by foreign invaders these are primarily, how to boost your immune system harvard health - on the whole your immune system does a remarkable job of defending you against disease causing microorganisms but sometimes it fails a germ invades successfully, immunotherapy using the immune system to ...
... attacks by foreign invaders these are primarily, how to boost your immune system harvard health - on the whole your immune system does a remarkable job of defending you against disease causing microorganisms but sometimes it fails a germ invades successfully, immunotherapy using the immune system to ...
Invasive Pneumococcal Infections
... towards a conjugate vaccine had already been taken some years earlier, in 1931, when Avery showed that a serotype III polysaccharide retained its immunogenicity when conjugated to a protein [14]. The same Avery was going to be famous some decades later, when he and his co-workers showed that DNA is ...
... towards a conjugate vaccine had already been taken some years earlier, in 1931, when Avery showed that a serotype III polysaccharide retained its immunogenicity when conjugated to a protein [14]. The same Avery was going to be famous some decades later, when he and his co-workers showed that DNA is ...
curriculum vitae
... Simpson, R. S. Struthers, and D. G. Alleva. 2005. A high-throughput chemotaxis assay for pharmacological characterization of chemokine receptors: Utilization of U937 monocytic cells. J Pharmacol Toxicol Methods 51:105. 9. Heise, C. E., A. Pahuja, S. C. Hudson, M. S. Mistry, A. L. Putnam, M. M. Gross ...
... Simpson, R. S. Struthers, and D. G. Alleva. 2005. A high-throughput chemotaxis assay for pharmacological characterization of chemokine receptors: Utilization of U937 monocytic cells. J Pharmacol Toxicol Methods 51:105. 9. Heise, C. E., A. Pahuja, S. C. Hudson, M. S. Mistry, A. L. Putnam, M. M. Gross ...
Toward a Universal Influenza Vaccine
... affected during the 2009 pandemic. Older individuals seemed to demonstrate a level of protection against severe A(H1N1) pdm09 infection (58, 59). According to Hancock et al. (59), a proportion of individuals (39/115, 34%) born before 1950 (.59 y of age) had detectable cross-reactive Nab titers again ...
... affected during the 2009 pandemic. Older individuals seemed to demonstrate a level of protection against severe A(H1N1) pdm09 infection (58, 59). According to Hancock et al. (59), a proportion of individuals (39/115, 34%) born before 1950 (.59 y of age) had detectable cross-reactive Nab titers again ...
PD-1 / PD-L1 Combination Therapies
... These agents work by latching on to antigens that tumour cells display periodically, like PD-L1, or by hitting T-cell receptors that damp down cytotoxic activity, such as PD-1 or CTLA4. The keyword here is “periodically”. Not every tumour contains high expression levels of PD-L1, for example. This f ...
... These agents work by latching on to antigens that tumour cells display periodically, like PD-L1, or by hitting T-cell receptors that damp down cytotoxic activity, such as PD-1 or CTLA4. The keyword here is “periodically”. Not every tumour contains high expression levels of PD-L1, for example. This f ...
Vaccine
A vaccine is a biological preparation that provides active acquired immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing micro-organism and is often made from weakened or killed forms of the microbe, its toxins or one of its surface proteins. The agent stimulates the body's immune system to recognize the agent as a threat, destroy it, and keep a record of it, so that the immune system can more easily recognize and destroy any of these micro-organisms that it later encounters.The administration of vaccines is called vaccination. The effectiveness of vaccination has been widely studied and verified; for example, the influenza vaccine, the HPV vaccine, and the chicken pox vaccine. Vaccination is the most effective method of preventing infectious diseases; widespread immunity due to vaccination is largely responsible for the worldwide eradication of smallpox and the restriction of diseases such as polio, measles, and tetanus from much of the world. The World Health Organization (WHO) reports that licensed vaccines are currently available to prevent or contribute to the prevention and control of twenty-five infections.Vaccines can be prophylactic (example: to prevent or ameliorate the effects of a future infection by any natural or ""wild"" pathogen), or therapeutic (e.g., vaccines against cancer are also being investigated; see cancer vaccine).The terms vaccine and vaccination are derived from Variolae vaccinae (smallpox of the cow), the term devised by Edward Jenner to denote cowpox. He used it in 1798 in the long title of his Inquiry into the...Variolae vaccinae...known...[as]...the Cow Pox, in which he described the protective effect of cowpox against smallpox. In 1881, to honour Jenner, Louis Pasteur proposed that the terms should be extended to cover the new protective inoculations then being developed.