
In Silico Protein Design: A Combinatorial and Global
... at each residue position of this protein results in 20 , or more than 1065 possible amino acid sequences. Clearly, clever optimization techniques are needed to deal with this level of combinatorial complexity. Although stochastic methods have been used [9, 23], the first successful computational des ...
... at each residue position of this protein results in 20 , or more than 1065 possible amino acid sequences. Clearly, clever optimization techniques are needed to deal with this level of combinatorial complexity. Although stochastic methods have been used [9, 23], the first successful computational des ...
Intro to Computer Algorithms Lecture 6
... Divide instance in to parts Solve problem on the parts Combine the solutions ...
... Divide instance in to parts Solve problem on the parts Combine the solutions ...
Mathematical optimization

In mathematics, computer science and operations research, mathematical optimization (alternatively, optimization or mathematical programming) is the selection of a best element (with regard to some criteria) from some set of available alternatives.In the simplest case, an optimization problem consists of maximizing or minimizing a real function by systematically choosing input values from within an allowed set and computing the value of the function. The generalization of optimization theory and techniques to other formulations comprises a large area of applied mathematics. More generally, optimization includes finding ""best available"" values of some objective function given a defined domain (or a set of constraints), including a variety of different types of objective functions and different types of domains.