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Bulletin PST 206, Grocery and Drug Stores
Bulletin PST 206, Grocery and Drug Stores

...  Work-related safety equipment and protective clothing designed to be worn by, or attached to, a worker if required under specified provincial work safety legislation when purchased or leased by an employer, self-employed person or educational institution,  Specifically listed work-related safety ...
Is there an interaction between erythromycin and statins?
Is there an interaction between erythromycin and statins?

Bulletin PST 206
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...  Work-related safety equipment and protective clothing designed to be worn by, or attached to, a worker if required under specified provincial work safety legislation when purchased or leased by an employer, self-employed person or educational institution,  Specifically listed work-related safety ...
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... Residual solvents in pharmaceuticals are defined here as organic volatile chemicals that are used or produced in the manufacture of drug substances or excipients, or in the preparation of drug products. The solvents are not completely removed by practical manufacturing techniques. Appropriate select ...
Electronic Yellow Card Reporting Integration into GP Systems
Electronic Yellow Card Reporting Integration into GP Systems

... facilitate the exchange of information about human pharmacovigilance within the Community. Similarly, Article 26 of Regulation (EC) No 726/2004 includes a requirement for the Commission, in consultation with the Agency, Member States and interested parties to draw up a guide. This guidance document ...
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... 9. New active ingredient means an active ingredient contained in the composition of a drug registered for the first time for circulation in Vietnam. 10. New drug means a drug registered for the first time in Vietnam, including: a/ Drugs containing new active ingredients; b/ Drugs with a new combinat ...
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... responsible for bringing Canada’s prices for patented medicines roughly in line with European comparators. Prices of generic products, which are not regulated, are relatively high although high penetration of the Canadian market has been achieved. All Canadians have coverage for drugs provided in ho ...
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... risedronate sodium 5mg, 30mg and 35mg tablets are already reimbursed on the Formulary as a General Benefits. Risedronate sodium 75mg tablets are taken on two consecutive days per month and risedronate sodium 150mg tablets are taken once monthly. The manufacturer implies that this would improve patie ...
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Evaluating Drugs Used To Treat: Constipation

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... absorption, distribution, metabolism, and excretion; that is why, average doses will produce average responses, and for many drugs with wide safety margins, this is sufficient. However, some drugs do not have wide safety margins and knowledge of clinical pharmacokinetics in the individual is vital t ...
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... Trazodone is a triazolopyridine derivative which differs chemically from other currently available antidepressants. Although trazodone bears some resemblance to the benzodiazepines, phenothiazines and tricyclic antidepressants, its pharmacological profile differs from each of these classes of drugs. ...
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... Furthermore, being a Carbapenem analogue of the β-lactam class of antibiotics, Meropenem is known to undergo degradation both in its solid state and in aqueous solutions. Meropenem also degrades under thermal pressure, leading to the formation of degradation products such as 4-methyl-3-(1Hpyrrol-3-y ...
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QUANTIFICATION OF HEALTH COMMODITIES: ARV COMPANION GUIDE Forecasting ARV Drugs Using the Morbidity

... patients on nonstandard ARV drug regimens who may have entered the program already on ART, as well as patients who are on individualized salvage therapy. ARV drugs have several characteristics that affect the management of the commodities and that pose unique challenges in quantification. Those char ...
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Biosimilar

A biosimilar (also known as follow-on biologic or subsequent entry biologic) is a biologic medical product which is a copy of an original product that is manufactured by a different company. Biosimilars are officially approved versions of original ""innovator"" products, and can be manufactured when the original product's patent expires. Reference to the innovator product is an integral component of the approval.Unlike the more common small-molecule drugs, biologics generally exhibit high molecular complexity, and may be quite sensitive to changes in manufacturing processes. Follow-on manufacturers do not have access to the originator's molecular clone and original cell bank, nor to the exact fermentation and purification process, nor to the active drug substance. They do have access to the commercialized innovator product.Drug related authorities such as European Medicines Agency (EMA), Food and Drug Administration (FDA), and Health Canada hold their own guidance on requirements for demonstration of the similar nature of two biological products in terms of safety and efficacy. According to them, analytical studies that demonstrate that the biological product is highly similar to the reference product notwithstanding minor differences in clinically inactive components; animal studies (including the assessment of toxicity); and a clinical study or studies (including the assessment of immunogenicity and pharmacokinetics or pharmacodynamics) that are sufficient to demonstrate safety, purity, and potency in one or more appropriate conditions of use for which the reference product is licensed and intended to be used and for which licensure is sought for the biological product.In case of a monoclonal antibody-containing medicinal product, such as Remsima, extensive physicochemical and biological characterization for it and its reference product Remicade was conducted in order to demonstrate their highly similar properties. Consequently, EMA have granted a marketing authorisation for only a few numbers of biosimilars since 2006 including a monoclonal antibody which is recently approved. Meanwhile, on March 6, 2015, the FDA approved the United States's first biosimilar product, the biosimilar filgrastim Zarxio.
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