Identification of chromosome intervals from 129 and C57BL/6 mouse
... developed an autoimmune phenotype. The humoral autoimmunity in this congenic strain was indistinguishable to that observed in a mouse carrying a deletion of the Apcs gene, located within the lupus-linked genomic region on distal chromosome 1 and considered as a candidate gene for murine SLE.6 Theref ...
... developed an autoimmune phenotype. The humoral autoimmunity in this congenic strain was indistinguishable to that observed in a mouse carrying a deletion of the Apcs gene, located within the lupus-linked genomic region on distal chromosome 1 and considered as a candidate gene for murine SLE.6 Theref ...
Modest evidence for linkage and possible confirmation of
... overly conservative. However, given that well over 100 tests were performed and that tests at each marker are close to being independent, it is likely that the appropriate significance threshold is at least an order of magnitude less than 0.05. It is, however, also appropriate to note that we are co ...
... overly conservative. However, given that well over 100 tests were performed and that tests at each marker are close to being independent, it is likely that the appropriate significance threshold is at least an order of magnitude less than 0.05. It is, however, also appropriate to note that we are co ...
gaba-mediated inhibition correlates with orientation selectivity in
... Fig. 1. Polar plots obtained from three representative cells in the Weakly-OS (A), Moderately-OS (B) and Strongly-OS (C) groups, that received treatment with GABA and bicuculline. The OB, maximum (peak) responses (MR) and spontaneous activity (Spon.) are shown for each condition. The radius of each ...
... Fig. 1. Polar plots obtained from three representative cells in the Weakly-OS (A), Moderately-OS (B) and Strongly-OS (C) groups, that received treatment with GABA and bicuculline. The OB, maximum (peak) responses (MR) and spontaneous activity (Spon.) are shown for each condition. The radius of each ...
Identification and mapping of RAPD and RFLP markers linked to a
... ratio of: (1) the sexual phenotypes, and (2) the co-segregant RAPD markers detected by BSA. To produce this ratio, the parents must be respectively heterozygous and recessive homozygous at these loci. It was therefore assumed that the sexual phenotype variation was determined by the polymorphism of ...
... ratio of: (1) the sexual phenotypes, and (2) the co-segregant RAPD markers detected by BSA. To produce this ratio, the parents must be respectively heterozygous and recessive homozygous at these loci. It was therefore assumed that the sexual phenotype variation was determined by the polymorphism of ...
RECIPROCAL CHROMOSOME TRANSLOCATIONS IN 437
... karyotype in variable proportions, e.g. 54% for reciprocal translocations and 13.7% for Robertsonian translocations (Martin et al. 1993). There is only limited information available about the effects of structural aberrations on oogenesis. It is not clear why reciprocal translocations cause male fac ...
... karyotype in variable proportions, e.g. 54% for reciprocal translocations and 13.7% for Robertsonian translocations (Martin et al. 1993). There is only limited information available about the effects of structural aberrations on oogenesis. It is not clear why reciprocal translocations cause male fac ...
PDF - Oxford Academic - Oxford University Press
... Longevity and Healthy Aging Phenotypes: Definitions and Heritability Longevity is often defined as age at death or survival to an exceptional age such as 90 years or older or 100 years or older. Because life expectancy has improved dramatically across birth cohorts since 1900, care must be taken whe ...
... Longevity and Healthy Aging Phenotypes: Definitions and Heritability Longevity is often defined as age at death or survival to an exceptional age such as 90 years or older or 100 years or older. Because life expectancy has improved dramatically across birth cohorts since 1900, care must be taken whe ...
PDF preprint - The Computational Neurobiology Laboratory
... where δ(·) is the Dirac delta function, eφ is a unit vector in the φ–direction, β is a parameter that measures the weight of lateral relative to local connections, and wLAT (s) is the weight of lateral connections between iso–orientation patches separated by a cortical distance s along a visuotopic ...
... where δ(·) is the Dirac delta function, eφ is a unit vector in the φ–direction, β is a parameter that measures the weight of lateral relative to local connections, and wLAT (s) is the weight of lateral connections between iso–orientation patches separated by a cortical distance s along a visuotopic ...
Wired for reproduction: Organization and Development of Sexually
... THE ANTEROVENTRAL PERIVENTRICULAR NUCLEUS (AVPV) Because gonadotropin secretion is perhaps the most significant sex difference in reproductive physiology, some of the earliest studies of sexual differentiation focused on the impact of sex steroid hormones on the phasic secretion of luteinizing hormo ...
... THE ANTEROVENTRAL PERIVENTRICULAR NUCLEUS (AVPV) Because gonadotropin secretion is perhaps the most significant sex difference in reproductive physiology, some of the earliest studies of sexual differentiation focused on the impact of sex steroid hormones on the phasic secretion of luteinizing hormo ...
Heritable variation in testosterone levels in male garter snakes
... suggested by a significant correlation between litter sex ratio and garter snake subcaudal scalation, a sexually dimorphic trait (Osypka & Arnold, 1999). However, this effect was seen in only one of two populations studied. Whether such in utero effects also influence post-natal offspring hormone pr ...
... suggested by a significant correlation between litter sex ratio and garter snake subcaudal scalation, a sexually dimorphic trait (Osypka & Arnold, 1999). However, this effect was seen in only one of two populations studied. Whether such in utero effects also influence post-natal offspring hormone pr ...
Y chromosome polymorphisms in medicine
... is present in a given population, two possible explanations can be given. First, a functional variation predisposing to a given disease could have appeared before the generation of the polymorphisms that de®ne Y chromosome haplogroups. In this case, all Y chromosomes belonging to these haplogroups w ...
... is present in a given population, two possible explanations can be given. First, a functional variation predisposing to a given disease could have appeared before the generation of the polymorphisms that de®ne Y chromosome haplogroups. In this case, all Y chromosomes belonging to these haplogroups w ...
Defining the biological bases of individual differences in musicality
... causal connections between particular genes and phenotypes of interest, in this case key features of musicality. Once relevant genes have been pinpointed, they can be used as entry points into the critical neurobiological pathways and can potentially complement other approaches to understanding musi ...
... causal connections between particular genes and phenotypes of interest, in this case key features of musicality. Once relevant genes have been pinpointed, they can be used as entry points into the critical neurobiological pathways and can potentially complement other approaches to understanding musi ...
CURRICULUM VITAE - Max Planck Institute for Chemical Ecology
... Symposium 12 at IXth ESEB meeting, Leeds, UK 2003 (organized with Prof. Anneli Hoikkala) Annual symposium of the W.M. Keck Center for Behavioral Biology for students and postdocs 2003, 2004, 2005 (organized with Prof. Robert Anholt and Prof. John Vandenbergh) "Insect-resistant transgenic plants ...
... Symposium 12 at IXth ESEB meeting, Leeds, UK 2003 (organized with Prof. Anneli Hoikkala) Annual symposium of the W.M. Keck Center for Behavioral Biology for students and postdocs 2003, 2004, 2005 (organized with Prof. Robert Anholt and Prof. John Vandenbergh) "Insect-resistant transgenic plants ...
Novel genetic aspects of Klinefelter`s syndrome
... years, new screening methods have been published: fluorescence in situ hybridization (FISH) may be used to estimate mosaicism in more detail by analyzing a larger number of interphase nuclei (Abdelmoula et al., 2004; Lenz et al., 2005). The extra X can also be detected by quantitative real-time PCR ( ...
... years, new screening methods have been published: fluorescence in situ hybridization (FISH) may be used to estimate mosaicism in more detail by analyzing a larger number of interphase nuclei (Abdelmoula et al., 2004; Lenz et al., 2005). The extra X can also be detected by quantitative real-time PCR ( ...
Kasiemobi Udo-okoye - The Genomics of Smoking Addiction
... other words, this crude indicator of the social environment is highest when the genetic factors are the lowest and is non-existent when genetic factors are most noticeable. Taken together, these findings provide strong support for the social push hypothesis.” That is, the model that posits that remo ...
... other words, this crude indicator of the social environment is highest when the genetic factors are the lowest and is non-existent when genetic factors are most noticeable. Taken together, these findings provide strong support for the social push hypothesis.” That is, the model that posits that remo ...
Orientation topography of layer 4 lateral networks revealed by
... The functional speci®city of corticocortical connections with respect to the topography of orientation selectivity was studied by optical imaging of intrinsic signals and bulk injections of ¯uorescent latex beads (green and red) and biocytin into layer 4. The distributions of retrogradely labelled c ...
... The functional speci®city of corticocortical connections with respect to the topography of orientation selectivity was studied by optical imaging of intrinsic signals and bulk injections of ¯uorescent latex beads (green and red) and biocytin into layer 4. The distributions of retrogradely labelled c ...
Physiology of Ejaculation
... with strong Fos activity, providing further support for a spinothalamic pathway of ejaculation [38]. Galanin may be responsible for the inhibition of sexual activity after ejaculation as determined by brain infusion studies [45]. Additional evidence for a LSt-medial SPFp-forebrain pathway is bolster ...
... with strong Fos activity, providing further support for a spinothalamic pathway of ejaculation [38]. Galanin may be responsible for the inhibition of sexual activity after ejaculation as determined by brain infusion studies [45]. Additional evidence for a LSt-medial SPFp-forebrain pathway is bolster ...
Chromosomal Aberrations
... translocated onto the long arm of one chromosome 14 at the centromere. Because chromosomes 14 and 21 are acrocentric chromosomes, Tyler is said to have a Robertsonian translocation. Chromosome analysis reveals that Tyler's father, Josh, has normal chromosomes, but Tyler's mother, Dawn, has 45 chromo ...
... translocated onto the long arm of one chromosome 14 at the centromere. Because chromosomes 14 and 21 are acrocentric chromosomes, Tyler is said to have a Robertsonian translocation. Chromosome analysis reveals that Tyler's father, Josh, has normal chromosomes, but Tyler's mother, Dawn, has 45 chromo ...
7.014 Genetics Section Problems
... iii) To be type B, individual 3 must have gotten an io ALK- chromosome from Dad and an I B ALK+ chromosome from Mom. iv) Individual 4 got an IA ALK- chromosome from Mom and an io ALK- chromosome from Dad. If no recombination occurred, then for this impending child the chance of getting I B ALK+ chro ...
... iii) To be type B, individual 3 must have gotten an io ALK- chromosome from Dad and an I B ALK+ chromosome from Mom. iv) Individual 4 got an IA ALK- chromosome from Mom and an io ALK- chromosome from Dad. If no recombination occurred, then for this impending child the chance of getting I B ALK+ chro ...
PDF - NIMH Genetics
... For each test, we adjusted the significance level for the number of markers using the Bonferroni procedure. In this study, since we used microsatellite DNA as markers, all markers had more than two alleles and we had no a priori hypothesis that one specific allele was associated with schizophrenia. ...
... For each test, we adjusted the significance level for the number of markers using the Bonferroni procedure. In this study, since we used microsatellite DNA as markers, all markers had more than two alleles and we had no a priori hypothesis that one specific allele was associated with schizophrenia. ...
Ch. 7: Presentation Slides
... shared X-Y homology – SRY – master sex controller gene that encodes testis determining factor (TDF) for male development ...
... shared X-Y homology – SRY – master sex controller gene that encodes testis determining factor (TDF) for male development ...
Lecture Notes
... chromosome); monosomies of the autosomes are rare. B) Nondisjunction is the most common mechanism leading to aneuploidy. 1) Nondisjunction in mitosis at an early cleavage division may lead to a clinically significant mosaicism. ...
... chromosome); monosomies of the autosomes are rare. B) Nondisjunction is the most common mechanism leading to aneuploidy. 1) Nondisjunction in mitosis at an early cleavage division may lead to a clinically significant mosaicism. ...
Severe oligozoospermia resulting from deletions
... had variant Y chromosomesand these variants may resemble the de-novo AZF-region deletions we describe. However, since the fathers of the two Japanese men were not studied, the functional significance of their Y variants remains unclear. A small set of Y-DNA markers was used to study the Japanese men ...
... had variant Y chromosomesand these variants may resemble the de-novo AZF-region deletions we describe. However, since the fathers of the two Japanese men were not studied, the functional significance of their Y variants remains unclear. A small set of Y-DNA markers was used to study the Japanese men ...
Cytogenetics Cytogenetics
... • Chromosomes arranged into homologous pairs based on size and banding patterns • The normal human karyotype is made of 46 chromosomes: • 22 pairs of autosomes, numbered from 1 to 22 by order of decreasing length • 1 pair of gonosomes, or sex chromosomes: XX in the female, XY in the male. ...
... • Chromosomes arranged into homologous pairs based on size and banding patterns • The normal human karyotype is made of 46 chromosomes: • 22 pairs of autosomes, numbered from 1 to 22 by order of decreasing length • 1 pair of gonosomes, or sex chromosomes: XX in the female, XY in the male. ...
Supplementary Information (doc 94K)
... but declined at the 8 month follow-up. - At the 8 month follow-up 73% of the consultands in both groups reported that they had informed all their relatives. - Consultands in the intervention group were significantly more satisfied with the content of the given information and with the way of informi ...
... but declined at the 8 month follow-up. - At the 8 month follow-up 73% of the consultands in both groups reported that they had informed all their relatives. - Consultands in the intervention group were significantly more satisfied with the content of the given information and with the way of informi ...
Winge`s sex-linked color patterns and SDL in the guppy: genes or
... Since the beginning of the 1900s Poecilia reticulata, at that time Lebistes reticulatus, has been the subject of scientific inquiry in a few disciplines and it has become dear to hearts of aquarists of all ages. Guppy is native to Venezuela, Guyanas, Northern Brazil, Trinidad and Barbados. They exhi ...
... Since the beginning of the 1900s Poecilia reticulata, at that time Lebistes reticulatus, has been the subject of scientific inquiry in a few disciplines and it has become dear to hearts of aquarists of all ages. Guppy is native to Venezuela, Guyanas, Northern Brazil, Trinidad and Barbados. They exhi ...