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Clinical Slide Set. Depression
Clinical Slide Set. Depression

BUSULFEX (BUSULFAN) INJECTION IS A POTENT CYTOTOXIC
BUSULFEX (BUSULFAN) INJECTION IS A POTENT CYTOTOXIC

... Busulfan may be a human carcinogen. Several cases of leukemia have occurred 5-8 years following oral busulfan treatment. Ovarian suppression and amenorrhea commonly occur in premenopausal women undergoing chronic, low-dose busulfan therapy for chronic myelogenous leukemia. Sterility, azoospermia, an ...
Herbal CNS stimulants - International Journal of Herbal Medicine
Herbal CNS stimulants - International Journal of Herbal Medicine

... Disorder (ADHD) for children but National Department of Health reported that the these drugs are used by 2-3.5% of adults in USA [1]. It produces generalized action which on higher doses may produce convulsions [2]. The use of Ma huang (Ephedra vulgaris) in China, khat (Catha edulis) in Africa, and ...
15. Recent Trends in Sustained Release Drug Delivery System
15. Recent Trends in Sustained Release Drug Delivery System

... Delayed Release These systems are those that use repetitive, intermittent dosing of a drug from one or more immediate release units incorporated into a single dosage form. Examples of delayed release systems include repeat action tablets and capsules and enteric-coated tablets where timed release is ...
Anti-anemics
Anti-anemics

... Low molecular weight heparin (LMWH; 2000-9000 g/mol) Fondaparinux (Pentasaccharide of active heparin residues) – Clinical Use: Prevention and treatment of embolism (i.e., post-op or following myocardial infarction), deep vein thrombosis. – MOA: Inhibits factor Xa, very little effect on factor IIa; a ...
Research and Development at Sun Pharma
Research and Development at Sun Pharma

...  Key features of technology for cytotoxic substances Avoids toxic excipients Better safety index as proven in animal model Increases circulation half life and improved efficacy More drugs can be delivered at target site Avoids hypersensitivity reaction to toxic excipients Uses all approved ex ...
Drug regulatory failure in Canada: The case of Diane-35
Drug regulatory failure in Canada: The case of Diane-35

... Severe acne that is unresponsive to other treatments may differ from other forms of acne. It is likely to prove harder to treat. If a drug is approved only as a treatment for these women, it’s important to know how well it works for them. Additionally, these trials only reported outcomes for women w ...
Melanotan II - Rebound Health
Melanotan II - Rebound Health

... to darken and increase in size over a short period, "an early warning sign of skin cancer".[32][33][34][35] Academic researchers at Liverpool John Moores University specialized in performance-enhancing drugs published an editorial in the British Medical Journal suggesting that use of 'melanotan I an ...
PART III: CONSUMER INFORMATION Pr ADALAT® XL® Nifedipine
PART III: CONSUMER INFORMATION Pr ADALAT® XL® Nifedipine

... result in a large immediate release of the drug. You can take this medication with or without food. Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Follow your doctor's treatment pl ...
Department of Pharmacology
Department of Pharmacology

... mechanism of action, organ system effects – acetylcholine, betanechol, carbachol, cevimeline, pilocarpine). Basic pharmacology of the indirect-acting cholinomimetics (pharmacokinetics, mechanism of action, organ system effects – cholinesterase inhibitors). Therapeutic uses and toxicity of cholinomim ...
Strategies for discovering drugs from previously unexplored natural
Strategies for discovering drugs from previously unexplored natural

... Why should this be? This is partly because of the difficulties perceived in using complex mixtures (plant extracts) in HTS and partly because many of the most biodiverse regions of the world have been relatively inaccessible to collectors. The first problem is being addressed by several companies th ...
Cilansetron - Open Access Journals
Cilansetron - Open Access Journals

... three-times daily dose showed the largest improvement in adequate relief of IBS symptoms (abdominal pain/discomfort and abnormal bowel habits) as assessed by patient response over the 1, 4 mg, and 16 mg threetimes daily doses. The results have been reported in abstract form. Caras and colleagues rep ...
T-Class Monograph template
T-Class Monograph template

... Key Questions/Issues and Results of Investigation: Issue 1: What is the evidence of efficacy for each drug from clinical trials? Romiplostim has been proven in clinical trials to be more effective than placebo in raising and maintaining platelet counts. The two studies used to gain FDA approval look ...
Research and Development at Sun Pharma
Research and Development at Sun Pharma

...  Key features of technology for cytotoxic substances Avoids toxic excipients Better safety index as proven in animal model Increases circulation half life and improved efficacy More drugs can be delivered at target site Avoids hypersensitivity reaction to toxic excipients Uses all approved ex ...
Luke Lin, MD
Luke Lin, MD

...  Clinical investigation is underway in lung cancer settings  Currently in Phase II ...
Adverse Drug Reactions and Interactions
Adverse Drug Reactions and Interactions

... be secreted by the distal tubule. This is an energy-dependent process and drugs can be effectively cleared, with a tubular secretion of ampicillin of around 400 ml/min in subjects with normal renal function. Tubular secretion is relatively spared in renal impairment, so dose reduction of those drugs ...
Breathe in, Breathe out, How to Pick `em Out: Selecting Inhalers for
Breathe in, Breathe out, How to Pick `em Out: Selecting Inhalers for

... Safety of LABAs in Asthma • FDA Black Box Warning – CT comparing salmeterol vs placebo added to usual asthma therapy • Increased risk of asthma-related deaths in patients treated with salmeterol – 13/13176 vs 3/13179 treated for 28 weeks ...
EURYCOMA  LONGIFOLIA Research Article  PURWANTININGSIH
EURYCOMA  LONGIFOLIA Research Article  PURWANTININGSIH

... effect  of TAF‐273 in the increasing of amynopyrine metabolism in male and female rat hepatocytes was dose‐independent.  Keywords: Eurycoma longifolia Jack (Simaroubaceae), Phase I metabolism, Rat hepatocytes  ...
Research and Development at Sun Pharma
Research and Development at Sun Pharma

...  Key features of technology for cytotoxic substances Avoids toxic excipients Better safety index as proven in animal model Increases circulation half life and improved efficacy More drugs can be delivered at target site Avoids hypersensitivity reaction to toxic excipients Uses all approved ex ...
(Received on 27 /7/2005) (Accepted for publication on 29/4 /2006)
(Received on 27 /7/2005) (Accepted for publication on 29/4 /2006)

... peak concentration and area under the curve of plasma concentration were analyzed to obtain 92% confidence intervals. The elimination half-life of boh formula were ranged from 30-45 hours with mean value of 37.86 and 39.026 hours for test and reference drugs respectively. The calibration curve for p ...
汤慧芳_大环内酯类&林可霉素
汤慧芳_大环内酯类&林可霉素

... generally mild. – Thrombocytopenia(血小板减少症) is the most common manifestation (seen in approximately 3% of treatment courses), particularly when the drug is administered for longer than 2 weeks. – Neutropenia may also occur, most commonly in patients with a predisposition to or underlying bone marrow ...
06Gout_-_Copy[1].
06Gout_-_Copy[1].

... uric acid level below the saturation point (<6 mg/dL), thus preventing the deposition of urate crystals. This can be accomplished by: 1.interfering with uric acid synthesis with allopurinol 2.increasing uric acid excretion with probenecid or sulfinpyrazone 3.inhibiting leukocyte entry into the affec ...
FORMULATION AND EVALUATION OF DICLOFANAC POTASSIUM ETHOSOMES  Research Article  VIJAYAKUMAR M.R., ABDUL HASAN SATHALI A , ARUN K. 
FORMULATION AND EVALUATION OF DICLOFANAC POTASSIUM ETHOSOMES  Research Article  VIJAYAKUMAR M.R., ABDUL HASAN SATHALI A , ARUN K. 

... wall, with the corneocytes as the bricks surrounded by the mortar of  the intercellular lipid lamellae. Many techniques have been aimed to  disrupt  and  weaken  the  highly  organized  intercellular  lipids  in  an  attempt to enhance drug transport across the intact skin. One of the  most  controv ...
Phase II Metabolism of Drugs
Phase II Metabolism of Drugs

... • Formation of quanternary amine glucuronides, once thought only to occur in man, has been noted in guinea pig and rabbit. • Gunn rat is lacking UGT1A’s and thus unable to conjugate bilirubin as well as many other substrates that are glucuronidated in normal rats. ...
Assessing Statin Therapy: What are Their Differences? - Pri-Med
Assessing Statin Therapy: What are Their Differences? - Pri-Med

... Amit Khera, MD, MSc, FACC, is an associate professor of medicine at the University of Texas, Southwestern Medical School in Dallas, Texas, where he serves as director of the preventive cardiology program and program director for the cardiology fellowship. He is also medical director of cardiac rehab ...
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Bad Pharma



Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.
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