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Full Report - Center for Strategic Philanthropy
Full Report - Center for Strategic Philanthropy

... Solution 2: Create large-scale infrastructure to support biomarker discovery using Patient Samples ............. 33 Solution 3: Improve Precision Diagnostic Tools ................................................................................................. 34 Problem: Inefficient Process for B ...
Evidence-Based Practice Guideline for the Management of Croup in Children
Evidence-Based Practice Guideline for the Management of Croup in Children

... can occasionally cause severe respiratory obstruction. Croup is a very common reason for children to present to hospital. In the 5 years from 1 July 1999 to June 30 2004, there were more than 26,000 presentations by children with croup to Victorian emergency departments20. Approximately 30% of these ...
Australian Public Assessment Report for fluticasone propionate
Australian Public Assessment Report for fluticasone propionate

... The TGA administers the Therapeutic Goods Act 1989 (the Act), applying a risk management approach designed to ensure therapeutic goods supplied in Australia meet acceptable standards of quality, safety and efficacy (performance), when necessary. ...
2012 Medical Marijuana for the Treatment of Migraine Headaches:
2012 Medical Marijuana for the Treatment of Migraine Headaches:

... migraines was 2 years before mean age of onset of substance abuse. Substances abused not described. Unknown how many were marijuana users. No data on effect of abused drugs on headaches. All 3 on cessation of marijuana use developed migraine headaches. One was also a cocaine user. Very little clinic ...
as a PDF
as a PDF

... Secondly, the HTA Programme provides grants for clinical trials for researchers who identify research questions. These are assessed for importance to patients and the NHS, and scientific rigour. Thirdly, through its Technology Assessment Report (TAR) call-off contract, the HTA Programme commissions ...
VENTOLIN HFA Inhalation Aerosol prescribing
VENTOLIN HFA Inhalation Aerosol prescribing

... The safety data described below reflects exposure to VENTOLIN HFA in 248 patients treated with VENTOLIN HFA in 3 placebo-controlled clinical trials of 2 to 12 weeks’ duration. The data from adults and adolescents is based upon 2 clinical trials in which 202 patients with asthma 12 years of age and o ...
STAXYN PRODUCT MONOGRAPH
STAXYN PRODUCT MONOGRAPH

... The safety and efficacy of combinations of STAXYN with other agents for the treatment of erectile dysfunction have not been studied. Therefore, the use of such combinations is not recommended. Information for Patients Physicians should discuss with patients the contraindications of STAXYN with regul ...
Astelin
Astelin

... Clinical trials of Astelin Nasal Spray did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently from younger patients. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In gene ...
ENCLOSURE  1
ENCLOSURE 1

... the number of subjects in some of the subgroups was small, there were no significant differences in the effect of fexofenadine hydrochloride across subgroups of subjects defined by gender, age, and race . Onset of action for reduction in total symptom scores, excluding nasal congestion, was observed ...
Dual versus Single Chamber Pacemaker Therapy for
Dual versus Single Chamber Pacemaker Therapy for

... The quality of the clinical effectiveness evidence was poor, and therefore the findings of this review are potentially subject to bias and overestimation of effect size. There was heterogeneity between studies in terms of population characteristics, outcomes measured and type of randomisation (mode ...
Academy of Applied Hypnosis
Academy of Applied Hypnosis

... Svensson, 2011; Tahiri, Mottillo, Joseph, Pilote, & Eisenberg, 2012) demonstrates encouraging outcomes and calls for further high quality research. As hypnotherapy training is only available in the vocational sector and research methods are taught in the higher education sector, research is primaril ...
Ginkgo Biloba Extract: A Review
Ginkgo Biloba Extract: A Review

... oldest tree on earth have been shown to exhibit what might be described as “anti-aging” effects. Even if you do not wish to grant Mother Nature that poetic license, there is a considerable amount of scientific research supporting the use of ginkgo as a treatment for age-related problems, as well as ...
AusPAR: Ivermectin - Therapeutic Goods Administration
AusPAR: Ivermectin - Therapeutic Goods Administration

... The TGA administers the Therapeutic Goods Act 1989 (the Act), applying a risk management approach designed to ensure therapeutic goods supplied in Australia meet acceptable standards of quality, safety and efficacy (performance), when necessary. ...
Pr VIAGRA*
Pr VIAGRA*

... The evaluation of erectile dysfunction should include a determination of potential underlying causes and the identification of appropriate treatment following a complete medical assessment. Cardiovascular As with all treatments for erectile dysfunction, there is a potential cardiac risk of sexual ac ...


... Clinical audit A systematic process for setting and monitoring standards of clinical care. Whereas ‘guidelines’ define what the best clinical practice should be, ‘audit’ investigates whether best practice is being carried out. Clinical audit can be described as a cycle or spiral. Within the cycle t ...
Quesito 7 Quali sono i benefici dell`impiego di CVC impregnati con
Quesito 7 Quali sono i benefici dell`impiego di CVC impregnati con

... PROBLEM: Bloodstream infections associated with catheters were the most common nosocomial infections in one paediatric intensive care unit in 1994-7, with rates well above the national average. DESIGN: Clinical data were collected prospectively to assess the rates of infection from 1994 onwards. The ...
Bevacizumab, sorafenib tosylate, sunitinib and temsirolimus for
Bevacizumab, sorafenib tosylate, sunitinib and temsirolimus for

... Second, the HTA programme provides grants for clinical trials for researchers who identify research questions. These are assessed for importance to patients and the NHS, and scientific rigour. Third, through its Technology Assessment Report (TAR) call-off contract, the HTA programme commissions besp ...
do patients managed within a trial experience different outcomes
do patients managed within a trial experience different outcomes

... in particular showed that hospitals conducting more RCTs than their counterparts had lower mortality rates, even after controlling for hospital characteristics (i.e. size, setting) 4. Whether or not the institution conducting the RCT is privately or publicly funded may further impact the quality of ...
BREO ELLIPTA
BREO ELLIPTA

... LABA, such as vilanterol, one of the active ingredients in BREO ELLIPTA, increase the risk of asthma-related death. Currently available data are inadequate to determine whether concurrent use of inhaled corticosteroids or other long-term asthma control drugs mitigates the increased risk of asthma-re ...
AusPAR Nivolumab  - Therapeutic Goods Administration
AusPAR Nivolumab - Therapeutic Goods Administration

... The TGA administers the Therapeutic Goods Act 1989 (the Act), applying a risk management approach designed to ensure therapeutic goods supplied in Australia meet acceptable standards of quality, safety and efficacy (performance) when necessary. ...
First-line chemotherapy for women with epithelial ovarian cancer
First-line chemotherapy for women with epithelial ovarian cancer

... surgical staging and histological subtype. This Cochrane review found that overall and progression-free survival was improved in early stage ovarian cancer patients who had chemotherapy compared with those on observation. Subgroup analysis suggested that women who had optimal surgical staging of the ...
Appendix G Overall and progression free survival
Appendix G Overall and progression free survival

... surgical staging and histological subtype. This Cochrane review found that overall and progression-free survival was improved in early stage ovarian cancer patients who had chemotherapy compared with those on observation. Subgroup analysis suggested that women who had optimal surgical staging of the ...
Berberine Monograph - Alternative Medicine Review
Berberine Monograph - Alternative Medicine Review

... Diarrhea caused by Vibrio cholera and Escherichia coli has been the focus of numerous berberine studies, and results indicate several mechanisms which may explain its ability to inhibit bacterial diarrhea. An animal study found berberine reduced the intestinal secretion of water and electrolytes ind ...
Aloe vera: Plant of Immortality - International Journal of Pharma
Aloe vera: Plant of Immortality - International Journal of Pharma

... Aloe vera gel should not be used externally after laparotomy or caesarean delivery because it may delay wound healing. Drug aloe should not be taken for more than 10 days. It should not be used by pregnant or lactating women and is contraindicated in the following conditions: intestinalobstruction o ...
available pharmaceutical products
available pharmaceutical products

... actual or potential M&A discussions are taking place. We have divided opportunities by therapeutic area. Items involving public companies are only listed where it is broadly understood that a licensing / sale process is underway or where a product that is an excellent candidate for outlicensing is a ...
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Clinical trial

Clinical trials are experiments done in clinical research. Such prospective biomedical or behavioral research studies on human participants are designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on safety and efficacy. They are conducted only after they have received health authority/ethics committee approval in the country where approval of the therapy is sought. These authorities are responsible for vetting the risk/benefit ratio of the trial - their approval does not mean that the therapy is 'safe' or effective, only that the trial may be conducted.Depending on product type and development stage, investigators initially enroll volunteers and/or patients into small pilot studies, and subsequently conduct progressively larger scale comparative studies. Clinical trials can vary in size and cost, and they can involve a single research center or multiple centers, in one country or in multiple countries. Clinical study design aims to ensure the scientific validity and reproducibility of the results.Trials can be quite costly, depending on a number of factors. The sponsor may be a governmental organization or a pharmaceutical, biotechnology or medical device company. Certain functions necessary to the trial, such as monitoring and lab work, may be managed by an outsourced partner, such as a contract research organization or a central laboratory.Only 10% of all drugs started in human clinical trials become an approved drug.
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