Salmeterol vs. Combination Therapy
... A total of 15 studies of good methodological quality met the inclusion criteria by randomly assigning 7814 participants with predominantly poorly reversible, severe COPD. Data were most plentiful for the FPS combination. Exacerbation rates were significantly reduced with combination therapies (rate ...
... A total of 15 studies of good methodological quality met the inclusion criteria by randomly assigning 7814 participants with predominantly poorly reversible, severe COPD. Data were most plentiful for the FPS combination. Exacerbation rates were significantly reduced with combination therapies (rate ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These
... --------------------------- INDICATIONS AND USAGE---------------------------ALECENSA is a kinase inhibitor indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive, metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to crizotinib. Thi ...
... --------------------------- INDICATIONS AND USAGE---------------------------ALECENSA is a kinase inhibitor indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive, metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to crizotinib. Thi ...
Genmab Announces New Phase III Combination Study of
... pomalidomide and dexamethasone may represent a new approach for patients who have been previously treated with an immunomodulatory drug and a PI. We look forward to the readout of this study,” said Jan van de Winkel, Ph.D., Chief Executive Officer of Genmab. About the MMY3013 (APOLLO) study This is ...
... pomalidomide and dexamethasone may represent a new approach for patients who have been previously treated with an immunomodulatory drug and a PI. We look forward to the readout of this study,” said Jan van de Winkel, Ph.D., Chief Executive Officer of Genmab. About the MMY3013 (APOLLO) study This is ...
Pharmacological Treatment of Bulimia Nervosa
... We have had more success in starting patients on the generally weight-neutral antipsychotics aripiprazole and ziprasidone. Our patients who find these medications helpful describe a reduction in distress around eating, more willingness to attempt their prescribed meal plans, fewer obsessional though ...
... We have had more success in starting patients on the generally weight-neutral antipsychotics aripiprazole and ziprasidone. Our patients who find these medications helpful describe a reduction in distress around eating, more willingness to attempt their prescribed meal plans, fewer obsessional though ...
The Hollow Fiber Infection Model for
... cartridge will necessarily go through the insides of the fibers. The pore size of the fibers is selected to retain the organisms while allowing drugs and other small molecule to freely cross the fiber. Bacteria or cells are inoculated on the outside of the fibers, trapped in the space called the ext ...
... cartridge will necessarily go through the insides of the fibers. The pore size of the fibers is selected to retain the organisms while allowing drugs and other small molecule to freely cross the fiber. Bacteria or cells are inoculated on the outside of the fibers, trapped in the space called the ext ...
The appropriate dose of angiotensin-converting
... Heart failure is a major public issue, and dilated cardiomyopathy (DCM) is one of the common etiologies of heart failure. DCM is generally progressive, and some patients with DCM need heart transplant despite optimal medical and mechanical therapy. Current guidelines recommend inhibitors of renin–an ...
... Heart failure is a major public issue, and dilated cardiomyopathy (DCM) is one of the common etiologies of heart failure. DCM is generally progressive, and some patients with DCM need heart transplant despite optimal medical and mechanical therapy. Current guidelines recommend inhibitors of renin–an ...
HYDROXYCHLOROQUINE SULFATE TABLETS, USP
... accidental overdosage, or rarely with lower doses in hypersensitive patients, toxic symptoms may occur within 30 minutes. The symptoms of overdosage may include headache, drowsiness, visual disturbances, cardiovascular collapse, convulsions, hypokalemia, rhythm and conduction disorders including QT ...
... accidental overdosage, or rarely with lower doses in hypersensitive patients, toxic symptoms may occur within 30 minutes. The symptoms of overdosage may include headache, drowsiness, visual disturbances, cardiovascular collapse, convulsions, hypokalemia, rhythm and conduction disorders including QT ...
formulation and evaluation of release of trimetazidine
... pectoris crisis, its short biological half life (6 h) that calls for frequent daily dosing (2 to 3 times) and therapeutic use in angina pectoris crisis disease necessitates its formulat ion into modified release dosage form1 . The development of Modified / Controlled release formulat ion of Trimetaz ...
... pectoris crisis, its short biological half life (6 h) that calls for frequent daily dosing (2 to 3 times) and therapeutic use in angina pectoris crisis disease necessitates its formulat ion into modified release dosage form1 . The development of Modified / Controlled release formulat ion of Trimetaz ...
Skeletal Muscle Relaxants
... Faigle JW, Keberle H. The chemistry and kinetics of Lioresal. Postgrad Med J. 1972; 48:Suppl 5: 9-13. Meyler WJ, Mois-Thürkow, Wesseling H. Relationship Between Plasma Concentration and Effect of Dantrolene Sodium in Man. Eur J Clin Pharmacol. 1979; 16(3):203-9. Locniskar A, Greenblatt DJ, Harmatz J ...
... Faigle JW, Keberle H. The chemistry and kinetics of Lioresal. Postgrad Med J. 1972; 48:Suppl 5: 9-13. Meyler WJ, Mois-Thürkow, Wesseling H. Relationship Between Plasma Concentration and Effect of Dantrolene Sodium in Man. Eur J Clin Pharmacol. 1979; 16(3):203-9. Locniskar A, Greenblatt DJ, Harmatz J ...
POTENTIAL DRUG ABUSE - Canadian Society of Addiction Medicine
... Why Worry About Potential Drug Abuse? Over 6.3 million Americans admitted current use of Rx prescriptions for nonmedical purposes in 2004 ...
... Why Worry About Potential Drug Abuse? Over 6.3 million Americans admitted current use of Rx prescriptions for nonmedical purposes in 2004 ...
Tykerb - Novartis Pharmaceuticals Corporation
... organogenesis and through lactation led to death of offspring within the first 4 days after birth [see Use in Specific Populations (8.1)]. There are no adequate and well-controlled studies with TYKERB in pregnant women. Women should be advised not to become pregnant when taking TYKERB. If this drug ...
... organogenesis and through lactation led to death of offspring within the first 4 days after birth [see Use in Specific Populations (8.1)]. There are no adequate and well-controlled studies with TYKERB in pregnant women. Women should be advised not to become pregnant when taking TYKERB. If this drug ...
Document
... controlled release capsules. Adults with OCD are often started at a dose of 50 mg administered at bedtime. The dose may be increased by 50 mg every 4 to 7 days. The effective dosing range in premarketing trials with OCD was 100 to 300 mg per day, although, clearly, some patients do respond to higher ...
... controlled release capsules. Adults with OCD are often started at a dose of 50 mg administered at bedtime. The dose may be increased by 50 mg every 4 to 7 days. The effective dosing range in premarketing trials with OCD was 100 to 300 mg per day, although, clearly, some patients do respond to higher ...
File
... Often kids at these drug fests get so revved up, they unwittingly mix different drugs. Youngsters who take Ecstasy or any illicit drug given away or peddled at giant gatherings take an immense ...
... Often kids at these drug fests get so revved up, they unwittingly mix different drugs. Youngsters who take Ecstasy or any illicit drug given away or peddled at giant gatherings take an immense ...
Psychopharmacology for the Clinician
... TR and SE, but it is difficult to identify this minority a priori. Generics, in contrast to brand-name medications, are not required to undergo efficacy and safety studies before being marketed.8 Bioequivalence studies of generics involve single-dose studies in young, healthy volunteers, and are th ...
... TR and SE, but it is difficult to identify this minority a priori. Generics, in contrast to brand-name medications, are not required to undergo efficacy and safety studies before being marketed.8 Bioequivalence studies of generics involve single-dose studies in young, healthy volunteers, and are th ...
PDF, 623 KB - Center for the Study of Democracy
... categories can be indetified: lifetime prevalence use, recreational drug use, and problem drug use, the latter being where the dependent users fall. Taking into account both criteria, we come up with the structure below: “Soft drugs” (products of cannabis) - Surveys conducted by the Vitosha Resear ...
... categories can be indetified: lifetime prevalence use, recreational drug use, and problem drug use, the latter being where the dependent users fall. Taking into account both criteria, we come up with the structure below: “Soft drugs” (products of cannabis) - Surveys conducted by the Vitosha Resear ...
C u t t i n g E...
... treated with low-dose total body irradiation.21 In addition, single-node resection or radiation therapy for solitary resistant nodes has occasionally proved beneficial. ...
... treated with low-dose total body irradiation.21 In addition, single-node resection or radiation therapy for solitary resistant nodes has occasionally proved beneficial. ...
The use of animals for research in the
... rapid and detailed analysis of the full range of effects in whole animals. The very large amounts of data generated from these new methods are then integrated and analysed further by means of statistical and computational methods. Stage 1: target identification 8.7 The search for new medicines begin ...
... rapid and detailed analysis of the full range of effects in whole animals. The very large amounts of data generated from these new methods are then integrated and analysed further by means of statistical and computational methods. Stage 1: target identification 8.7 The search for new medicines begin ...
Jan p. 2 - Epocrates
... when a clinically important DDI was identified. A false negative occurred when a clinically significant interaction was not identified but should have been. A true negative occurred when a clinically unimportant DDI was not identified, and a false positive occurred when a DDI was identified but was ...
... when a clinically important DDI was identified. A false negative occurred when a clinically significant interaction was not identified but should have been. A true negative occurred when a clinically unimportant DDI was not identified, and a false positive occurred when a DDI was identified but was ...
Issue 25, January 2006 - Medication Access Program
... patients with a glomerular filtration rate (GFR) of less than 10 mL/min. Contraindications to ZMAX™ include hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic. If an allergic reaction occurs, the drug should be discontinued and an appropriate regimen should be in ...
... patients with a glomerular filtration rate (GFR) of less than 10 mL/min. Contraindications to ZMAX™ include hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic. If an allergic reaction occurs, the drug should be discontinued and an appropriate regimen should be in ...
ANTIGLAUCOMA MEDICATIONS
... • some regain responsiveness to timolol after a washout period • a treatment strategy of pulsatile therapy, in which 0.5% timolol is given for 6 months and then alternates with dipivefrin for 2 months, was studied and shown to minimize long-term drift compared with continuous use of timolol ...
... • some regain responsiveness to timolol after a washout period • a treatment strategy of pulsatile therapy, in which 0.5% timolol is given for 6 months and then alternates with dipivefrin for 2 months, was studied and shown to minimize long-term drift compared with continuous use of timolol ...
an evaluation of patent foramen ovale closure using radiofrequency
... judged with bubble-TTE and TEE evaluation at 3 months. Results: Complete PFO closure was seen in 3 patients, shunt size reduction was seen in 2, and no change was seen in 3. Pre-procedure tunnel length was shorter where closure succeeded (0.6-1.3cm) compared to the rest (1.8-2.1cm), and tunnel contr ...
... judged with bubble-TTE and TEE evaluation at 3 months. Results: Complete PFO closure was seen in 3 patients, shunt size reduction was seen in 2, and no change was seen in 3. Pre-procedure tunnel length was shorter where closure succeeded (0.6-1.3cm) compared to the rest (1.8-2.1cm), and tunnel contr ...
Bad Pharma
Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.