LOCATION: CYTOPLASM
... Traps glucose in cell, creates more reactive compound Hexokinase: relatively non-specific-acts on glu, mann, fruc, Km in low uM range, bld glu 4-8 mM therefore active most of the time, occurs in muscle and brain. Inhibited by G-6-P Glucokinase: (hexokinase IV, an isozyme) predominates in liver. Km 5 ...
... Traps glucose in cell, creates more reactive compound Hexokinase: relatively non-specific-acts on glu, mann, fruc, Km in low uM range, bld glu 4-8 mM therefore active most of the time, occurs in muscle and brain. Inhibited by G-6-P Glucokinase: (hexokinase IV, an isozyme) predominates in liver. Km 5 ...
Custom RT-qPCR Assays and Panels for any Human, Mouse, or Rat
... 9/8/2015)) and corresponding patent claims outside the United States. The purchase of this product includes a limited, non-transferable immunity from suit under the foregoing patent claims for using only this amount of product for the purchaser’s own internal research. The right to use this product ...
... 9/8/2015)) and corresponding patent claims outside the United States. The purchase of this product includes a limited, non-transferable immunity from suit under the foregoing patent claims for using only this amount of product for the purchaser’s own internal research. The right to use this product ...
Three-Dimensional Structure of Adenosylcobinamide Kinase
... employed for the structural investigation of the native form of CobU were grown by microbatch from 6% poly(ethylene glycol) 3350, 200 mM NaCl, and 50 mM succinate, pH 5.5, at 4 °C at a protein concentration of 5-8 mg/mL. Crystals grew spontaneously or were microseeded and achieved sizes of 0.8 mm × ...
... employed for the structural investigation of the native form of CobU were grown by microbatch from 6% poly(ethylene glycol) 3350, 200 mM NaCl, and 50 mM succinate, pH 5.5, at 4 °C at a protein concentration of 5-8 mg/mL. Crystals grew spontaneously or were microseeded and achieved sizes of 0.8 mm × ...
No Slide Title
... 1. By flux of nitrogen through cycle - depends on diet lots protein in diet = carbon skeletons used for fuel, lots of urea starvation = breakdown muscle protein for energy, lots of urea All enzymes (CPS-I and 4 in cycle) synthesized at higher rates in starving animals and animals on high protein die ...
... 1. By flux of nitrogen through cycle - depends on diet lots protein in diet = carbon skeletons used for fuel, lots of urea starvation = breakdown muscle protein for energy, lots of urea All enzymes (CPS-I and 4 in cycle) synthesized at higher rates in starving animals and animals on high protein die ...
Regulation 1. Short term control
... synthesis occuring in the cytoplasm. In this way, if one pathway is turned on, there is no competition from the other pathway operating in the opposite direction. (b) hormonal: The effect of hormones was mentioned in a few sections, but the main contact was in glycogen metabolism where adrenalin was ...
... synthesis occuring in the cytoplasm. In this way, if one pathway is turned on, there is no competition from the other pathway operating in the opposite direction. (b) hormonal: The effect of hormones was mentioned in a few sections, but the main contact was in glycogen metabolism where adrenalin was ...
Binding of a Growth Hormone- Inducible Nuclear Factor Is Mediated
... are part of the phosphorylationcascadein the response after GH binding to GH receptor in 3T3-F442A preadipocytes (22, 23). This also was noted in Chinesehamster ovary cells transfected with GH receptor (24) and in GH-treated liver nuclear extracts (12). Ultimately, many aspectsof MAP kinase-activate ...
... are part of the phosphorylationcascadein the response after GH binding to GH receptor in 3T3-F442A preadipocytes (22, 23). This also was noted in Chinesehamster ovary cells transfected with GH receptor (24) and in GH-treated liver nuclear extracts (12). Ultimately, many aspectsof MAP kinase-activate ...
C485 Exam I
... Branching enzyme transfers blocks of (usually) seven residues to an internal C-6 OH of the chain. Must be at least 4 residues away from an existing branch. Tends to make branches on average of every 10 residues. b) 3 pts What is meant by reciprocal regulation? Give an example associated with glycoge ...
... Branching enzyme transfers blocks of (usually) seven residues to an internal C-6 OH of the chain. Must be at least 4 residues away from an existing branch. Tends to make branches on average of every 10 residues. b) 3 pts What is meant by reciprocal regulation? Give an example associated with glycoge ...
Evolution of Cellular Data Processing
... PEP (phosphoenol pyruvate)-powered phosphotransferase systems, abbreviated as PTS. They combine membrane transport with the regulation of gene transcription. Prokaryotes are capable of switching their genes on and off in a specific and signal-controlled mode in order to adapt to the actual condition ...
... PEP (phosphoenol pyruvate)-powered phosphotransferase systems, abbreviated as PTS. They combine membrane transport with the regulation of gene transcription. Prokaryotes are capable of switching their genes on and off in a specific and signal-controlled mode in order to adapt to the actual condition ...
Lecture_4_Glycolysis
... Cataracts, a clouding of the lens, form because galactose is converted into galactitol, which is poorly metabolized and accumulates in the lens. Water diffuses into the lens to maintain osmotic balance, causing cataract formation. ...
... Cataracts, a clouding of the lens, form because galactose is converted into galactitol, which is poorly metabolized and accumulates in the lens. Water diffuses into the lens to maintain osmotic balance, causing cataract formation. ...
Modular evolution of phosphorylation
... indicates its importance in cellular function. The relative abundance of pSer/pThr-binding domains when compared with pTyr-recognition modules reflects the fact that the phosphorylation of serine/threonine sites is more ancient and more prevalent than tyrosine phosphorylation. A particular phosphope ...
... indicates its importance in cellular function. The relative abundance of pSer/pThr-binding domains when compared with pTyr-recognition modules reflects the fact that the phosphorylation of serine/threonine sites is more ancient and more prevalent than tyrosine phosphorylation. A particular phosphope ...
The Photosynthetic Dark Reactions Do Not Operate
... evolved is a set of two photosynthetic reactions— the light reactions and the Calvin cycle reactions— that are regulated and operate together in the light, but do not operate in the absence of light. Carbohydrate production is therefore shut off at night because of enzyme inactivity, closure of stom ...
... evolved is a set of two photosynthetic reactions— the light reactions and the Calvin cycle reactions— that are regulated and operate together in the light, but do not operate in the absence of light. Carbohydrate production is therefore shut off at night because of enzyme inactivity, closure of stom ...
Brassinosteroid Signal Transduction from Receptor Kinases to
... established the BR signal transduction cascade, which includes BR perception by the BRI1 receptor kinase at the cell surface, activation of BRI1/BAK1 kinase complex by transphosphorylation, subsequent phosphorylation of the BSK kinases, activation of the BSU1 phosphatase, dephosphorylation and inact ...
... established the BR signal transduction cascade, which includes BR perception by the BRI1 receptor kinase at the cell surface, activation of BRI1/BAK1 kinase complex by transphosphorylation, subsequent phosphorylation of the BSK kinases, activation of the BSU1 phosphatase, dephosphorylation and inact ...
AP151 ENZYMES
... • Allow chemical rxns to occur at needed rates under conditions that are compatible with life (i.e., that the human body can survive). • Allow chemical rxns to be regulated so specific processes can occur when and where they are needed. ...
... • Allow chemical rxns to occur at needed rates under conditions that are compatible with life (i.e., that the human body can survive). • Allow chemical rxns to be regulated so specific processes can occur when and where they are needed. ...
Lecture # 7 Pentose Phosphate Pathway
... The pentose pathway is a shunt. • The pathway begins with the glycolytic intermediate glucose 6-P. • It reconnects with glycolysis because two of the end products of the pentose pathway are glyceraldehyde 3-P and fructose 6-P; two intermediates further down in the glycolytic pathway. • It is for th ...
... The pentose pathway is a shunt. • The pathway begins with the glycolytic intermediate glucose 6-P. • It reconnects with glycolysis because two of the end products of the pentose pathway are glyceraldehyde 3-P and fructose 6-P; two intermediates further down in the glycolytic pathway. • It is for th ...
Slides
... Indicates types of Rxn as: Small molecule rxn, transport rxn, protein-small-molecule rxn (one substrate is protein and one is a small molecule), protein rxn (all substrates are proteins), etc. ...
... Indicates types of Rxn as: Small molecule rxn, transport rxn, protein-small-molecule rxn (one substrate is protein and one is a small molecule), protein rxn (all substrates are proteins), etc. ...
Fermentation Fermentation is an ancient mode of metabolism, and it
... 4. Butyric acid fermentations, as well as the butanol-acetone fermentation , are run by the clostridia, the masters of fermentation. In addition to butyric acid, the clostridia form acetic acid, CO2 and H2 from the fermentation of sugars. 5. Butanol-acetone fermentation. Butanol and acetone were dis ...
... 4. Butyric acid fermentations, as well as the butanol-acetone fermentation , are run by the clostridia, the masters of fermentation. In addition to butyric acid, the clostridia form acetic acid, CO2 and H2 from the fermentation of sugars. 5. Butanol-acetone fermentation. Butanol and acetone were dis ...
REGULATORY ENZYMES
... mitochondria, etc.) is another form of regulation. Enzymes associated with a given pathway frequently form organized, multi-component macromolecular complexes that perform a particular cellular process. Similarly, it follows that the substrates associated with a given pathway can also be localized t ...
... mitochondria, etc.) is another form of regulation. Enzymes associated with a given pathway frequently form organized, multi-component macromolecular complexes that perform a particular cellular process. Similarly, it follows that the substrates associated with a given pathway can also be localized t ...
Elucidating Substrate and Inhibitor Binding Sites on the Surface of
... Fig. 1. The 89–95 loop defines a substrate binding subsite for GSK-3β. (a) Features of the substrate binding site of GSK-3β. The structure of GSK-3β is based on the available crystal structures,30,40 as described in Ref. 39. The surface of GSK-3β is shown in gray, with the loop 89–95 shown in yellow ...
... Fig. 1. The 89–95 loop defines a substrate binding subsite for GSK-3β. (a) Features of the substrate binding site of GSK-3β. The structure of GSK-3β is based on the available crystal structures,30,40 as described in Ref. 39. The surface of GSK-3β is shown in gray, with the loop 89–95 shown in yellow ...
File - Wk 1-2
... PKB phosphorylates existing target proteins: o movement of GLUT4 to membrane o phosphorylation of glycogen synthase kinase which inactivates it, thereby allowing glycogen synthase to remain active o synthesis of lipids, proteins and glucagon ...
... PKB phosphorylates existing target proteins: o movement of GLUT4 to membrane o phosphorylation of glycogen synthase kinase which inactivates it, thereby allowing glycogen synthase to remain active o synthesis of lipids, proteins and glucagon ...
Metabolic Crosstalk: Interactions between the
... plants—particularly in trees, which can get big in no small part because of the lignin produced through this pathway. In addition to the huge carbon sink represented by lignin (reviewed in Eudes et al., 2014), the phenylpropanoid pathway also produces important small molecules such as flavonoids. By ...
... plants—particularly in trees, which can get big in no small part because of the lignin produced through this pathway. In addition to the huge carbon sink represented by lignin (reviewed in Eudes et al., 2014), the phenylpropanoid pathway also produces important small molecules such as flavonoids. By ...
Src protein–tyrosine kinase structure and regulation
... SH3 domains (60 amino acid residues) bind to sequences that can adopt a left-handed helical conformation. These sequences are usually rich in proline. RPLPPLP is an optimal Class 1 Src SH3 ligand [2,14]. UPPLPXR is an optimal Class 2 Src SH3 ligand that binds with an inverted orientation on the SH3 ...
... SH3 domains (60 amino acid residues) bind to sequences that can adopt a left-handed helical conformation. These sequences are usually rich in proline. RPLPPLP is an optimal Class 1 Src SH3 ligand [2,14]. UPPLPXR is an optimal Class 2 Src SH3 ligand that binds with an inverted orientation on the SH3 ...
PDF file
... is associated to the initiator and gives rise to unbranched amylose chains. Glycogen formation is completed by the so-called branching enzyme, that ramifies the amylose glucan (Tolmasky and Krisman, 1987; Tolmasky et al., 1998) to form mature glycogen molecules. No insect homologue of mammalian or y ...
... is associated to the initiator and gives rise to unbranched amylose chains. Glycogen formation is completed by the so-called branching enzyme, that ramifies the amylose glucan (Tolmasky and Krisman, 1987; Tolmasky et al., 1998) to form mature glycogen molecules. No insect homologue of mammalian or y ...
EMBO_only European Molecular Biology Organization European
... critical negative regulator of mTORC1 (Huang and Manning, 2008b). Because of its central role in regulating mTORC1, 34 species depicting extensive details about the TSC1–TSC2 complex (posttranslation modifications, interactors, cellular locations) were represented in the comprehensive mTOR map. In r ...
... critical negative regulator of mTORC1 (Huang and Manning, 2008b). Because of its central role in regulating mTORC1, 34 species depicting extensive details about the TSC1–TSC2 complex (posttranslation modifications, interactors, cellular locations) were represented in the comprehensive mTOR map. In r ...