In immunology, an adjuvant is an agent that may stimulate the
... A sporozoite (G. sporos, seed + zoon, animal) is the cell form that infects new hosts. In Plasmodium, for instance, the sporozoites are cells that develop in the mosquito's salivary glands, leave the mosquito during a blood meal, and enter the liver where they multiply. Cells infected with sporozoit ...
... A sporozoite (G. sporos, seed + zoon, animal) is the cell form that infects new hosts. In Plasmodium, for instance, the sporozoites are cells that develop in the mosquito's salivary glands, leave the mosquito during a blood meal, and enter the liver where they multiply. Cells infected with sporozoit ...
Immunotherapy and Prevention
... meaning protection. Anaphylaxis is an inclusive term for the reactions caused when certain antigens combine with IgE antibodies. Anaphylactic responses can be systemic reactions, which produce shock and breathing difficulties and are sometimes fatal, or localized reactions, which include common alle ...
... meaning protection. Anaphylaxis is an inclusive term for the reactions caused when certain antigens combine with IgE antibodies. Anaphylactic responses can be systemic reactions, which produce shock and breathing difficulties and are sometimes fatal, or localized reactions, which include common alle ...
Haptoglobin, inflammation and disease
... of intravascular or extravascular haemolysis. The protein exists in humans as three main phenotypes, Hp1-1, Hp2-2 and Hp2-1. Accumulated data on the protein’s function has established its strong association with diseases that have inflammatory causes. These include parasitic (malaria), infectious (HI ...
... of intravascular or extravascular haemolysis. The protein exists in humans as three main phenotypes, Hp1-1, Hp2-2 and Hp2-1. Accumulated data on the protein’s function has established its strong association with diseases that have inflammatory causes. These include parasitic (malaria), infectious (HI ...
Immune Cells
... • The immune cells have receptors that attach to MHC proteins and “see” the antigen • They also have antigen receptors • Only those T cells whose antigen receptors “fit” the antigen being displayed will respond to it Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins ...
... • The immune cells have receptors that attach to MHC proteins and “see” the antigen • They also have antigen receptors • Only those T cells whose antigen receptors “fit” the antigen being displayed will respond to it Copyright © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins ...
Chapter 15 - UBC Physics
... hemolytic anemia and many more. Self-nonself discrimination is not perfect also in a healthy animal; some anti-self antibodies can often be detected transiently during immune responses to foreign antigens. An early hypothesis to explain autoimmunity was that self-reactive V regions are somehow elimi ...
... hemolytic anemia and many more. Self-nonself discrimination is not perfect also in a healthy animal; some anti-self antibodies can often be detected transiently during immune responses to foreign antigens. An early hypothesis to explain autoimmunity was that self-reactive V regions are somehow elimi ...
Introduction Tuberculosis (TB) is a global public health hazard. Out
... Tuberculosis (TB) is a global public health hazard. Out of the total 14 million prevalent cases (range, 12 million–16 million), most cases were in the South-East Asia, African and Western Pacific regions (35%, 30% and 20%, respectively). An estimated 11–13% of incident cases are HIV-positive [1]. Re ...
... Tuberculosis (TB) is a global public health hazard. Out of the total 14 million prevalent cases (range, 12 million–16 million), most cases were in the South-East Asia, African and Western Pacific regions (35%, 30% and 20%, respectively). An estimated 11–13% of incident cases are HIV-positive [1]. Re ...
antigen saturation, natural antibodies and a quantitative
... such an extent (except for pathological antibodies in disease, like monoclonal gammopathies). Multiple binding sites increase the apparent affinity of the interaction by avidity effects, but not to the value required here. A combination of these effects, large concentration achieved by large numbe ...
... such an extent (except for pathological antibodies in disease, like monoclonal gammopathies). Multiple binding sites increase the apparent affinity of the interaction by avidity effects, but not to the value required here. A combination of these effects, large concentration achieved by large numbe ...
Antigen Presentation and Dendritic Cells
... 1. DCs are the most effective professional APCs -Only professional APCs are capable activation of naïve T cells -Amateur APCs lack the ability to elicit signal 2 and therefore only recognize previously activated T cells. Most cells that become infected are amateur APCs. -DCs: most effective because ...
... 1. DCs are the most effective professional APCs -Only professional APCs are capable activation of naïve T cells -Amateur APCs lack the ability to elicit signal 2 and therefore only recognize previously activated T cells. Most cells that become infected are amateur APCs. -DCs: most effective because ...
T cell receptor-transgenic mouse models for studying cellular
... 106 TCR-transgenic T cells from Do11.10 mice. Transgenic T cells accumulated in the draining lymph nodes and spleens of mice infected with ovalbumin-expressing Salmonella but not in mice infected with control Salmonella, indicating a speci¢c induction and proliferation of cognate T cells. Surprising ...
... 106 TCR-transgenic T cells from Do11.10 mice. Transgenic T cells accumulated in the draining lymph nodes and spleens of mice infected with ovalbumin-expressing Salmonella but not in mice infected with control Salmonella, indicating a speci¢c induction and proliferation of cognate T cells. Surprising ...
Bacterial Agglutination
... ▪ Latex agglutination- are coated with polyvalent antisera against a wide range of antigens, when mixed with the suspension of microorganism latex particles rapidly agglutinate to form visible clumps ▪ Coagglutination – the aggregation of particulate antigens combined with agglutinins with more than ...
... ▪ Latex agglutination- are coated with polyvalent antisera against a wide range of antigens, when mixed with the suspension of microorganism latex particles rapidly agglutinate to form visible clumps ▪ Coagglutination – the aggregation of particulate antigens combined with agglutinins with more than ...
Both Lewis and Secretor Status Mediate
... dependent manner, suggesting them to be putative receptors for RV. The diversity of HBGA phenotypes in different ethnic populations, combined with prevalence/absence of specific RV genotypes, led us to hypothesize whether the genetic variations in HBGAs in a population limit susceptibility to certain ...
... dependent manner, suggesting them to be putative receptors for RV. The diversity of HBGA phenotypes in different ethnic populations, combined with prevalence/absence of specific RV genotypes, led us to hypothesize whether the genetic variations in HBGAs in a population limit susceptibility to certain ...
169) `Immune Epitope Database (IEDB) and its use of formal
... Randi Vita, M.D. Ontology Usage by the Immune Epitope Database and Analysis Project La Jolla Institute for Allergy & Immunology Division of Vaccine Discovery La Jolla, California ...
... Randi Vita, M.D. Ontology Usage by the Immune Epitope Database and Analysis Project La Jolla Institute for Allergy & Immunology Division of Vaccine Discovery La Jolla, California ...
Immunology
... The combined strength of the noncovalent interactions between a single antigen-binding site on an antibody and a single epitope is the affinity of the antibody for that epitope. Low-affinity antibodies bind antigen weakly and tend to dissociate readily, whereas high-affinity antibodies bind antigen ...
... The combined strength of the noncovalent interactions between a single antigen-binding site on an antibody and a single epitope is the affinity of the antibody for that epitope. Low-affinity antibodies bind antigen weakly and tend to dissociate readily, whereas high-affinity antibodies bind antigen ...
Antibodies Formerly Known as - Mississippi Valley Regional
... on what to call these antibodies and many facilities are struggling to come up with appropriate terminology o On April 24th Medical Director Dr. Bruce Marshall is attending two seminars regarding this ever-evolving issue and more united decisions may come from these. ...
... on what to call these antibodies and many facilities are struggling to come up with appropriate terminology o On April 24th Medical Director Dr. Bruce Marshall is attending two seminars regarding this ever-evolving issue and more united decisions may come from these. ...
Role of Neutrophils in Dengue Patients: Clearance of Dengue Virus
... The importance of neutrophils in acute inflammatory response, the activation, regulation and effector functions of innate and adaptive immune cells has been a central focus recently, with a primary role in clearance of extracellular pathogens. A unique type of cell death of neutrophil characterized ...
... The importance of neutrophils in acute inflammatory response, the activation, regulation and effector functions of innate and adaptive immune cells has been a central focus recently, with a primary role in clearance of extracellular pathogens. A unique type of cell death of neutrophil characterized ...
Differential expression of surface membrane Trypanosoma congolense
... antigens on bovine monocytes activated with recombinant cytokines and during Trypanosoma congolense infection . Onderstepoort Journal of Veterinary Research, 67:289-296 The expression of surface membrane antigens on peripheral blood monocytes (PBM) of cattle of the Boran and N'Dama breeds activated ...
... antigens on bovine monocytes activated with recombinant cytokines and during Trypanosoma congolense infection . Onderstepoort Journal of Veterinary Research, 67:289-296 The expression of surface membrane antigens on peripheral blood monocytes (PBM) of cattle of the Boran and N'Dama breeds activated ...
Interaction of bacteria with antigen presenting cells: influences on
... CD86) increases on both MFs and DCs upon bacterial and/or in¯ammatory stimuli, the levels of cell surface MHC-II and CD86 are higher on bone marrow-derived DCs in comparison to the level of expression on MFs when exposed to Salmonella [1,2]. Moreover, the migratory capacity of DCs from tissues into ...
... CD86) increases on both MFs and DCs upon bacterial and/or in¯ammatory stimuli, the levels of cell surface MHC-II and CD86 are higher on bone marrow-derived DCs in comparison to the level of expression on MFs when exposed to Salmonella [1,2]. Moreover, the migratory capacity of DCs from tissues into ...
A generalized quantitative antibody homeostasis model
... stalk of C1q. C1q binds to all sorts of molecules, recognizing charge and structure. It also efficiently binds to IgM in immune complexes. The recently described IgM receptor, FcmuR, is also expressed by CD19 positive cells in human bone marrow(11). Furthermore in the mouse, FcmuR has been shown t ...
... stalk of C1q. C1q binds to all sorts of molecules, recognizing charge and structure. It also efficiently binds to IgM in immune complexes. The recently described IgM receptor, FcmuR, is also expressed by CD19 positive cells in human bone marrow(11). Furthermore in the mouse, FcmuR has been shown t ...
Trafficking of B Cell Antigen in Lymph Nodes
... nodes (26–30). For example, chemoattractants such as monocyte chemoattractant protein 1 (MCP-1) (now known as CCL2) draining from a possible infection in the skin are delivered to the HEV of local lymph nodes, where they provide a signal to circulating leukocytes, as proposed by the “remote control ...
... nodes (26–30). For example, chemoattractants such as monocyte chemoattractant protein 1 (MCP-1) (now known as CCL2) draining from a possible infection in the skin are delivered to the HEV of local lymph nodes, where they provide a signal to circulating leukocytes, as proposed by the “remote control ...
The phenotype of alveolar macrophages ... with immune cells in bronchoalveolar ...
... BAL was performed in 76 consecutive patients, including 32 with sarcoidosis, 8 with idiopathic pulmonary fibrosis, 9 with pneumoconiosis, 13 with other respiratory disorders, and 14 oontrols without evidence of interstitial lung disease. The phenotype of AMs was studied by a panel of 15 monoclonal a ...
... BAL was performed in 76 consecutive patients, including 32 with sarcoidosis, 8 with idiopathic pulmonary fibrosis, 9 with pneumoconiosis, 13 with other respiratory disorders, and 14 oontrols without evidence of interstitial lung disease. The phenotype of AMs was studied by a panel of 15 monoclonal a ...
Algae-based oral recombinant vaccines
... hypertension, consisting of a fusion between angiotensin and a Hepatitis B antigen as a carrier, was the first algal vaccine to be expressed from the nuclear genome without chloroplast targeting. While it only accumulated to 0.05% TSP, it was detectable by Western blot from algal total soluble prote ...
... hypertension, consisting of a fusion between angiotensin and a Hepatitis B antigen as a carrier, was the first algal vaccine to be expressed from the nuclear genome without chloroplast targeting. While it only accumulated to 0.05% TSP, it was detectable by Western blot from algal total soluble prote ...
An open letter to our readers on the use of antibodies
... The use of immunohistochemistry has become ubiquitous in neuroscience. A large majority of papers now published in The Journal of Comparative Neurology use immunohistochemistry, and some papers may employ a battery of ten or more antibodies to examine issues of colocalization or cell typing. This pa ...
... The use of immunohistochemistry has become ubiquitous in neuroscience. A large majority of papers now published in The Journal of Comparative Neurology use immunohistochemistry, and some papers may employ a battery of ten or more antibodies to examine issues of colocalization or cell typing. This pa ...
Vaccine development strategies Plasmodium falciparum
... malaria parasite Plasmodium falciparum is considered of high priority. The aim of the work presented in this thesis was to develop and characterize recombinant vaccine constructs based on the P. falciparum asexual bloodstage antigen Pf332. We have studied the humoral responses in mice elicited by va ...
... malaria parasite Plasmodium falciparum is considered of high priority. The aim of the work presented in this thesis was to develop and characterize recombinant vaccine constructs based on the P. falciparum asexual bloodstage antigen Pf332. We have studied the humoral responses in mice elicited by va ...