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Chapter 23 Viruses and Prokaryotes
Chapter 23 Viruses and Prokaryotes

... • Takes over cell’s translation and transcription to reproduce Copyright © 2005 Brooks/Cole — Thomson Learning ...
counting viruses in mat - Research Explorer
counting viruses in mat - Research Explorer

... hotosynthetic microbial mats are vertically stratified benthic microbial communities that are found worldwide in environments ranging from hot springs to sea ice (e.g., see reference 1). The top layer of these mats is mostly composed of photoautotrophs (filamentous cyanobacteria and eukaryotic phyto ...
RNA genomes
RNA genomes

... (+)ssRNA genomes may be translated to make viral protein   dsRNA genomes can be directly translated to make viral protein  (+)ssRNA virus replication cycles do not require a (-) strand intermediate RNA genomes can be copied by host cell RNA-dependent RNA polymerases All of the above  ...
Principles of Virology
Principles of Virology

... 1. Virions initially randomly interact with cells – no specificity (Virions are inanimate: Driven by Brownian motion, laws of diffusion and electrostatics) 2. Attach to specific receptor molecules on cell surface - More than one receptor may be involved 3. This enables transfer of the genome into th ...
Ammonia as an In Situ Sanitizer: Influence of Virus Genome Type on
Ammonia as an In Situ Sanitizer: Influence of Virus Genome Type on

... environment. Here, we investigated the factors that determine the persistence of viruses in HEAM, and we determined the main mechanisms that lead to their inactivation. Unlike other organisms, viruses can have four different genome types (double- or single-stranded RNA or DNA), and the viruses studi ...
Biology 11 Classification, Viruses and Bacteria Study Guide Chart
Biology 11 Classification, Viruses and Bacteria Study Guide Chart

...  Draw conclusions based on data (understanding experimental error, confidence in data and role of control group as comparison). Card 4: Bacteria  Describe the characteristics common to bacteria.  Describe bacterial types by shape (cocci, bacilli, spirillum).  Describe differences in bacterial re ...
Classification Viruses and Bacteria Study Guide
Classification Viruses and Bacteria Study Guide

... 5. Draw conclusions based on data (understanding experimental error, confidence in data and role of control group as comparison). ...
Rabies*what is it???
Rabies*what is it???

... How can I get a sure answer on if my pet has it? The most used method for diagnosing rabies is by performing PCR or viral culture of brain samples taken post-mortem. Another method of diagnosing rabies is to take skin samples. Though not as sensitive, you can also use saliva, urine, and cerebrospin ...
Characterization of bovine viral diarrhea viruses by their interactions
Characterization of bovine viral diarrhea viruses by their interactions

... these authors suggested that BVD agents could be classified as adenoviruses rather than myxovlruses which are also In a similar size range. Gillespie et al. (26) state: "Because virus diarrhea virus of cattle is ether susceptible. It would not currently be classified as an enterovirus even though it ...
Specific detection of minus strand hepatitis A
Specific detection of minus strand hepatitis A

... degradation of plus strand RNA after cDNA synthesis, and secondly the RTase activity of the Taq DNA polymerase (6,7). They concluded that reliable detection of minus strand HCV RNA is not yet achievable by current methods. By designing suitable primers for a modified nested PCR (TailPCR), and also b ...
A biochemical portrait of the nidovirus RNA polymerases and helicase
A biochemical portrait of the nidovirus RNA polymerases and helicase

... active site and the (meta- or catabolic) activity of other (enzymatic) domains in the polymerase amino acid chain all contribute to defining key virus properties such as genomic architecture, replication speed, immune-escape, evolution and pathogenicity. Here we will review our current knowledge of ...
Hemorrhagic Fever With Renal Syndrome and Its History in Iran
Hemorrhagic Fever With Renal Syndrome and Its History in Iran

... was very soon reported from another region, what nowadays known as HFRS. Hemorrhagic fever of Manchuria, hemorrhagic nephros-nephritis in the Soviet Union, and nephropathia epidemica in Europe all were diverse nominations for same condition.1,2,5 In Asia and Russia, important pathogens for HFRS incl ...
Functions of glycoprotein G of herpes simplex virus type 2
Functions of glycoprotein G of herpes simplex virus type 2

... enhanced Th1 response and IFN-γ production in re-stimulated CD4+ T cells. Conclusion: Native sgG-2 and mgG-2 proteins induce type specific antibody responses and perform well in ELISA in low as well as in high HSV-2 prevalence populations. The mgG-2 protein has an important function in the ability o ...
A plant virus vector for systemic expression of foreign genes in cereals
A plant virus vector for systemic expression of foreign genes in cereals

... Inserts bearing the coding sequences of NPTll and P-glucuronidase (GUS) were placed between the nuclear inclusion b (Nlb) and coat protein (CP) domains of the wheat streak mosaic virus (WSMV) polyprotein ORF. The WSMV Nlb-CP junction containing the nuclear inclusiona (Nla) protease cleavage site was ...
Lecture Exam 3
Lecture Exam 3

... cold-weather months in locales with temperate climates. Respiratory tract infections are primarily spread by inhalation of aerosolized respiratory secretions from infected hosts. Some respiratory tract pathogens such as rhinoviruses can also be spread by direct contact with mucous membranes, but thi ...
Wolbachia and Dengue
Wolbachia and Dengue

18.1 Studying Viruses and Prokaryotes
18.1 Studying Viruses and Prokaryotes

... • Infect a cell without causing its immediate destruction - temperate virus • Viral DNA is integrated into hosts DNA – prophage • Can stay in host cell for an extended period of time • Every time host cell reproduces = prophage is replicated • Every cell is also infected • Trigger will activate lyti ...
Primary Liver Cancer - Canadian Cancer Society
Primary Liver Cancer - Canadian Cancer Society

... Cancer is a disease that starts in our cells. Our bodies are made up of trillions of cells, grouped together to form tissues and organs such as muscles and bones, the lungs and the liver. Genes inside each cell order it to grow, work, reproduce and die. Normally, our cells obey these orders and we r ...
Replication Patterns of Specific Viruses
Replication Patterns of Specific Viruses

... plant viruses. Indeed, close genetic relationships among many of these viruses are well established. The poliovirus genetic map and expression of poliovirus proteins A schematic of the icosahedral poliovirus virion is shown in Fig. 15.2. In accordance with its classification as a positive-sense RNA ...
Hostparasite coevolution: genetic variation in a virus
Hostparasite coevolution: genetic variation in a virus

... pathogen of D. melanogaster that on average infects about 4% of flies in natural populations (Carpenter et al., 2007). The virus is transmitted exclusively from parent to offspring via both eggs and sperm. Drosophila melanogaster is expected to be under selection to evolve resistance and reduce tran ...
Targets for breast cancer diagnosis and treatment
Targets for breast cancer diagnosis and treatment

... human genetics. Morespeci?cally. it relates to the identi? cation of novel genes associated with overabundance of RNA in human cancer. particularly breast cancer. It pertains especially to those genes and the products thereof which may be important in diagnosis and treatment. ...
Assembly and budding of rabies virus
Assembly and budding of rabies virus

... domain  mutants.  Since  the  viruses  were  not  severely  attenuated,  we  considered  other  requirements  of  RV  assembly  to  exist  and  found  the  phosphoprotein  (P)  to  play  an  essential  role  in  this  process.  A  virus  with  a  mutation  at  the  C‐terminus  of  P,  SAD P 288AAA,  ...
Viral adaptation to host - Molecular Systems Biology
Viral adaptation to host - Molecular Systems Biology

... history of viral adaptation propose a cross talk between codon usage, replication mode, genome size, and host range (Koonin et al, 2006). Furthermore, the observation that there exist both eukaryotic viruses that have adapted their codon usage toward their hosts and those that show little evidence f ...
Chapter 34
Chapter 34

... Long interspersed elements (LINEs) are the most common RTs in human genome – DNA transcribed to RNA – reverse transcribed to DNA by enzyme encoded by LINES – resulting DNA integrates into new site on host genome – no virion protein gene – do not produce virions ...
18.1 Studying Viruses and Prokaryotes
18.1 Studying Viruses and Prokaryotes

... Although the prophage is not active, it replicates along with the host cell’s DNA. ...
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Oncolytic virus

An oncolytic virus is a virus that preferentially infects and kills cancer cells. As the infected cancer cells are destroyed by lysis, they release new infectious virus particles to help destroy the remaining tumour. Oncolytic viruses are thought not only to cause direct destruction of the tumour cells, but also to stimulate host anti-tumour immune responses.The potential of viruses as anti-cancer agents was first realised in the early twentieth century, although coordinated research efforts did not begin until the 1960s. A number of viruses including adenovirus, reovirus, measles, herpes simplex, Newcastle disease virus and vaccinia have now been clinically tested as oncolytic agents. Most current oncolytic viruses are engineered for tumour selectivity, although there are naturally occurring examples such as reovirus and the SVV-001 Seneca Valley virus, resulting in clinical trials.As of 2011, only limited human trials had been performed.Nevertheless, the drug talimogene laherparepvec (OncoVex, T-VEC) recently (Jan 2012) reported the first positive interim Phase III clinical trial results for an oncolytic virus, making it likely that it will also be the first one approved for use (for the treatment of advanced melanoma). However, skeptics have questioned the clinical relevance of this interim data citing that the awaited overall survival data will be the final judgement and that it is likely that patient benefit will be maximised in combination with other therapies, which this trial did not test. 2015 update: In a combined decision, members of the FDA’s Oncologic Drugs Advisory Committee (ODAC) and Cellular, Tissue and Gene Therapies Advisory Committee (CTGTAC) voted 22-1 to recommend approval of the oncolytic immunotherapy talimogene laherparepvec (T-VEC) as a treatment for patients with advanced melanoma. A final approval decision from the FDA is scheduled by October 27, 2015. Approved in Latvia oncolytic virus RIGVIR was registered in Georgia in February 2015. Melanoma Research published new data on RIGVIR efficacy, showing that early stage melanoma patients treated with oncolytic virus RIGVIR had 4.39–6.57-fold lower mortality than those, who according to melanoma treatment guidelines did not receive virotherapy and were only observed.
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