DRI® Amphetamines Assay - Thermo Fisher Scientific
... Amphetamines are synthetic derivatives of ephedrine. The most common amphetamines include d-amphetamine, d-methamphetamine, and d,l-amphetamine. They act as stimulants for the central nervous system. Amphetamine is the most sympathomimetic amine.3,4 When amphetamine is ingested, it is either rapidly ...
... Amphetamines are synthetic derivatives of ephedrine. The most common amphetamines include d-amphetamine, d-methamphetamine, and d,l-amphetamine. They act as stimulants for the central nervous system. Amphetamine is the most sympathomimetic amine.3,4 When amphetamine is ingested, it is either rapidly ...
Pharmacokinetic Interactions Between the Hepatitis C Virus
... This was a single-center, randomized, open-label study conducted in accordance with principles of good clinical practice and approved by the appropriate institutional review board (Celerion IRB, Lincoln, Nebraska). All subjects provided written informed consent. Healthy male and female subjects aged ...
... This was a single-center, randomized, open-label study conducted in accordance with principles of good clinical practice and approved by the appropriate institutional review board (Celerion IRB, Lincoln, Nebraska). All subjects provided written informed consent. Healthy male and female subjects aged ...
Full-Text PDF
... Some of the proposed biomarkers are not liver or not drug specific, others are difficult to be assessed due to the requirement of mass spectroscopy (Table 1) [21]. Microarray RNAs (microRNAs) including microRNA-122 have been evaluated in experimental liver injury and in human intrinsic DILI caused b ...
... Some of the proposed biomarkers are not liver or not drug specific, others are difficult to be assessed due to the requirement of mass spectroscopy (Table 1) [21]. Microarray RNAs (microRNAs) including microRNA-122 have been evaluated in experimental liver injury and in human intrinsic DILI caused b ...
DILT-XR - Apotex
... Diltiazem Hydrochloride Extended-Release Capsules, USP (Once-a-day dosage) contain a degradable controlled-release tablet formulation designed to release diltiazem over a 24-hour period. Controlled absorption of diltiazem begins within 1 hour, with maximum plasma concentrations being achieved 4 to 6 ...
... Diltiazem Hydrochloride Extended-Release Capsules, USP (Once-a-day dosage) contain a degradable controlled-release tablet formulation designed to release diltiazem over a 24-hour period. Controlled absorption of diltiazem begins within 1 hour, with maximum plasma concentrations being achieved 4 to 6 ...
cocaine 68, 111, 145, 150, 164, 192, 201, 208, 209, 226, 270, 274
... we used the self-administration paradigm to evaluate the role of CB1 cannabinoid receptors in several aspects of cocaine reward, including acquisition, maintenance, and motivation to seek the drug. For this purpose, both CB1 receptor knockout mice and wild-type littermates were trained to intravenou ...
... we used the self-administration paradigm to evaluate the role of CB1 cannabinoid receptors in several aspects of cocaine reward, including acquisition, maintenance, and motivation to seek the drug. For this purpose, both CB1 receptor knockout mice and wild-type littermates were trained to intravenou ...
SLCO1B1 polymorphism markedly affects the pharmacokinetics of
... Results are expressed as mean ± SD in the text and tables and, for clarity, as mean ± SEM in Fig. 1. The pharmacokinetic variables of simvastatin and simvastatin acid between the SLCO1B1 c.521TT, c.521TC and c.521CC genotype groups were compared using analysis of variance and pairwise testing with t ...
... Results are expressed as mean ± SD in the text and tables and, for clarity, as mean ± SEM in Fig. 1. The pharmacokinetic variables of simvastatin and simvastatin acid between the SLCO1B1 c.521TT, c.521TC and c.521CC genotype groups were compared using analysis of variance and pairwise testing with t ...
APO–KETOCONAZOLE
... Cases of idiosyncratic hepatocellular dysfunction have been reported during ketoconazole treatment. It is important to recognize that liver disorders can occur during therapy with APO– KETOCONAZOLE (ketoconazole). The occurrence of liver disorders while on APO–KETOCONAZOLE could be fatal unless prop ...
... Cases of idiosyncratic hepatocellular dysfunction have been reported during ketoconazole treatment. It is important to recognize that liver disorders can occur during therapy with APO– KETOCONAZOLE (ketoconazole). The occurrence of liver disorders while on APO–KETOCONAZOLE could be fatal unless prop ...
Important Drug Information
... toxic effect, mucositis. However, there are some regimens which divide the dose over three successive days (20-25 mg/m2 or 0.4-0.8 mg/kg). It is thought that this regimen has greater effectiveness although at a cost of higher toxicity. Administration of doxorubicin in a weekly regimen has been shown ...
... toxic effect, mucositis. However, there are some regimens which divide the dose over three successive days (20-25 mg/m2 or 0.4-0.8 mg/kg). It is thought that this regimen has greater effectiveness although at a cost of higher toxicity. Administration of doxorubicin in a weekly regimen has been shown ...
PRODUCT MONOGRAPH CYPROTERONE Cyproterone Acetate
... relevance of this in prostatic carcinoma is not known; however, it would be prudent to inform the patients that the use of alcohol during cyproterone acetate therapy is not advisable. Physical Performance Patients should be informed that fatigue and lassitude are common in the first few weeks of the ...
... relevance of this in prostatic carcinoma is not known; however, it would be prudent to inform the patients that the use of alcohol during cyproterone acetate therapy is not advisable. Physical Performance Patients should be informed that fatigue and lassitude are common in the first few weeks of the ...
Tumescent Technique Chronicles Local Anesthesia, Liposuction
... lidocaine levels occur within 2 hours after infiltration. The perfunctory explanation was that lidocaine was being rapidly metabolized in the liver. Only later was it realized that the peak lidocaine plasma levels were higher and occurred up to 12 hours after completion of tumescent liposuction. Def ...
... lidocaine levels occur within 2 hours after infiltration. The perfunctory explanation was that lidocaine was being rapidly metabolized in the liver. Only later was it realized that the peak lidocaine plasma levels were higher and occurred up to 12 hours after completion of tumescent liposuction. Def ...
SODIUM POLYSTYRENE SULFONATE Suspension, USP
... Digitalis: The toxic effects of digitalis on the heart, especially various ventricular arrhythmias and A-V nodal dissociation, are likely to be exaggerated by hypokalemia, even in the face of serum digoxin concentrations in the “normal range” (see WARNINGS). Sorbitol: Concomitant use of sorbitol wit ...
... Digitalis: The toxic effects of digitalis on the heart, especially various ventricular arrhythmias and A-V nodal dissociation, are likely to be exaggerated by hypokalemia, even in the face of serum digoxin concentrations in the “normal range” (see WARNINGS). Sorbitol: Concomitant use of sorbitol wit ...
Document
... AE. Study drug–related AEs (nausea, abdominal distension, and asthenia) were reported for 1 subject, in the RTV group on day 1 and resolved the same day without treatment. In cohort 2, treatment-emergent AEs were reported for 7 of 18 subjects (38.9%) receiving COBI. AEs were predominantly grade 1 or ...
... AE. Study drug–related AEs (nausea, abdominal distension, and asthenia) were reported for 1 subject, in the RTV group on day 1 and resolved the same day without treatment. In cohort 2, treatment-emergent AEs were reported for 7 of 18 subjects (38.9%) receiving COBI. AEs were predominantly grade 1 or ...
Levitra - GSK Source
... inhibitors. Based on published literature, the annual incidence of NAION is 2.5–11.8 cases per 100,000 in males aged ≥50. An observational study evaluated whether recent use of PDE5 inhibitors, as a class, was associated with acute onset of NAION. The results suggest an approximate 2 fold increase i ...
... inhibitors. Based on published literature, the annual incidence of NAION is 2.5–11.8 cases per 100,000 in males aged ≥50. An observational study evaluated whether recent use of PDE5 inhibitors, as a class, was associated with acute onset of NAION. The results suggest an approximate 2 fold increase i ...
Astelin
... There have been no reported overdosages with Astelin Nasal Spray. Acute overdosage by adults with this dosage form is unlikely to result in clinically significant adverse reactions, other than increased somnolence, since one bottle of Astelin Nasal Spray contains 30 mg of azelastine hydrochloride. C ...
... There have been no reported overdosages with Astelin Nasal Spray. Acute overdosage by adults with this dosage form is unlikely to result in clinically significant adverse reactions, other than increased somnolence, since one bottle of Astelin Nasal Spray contains 30 mg of azelastine hydrochloride. C ...
Product Monograph ZANTAC
... Bioavailability of oral ranitidine is approximately 50% to 60%. Serum protein binding of ranitidine in man is in the range of 10 to 19%. The elimination half-life is approximately 2 to 3 hours. The principal route of excretion is the urine (40% recovery of free and metabolized drug in 24 hours). Th ...
... Bioavailability of oral ranitidine is approximately 50% to 60%. Serum protein binding of ranitidine in man is in the range of 10 to 19%. The elimination half-life is approximately 2 to 3 hours. The principal route of excretion is the urine (40% recovery of free and metabolized drug in 24 hours). Th ...
states that require prescribers and/or dispensers to access pmp
... F. If medically necessary, the carrier, self-insured employer or commission shall provide drug rehabilitation and detoxification treatment for an employee who becomes dependent on or addicted to opioids that are prescribed for a work-related injury. In the event of a medical conflict regarding the n ...
... F. If medically necessary, the carrier, self-insured employer or commission shall provide drug rehabilitation and detoxification treatment for an employee who becomes dependent on or addicted to opioids that are prescribed for a work-related injury. In the event of a medical conflict regarding the n ...
Pfizer Inc 235 East 42"° Street 235/24/l0A New York, NY 10017-5755
... Because the Lotrel* NDA is an application under section 505(b)(2) subject to pediatric exclusivity, FDA must rescind final, effective approval of the NDA and convert the NDA's approval status to "tentative approval ." This occurs by operation of law, consistent with how FDA has effectuated pediatric ...
... Because the Lotrel* NDA is an application under section 505(b)(2) subject to pediatric exclusivity, FDA must rescind final, effective approval of the NDA and convert the NDA's approval status to "tentative approval ." This occurs by operation of law, consistent with how FDA has effectuated pediatric ...
avodart - Urological Sciences Research Foundation
... Metabolism and Elimination: Dutasteride is extensively metabolized in humans. While not all metabolic pathways have been identified, in vitro studies showed that dutasteride is metabolized by the CYP3A4 isoenzyme to 2 minor mono-hydroxylated metabolites. Dutasteride is not metabolized in vitro by h ...
... Metabolism and Elimination: Dutasteride is extensively metabolized in humans. While not all metabolic pathways have been identified, in vitro studies showed that dutasteride is metabolized by the CYP3A4 isoenzyme to 2 minor mono-hydroxylated metabolites. Dutasteride is not metabolized in vitro by h ...
hollyhanzel
... symptoms of ALS. These studies will not be analyzed in detail like the muscular studies because my primary concern is your muscular symptoms. I am using them to strengthen my claim that creatine can help you. These sources date from 1994 through 2003, and were obtained by computerized searches of Pu ...
... symptoms of ALS. These studies will not be analyzed in detail like the muscular studies because my primary concern is your muscular symptoms. I am using them to strengthen my claim that creatine can help you. These sources date from 1994 through 2003, and were obtained by computerized searches of Pu ...
Reynolds-Psych-Panels-11-20-12
... lower than extensive metabolizers. Common CYP3A5 medications below. ...
... lower than extensive metabolizers. Common CYP3A5 medications below. ...
Timolol Maleate Ophthalmic Solution, USP 0.25% and 0.5%
... The maximum effect usually occurs in one to two hours and significant lowering of intraocular pressure can be maintained for periods as long as 24 hours with a single dose. Repeated observations over a period of one year indicate that the intraocular pressure-lowering effect of timolol is well maint ...
... The maximum effect usually occurs in one to two hours and significant lowering of intraocular pressure can be maintained for periods as long as 24 hours with a single dose. Repeated observations over a period of one year indicate that the intraocular pressure-lowering effect of timolol is well maint ...
Shaping the future of retail pharmacy
... Shoppers Drug Mart Corporation is the licensor of full-service retail drug stores operating under the names Shoppers Drug Mart® and Pharmaprix®. Founded in 1962 by Toronto pharmacist Murray Koffler, the Company has grown to a network of more than 1,240 full-service drug stores across Canada. These c ...
... Shoppers Drug Mart Corporation is the licensor of full-service retail drug stores operating under the names Shoppers Drug Mart® and Pharmaprix®. Founded in 1962 by Toronto pharmacist Murray Koffler, the Company has grown to a network of more than 1,240 full-service drug stores across Canada. These c ...
The Effects of the Preferential 5
... in the respective subscales of the FPI (ie, openness and neuroticism) were used as exclusion criteria. No subjects were excluded using these criteria. Some subjects had minimal prior drug experiences (once or twice, all more than 6 months prior to the study); all other subjects were drug-naı̈ve. Spe ...
... in the respective subscales of the FPI (ie, openness and neuroticism) were used as exclusion criteria. No subjects were excluded using these criteria. Some subjects had minimal prior drug experiences (once or twice, all more than 6 months prior to the study); all other subjects were drug-naı̈ve. Spe ...
cannabis 2009 - addiction education home
... to use one drug (legal or illicit) instead of, or in conjunction with, another due to issues such as: perceived safety; level of addiction potential; effectiveness in relieving symptoms; access and level of acceptance. This practice of substitution has been observed among individuals using cannabis ...
... to use one drug (legal or illicit) instead of, or in conjunction with, another due to issues such as: perceived safety; level of addiction potential; effectiveness in relieving symptoms; access and level of acceptance. This practice of substitution has been observed among individuals using cannabis ...
Bad Pharma
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Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.