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Human Anatomy & Physiology
Human Anatomy & Physiology

Addressing the Inflammatory Response to Clinically Relevant
Addressing the Inflammatory Response to Clinically Relevant

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Haematological aspects of systemic disease

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... enhanced cardiac function enhanced vascular reactivity decreased endothelial permeability 3. Fluid volume ADH Aldosterone 4. Inflammatory response blocks prostaglandin production a. decreases vasodilation b. decrease permeability of membranes c. decrease migration of monocytes and lymphocytes blocks ...
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Pathophysiology Multiple Organ Dysfunction Syndrome

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The 21st century epidemic: infections as inductors of neuro-degeneration associated with Alzheimer

... CMV infection is usually asymptomatic, but once established, the virus remains latent in blood monocytes [24]. CMV has also been associated with other chronic diseases of aging, including cardiovascular disease, cognitive decline and cancer. The specific mechanisms responsible for these associations ...
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Human perinatal immunity in physiological conditions and during

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Basic Pathological Sciences Syllabus

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basic immunology - School of Physical Sciences

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Adaptogens for Health and Vitality

... During times of moderate stress, the body engages defence molecules. These molecules not only deal with the immediate threat, but also increase resistance to other threats. They can even repair existing damage. Examples of these molecular defence agents include heat shock proteins (HSPs), sirtuin1 ( ...
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Pancreatic, Hepatic and Biliary Disease: An Overview

The Stress Response and Its Functional Implications
The Stress Response and Its Functional Implications

... paracrine or endocrine. Some cytokines are known to act in either synergistic or antagonistic way. Cytokines may affect the action of each other which may give synergistic or antagonistic effect on the targeted cells. Both the synthesis and activity of cytokines are regarded at different levels. Dif ...
Mitochondrial damage-associated molecular patterns and vascular
Mitochondrial damage-associated molecular patterns and vascular

Staining whole mounts of the diaphragm muscle
Staining whole mounts of the diaphragm muscle

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Inflammation



Inflammation (Latin, inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants.Inflammation is a protective response that involves immune cells, blood vessels, and molecular mediators. The purpose of inflammation is to eliminate the initial cause of cell injury, clear out necrotic cells and tissues damaged from the original insult and the inflammatory process, and to initiate tissue repair.The classical signs of acute inflammation are pain, heat, redness, swelling, and loss of function. Inflammation is a generic response, and therefore it is considered as a mechanism of innate immunity, as compared to adaptive immunity, which is specific for each pathogen.Too little inflammation could lead to progressive tissue destruction by the harmful stimulus (e.g. bacteria) and compromise the survival of the organism. In contrast, chronic inflammation may lead to a host of diseases, such as hay fever, periodontitis, atherosclerosis, rheumatoid arthritis, and even cancer (e.g., gallbladder carcinoma). Inflammation is therefore normally closely regulated by the body.Inflammation can be classified as either acute or chronic. Acute inflammation is the initial response of the body to harmful stimuli and is achieved by the increased movement of plasma and leukocytes (especially granulocytes) from the blood into the injured tissues. A series of biochemical events propagates and matures the inflammatory response, involving the local vascular system, the immune system, and various cells within the injured tissue. Prolonged inflammation, known as chronic inflammation, leads to a progressive shift in the type of cells present at the site of inflammation and is characterized by simultaneous destruction and healing of the tissue from the inflammatory process.Inflammation is not a synonym for infection. Infection describes the interaction between the action of microbial invasion and the reaction of the body's inflammatory defensive response — the two components are considered together when discussing an infection, and the word is used to imply a microbial invasive cause for the observed inflammatory reaction. Inflammation on the other hand describes purely the body's immunovascular response, whatever the cause may be. But because of how often the two are correlated, words ending in the suffix -itis (which refers to inflammation) are sometimes informally described as referring to infection. For example, the word urethritis strictly means only ""urethral inflammation"", but clinical health care providers usually discuss urethritis as a urethral infection because urethral microbial invasion is the most common cause of urethritis.It is useful to differentiate inflammation and infection as there are many pathological situations where inflammation is not driven by microbial invasion - for example, atherosclerosis, type III hypersensitivity, trauma, ischaemia. There are also pathological situations where microbial invasion does not result in classic inflammatory response—for example, parasitosis, eosinophilia.
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