the Kancera Project Update Feb. 2017
... is paid in total 6 million Kancera shares divided into three steps, which can only be achieved if the project is successfully developed. This payment model means that the two companies share the risk in product development up to when the first study has been conducted in humans. Kancera intends to s ...
... is paid in total 6 million Kancera shares divided into three steps, which can only be achieved if the project is successfully developed. This payment model means that the two companies share the risk in product development up to when the first study has been conducted in humans. Kancera intends to s ...
Updates on Endovascular Revascularization for Lower
... With aging population and increasing prevalence of metabolic syndrome, peripheral arterial disease (PAD) becomes an important burden to developed cities and countries. PAD can result in complications such as lifestyle-limiting claudication, critical limb ischemia (CLI) and amputation. Treatmen ...
... With aging population and increasing prevalence of metabolic syndrome, peripheral arterial disease (PAD) becomes an important burden to developed cities and countries. PAD can result in complications such as lifestyle-limiting claudication, critical limb ischemia (CLI) and amputation. Treatmen ...
Regeneron and The University of Texas Southwestern Medical
... that it has entered into an agreement with The University of Texas Southwestern Medical Center (UT Southwestern Medical Center) that will provide researchers at the Dallas-based medical center with access to Regeneron's VelocImmune technology to discover fully human monoclonal antibodies. Under the ...
... that it has entered into an agreement with The University of Texas Southwestern Medical Center (UT Southwestern Medical Center) that will provide researchers at the Dallas-based medical center with access to Regeneron's VelocImmune technology to discover fully human monoclonal antibodies. Under the ...
European Heart Rhythm Association Practical Guide on the use of
... deal with NOAC in specific clinical situations. Moreover, despite the different AF anticoagulation trials, there are still many under-explored aspects of NOAC that are relevant already today when these drugs are used by cardiologists, neurologists, geriatricians, and general practitioners. Each of t ...
... deal with NOAC in specific clinical situations. Moreover, despite the different AF anticoagulation trials, there are still many under-explored aspects of NOAC that are relevant already today when these drugs are used by cardiologists, neurologists, geriatricians, and general practitioners. Each of t ...
Factor Xa inhibitors
... protein that binds heparin with high affinity. The large amounts of PF4 found in the vicinity of platelet-rich ...
... protein that binds heparin with high affinity. The large amounts of PF4 found in the vicinity of platelet-rich ...
Administration
... monitoring aims to avoid both excessive and sub-therapeutic concentrations thereby preventing toxicity and ensuring efficacy. The following sections provide detailed instructions on how to dose, monitor and administer these agents. Antibiotic doses should not be withheld pending on antibiotic assays ...
... monitoring aims to avoid both excessive and sub-therapeutic concentrations thereby preventing toxicity and ensuring efficacy. The following sections provide detailed instructions on how to dose, monitor and administer these agents. Antibiotic doses should not be withheld pending on antibiotic assays ...
Abstract Book - cannabis medicine
... GREETINGS BY FRANJO GROTENHERMEN Cannabis and single substances that influence the endogenous cannabinoid system have a remarkable broad therapeutic potential. Several effects that are not mediated by cannabinoid receptors or by unknown mechanisms have come into focus as well. Some people show grea ...
... GREETINGS BY FRANJO GROTENHERMEN Cannabis and single substances that influence the endogenous cannabinoid system have a remarkable broad therapeutic potential. Several effects that are not mediated by cannabinoid receptors or by unknown mechanisms have come into focus as well. Some people show grea ...
DDAVP Rhinal Tube PI
... electrolyte imbalance, such as cystic fibrosis, heart failure and renal disorders because these patients are prone to hyponatremia. Ensure that in children administration is under adult supervision in order to control the dose intake. Rare severe allergic reactions have been reported with DDAVP. Ana ...
... electrolyte imbalance, such as cystic fibrosis, heart failure and renal disorders because these patients are prone to hyponatremia. Ensure that in children administration is under adult supervision in order to control the dose intake. Rare severe allergic reactions have been reported with DDAVP. Ana ...
72 jems august 2008
... ambulance crew came into the dance club to treat an unconscious 17-year-old patient who was reported as turning blue. “Honestly, I swear, none of us has had anything to drink,” said the patient’s best friend. “We got here about an hour ago. Jeremy said he wasn’t feeling good, then he started getting ...
... ambulance crew came into the dance club to treat an unconscious 17-year-old patient who was reported as turning blue. “Honestly, I swear, none of us has had anything to drink,” said the patient’s best friend. “We got here about an hour ago. Jeremy said he wasn’t feeling good, then he started getting ...
Guide to Fibromyalgia Management
... Despite their reported usefulness in the treatment of episodes of severe FM pain, the effectiveness of narcotics in treating long-term, chronic pain is still uncertain. Rheumatologist Russell Rothenberg, M.D., Chair of the Medical Advisory Board of the National Fibromyalgia Partnership, notes that w ...
... Despite their reported usefulness in the treatment of episodes of severe FM pain, the effectiveness of narcotics in treating long-term, chronic pain is still uncertain. Rheumatologist Russell Rothenberg, M.D., Chair of the Medical Advisory Board of the National Fibromyalgia Partnership, notes that w ...
Meloxicam Tablets USP (mel-OX-i-kam) 7.5 mg and 15 mg Rx Only
... skin rash or blisters with fever swelling of the arms and legs, hands and feet These are not all the side effects with NSAID medicines. Talk to your healthcare provider or pharmacist for more information about NSAID medicines. Call your doctor for medical advice about side effects. You may repor ...
... skin rash or blisters with fever swelling of the arms and legs, hands and feet These are not all the side effects with NSAID medicines. Talk to your healthcare provider or pharmacist for more information about NSAID medicines. Call your doctor for medical advice about side effects. You may repor ...
Cefakliman mono
... If patients, suffering from estrogen-dependent tumours, are/were in medical care, Cefakliman® mono must not be used as it is not known if Cimicifuga rootstock extracts support estrogen-dependent tumours or if they do not have any influence. There has not been sufficient research for the application ...
... If patients, suffering from estrogen-dependent tumours, are/were in medical care, Cefakliman® mono must not be used as it is not known if Cimicifuga rootstock extracts support estrogen-dependent tumours or if they do not have any influence. There has not been sufficient research for the application ...
Research Report Series
... creating long-term imbalances in neuronal and hormonal systems that are not easily reversed.14,15 Studies have shown some deterioration of the brain’s white matter due to heroin use, which may affect decision-making abilities, the ability to regulate behavior, and responses to stressful situations.1 ...
... creating long-term imbalances in neuronal and hormonal systems that are not easily reversed.14,15 Studies have shown some deterioration of the brain’s white matter due to heroin use, which may affect decision-making abilities, the ability to regulate behavior, and responses to stressful situations.1 ...
Effects of Tolvaptan, a Vasopressin Antagonist, in
... The ACTIV in CHF trial was a multicenter, randomized, double-blind, placebo-controlled, parallel-group, doseranging, phase 2 feasibility trial that compared the use of 3 oral, once-daily doses of tolvaptan (30 mg, 60 mg, 90 mg) with placebo. Detailed information about the study design rationale has ...
... The ACTIV in CHF trial was a multicenter, randomized, double-blind, placebo-controlled, parallel-group, doseranging, phase 2 feasibility trial that compared the use of 3 oral, once-daily doses of tolvaptan (30 mg, 60 mg, 90 mg) with placebo. Detailed information about the study design rationale has ...
sustained and controlled drug delivery system - as a part
... comparison with the frequency required by a conventional dosage form. It is designed to maintain constant levels of a drug in the patient's bloodstream by releasing the drug over an extended period. Maintaining constant blood levels of the drug in the bloodstream increases the therapeutic effectiven ...
... comparison with the frequency required by a conventional dosage form. It is designed to maintain constant levels of a drug in the patient's bloodstream by releasing the drug over an extended period. Maintaining constant blood levels of the drug in the bloodstream increases the therapeutic effectiven ...
Hydroxycarbamide for sickle cell disease
... Risk of secondary leukaemia associated with long-term hydroxycarbamide use. ...
... Risk of secondary leukaemia associated with long-term hydroxycarbamide use. ...
Semen Coicis
... Modern pharmacological studies have demonstrated that Coix Seed and its preparation-KLT possessed extensive pharmacological activities. This paper will make a complete review on the progress in pharmacological activities studies on antitumor and immunomodulation. 1. Pharmacodynamic studies Early mo ...
... Modern pharmacological studies have demonstrated that Coix Seed and its preparation-KLT possessed extensive pharmacological activities. This paper will make a complete review on the progress in pharmacological activities studies on antitumor and immunomodulation. 1. Pharmacodynamic studies Early mo ...
Endocrine draft for consultation
... also NICE Algorithm for blood glucose lowering therapy in adults with type 2 diabetes Please avoid prescribing large quantities to prevent waste, GLP-1 agonists require refrigeration and are expensive. One month’s supply should be adequate for most patients Stopping rules with GLP-1 mimetics: NICE s ...
... also NICE Algorithm for blood glucose lowering therapy in adults with type 2 diabetes Please avoid prescribing large quantities to prevent waste, GLP-1 agonists require refrigeration and are expensive. One month’s supply should be adequate for most patients Stopping rules with GLP-1 mimetics: NICE s ...
Letter to the Editor - Drug Metabolism and Disposition
... up to 70% inhibition of testosterone 6-hydroxylase activity was observed when EE (50 M) was preincubated (30 min) with NADPHfortified human liver microsomes. In contrast, preincubation of EE (0.1 to 50 M) with human liver microsomes resulted in no inhibition of (S)-mephenytoin 4⬘-hydroxylase acti ...
... up to 70% inhibition of testosterone 6-hydroxylase activity was observed when EE (50 M) was preincubated (30 min) with NADPHfortified human liver microsomes. In contrast, preincubation of EE (0.1 to 50 M) with human liver microsomes resulted in no inhibition of (S)-mephenytoin 4⬘-hydroxylase acti ...
oral proton pump inhibitors
... effect was most apparent within the first seven days of acid suppression therapy. Additionally higher doses of PPI was more strongly associated with pneumonia.26 However, other authors have suggested that the effects observed may be due to confounding.27 A recent large cohort study found that PPIs w ...
... effect was most apparent within the first seven days of acid suppression therapy. Additionally higher doses of PPI was more strongly associated with pneumonia.26 However, other authors have suggested that the effects observed may be due to confounding.27 A recent large cohort study found that PPIs w ...
Recreational ketamine: from pleasure to pain
... young (17–45 years at presentation) and almost all are recreational users. We have developed four principal questions: 1. Is there a true causal relationship between ketamine and the LUTS? 2. What is the mechanism(s) of damage? 3. What is an effective and appropriate treatment regime for such patien ...
... young (17–45 years at presentation) and almost all are recreational users. We have developed four principal questions: 1. Is there a true causal relationship between ketamine and the LUTS? 2. What is the mechanism(s) of damage? 3. What is an effective and appropriate treatment regime for such patien ...
Health Services Insights public Health Implications of Household
... c onsume or use at least one pharmaceutical, and many consume or use multiple pharmaceuticals. Using data from the National Social life, Health and Aging Project (NSHAP), researchers studied pharmaceutical use among a nationally representative probability sample of community-residing individuals ag ...
... c onsume or use at least one pharmaceutical, and many consume or use multiple pharmaceuticals. Using data from the National Social life, Health and Aging Project (NSHAP), researchers studied pharmaceutical use among a nationally representative probability sample of community-residing individuals ag ...
Intentional low-molecular-weight heparin overdose: a case report
... The American College of Chest Physicians (ACCP) recommendations for the treatment of LMWH overdose are consistent with the manufacturer’s instructions. If reversal is sought within 8 h of LMWH administration, their guidelines recommend protamine 1 mg/100 antifactor Xa units followed by a second dose ...
... The American College of Chest Physicians (ACCP) recommendations for the treatment of LMWH overdose are consistent with the manufacturer’s instructions. If reversal is sought within 8 h of LMWH administration, their guidelines recommend protamine 1 mg/100 antifactor Xa units followed by a second dose ...
CARDOXIN doctor leaflet
... In the case of severe hypotension, the patient should be placed in a supine position with the head tilted down if necessary, before administration of parenteral aminophylline. If aminophylline does not relieve chest pain symptoms within a few minutes, sublingual nitroglycerin may be administered. If ...
... In the case of severe hypotension, the patient should be placed in a supine position with the head tilted down if necessary, before administration of parenteral aminophylline. If aminophylline does not relieve chest pain symptoms within a few minutes, sublingual nitroglycerin may be administered. If ...
Bad Pharma
Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.