-handouts
... Prevention and Control; 2013. http://www.cdc.gov/homeandrecreationalsafety/rxbrief/. Updated July 2013. Last accessed 21 October 2014. ...
... Prevention and Control; 2013. http://www.cdc.gov/homeandrecreationalsafety/rxbrief/. Updated July 2013. Last accessed 21 October 2014. ...
GP/Locum Drug List – 5 May 2013
... and psoriasis Promotes dyslipidemia and insulin resistance and erectile dysfunction. Avoid in DM, obesity and metabolic syndrome Packs of 30 for beta-nicardia Cardioselective beta blocker for chronic heart failure usage Initiate at 1.25mg OM and weekly-2 weekly titration by 1.25mg daily until a maxi ...
... and psoriasis Promotes dyslipidemia and insulin resistance and erectile dysfunction. Avoid in DM, obesity and metabolic syndrome Packs of 30 for beta-nicardia Cardioselective beta blocker for chronic heart failure usage Initiate at 1.25mg OM and weekly-2 weekly titration by 1.25mg daily until a maxi ...
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... should be alerted to the potential for additive central nervous system depression if Dronabinol Capsules is used concomitantly with alcohol or other CNS depressants such as benzodiazepines and barbiturates. Patients receiving treatment with Dronabinol Capsules should be specifically warned not to dr ...
... should be alerted to the potential for additive central nervous system depression if Dronabinol Capsules is used concomitantly with alcohol or other CNS depressants such as benzodiazepines and barbiturates. Patients receiving treatment with Dronabinol Capsules should be specifically warned not to dr ...
O v e r d o s e and Response
... The extreme agitation or panic that some people commonly refer to as “stimulant overdose,” while unpleasant, are NOT symptoms of a true overdose, and are more accurately described as a product of several factors, often including the drug itself as well as lack of sleep or dehydration. A person exper ...
... The extreme agitation or panic that some people commonly refer to as “stimulant overdose,” while unpleasant, are NOT symptoms of a true overdose, and are more accurately described as a product of several factors, often including the drug itself as well as lack of sleep or dehydration. A person exper ...
Morphine Sulfate Extended-Release Tablets
... reliability of the relative potency estimate used to calculate the dose of morphine needed [N.B. potency estimates may vary with the route of administration], 3) the degree of opioid tolerance, if any, and 4) the general condition and medical status of the patient. Selection of patients for treatmen ...
... reliability of the relative potency estimate used to calculate the dose of morphine needed [N.B. potency estimates may vary with the route of administration], 3) the degree of opioid tolerance, if any, and 4) the general condition and medical status of the patient. Selection of patients for treatmen ...
Wolfe - Intranasal naloxone in safe injection setting
... reversible but due to legal fears – little intervention is instituted There is also an epidemic (especially in my country, but increasingly here as well) related to accidental prescription opiate overdoses There is time to intervene if an easy, effective intervention is instituted in the public doma ...
... reversible but due to legal fears – little intervention is instituted There is also an epidemic (especially in my country, but increasingly here as well) related to accidental prescription opiate overdoses There is time to intervene if an easy, effective intervention is instituted in the public doma ...
ACMD Advisory Council on the Misuse of Drugs ACMD consideration of tramadol
... tramadol for the µ-opioid receptor is only 1/6000 of that of morphine although its selectivity for this sub-type of receptor is greater than that of morphine. Its analgesic activity is also probably contributed to by monoaminergic activity resulting from inhibition of re-uptake of both noradrenaline ...
... tramadol for the µ-opioid receptor is only 1/6000 of that of morphine although its selectivity for this sub-type of receptor is greater than that of morphine. Its analgesic activity is also probably contributed to by monoaminergic activity resulting from inhibition of re-uptake of both noradrenaline ...
Naloxone: Frequently Asked Questions
... risk of withdrawal increases with larger doses of naloxone as well as the strength of a person’s drug dependency. Common opioid withdrawal symptoms include aches, irritability, sweating, runny nose, diarrhea, nausea, and vomiting. Still, the potential complications of opioid overdose are more alarmi ...
... risk of withdrawal increases with larger doses of naloxone as well as the strength of a person’s drug dependency. Common opioid withdrawal symptoms include aches, irritability, sweating, runny nose, diarrhea, nausea, and vomiting. Still, the potential complications of opioid overdose are more alarmi ...
Presentations Indications Dosage and Administration
... although cases have been reported in patients receiving doses commonly used for maintenance treatment of opioid addiction. Methadone should be administered with particular caution to patients already at risk for development of prolonged QT interval (These risks include cardiac hypertrophy, history o ...
... although cases have been reported in patients receiving doses commonly used for maintenance treatment of opioid addiction. Methadone should be administered with particular caution to patients already at risk for development of prolonged QT interval (These risks include cardiac hypertrophy, history o ...
Epidural Analgesia in Infants and Children
... albumin and α-1-acid glycoprotein and therefore reduced protein binding of amide local anesthetics and other protein-bound drugs. Preterm infants have even lower levels of α-1-acid glycoprotein than term infants making them particularly susceptible to local anesthetic toxicity. Decreased levels of ...
... albumin and α-1-acid glycoprotein and therefore reduced protein binding of amide local anesthetics and other protein-bound drugs. Preterm infants have even lower levels of α-1-acid glycoprotein than term infants making them particularly susceptible to local anesthetic toxicity. Decreased levels of ...
Hydroxyzine Dihydrochloride
... Hydroxyzine 2 mg/ml syrup contains small amounts (0.1 vol %) of ethanol (alcohol). The concentration of alcohol after the administration of 100 ml syrup (equivalent to 200 mg of hydroxyzine) will be up to 100 mg, equivalent to 2 ml beer or 1 ml wine. This has to be taken into account for patient suf ...
... Hydroxyzine 2 mg/ml syrup contains small amounts (0.1 vol %) of ethanol (alcohol). The concentration of alcohol after the administration of 100 ml syrup (equivalent to 200 mg of hydroxyzine) will be up to 100 mg, equivalent to 2 ml beer or 1 ml wine. This has to be taken into account for patient suf ...
Buprenorphine and Naloxone: Clinical Pharmacology Abuse Liability
... – Antagonizes fentanyl induced respiratory depression without complete loss of anesthesia Indicates high affinity for µ-receptor – Can precipitate opiate withdrawal in highly µ-dependent people ...
... – Antagonizes fentanyl induced respiratory depression without complete loss of anesthesia Indicates high affinity for µ-receptor – Can precipitate opiate withdrawal in highly µ-dependent people ...
(Acetaminophen) in products with and without opioid: an analysis
... survive with no permanent damage; in more than 90% of these cases, the patients will recover completely.3 However, there are hundreds of deaths every year in the United States caused by acetaminophen poisoning, and the mortality rates for patients with acute liver failure caused by acetaminophen ove ...
... survive with no permanent damage; in more than 90% of these cases, the patients will recover completely.3 However, there are hundreds of deaths every year in the United States caused by acetaminophen poisoning, and the mortality rates for patients with acute liver failure caused by acetaminophen ove ...
ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS
... Dependence: Buprenorphine is a partial agonist at the mu-opiate receptor and chronic administration produces dependence of the opioid type. Discontinuation of treatment may result in a withdrawal syndrome that may be delayed. ...
... Dependence: Buprenorphine is a partial agonist at the mu-opiate receptor and chronic administration produces dependence of the opioid type. Discontinuation of treatment may result in a withdrawal syndrome that may be delayed. ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights
... abusers and people with addiction disorders and are subject to criminal diversion. Consider these risks when prescribing or dispensing KADIAN in situations where there is concern about increased risks of misuse, abuse, or diversion. Concerns about abuse, addiction, and diversion should not, however, ...
... abusers and people with addiction disorders and are subject to criminal diversion. Consider these risks when prescribing or dispensing KADIAN in situations where there is concern about increased risks of misuse, abuse, or diversion. Concerns about abuse, addiction, and diversion should not, however, ...
butorphanol tartrate injection usp
... insufficiency should be limited to those situations where the benefits clearly outweigh the risk (see CLINICAL PHARMACOLGY). Severe hypertension has been reported rarely during butorphanol therapy. In such cases, butorphanol should be discontinued and the hypertension treated with antihypertensive d ...
... insufficiency should be limited to those situations where the benefits clearly outweigh the risk (see CLINICAL PHARMACOLGY). Severe hypertension has been reported rarely during butorphanol therapy. In such cases, butorphanol should be discontinued and the hypertension treated with antihypertensive d ...
hydrocodone bitartrate and acetaminophen tablets, usp
... Hydrocodone is a semisynthetic narcotic analgesic and antitussive with multiple actions qualitatively similar to those of codeine. Most of these involve the central nervous system and smooth muscle. The precise mechanism of action of hydrocodone and other opiates is not known, although it is believe ...
... Hydrocodone is a semisynthetic narcotic analgesic and antitussive with multiple actions qualitatively similar to those of codeine. Most of these involve the central nervous system and smooth muscle. The precise mechanism of action of hydrocodone and other opiates is not known, although it is believe ...
Reynolds-Psych-Panels-11-20-12
... Patients who are homozygous for the CYP1A2*1F/*1F genotype may exhibit even higher rates of CYP1A2 enzymatic activity and have been described as ultra-rapid metabolizers for olanzapine. As an example, carriers of CY1A2*1F with the hyperinduction phenotype may exhibit as much as 50% lower than expect ...
... Patients who are homozygous for the CYP1A2*1F/*1F genotype may exhibit even higher rates of CYP1A2 enzymatic activity and have been described as ultra-rapid metabolizers for olanzapine. As an example, carriers of CY1A2*1F with the hyperinduction phenotype may exhibit as much as 50% lower than expect ...
Depakene/Depakote/ Depakote
... Depakene (valproic acid) and Depakote (divalproex sodium) are better known as anticonvulsants—medications for treating epilepsy. This may present some confusion for patients, as well as their families, when they are prescribed an anticonvulsant without a history of seizures. In the past decade, anti ...
... Depakene (valproic acid) and Depakote (divalproex sodium) are better known as anticonvulsants—medications for treating epilepsy. This may present some confusion for patients, as well as their families, when they are prescribed an anticonvulsant without a history of seizures. In the past decade, anti ...
PRODUCT INFORMATION NUELIN SR TABLETS
... There is no evidence that tolerance develops with continued use of theophylline. Relationship to Other Drugs: Theophylline is closely related to the other xanthines, caffeine and theobromine. Generally, the xanthines relax smooth muscle, act on the kidney to produce diuresis, stimulate the central n ...
... There is no evidence that tolerance develops with continued use of theophylline. Relationship to Other Drugs: Theophylline is closely related to the other xanthines, caffeine and theobromine. Generally, the xanthines relax smooth muscle, act on the kidney to produce diuresis, stimulate the central n ...
GHB - CAP Members
... muscles and cause weight loss. GHB and its analogues are also misused for their ability to increase libido, suggestibility, passivity, and to cause amnesia (no memory of events while under the influence of the substance) — traits that make users vulnerable to sexual assault and other criminal acts.G ...
... muscles and cause weight loss. GHB and its analogues are also misused for their ability to increase libido, suggestibility, passivity, and to cause amnesia (no memory of events while under the influence of the substance) — traits that make users vulnerable to sexual assault and other criminal acts.G ...
Transdermal Buprenorphine, Opioid Rotation to Sublingual
... function as compared with other evaluated full agonist opioids.5,6,8 As previously noted, buprenorphine is a high-potency partial mu-receptor agonist and kappa-receptor antagonist, with very high binding affinity for the mu-receptor. Consequently, if taken by a patient who is opioid dependent, subli ...
... function as compared with other evaluated full agonist opioids.5,6,8 As previously noted, buprenorphine is a high-potency partial mu-receptor agonist and kappa-receptor antagonist, with very high binding affinity for the mu-receptor. Consequently, if taken by a patient who is opioid dependent, subli ...
Prescribing Information as of XXXX ALLEGRA (fexofenadine hydrochloride)
... trials. The safety of ALLEGRA for the treatment of chronic idiopathic urticaria in patients 6 to 11 years of age is based on cross-study comparison of the pharmacokinetics of ALLEGRA in adult and pediatric patients and on the safety profile of fexofenadine in both adult and pediatric patients at dos ...
... trials. The safety of ALLEGRA for the treatment of chronic idiopathic urticaria in patients 6 to 11 years of age is based on cross-study comparison of the pharmacokinetics of ALLEGRA in adult and pediatric patients and on the safety profile of fexofenadine in both adult and pediatric patients at dos ...
TUSSIONEX Pennkinetic (hydrocodone polistirex
... to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the d ...
... to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the d ...
Dextropropoxyphene
Dextropropoxyphene is an analgesic in the opioid category, patented in 1955 and manufactured by Eli Lilly and Company. It is an optical isomer of levopropoxyphene. It is intended to treat mild pain and also has antitussive (cough suppressant) and local anaesthetic effects. The drug has been taken off the market in Europe and the US due to concerns of fatal overdoses and heart arrhythmias. Its onset of analgesia (pain relief) is said to be 20–30 minutes and peak effects are seen about 1.5–2 hours after oral administration.Dextropropoxyphene is sometimes combined with acetaminophen or aspirin. Trade names include Darvocet-N and Di-Gesic, Darvon with APAP (for dextropropoxyphene and paracetamol) and Darvon with ASA (for dextropropoxyphene and aspirin). The British approved name (i.e. the generic name of the active ingredient) of the paracetamol/dextropropoxyphene preparation is ""co-proxamol"" (sold under a variety of brand names); however, it has been withdrawn since 2007, and is no longer available to new patients, with exceptions. The paracetamol combination(s) are known as Capadex or Di-Gesic in Australia, Lentogesic in South Africa, and Di-Antalvic in France (unlike co-proxamol, which is an approved name, these are all brand names).Dextropropoxyphene is known under several synonyms, including: Alpha-d-4-dimethylamino-3-methyl-1,2-diphenyl-2-butanol propionate [(2S,3S)-4-(Dimethylamino)-3- methyl-1,2-diphenylbutan-2-yl] propanoate (+)-1,2-Diphenyl-2-propionoxy- 3-methyl-4-di-methylaminobutane Desoxypropiophen↑ 1.0 1.1 1.2 1.3 1.4 ↑ ↑ ↑ ↑ ↑ ↑ ↑