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comments - Association of National Advertisers
comments - Association of National Advertisers

... conveys an accurate and non-misleading impression of the benefits and risks of the promoted product. This proposition that risk communication be evaluated based on overall “net impression” and what “the piece as a whole conveys” about both “benefits and risks” can be reframed in terms of the NUNO pr ...
How to Use this Assessment Toolkit
How to Use this Assessment Toolkit

... than two drinks daily, problem drinkers prefer a higher limit; a daily maximum of three drinks and a weekly maximum of 12 drinks is recommended as a prudent compromise. Step 2. Offer information on the health effects of alcohol. Tailor messages to patients' age and health status. (e.g. a young man m ...
Design fabrication and characterization of controlled
Design fabrication and characterization of controlled

... constant plasma levels, which is also favorable for compliance of the patient to his treatment. Various types of oral controlled release formulation have been developed to improve the clinical efficacy of drugs having short half-lives as well as to increase patient compliance. [4] These formulations ...
hallucinogens and dissociative drugs
hallucinogens and dissociative drugs

... As with some other hallucinogens, there is little information to suggest that ayahuasca use creates lasting physiological or neurological deficits, ...
Patient adherence with amlodipine, lisinopril, or valsartan
Patient adherence with amlodipine, lisinopril, or valsartan

... CDS, and use of antihyperlipidemic agents (yes/no), beta-blockers (yes/no), and nitrates (yes/no) were all significant predictors of compliance. Use of diuretics and combination diuretic products, antiplatelet agents, and digitalis significantly predicted patient MPR. However, when compliance and MP ...
CTI PRE-PROPOSAL
CTI PRE-PROPOSAL

... mechanism(s). What is/are the unmet medical need(s) this target/pathway could address? Is this pathway targetable with a biotherapeutic? ...
PR BEZALIP SR
PR BEZALIP SR

... BEZALIP SR may not be adequate therapy in some patients with familial combined hyperlipidemia with type IIb and type IV hyperlipoproteinemia. Initial therapy for dyslipidemia should include at least an equivalent of the American Heart Association (AHA) step 1 diet. There is evidence from coronary an ...
STUDIES ON DISSOLUTION ENHANCEMENT OF LOVASTATIN USING SOLUPLUS BY SOLID
STUDIES ON DISSOLUTION ENHANCEMENT OF LOVASTATIN USING SOLUPLUS BY SOLID

... humidity, photo-stability, compatibility with solvents etc. Among all these, Solubility is the most important property for developing formulations. The present study is an attempt to improve the solubility and dissolution rate using solid dispersion of a poorly soluble drug Lovastatin by using Solup ...
Bupropion/naltrexone fixed-dose combination for
Bupropion/naltrexone fixed-dose combination for

... SCOUT. It is surprising, if not worrisome, that despite the increase in the prevalence of obesity and its related diseases, the FDA is continuously rejecting new antiobesity drugs, as recently occurred with the combination of phentermine/topiramate and with lorcaserin (20, 22, 23). Rimonabant, a can ...
Proceedings of the 33rd World Small Animal Veterinary
Proceedings of the 33rd World Small Animal Veterinary

... decreases the clearance of many drugs: • Chloramphenicol: risk of dose-dependent leukopenia • Metronidazole: risk of neurologic side effects • Lidocaine: enhanced GI and neurologic side effects • Theophylline and aminophylline: theophylline toxicity • Warfarin, propranolol, diazepam, midazolam, ...
Consumer Safety Officer,  Division  of  Dietary Supplement... Nutritional  Products, Labeling and Dietary Supplements, MFS-8 10
Consumer Safety Officer, Division of Dietary Supplement... Nutritional Products, Labeling and Dietary Supplements, MFS-8 10

... Under 21 USC. 350b(a), the manufacturer or distributor of a dietary,supplement eontaining a new dietary ingredient that has not been present,in the food”supply as an article used for food in a form in which the food has not been chemically altered must submit to FDA, at least 75 days before the diet ...
Effect of Oral Pseudoephedrine on Blood Pressure and Heart Rate
Effect of Oral Pseudoephedrine on Blood Pressure and Heart Rate

... change” (n=21), and were not randomized placebo-controlled trials (n = 16) and for other miscellaneous reasons (n = 1). The final list of included articles comprised 24 studies with 45 treatment arms ...
intramuscularly
intramuscularly

...  Rises quickly with regular use and lasts about three days ...
University of Cincinnati/Health Alliance Reynolds Geriatric
University of Cincinnati/Health Alliance Reynolds Geriatric

... Is there one medication that could be prescribed to treat two conditions? ...
SSRIs for the treatment of Depression in children and
SSRIs for the treatment of Depression in children and

... Parents/ carers should be specifically warned about this risk, and this should be recorded in the notes. Where necessary patients should be monitored for suicidal behaviour, selfharm, or hostility, particularly at the beginning of treatment or if the dose is changed. Specific arrangements must be ma ...
Document
Document

... visits due to ADRs in the elderly. This points out that although a medication might be justified we are not appropriately monitoring these for side-effects such as blood glucose, INRs and serum levels or ECGs. ...
also see p. S21 - Viktor`s Notes for the Neurosurgery Resident
also see p. S21 - Viktor`s Notes for the Neurosurgery Resident

... (4) aberrant drug-related behaviors (such as asking for early refill).  use correct language in charts; "narcotic" is law-enforcement term → use "opioid" or "controlled medication". patients should be "tapered" off opioids, not "detoxed" or "weaned".  according to US Drug Enforcement Agency (DEA) ...
05-20-08 Kinetics CRRT - Pediatric Continuous Renal
05-20-08 Kinetics CRRT - Pediatric Continuous Renal

... fraction of drug but infers the free fraction of drug available for pharmacological action ...
Dry Suspension Formulation of Taste Masked Antibiotic Drug for
Dry Suspension Formulation of Taste Masked Antibiotic Drug for

... (KDP, 0.067 mol/l) acetonitrile (35:65), was delivered at a flowrate of 1.0 ml/min; Detection was set at 220 nm and the column temperature was maintained at 50°C. Stop time 15.0 mins. Standard Calibration Curve of Clarithromycin: Preparation of working solution for standard calibration curve A 10 ml ...
From fragment to clinical candidate—a historical perspective
From fragment to clinical candidate—a historical perspective

... that some of the favourable positions found for individual molecular fragments were present in known inhibitors. Fragments and large molecules have to obey to the same set of molecular recognition rules when they bind to a target protein. During a binding event both fragments and large molecules hav ...
PPT
PPT

... • In elderly < 80 years old with SBP ≥160 mmHg there is solid evidence to reducing SBP to 150 and 140 mmHg (IA) • In fit elderly patients < 80 years old SBP values <140 mmHg may be considered, whereas in the fragile elderly population SBP goals should be adapted to individual tolerability (IIb C) • ...
Herceptin: monoclonal antibody therapy for metastatic breast cancer
Herceptin: monoclonal antibody therapy for metastatic breast cancer

... The Canadian Coordinating Office for Health Technology Assessment is a non-profit organization funded by the federal, provincial and territorial governments. ...
Title of PowerPoint 32 pt Arial
Title of PowerPoint 32 pt Arial

... products (even if already approved for other uses in US), or highly purified/chemically modified substances derived from botanical substances. • Unique situation in that many of the products in development have been taken/sold for many years with no nonclinical support. ...
Cyclodextrins as Sustained
Cyclodextrins as Sustained

... plasma levels of buserelin that lasted for at least 7 weeks. It provided a 70-fold-longer mean residence time of the drug complex in plasma as compared with that of the drug alone (4). Flufenamic acid (FA). Studies have shown that FA, which belongs to the class of nonsteroidal anti-inflammatory drug ...
UNIVERSITAT DE BARCELONA FACULTAT DE FARMÀCIA  TARGETING OF ANTILEISHMANIAL DRUGS PRODUCED BY
UNIVERSITAT DE BARCELONA FACULTAT DE FARMÀCIA TARGETING OF ANTILEISHMANIAL DRUGS PRODUCED BY

... first-line drugs for the treatment of Leishmania in humans for 60 years. These must be administered either intravenously or intramuscularly and are associated with considerable gastrointestinal, liver, pancreatic, and cardiac toxicity, sometimes requiring cessation of therapy. Antimony is excreted q ...
< 1 ... 373 374 375 376 377 378 379 380 381 ... 707 >

Bad Pharma



Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.
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