The Value of Observational Datasets in the Economic
... contain data to various levels of detail on one or more of the core data areas outlined in the previous section. These datasets could be general collecting a core set of data for different diseases, or disease/condition specific. Data is collected for a defined time period (which may be a short time ...
... contain data to various levels of detail on one or more of the core data areas outlined in the previous section. These datasets could be general collecting a core set of data for different diseases, or disease/condition specific. Data is collected for a defined time period (which may be a short time ...
(PSD) July 2015 PBAC Meeting
... The PBAC noted in the PI for the 6-month intramuscular formulation that in the clinical trials with the 3- and 4-month formulations, possible or probable treatment related reactions occurred in around 5% of patients. The PBAC considered, however, that the adverse events profile remained acceptable. ...
... The PBAC noted in the PI for the 6-month intramuscular formulation that in the clinical trials with the 3- and 4-month formulations, possible or probable treatment related reactions occurred in around 5% of patients. The PBAC considered, however, that the adverse events profile remained acceptable. ...
Preventive nebulization of mucolytic agents and bronchodilating
... consecutive patients admitted to one of the participating ICUs to verify the source population and conformance with enrolment criteria will be performed by the local investigators in all ...
... consecutive patients admitted to one of the participating ICUs to verify the source population and conformance with enrolment criteria will be performed by the local investigators in all ...
Statistics Guide for Research Grant Applicants
... All six authors routinely reviewed grant proposals for The South East Research and Development Project Grant Scheme. This was a responsive funding scheme for the South East Regional Office which ran for a number of years until it ended in October 2001. The scheme was responsible for spending of appr ...
... All six authors routinely reviewed grant proposals for The South East Research and Development Project Grant Scheme. This was a responsive funding scheme for the South East Regional Office which ran for a number of years until it ended in October 2001. The scheme was responsible for spending of appr ...
Bachelor of Nursing - Medicine, Nursing and Health Sciences
... A clinical teacher may make unsatisfactory assessments for a number of reasons. These may include unsafe practice, poorly developed clinical skills, or illness during the placement making achievement of clinical objectives difficult. The assessment may also be based upon a clinical teacher’s decisio ...
... A clinical teacher may make unsatisfactory assessments for a number of reasons. These may include unsafe practice, poorly developed clinical skills, or illness during the placement making achievement of clinical objectives difficult. The assessment may also be based upon a clinical teacher’s decisio ...
GAP 2017 Conference CFA - MD Anderson Cancer Center
... new cancer therapeutic agents. Many first-in-human trials and trials with novel therapeutic approaches are conducted at MD Anderson that allows us to offer personalized, state-of-theart research driven patient care. The major breakthroughs and success of targeted/immunotherapeutic agents have helped ...
... new cancer therapeutic agents. Many first-in-human trials and trials with novel therapeutic approaches are conducted at MD Anderson that allows us to offer personalized, state-of-theart research driven patient care. The major breakthroughs and success of targeted/immunotherapeutic agents have helped ...
Third round table conference in Monaco on 19 June 2004: Transfer
... 2.5 million base pairs (genetic “letters”) long which are grouped in 79 exons with a total of only 11.000 base pairs, its active regions, that contain the information for the production of dystrophin. This protein stabilizes the muscle cell membranes. If a mutation of the gene changes the genetic in ...
... 2.5 million base pairs (genetic “letters”) long which are grouped in 79 exons with a total of only 11.000 base pairs, its active regions, that contain the information for the production of dystrophin. This protein stabilizes the muscle cell membranes. If a mutation of the gene changes the genetic in ...
Transdermal Drug Delivery Market & Clinical Pipeline Insight Brochure
... of the skin. The major underlying factor driving this method is that the human skin is the most readily accessible surface for the delivery of drugs. A transdermal patch is defined as a medicated adhesive patch which is placed on the skin for delivering a specific dose of medication through the laye ...
... of the skin. The major underlying factor driving this method is that the human skin is the most readily accessible surface for the delivery of drugs. A transdermal patch is defined as a medicated adhesive patch which is placed on the skin for delivering a specific dose of medication through the laye ...
Preliminary, Open-Label, Pilot Study of Add-On Oral D
... individuals with PTSD reported greater motivation to use cannabis for sleep compared with those without PTSD [23]. D9-THC can modify sleep architecture by depleting rapid eye movement (REM) sleep, the sleep phase in which nightmares occur, and enhancing non-REM phase 4 sleep, the restoring phase of ...
... individuals with PTSD reported greater motivation to use cannabis for sleep compared with those without PTSD [23]. D9-THC can modify sleep architecture by depleting rapid eye movement (REM) sleep, the sleep phase in which nightmares occur, and enhancing non-REM phase 4 sleep, the restoring phase of ...
Tedizolid Phosphate vs Linezolid for Treatment of Acute Bacterial
... before the first dose of study drug or those with previous treatment failure of the same infection site. The institutional review board, or equivalent, at each study center approved the trial and all patients provided written informed consent. A data and safety monitoring board reviewed safety data ...
... before the first dose of study drug or those with previous treatment failure of the same infection site. The institutional review board, or equivalent, at each study center approved the trial and all patients provided written informed consent. A data and safety monitoring board reviewed safety data ...
highlights of prescribing information
... decreased number of implantations and fetuses were noted, however, in a separate study in female rats at approximately 120 times the AUC in humans at the recommended daily oral dose. Reduced body weight and slow righting reflex were reported in pups at approximately 50 times or greater than the AUC ...
... decreased number of implantations and fetuses were noted, however, in a separate study in female rats at approximately 120 times the AUC in humans at the recommended daily oral dose. Reduced body weight and slow righting reflex were reported in pups at approximately 50 times or greater than the AUC ...
(PSD) November 2015 PBAC Meeting
... PBS-listed bDMARDs. The EULAR Guidelines recommend consideration of apremilast in patients who have experience with at least one conventional synthetic DMARD, where bDMARD treatment is not appropriate. ...
... PBS-listed bDMARDs. The EULAR Guidelines recommend consideration of apremilast in patients who have experience with at least one conventional synthetic DMARD, where bDMARD treatment is not appropriate. ...
an open-label, randomized, 3
... Treatment A: DRV/rtv 800/100 mg q.d. for 7 days Treatment B: DRV/rtv 800/50 mg q.d. for 7 days Treatment C: DRV/rtv 800/20 mg q.d. for 7 days 21 days 21 days (excluding a screening period of maximum 21 days, a washout period of at least 7 days between subsequent DRV intakes, and a follow-up period o ...
... Treatment A: DRV/rtv 800/100 mg q.d. for 7 days Treatment B: DRV/rtv 800/50 mg q.d. for 7 days Treatment C: DRV/rtv 800/20 mg q.d. for 7 days 21 days 21 days (excluding a screening period of maximum 21 days, a washout period of at least 7 days between subsequent DRV intakes, and a follow-up period o ...
Renagel® Tablets (sevelamer hydrochloride)
... amine that binds phosphate and is meant for oral administration. Sevelamer hydrochloride is poly(allylamine hydrochloride) crosslinked with epichlorohydrin in which forty percent of the amines are protonated. It is known chemically as poly(allylamine-co-N,N’-diallyl-1,3-diamino-2-hydroxypropane) hyd ...
... amine that binds phosphate and is meant for oral administration. Sevelamer hydrochloride is poly(allylamine hydrochloride) crosslinked with epichlorohydrin in which forty percent of the amines are protonated. It is known chemically as poly(allylamine-co-N,N’-diallyl-1,3-diamino-2-hydroxypropane) hyd ...
Effect of Ularitide on Cardiovascular Mortality in Acute Heart Failure
... heart failure and rapid worsening of preexisting heart failure are two of the most common causes of hospitalization worldwide.1 The disorder in each case is characterized by intravascular volume expansion and ventricular distention, which may cause myocardial injury in the absence of coronary artery ...
... heart failure and rapid worsening of preexisting heart failure are two of the most common causes of hospitalization worldwide.1 The disorder in each case is characterized by intravascular volume expansion and ventricular distention, which may cause myocardial injury in the absence of coronary artery ...
BMC Dermatology Orest Szczurko and Heather S Boon* Research article
... supplements that may have efficacy in the treatment of vitiligo. We searched eight databases including MEDLINE and EMBASE for vitiligo, leucoderma, and various NHP terms. Prospective controlled clinical human trials were identified and assessed for quality. Results: Fifteen clinical trials were iden ...
... supplements that may have efficacy in the treatment of vitiligo. We searched eight databases including MEDLINE and EMBASE for vitiligo, leucoderma, and various NHP terms. Prospective controlled clinical human trials were identified and assessed for quality. Results: Fifteen clinical trials were iden ...
INC News - Critical Path Institute
... defining BPD. Two wellvalidated endpoints are critical: an early assessment to identify babies at high risk for BPD in the first few days of life, and a late endpoint to assess outcomes. From a drug development standpoint, understanding which babies are most likely to get BPD helps enroll the right ...
... defining BPD. Two wellvalidated endpoints are critical: an early assessment to identify babies at high risk for BPD in the first few days of life, and a late endpoint to assess outcomes. From a drug development standpoint, understanding which babies are most likely to get BPD helps enroll the right ...
5.01.558 Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9
... Familial Hypercholesterolemia encompasses a group of genetic defects that causes severe elevations in LDL-C levels, as well as other lipid parameters. Heterozygous familial hypercholesterolemia (HeFH) occurs in roughly 1 in 300 to 500 patients, and is present in childhood. Total cholesterol levels i ...
... Familial Hypercholesterolemia encompasses a group of genetic defects that causes severe elevations in LDL-C levels, as well as other lipid parameters. Heterozygous familial hypercholesterolemia (HeFH) occurs in roughly 1 in 300 to 500 patients, and is present in childhood. Total cholesterol levels i ...
- Boehringer Ingelheim (Canada)
... Patients with Congestive Heart Failure: A limited number of patients with history of congestive heart failure participated in clinical studies with TRAJENTA. In clinical trials, patients with a clinically significant history of cardiac disease or presence of active cardiac disease within 6 months we ...
... Patients with Congestive Heart Failure: A limited number of patients with history of congestive heart failure participated in clinical studies with TRAJENTA. In clinical trials, patients with a clinically significant history of cardiac disease or presence of active cardiac disease within 6 months we ...
Investor Presentation - NovaBay Pharmaceuticals
... CL1001 Synopsis • Objective: Assess the ability of Auriclosene Irrigation Solution to prevent or reduce the blockage and encrustation of indwelling urinary catheters • Population: Patients with indwelling transurethral or suprapubic urinary catheters who have a recent history of urinary catheter en ...
... CL1001 Synopsis • Objective: Assess the ability of Auriclosene Irrigation Solution to prevent or reduce the blockage and encrustation of indwelling urinary catheters • Population: Patients with indwelling transurethral or suprapubic urinary catheters who have a recent history of urinary catheter en ...
PRECIS-2 - UW Department of Family Medicine
... Does this intervention work under usual conditions? ...
... Does this intervention work under usual conditions? ...
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... • In our completed Phase I study in solid tumors, a TNBC pa6ent who had failed mul6ple chemotherapy regimens had clinically significant stabiliza6on of disease for 41 weeks • Effec6ve doses between 150 mg ...
... • In our completed Phase I study in solid tumors, a TNBC pa6ent who had failed mul6ple chemotherapy regimens had clinically significant stabiliza6on of disease for 41 weeks • Effec6ve doses between 150 mg ...
A mathematical model for maximizing the value of phase 3
... are expected to become available at various times. Furthermore, many of the potential phase 3 drugs will have uncertainty surrounding their availability because they will be in earlier stages of development and may fail to progress to phase 3. Portfolio planning is also affected by external dynamics ...
... are expected to become available at various times. Furthermore, many of the potential phase 3 drugs will have uncertainty surrounding their availability because they will be in earlier stages of development and may fail to progress to phase 3. Portfolio planning is also affected by external dynamics ...
Endocrine effects of inhaled steroids in respiratory disease
... Position statement of the Society for Endocrinology on the endocrine effects of inhaled corticosteroids in respiratory disease The use of corticosteroids (“steroids”) to treat bronchoconstriction and other disorders in lung disease was revolutionised by the introduction of inhaled steroids, as by th ...
... Position statement of the Society for Endocrinology on the endocrine effects of inhaled corticosteroids in respiratory disease The use of corticosteroids (“steroids”) to treat bronchoconstriction and other disorders in lung disease was revolutionised by the introduction of inhaled steroids, as by th ...