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... strongly with drug metabolism. Based on available literature, Kirchheiner et al extrapolated dose recommendations based on genotype for several antidepressants and antipsychotics. From this work, it is very clear that although multiple drugs are a substrate of CYP2D6, the clinical consequence of bei ...
Can Drugs Cause Depression? A Review of the Evidence
Can Drugs Cause Depression? A Review of the Evidence

... on the basis of the analysis, determined that the three variables described above were confounders. This type of determination is somewhat exploratory and requires confirmation by further studies. Several other studies have failed to find associations between the use of ,B-blockers and depression. O ...
Tylenol (Acetaminophen) Ingestion
Tylenol (Acetaminophen) Ingestion

... 3. Gastric Lavage a. Insert a large bore NG tube and check position b. Suction out stomach contents and save for analysis c. Place patient on side d. Inject 15 cc/kg of saline per lavage e. Contraindications: unprotected airway, coma, convulsions 4. Activated Charcoal a. 1 g/kg b. Not recommended if ...
Biopharma Discovery and Development Contract Services – Indiana
Biopharma Discovery and Development Contract Services – Indiana

... regulatory pressures, strategic utilization of third party vendors to perform essential, but noncore functions is increasing at unprecedented rates. The contract service providers (CSPs) that serve as partners in this emerging “networked” model of drug development are consequently experiencing recor ...
A stability indicating RP-HPLC method for the determination of
A stability indicating RP-HPLC method for the determination of

... A simple isocratic RP-HPLC method was developed for the determination of amitriptyline HCl in pure and dosage forms. A Waters HPLC equipped with Alliance 2695 separation module and 2487 dual wavelength UV-Visible detector and Symmetry C18 (4.6x150mm, 3.5 µm, Make: XBridge) HPLC column thermostated a ...
Antithyroid Drugs
Antithyroid Drugs

... for 18 months, as compared with those treated for 6 months (42 percent vs. 62 percent).60 However, data from other prospective trials with up to four years of follow-up do not indicate that treatment for longer than one year has any effect on relapse rates.61,62 Given these results, treatment with a ...
Potential antimicrobial agents for the treatment of multidrug-resistant tuberculosis
Potential antimicrobial agents for the treatment of multidrug-resistant tuberculosis

... Groups of five female BALB/c mice were injected intraperitoneally with 16106 CFU?mL-1 of M. tuberculosis and treated with thioridazine in a dose range of 0.05–0.5 mg?day-1, which is equivalent to that used for psychosis in humans (1200 mg?day-1). There was a .5-log reduction in the number of CFU per ...
Phospholipid Complex Technique for Superior Bioavailability of
Phospholipid Complex Technique for Superior Bioavailability of

... Phytoconstituents have been utilized as medicines for thousands of years, yet their application is limited owing to major hurdles like deficit lipid solubility, large molecular size and degradation in the gastric environment of gut. Recently, phospholipid-complex technique has unveiled in addressing ...
Intranasal medications for Hospice
Intranasal medications for Hospice

...  Generic concentrations of midazolam are fairly dilute – if they are not effective, try lorazepam 0.1 mg/kg  Timing: Sedation onset at about 10 minutes, maximal at 10-20 and starts to wear off at 25-30 so if you plan a procedure, be ready to do procedure in this time frame.  Efficacy: Sedation is ...
Final Report
Final Report

... result, the regulatory path will proceed through the FDA’s Office of Combination Products (OCP). OCP will assign a lead Agency center to the product that will have primary jurisdiction over its review and regulation. The specific lead Agency center to which the product is assigned depends on the pro ...
JDP Featured in BioCentury
JDP Featured in BioCentury

... I testing of JDP-207, an intramuscular formulation of the same compound. The product could be used at home to stop milder reactions, or to slow more serious reactions before hospitalization. For JDP-207, Du hopes to use an offthe-shelf auto-injector pen. The company hopes to receive approval of the ...
EVALUATION OF REMIFENTANIL IN ENDOSCOPIC RETROGRADE CHOLANGIO-PANCREATOGRAPHY N. EL B
EVALUATION OF REMIFENTANIL IN ENDOSCOPIC RETROGRADE CHOLANGIO-PANCREATOGRAPHY N. EL B

... The narrow margin of safety concerning depression of spontaneous respiration must be considered seriously. Another disadvantage to consider would be the constrictive effects of morphine derivatives on the ampulla of Vater. However, if this does not surface as an added difficulty, then this possible ...
Delivery of Quercetin as an Antioxidant Agent to Cancer Cells... Carbon Nanotubes  Jafar Ezzati Nazhad Dolatabadi
Delivery of Quercetin as an Antioxidant Agent to Cancer Cells... Carbon Nanotubes Jafar Ezzati Nazhad Dolatabadi

... years for drug delivery applications including: nanoparticles, nanotubes, nanofibers, dendrimers, liposomes, polymer micelles, nanogels, nanocrystals, viral vectors, and virus-like particles [11, 13-15]. Among them, CNTs that possess unique chemical and physical properties have received a great atte ...
40 Complementary and Alternative Medical Treatment for Depression
40 Complementary and Alternative Medical Treatment for Depression

... doctor of osteopathy (DO) degrees and by their allied health professionals, such as physical therapists, psychologists, and registered nurses. Other terms for conventional medicine include allopathic, Western, mainstream, orthodox, and regular medicine and biomedicine. Some conventional medical prac ...
FDA Regulation of Mobile Medical Apps
FDA Regulation of Mobile Medical Apps

... FDA does not intend to enforce compliance with the regulatory controls, including registration and listing, premarket review, postmarket reporting and quality system regulation for manufacturers of these types of ...
Coagulation assessment with the new generation of oral
Coagulation assessment with the new generation of oral

... apixaban (collectively, novel OACs, non-vitamin K OACs, or simply ‘NOACs’) have become available for long-term use. Protocols for assessing and managing warfarintreated patients in the ED are well established and include international normalised ratio (INR) testing, which helps guide patient managem ...
A Rare Case of Domperidone Induced Oculogyric Crisis in Young
A Rare Case of Domperidone Induced Oculogyric Crisis in Young

... chances of symptoms occurring again are high. ...
Study protocol - BioMed Central
Study protocol - BioMed Central

... quality of life, were compared between the dose reduction and control groups. The study was conducted in accordance with the Declaration of Helsinki and Good Clinical Practice. The study protocol was also examined and approved by the ethics review board of each center, and by the Ethics Review Board ...
interferon alfa-2b - Cancer Care Ontario
interferon alfa-2b - Cancer Care Ontario

... most are mild to moderate in severity, are transient and rapidly reversible usually within 24 hours. The most common reactions are flu-like symptoms, and local reactions such as pruritus, paresthesia, swelling or pain.  Low WBC and/or platelet counts and elevated LFTs have also been observed with in ...
Marketed products fact sheet
Marketed products fact sheet

... PAH (58%), PAH associated with connective tissue disease (29%), and PAH associated with congenital heart disease with repaired shunts (10%). In Europe, Uptravi is indicated for the long-term treatment of PAH in adult patients with WHO functional class II-III, either as combination therapy in patient ...
Kinase Inhibition with BAY 43–9006 in Renal Cell Carcinoma
Kinase Inhibition with BAY 43–9006 in Renal Cell Carcinoma

... time to progression (303 events needed). An interim analysis is planned by the data monitoring committee after 270 events. If current studies and the results from the trial described herein continue to support the therapeutic value of this kinase inhibitor in a relapse setting, it would be interesti ...
Mobic Clinical Overview and what`s up with the
Mobic Clinical Overview and what`s up with the

What`s New? - American Association of Diabetes Educators of Utah
What`s New? - American Association of Diabetes Educators of Utah

... Berberine - Summary • Alkaloid contained in several different plants • Has insulin sensitizing and AGI activity • May ↑ SDCs of drugs metabolized by CYP 3A4 (CyA, some statins, CCBs, etc.) • Constipation is main side effect • Should not be used in pregnancy • Has shown benefit on A1C, FPG, PPG, lip ...
Dirithromycin (Dynabac): same as erythromycin base but once daily
Dirithromycin (Dynabac): same as erythromycin base but once daily

... * S/Sx: profuse, watery diarrhea 1-20 times/day, bloody diarrhea in 5-10 % of cases, foul smelling, abdominal cramping, nausea, fever and leukocytosis * risk factors: recent hospitalization, recent broad-spectrum antibiotic use, history of colitis, advanced age, recent instrumentation of lower bowel ...
2014 - Atiner
2014 - Atiner

... Athens Institute for Education and Research. In total there were 33 papers, coming from 15 different countries (Austria, Brazil, Canada, China, Denmark, Egypt, India, Kingdom of Bahrain, Malaysia, Portugal, Saudi Arabia, Singapore, Turkey, UK, USA). The conference was organized into 8 sessions that ...
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Bad Pharma



Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.
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