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NOVEL PHARMACOTHERAPEUTIC STRATEGIES treatments FOR
NOVEL PHARMACOTHERAPEUTIC STRATEGIES treatments FOR

... spasticity and was studied in a multisite, double-blind RCT to assess safety and efficacy in treatment of cocaine dependence (Kahn, 2009) in subjects diagnosed with severe cocaine dependence. Ultimately, there were no differences found between the groups (treatment versus placebo) in terms of treatm ...
ZYBAN (bupropion hydrochloride) Sustained-Release
ZYBAN (bupropion hydrochloride) Sustained-Release

... Patients with MDD, both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior, whether or not they are taking antidepressant medications, and this risk may persist until significant remiss ...
A randomised phase IIb trial of BEvACizumab added to
A randomised phase IIb trial of BEvACizumab added to

... anticoagulants for at least two weeks at the time of randomisation th Blood pressure below 95 centile for age and sex. Use of antihypertensive medication is permitted Males or females of reproductive potential may not participate unless they agree to use an adequate method of birth control, i.e. wit ...
SUPERGEN INC (Form: DEFA14A, Received: 04/12
SUPERGEN INC (Form: DEFA14A, Received: 04/12

... similar expressions, or future or conditional verbs such as “will,” “would,” “should,” “could,” “may,” or similar expressions. SuperGen cautions that forward-looking statements are subject to numerous assumptions, risks and uncertainties, which change overtime. Forward-looking statements speak only ...
Eribulin mesilate - Therapeutic Goods Administration (TGA)
Eribulin mesilate - Therapeutic Goods Administration (TGA)

... The TGA administers the Therapeutic Goods Act 1989 (the Act), applying a risk management approach designed to ensure therapeutic goods supplied in Australia meet acceptable standards of quality, safety and efficacy (performance), when necessary. ...
Thyroid Disease - the British Acupuncture Council
Thyroid Disease - the British Acupuncture Council

... used in China and other eastern cultures for thousands of years to restore, promote and maintain good health. Its benefits are now widely acknowledged all over the world and in the past decade traditional acupuncture has begun to feature more prominently in mainstream healthcare in the UK. In conjun ...
Anticholinergic drugs versus other medications for overactive The Cochrane Library
Anticholinergic drugs versus other medications for overactive The Cochrane Library

... Anticholinergic drugs have been available in the treatment of overactive bladder for over thirty years and their use is widespread in clinical practice. The number of anticholinergic drugs available on the market is increasing and effectiveness has been assessed in both observational and randomised ...
DPC Quality Report (DOCX 104 KB) - Department of Veterans` Affairs
DPC Quality Report (DOCX 104 KB) - Department of Veterans` Affairs

... transferred to an overnight facility (in the instance of a free standing day procedure centre) or were admitted to a general hospital bed for an overnight stay (for day patients accommodated in general hospital beds or units or centres within a hospital). ...
The safety of nebulization with 3 to 5 ml of adrenaline (1:1000) in
The safety of nebulization with 3 to 5 ml of adrenaline (1:1000) in

... nebulization. The principal data extracted from the trials included adrenaline dosages and their effects on heart rate and blood pressure and any other side effects. Summary of the findings: Seven clinical trials with a total of 238 patients were included for this review. Two of the five trials in w ...
AusPAR: Glycopyrronium (as bromide)
AusPAR: Glycopyrronium (as bromide)

... TGA administers the Therapeutic Goods Act 1989 (the Act), applying a risk management approach designed to ensure therapeutic goods supplied in Australia meet acceptable standards of quality, safety and efficacy (performance), when necessary. ...
Product Monograph
Product Monograph

... estimated on a per-patient basis and categorised as very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000) and very rare (<1/10,000). ...
Diabetic Gastroparesis - American Neurogastroenterology and
Diabetic Gastroparesis - American Neurogastroenterology and

... 68%. However, many of these trials were small, some were not blind, and some included patients with gastroparesis due to causes other than diabetes. In addition, data from head-to-head comparisons of these agents are limited. In one such trial, involving children with diabetes, domperidone was found ...
WWWQ News 望闻问切 - American TCM Society 美国中医药针灸学会
WWWQ News 望闻问切 - American TCM Society 美国中医药针灸学会

... debate centers on whether the effect of acupuncture can be completely or mainly attributed to placebo effect. Although researchers have continuously altered and improved their study design and method of delivery, the demand for a gold-standard study satisfying the criteria of double-blinded randomiz ...
MP 2.02.21 Left-Atrial Appendage Closure Devices for Stroke
MP 2.02.21 Left-Atrial Appendage Closure Devices for Stroke

... atrial fibrillation. Currently, there are no devices that have FDA-approval for this indication. Case series have demonstrated that these devices can be successfully implanted percutaneously in most patients. Complications such as pericardial effusion and tamponade are reported in available studies ...
AusPAR: Mycophenolate sodium - Therapeutic Goods Administration
AusPAR: Mycophenolate sodium - Therapeutic Goods Administration

... The TGA administers the Therapeutic Goods Act 1989 (the Act), applying a risk management approach designed to ensure therapeutic goods supplied in Australia meet acceptable standards of quality, safety and efficacy (performance), when necessary. ...
PRACTICAL THERAPEUTICS Drugs 45 (6): 918
PRACTICAL THERAPEUTICS Drugs 45 (6): 918

... of life or life satisfaction has generally been ignored. The relevance of this outcome variable can be illustrated by an example. An effective treatment that significantly reduces symptoms may on the other hand negatively affect the quality of life because the treatment has a major impact on lifesty ...
TrialNet New Protocol –
TrialNet New Protocol –

... 2.2.1 Rationale for ATG Therapy in T1D Preclinical studies have shown that ALS treatment of the NOD mouse (18) and BB rat (19) with recent onset T1D can induce remission, supporting proof of principle for such an approach in humans. The case for combination of ATG with other agents received support ...
Pubmed Biofeedback
Pubmed Biofeedback

... with a number of difficulties. This article will provide an overview of three different approaches on how the new media may be integrated into the treatment of survivors of torture and war to face some of the challenges. Illiteracy is a common problem and makes it difficult to apply standardized psy ...
AusPAR: Aflibercept (rch) - Therapeutic Goods Administration
AusPAR: Aflibercept (rch) - Therapeutic Goods Administration

... The TGA administers the Therapeutic Goods Act 1989 (the Act), applying a risk management approach designed to ensure therapeutic goods supplied in Australia meet acceptable standards of quality, safety and efficacy (performance), when necessary. ...
DeLuca et al. 2011 J. Bone Min. Res. 26:538
DeLuca et al. 2011 J. Bone Min. Res. 26:538

... femur, femoral neck, and trochanter BMD at weeks 26 and 52; and the percent change in bone markers at week 26. The primary analysis was an ANOVA model applied to the primary endpoint, with contrasts used to determine treatment effects. The population for this analysis was the full analysis set, whic ...
SectionBAdvancedApr10.pdf
SectionBAdvancedApr10.pdf

... This policy is published annually in the Temple College Student Handbook. 5. Students shall wear the appropriate uniform to each clinical rotation. The uniform must be clean and neat and meet the criteria expressed in the dress code. The clinical uniform will be worn to all rotations with the except ...
Acute Poisoning with Dapsone – A Case Report
Acute Poisoning with Dapsone – A Case Report

... treatment according to the "Position statement and practice guidelines on the use of multidose activated charcoal in the treatment of acute poisoning" of the American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists (20). They stated that based on ex ...
E 3 Structure and Content of Clinical Study Reports
E 3 Structure and Content of Clinical Study Reports

... explanation of how the critical design features of the study were chosen and enough information on the plan, methods and conduct of the study so that there is no ambiguity in how the study was carried out. The report with its appendices should also provide enough individual patient data, including t ...
Acyclovir for treating primary herpetic gingivostomatitis (Review) The Cochrane Library
Acyclovir for treating primary herpetic gingivostomatitis (Review) The Cochrane Library

... Primary herpetic gingivostomatitis is a highly contagious infection of the oral cavity which is caused by the herpes simplex virus. It is prevalent in children and young adolescents and sometimes can cause uncomfortable symptoms including eating and drinking difficulties and even life-threatening in ...
Clinical Skills Education
Clinical Skills Education

... processes. The diminished opportunity to obtain a patient’s consent, respond to momentary concerns, and learn more about the patient as a person during these one-on-one interactions serve to limit the student further from clinical performance learning and practice. Equally concerning, students may c ...
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Clinical trial

Clinical trials are experiments done in clinical research. Such prospective biomedical or behavioral research studies on human participants are designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on safety and efficacy. They are conducted only after they have received health authority/ethics committee approval in the country where approval of the therapy is sought. These authorities are responsible for vetting the risk/benefit ratio of the trial - their approval does not mean that the therapy is 'safe' or effective, only that the trial may be conducted.Depending on product type and development stage, investigators initially enroll volunteers and/or patients into small pilot studies, and subsequently conduct progressively larger scale comparative studies. Clinical trials can vary in size and cost, and they can involve a single research center or multiple centers, in one country or in multiple countries. Clinical study design aims to ensure the scientific validity and reproducibility of the results.Trials can be quite costly, depending on a number of factors. The sponsor may be a governmental organization or a pharmaceutical, biotechnology or medical device company. Certain functions necessary to the trial, such as monitoring and lab work, may be managed by an outsourced partner, such as a contract research organization or a central laboratory.Only 10% of all drugs started in human clinical trials become an approved drug.
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