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Vitae Pharmaceuticals, Inc
Vitae Pharmaceuticals, Inc

... This release contains forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, including statements regarding the clinical development of VTP-34072. In some cases, you can identify forward-looking statements by terms such as “may,” “might,” “wi ...
vitae pharmaceuticals, inc. - corporate
vitae pharmaceuticals, inc. - corporate

... This release contains forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, including statements regarding the clinical development of VTP-34072. In some cases, you can identify forward-looking statements by terms such as “may,” “might,” “wi ...
ELOCON Lotion
ELOCON Lotion

... for suppression were: basal cortisol level of ≤5 mcg/dL, 30-minute post-stimulation level of ≤18 mcg/dL, or an increase of <7 mcg/dL. Follow-up testing 2 to 4 weeks after stopping treatment, available for 8 of the subjects, demonstrated suppressed HPA axis function in 1 subject, using these same cri ...
united states securities and exchange commission - corporate
united states securities and exchange commission - corporate

... 14-day study once-a-day dosing from five to 200 milligrams. And although the multiple ascending dose study was in otherwise healthy volunteers, they were selected to have cholesterols of at least 110 milligrams per deciliter to give us a chance to see effects on LDL cholesterol. 3196 is well-tolerat ...
Drug Metabolism Test Results
Drug Metabolism Test Results

... to harboring untested phenotypically important polymorphisms, drug-drug interactions, co-morbidities, lifestyle habits or other non-genetic factors. This report does not address drug allergies or drug-drug interactions. Laboratory Accreditation     This test was developed and its performance charact ...
THE PROMISE OF IMAGING BIOMARKERS
THE PROMISE OF IMAGING BIOMARKERS

... are used to visualize proteins, dominate early discovery work and are used in assessing target expression and function as well as compound screening and lead discovery. Preclinical animal studies - focused more on efficacy, toxicity, pharmacokinetics and pharmacodynamics - rely more on PET, SPECT, M ...
β-Blocker Ingestion: An Evidence-Based Consensus
β-Blocker Ingestion: An Evidence-Based Consensus

... this should occur regardless of the dose reported (Grade D). 2) Patients without evidence of self-harm should have further evaluation, including determination of the precise dose ingested, history of other medical conditions, and the presence of coingestants. Ingestion of either an amount that excee ...
MODIFIED DIBUTYRYLCHITIN FILMS AS MATRICES FOR
MODIFIED DIBUTYRYLCHITIN FILMS AS MATRICES FOR

... Analysis of active substance release from transdermal systems is an important area of scientific research for human health. Transdermal systems are presently more commonly [1 - 4] used. They are thin, single or multilayer membranes of any shape and size. Films are an alternative to standard forms of ...
Prescribing for Pregnant or Lactating Women
Prescribing for Pregnant or Lactating Women

... To best address all of these potential concerns, recommendations for drug use during pregnancy are often criteria-based using data and results from available studies. These criteria often include: - what (if any) information is known from studies conducted in humans and/or animals - if the nature of ...
ACCELERATED STABILITY TESTING OF BETAMETHASONE DIPROPIONATE NANOEMULSION
ACCELERATED STABILITY TESTING OF BETAMETHASONE DIPROPIONATE NANOEMULSION

... temperature (25ºC) during 3-months of storage period. However, the changes in these parameters were not statistically significant (p ≥0.05). The shelf-life of optimized nanoemulsion formulation was found to be 2.66 years at room temperature. These results indicated that the stability (physical and c ...
Colloids and crystalloids: does it matter to the kidney?
Colloids and crystalloids: does it matter to the kidney?

... The currently understood pathogenesis of this phenomenon indicates that the contrast agents themselves cause both renal ischemia and renal tubular cell toxicity, where epithelial cell necrosis occurs primarily in the thin ascending limb of the renal medullary loop of Henle [20]. Worse clinical outco ...
Demand reduction: A glossary of terms
Demand reduction: A glossary of terms

... UNITED NATIONS PUBLICATION Sales No. E.00.XI.9 ISBN: 92-1-148129-5 ...
Subsys Prescribing Information
Subsys Prescribing Information

...  When prescribing, do not convert patients on a mcg per mcg basis from any other fentanyl products to SUBSYS.  When dispensing, do not substitute a SUBSYS prescription for other fentanyl products. Addiction, Abuse, and Misuse SUBSYS exposes patients and other users to the risks of opioid addiction ...
Pharmacological and Medical Considerations in Hypnotic Use
Pharmacological and Medical Considerations in Hypnotic Use

... compared with all other sedative hypnotics, have larger therapeutic indices (IS), which is one reason they have become the preferred hypnotic. But it should be noted that these indices have not been determined in studies on patients with insomnia or with regard to combination with other drugs. The i ...
Pain Management
Pain Management

... • Pain patients: they’re all mad aren’t they? • What do X-rays and scans tell us about the cause of back pain? • They can’t exercise because it hurts can they? • Should I see all patients with pain? • Can we treat any of them, can we treat them all? ...
eTable 1. Study inclusion and exclusion criteria Inclusion criteria
eTable 1. Study inclusion and exclusion criteria Inclusion criteria

...  Meet DSM-5 criteria1 for moderate or severe opioid use disorder at screening and not seeking treatment for opioid use disorder  Age 18–55 years  BMI 18–33.0 kg/m2  Women of childbearing potential (defined as all women who are not surgically sterile or postmenopausal for ≥1 year prior to informe ...
AGNP Consensus Guidelines for Therapeutic Drug Monitoring in
AGNP Consensus Guidelines for Therapeutic Drug Monitoring in

... with intelligence disabilities, forensic patients, patients with known or suspected genetically determined pharmacokinetic abnormalities or individuals with pharmacokinetically relevant comorbidities. However, the potential benets of TDM for optimization of pharmacotherapy can only be obtained if t ...
Magnesium Sulfate
Magnesium Sulfate

... percent lower risk of dying from eclampsia than women who were administered a placebo.7,8 These results are consistent with other studies of the drug, notably the 1995 Collaborative Eclampsia Trial, in which the relative effectiveness of magnesium sulfate was compared with Diazepam and Phenytoin (tw ...
THE PREVALENCE AND CONTROL OF HYPERTENSION AMONG
THE PREVALENCE AND CONTROL OF HYPERTENSION AMONG

... hypercoagulation, increased inflammation and left ventricular hypertrophy. 47 This clustering risk factor in diabetic patients ultimately results in the development of CVD, which is the major cause of premature mortality in patients with type 2 diabetes. In all there is now considerable evidence for ...
PREPARATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF FINASTERIDE USING CO-PROCESSED EXCIPIENTS
PREPARATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF FINASTERIDE USING CO-PROCESSED EXCIPIENTS

... in comparison to the conventional tablets (Prosteride ®), this may be attributed to the effect of crospovidone that provides the fastest rate of dissolution of poorly soluble drugs and this will improve the drug release profile [24]. Moreover the stability study showed no significant difference (p > ...
Medical Emergencies in the Dental Surgery
Medical Emergencies in the Dental Surgery

... should be restricted to members of staff. Members of staff must ensure that patients or their carers or members of the public do not interfere with emergency drugs or equipment stored in the surgery. However, while Midazolam Buccal Liquid, midazolam 5mg /ml, and the other essential emergency drugs a ...
Relative potency of proton-pump inhibitors-comparison of
Relative potency of proton-pump inhibitors-comparison of

... in healthy volunteers with intragastric 24-h pH monitoring were included. We restricted the patient studies to those with GERD because very few studies with 24-h pH assessment were available for other diseases such as peptic ulcer or Zollinger-Elison syndrome. Studies performed exclusively in Hp-pos ...
Drug List
Drug List

...  Avoid in patients currently taking anticoagulants, such as coumadin. ...
Successful cases of Traceability in the Healthcare Sector in
Successful cases of Traceability in the Healthcare Sector in

... joined the Pharmaceutical Inspection Convention and Pharmaceutical Inspection Co-operation Scheme (known together as “PIC/S”), two international instruments, implemented between the countries and the pharmaceutical inspection authorities, who favor an active and constructive cooperation in the field ...
Prodrugs—from Serendipity to Rational Design
Prodrugs—from Serendipity to Rational Design

... In addition, the prodrug strategy has been used to increase the selectivity of drugs for their intended target. This can not only improve the efficacy of the drug but also decrease systemic and/or unwanted tissue/organspecific toxicity (T). Development of a prodrug with improved properties may also ...
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Bad Pharma



Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.
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