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clinical course and cellular pathology of tardive dyskinesia
clinical course and cellular pathology of tardive dyskinesia

... likelihood (61%) of developing a second episode within 1 year. Preliminary data suggest that prognosis for TD remission is better for patients who are treated for shorter times within the follow-up period after TD diagnosis and for those treated with lower doses of antipsychotic during follow-up (41 ...
RADIATION THERAPY ONCOLOGY GROUP
RADIATION THERAPY ONCOLOGY GROUP

... after cranial radiotherapy is associated with high radiation dose, large fraction-size, larger fieldsize, use of concurrent chemotherapy, and extremes of age at time of treatment.8,10-12 Elderly patients with vascular comorbidities (diabetes, hypertension, atherosclerosis) appear to be at particular ...
OXCARBAZEPINE
OXCARBAZEPINE

... augmenting agent for numerous other anticonvulsants, lithium, and atypical antipsychotics in treating bipolar disorder, although its use in bipolar disorder is not yet well studied • Oxcarbazepine may be a second- or thirdline augmenting agent for antipsychotics in treating schizophrenia, although i ...
Tuesday June 7, 2016 - Braeburn Pharmaceuticals
Tuesday June 7, 2016 - Braeburn Pharmaceuticals

...  changes in governmental regulations, tax rates and similar matters;  changes in generally accepted accounting principles by standard-setting bodies; and  the degree and nature of our competition. The forward-looking statements are based on our beliefs, assumptions and expectations of our future ...
Antinociceptive, anti-inflammatory and central nervous system
Antinociceptive, anti-inflammatory and central nervous system

... Scurrula parasitica (Linn.) has been used as traditional medicine against various diseases. Aim of the study was to evaluate analgesic, anti-inflammatory and CNS-depressant effects of methanol (MSPL), dichloromethane (DSPL), chloroform (CSPL) and aqueous (ASPL) extracts of S. parasitica leaves. Acet ...
OPTIMIZATION AND EVALUATION OF CIPROFLOXACIN SWELLABLE FLOATING MATRIX
OPTIMIZATION AND EVALUATION OF CIPROFLOXACIN SWELLABLE FLOATING MATRIX

... to incomplete absorption of drugs having absorption window especially in the upper part of the small intestine.3 Drugs having a short half-life are eliminated quickly from the blood circulation. Various oral controlled delivery systems have been designed which can overcome these problems and release ...
Balsalazide disodium for the treatment of ulcerative colitis Drug Profile
Balsalazide disodium for the treatment of ulcerative colitis Drug Profile

... Pentasa (mesalazine) approximately 15–20% and Colazal® (balsalazide) about 5–10%. The newly introduced Lialda™ (Mezavant; mesalazine) has gained approximately 5% of the market since its introduction in 2007. Given the multifactorial etiology of ulcerative colitis, medical management has centered on ...
Overdose in Toronto: Trends, Prevention and
Overdose in Toronto: Trends, Prevention and

... Notes: These are not unique cases, as individual may have had more than one opioid in their body. In the body, heroin breaks down quickly to become morphine. As a result, it is unknown how many of these deaths were caused by morphine, and how many by heroin. Data Source: Office of the Chief Coroner ...
Solid dosage forms
Solid dosage forms

... drug will dissolve at different rates. They are designed to produce drug effects over an extended time. SR tablets are administered less frequently (usually once daily). e.g. Isoptin SR, Ravel SR ...
Pharmacognosy at its Finest: Marijuana Strains, Pains, and Potential
Pharmacognosy at its Finest: Marijuana Strains, Pains, and Potential

... • “This product contains medical marijuana and was produced without regulatory oversight for health, safety or efficacy and there may be health risks associated with the consumption of the product.”  For MMJ-infused products, product identity and net weight statements must appear on the portion of ...
Dabigatran
Dabigatran

... • Treatment with apixaban as compared to warfarin in patients with AF (n>18,000) and at least one additional risk factor for stroke: – Reduces stroke and systemic embolism by 21% ...
Chapter 4 Lesson 2 - ROP Pharmacology for Health Care
Chapter 4 Lesson 2 - ROP Pharmacology for Health Care

... Figure 4–15 I.V. piggyback. Because I.V. antibiotic drugs are frequently ordered in the hospital, small I.V. bags often come premixed with the antibiotic drug in them; they can be attached quickly to the patient's existing I.V. line. This I.V. bag contains the trade name antibiotic drug Zosyn, a co ...
MINI REVIEW - “What Is The Safety Of Fluoroquinolones For...  Dorothy Koech
MINI REVIEW - “What Is The Safety Of Fluoroquinolones For... Dorothy Koech

... The fluoroquinolone class of antimicrobials has been in clinical use for over 17 years now [14]. For a long time quinolones had not been approved for use in children, primarily because of concerns they could cause irreversible damage to growing cartilage in weight bearing joints, concerns resulting ...
1 - The University of Liverpool Repository
1 - The University of Liverpool Repository

... falciparum, P. ovale, P. malariae, P. vivax and P. knowlesi). Disease in humans is initiated when an infected female Anopheles mosquito takes a blood meal during which infective forms of the parasite (named sporozoites) are injected into the blood stream (Figure 1).6 Within 15-30 minutes sporozoite ...
Pelagia Research Library Hydroxypropyl methylcellulose
Pelagia Research Library Hydroxypropyl methylcellulose

... retention, and as a binder. HPMC imparts little or no flavor to food. The historical record in the literature is not entirely clear on when HPMC was first introduced into food or any other commercial use. However, references point to a US patent on its preparation having been issued in 1960 to the D ...
Chapter 8. Hypertension in the elderly
Chapter 8. Hypertension in the elderly

... treated before the age of 65 years and have controlled blood pressure at o130/85 mm Hg, there is no need to attenuate treatment after the age of 65 years. Blood pressure levels obtained in large clinical studies and the results of comparisons among the groups that were set at different target levels ...
A Map to Learn your Way around Antibioticland
A Map to Learn your Way around Antibioticland

... Aztreonam.  Aztreonam cross allergy with Ceftazidime  Cephalosporins and Metronidazole: Disulfiram reaction  Ticarcillin: bleeding in uremic patients ...
Alternating antipyretics in the treatment of fever in children:
Alternating antipyretics in the treatment of fever in children:

... In three studies, the primary outcome analyzed was the mean difference in temperature among groups at different intervals, measured in hours22,24 or days.21 One of the studies23 presented its as primary outcome the time without fever, but data on mean difference in temperature were obtained after co ...
Effects of Laropiprant on Nicotinic Acid
Effects of Laropiprant on Nicotinic Acid

... and Christie M. Ballantyne, MDe Niacin (nicotinic acid) is not optimally used mainly because of flushing, a process mediated primarily by prostaglandin D2, which leads to poor patient compliance and suboptimal dosing. This phase II dose-ranging study was designed to assess whether the prostaglandin ...
  DEVELOPMENT AND EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF SALBUTAMOL  SULPHATE Research Article
  DEVELOPMENT AND EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF SALBUTAMOL  SULPHATE Research Article

... In vitro bioadhesion studies show that tablet containing HPMC K‐4M  & EC (2:1 ratio) has maximum bioadhesive strength, it means HPMC  K‐4M has more bioadhesive property than EC.  An  ideal  controlled  release  system  should  release  the  drug  immediately to attain the required therapeutic level, ...
Central Nervous System Toxicity of Chemotherapy
Central Nervous System Toxicity of Chemotherapy

... aphasia [4, 8, 16, 17]. Children are mainly affected [8, 16], but single cases in adults have been reported as well [17]. The mechanism of neurotoxicity is poorly understood: symmetrical hyperintense signals in diffusion-weighted imaging (DWI) and decreased apparent diffusion coefficient (ADC) on ma ...
Nutrients and Botanicals for Erectile Dysfunction: Examining the Evidence Erectile Dysfunction
Nutrients and Botanicals for Erectile Dysfunction: Examining the Evidence Erectile Dysfunction

... fewer than a dozen controlled human trials of yohimbine for ED and most of them lack sufficient power for credible statistical analysis. In addition, clinical trials of yohimbine have been criticized for having methodological problems and inconsistent data.34 A systematic review published in 1998 of ...
Effects of Various Penetration Enhancers on Penetration of
Effects of Various Penetration Enhancers on Penetration of

... in the results might be attributed to differences in physicochemical properties of drugs and type of skin models used in two studies. The enhancer effect of lauric acid, in both concentrations, has increased EF value. This effect was significantly higher at concentration of 15% (P < 0.05). On the ot ...
niaspan - Sunovion Pharmaceuticals Canada Inc.
niaspan - Sunovion Pharmaceuticals Canada Inc.

... of muscle pain, tenderness, or weakness, particularly during the initial months of therapy and during any periods of upward dosage titration of either drug (see DRUG INTERACTIONS). Periodic serum creatine phosphokinase (CPK) and potassium determinations should be carried out, but there is no assuran ...
Document
Document

... 20, 40, and 60 mg) before PCI in patients with STEMI  Results showed that incidence of bleeding events was infrequent and appeared to be similar in patients treated with all doses of elinogrel and in placebo ERASE-MI, published in the December 2009 issue of the American Heart JournalDr Jeffrey Berg ...
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Bad Pharma



Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.
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