Committee on Drugs 1997;99;918 DOI: 10.1542/peds.99.6.918
... in place of codeine or dextromethorphan. Prescription medications may substitute other narcotic agents (hydrocodone or hydromorphone) for codeine and may be more addictive than codeine.2,3 In addition, many of these cough products are elixirs, which may contain up to 25% alcohol by volume.3 The over ...
... in place of codeine or dextromethorphan. Prescription medications may substitute other narcotic agents (hydrocodone or hydromorphone) for codeine and may be more addictive than codeine.2,3 In addition, many of these cough products are elixirs, which may contain up to 25% alcohol by volume.3 The over ...
Full Article - Pharmascope.org
... typically short; in the range of <5–10 min. Buccal mucoadhesive formulations are expected to overcome this problem. Bioadhesive polymers offer a means by which a delivery system is attached to the buccal mucosa, and hence, provide substantially longer retention times at the absorption site. They als ...
... typically short; in the range of <5–10 min. Buccal mucoadhesive formulations are expected to overcome this problem. Bioadhesive polymers offer a means by which a delivery system is attached to the buccal mucosa, and hence, provide substantially longer retention times at the absorption site. They als ...
Full Resource - PCSS-MAT
... the body become less over time. A person developing tolerance to opioid drugs may: 1) Need larger amounts of the drug to get the same effect or “high” 2) Experience reduced effects when taking the same amount of a drug Tolerance levels can vary greatly between different people. How does the body dev ...
... the body become less over time. A person developing tolerance to opioid drugs may: 1) Need larger amounts of the drug to get the same effect or “high” 2) Experience reduced effects when taking the same amount of a drug Tolerance levels can vary greatly between different people. How does the body dev ...
- Wiley Online Library
... experimental horses were dose-dependent and included sweating, occasional tremors, increased urine production, ataxia, profound decreases in heart rate (as low as 10 to 15 beats per minute), and transient hypertension persisting for more than 15 minutes and, in some cases, for up to 60 minutes.” Sec ...
... experimental horses were dose-dependent and included sweating, occasional tremors, increased urine production, ataxia, profound decreases in heart rate (as low as 10 to 15 beats per minute), and transient hypertension persisting for more than 15 minutes and, in some cases, for up to 60 minutes.” Sec ...
New Goals and New Drugs for People With Heavy Anti-HIV
... CD4 cells are white blood cells that play an important part in fighting all types of infections and cancers. HIV attacks CD4 cells, which then die. Healthy people have a CD4 count around 750 or higher. When the CD4 count falls below 500, the ability to fight infections drops. A CD4 count under 200 i ...
... CD4 cells are white blood cells that play an important part in fighting all types of infections and cancers. HIV attacks CD4 cells, which then die. Healthy people have a CD4 count around 750 or higher. When the CD4 count falls below 500, the ability to fight infections drops. A CD4 count under 200 i ...
Ensuring availability of controlled medications for the relief of pain
... has previously released two discussion papers dealing with the use of opioid medication for drug treatment: “Reducing the adverse health and social consequences of drug abuse: a comprehensive approach”;19 and “Principles of drug dependence treatment”.20 The tragedy of the inadequate availability of ...
... has previously released two discussion papers dealing with the use of opioid medication for drug treatment: “Reducing the adverse health and social consequences of drug abuse: a comprehensive approach”;19 and “Principles of drug dependence treatment”.20 The tragedy of the inadequate availability of ...
Product Monograph Template - Standard
... Nursing Mothers: It is recommended that HIV-infected women not breast-feed their infants under any circumstances to avoid the transmission of HIV infection. Studies in lactating rats indicate that maraviroc is extensively excreted into rat milk. It is unknown whether maraviroc is excreted into human ...
... Nursing Mothers: It is recommended that HIV-infected women not breast-feed their infants under any circumstances to avoid the transmission of HIV infection. Studies in lactating rats indicate that maraviroc is extensively excreted into rat milk. It is unknown whether maraviroc is excreted into human ...
Newsletter - MercyCenters.org
... Clearly there is a market for these remarkable cannabinoid compounds. The market potential both as an herbal and an FDA approved pharmaceutical product. Expanded development of cannabinoid medicine can dramatically lower our health care costs as Dr. Christopher Fichtner argues in his book Cannabinoi ...
... Clearly there is a market for these remarkable cannabinoid compounds. The market potential both as an herbal and an FDA approved pharmaceutical product. Expanded development of cannabinoid medicine can dramatically lower our health care costs as Dr. Christopher Fichtner argues in his book Cannabinoi ...
A Human Vascular Model Based on Vasoconstrictive Dose-Response Effects of
... Twelve healthy subjects (6 males), mean age 23 (range 20-29) years, were included in the study. The subjects took no medication except for hormonal contraceptives, paracetamol up to 1 g four times daily, and nasal decongestants in the short term. They did not smoke tobacco or other nicotine-containi ...
... Twelve healthy subjects (6 males), mean age 23 (range 20-29) years, were included in the study. The subjects took no medication except for hormonal contraceptives, paracetamol up to 1 g four times daily, and nasal decongestants in the short term. They did not smoke tobacco or other nicotine-containi ...
ASMQ brochure
... a Brazilian government-owned pharmaceutical company, and, following a South-South technology transfer, with Cipla Ltd, an Indian pharmaceutical company. ASMQ FDC, produced by Cipla Ltd, was prequalified by WHO in September 2012, a recognition of the product’s quality and an important step in acceler ...
... a Brazilian government-owned pharmaceutical company, and, following a South-South technology transfer, with Cipla Ltd, an Indian pharmaceutical company. ASMQ FDC, produced by Cipla Ltd, was prequalified by WHO in September 2012, a recognition of the product’s quality and an important step in acceler ...
Erasmus Partner Universities of Ankara University Faculty of
... of hot summers and mild winters. July and August are the hottest months with temperatures around 30°C. The humidity is a little high during summer in these regions. Temperatures increase a few degrees when traveling to the south and water temperatures also become warmer. The swimming season is from ...
... of hot summers and mild winters. July and August are the hottest months with temperatures around 30°C. The humidity is a little high during summer in these regions. Temperatures increase a few degrees when traveling to the south and water temperatures also become warmer. The swimming season is from ...
iron isomaltoside 1000, 100mg/mL solution for injection/infusion
... least 18 years with iron deficiency anaemia, serum ferritin <800 microgram/L, a life expectancy >12 months and chronic kidney disease (CKD) in one study and chronic heart failure (CHF) in the other study. In the CKD study patients not currently treated with parenteral iron with a haemoglobin (Hb) ≤1 ...
... least 18 years with iron deficiency anaemia, serum ferritin <800 microgram/L, a life expectancy >12 months and chronic kidney disease (CKD) in one study and chronic heart failure (CHF) in the other study. In the CKD study patients not currently treated with parenteral iron with a haemoglobin (Hb) ≤1 ...
Hallucinogens - LSD, Peyote, Psilocybin, and PCP
... initiates of LSD increased only slightly. Peyote and Psilocybin It is difficult to gauge the extent of use of these hallucinogens because most data sources that quantify drug use exclude these drugs. ...
... initiates of LSD increased only slightly. Peyote and Psilocybin It is difficult to gauge the extent of use of these hallucinogens because most data sources that quantify drug use exclude these drugs. ...
The Haunting of Medical Journals: How Ghostwriting Sold ``HRT``
... into how pharmaceutical companies promote drugs, including the use of vendors to produce ghostwritten manuscripts and place them into medical journals. Dozens of ghostwritten reviews and commentaries published in medical journals and supplements were used to promote unproven benefits and downplay ha ...
... into how pharmaceutical companies promote drugs, including the use of vendors to produce ghostwritten manuscripts and place them into medical journals. Dozens of ghostwritten reviews and commentaries published in medical journals and supplements were used to promote unproven benefits and downplay ha ...
Formulation Development Of Ibuprofen Using
... Oral drug delivery poses a myriad of shortcomings like first pass metabolism, variable absorption rates, gastric irritation, drug instability in gastric pH among others. Drug delivery through the skin i.e. Transdermal drug delivery may also be compared to continuous intravenous infusion for some sys ...
... Oral drug delivery poses a myriad of shortcomings like first pass metabolism, variable absorption rates, gastric irritation, drug instability in gastric pH among others. Drug delivery through the skin i.e. Transdermal drug delivery may also be compared to continuous intravenous infusion for some sys ...
MODERN TASTE CONCEALING TECHNIQUES IN
... regenerate every two weeks. As with many of the senses, taste becomes altered as a function of the aging process, which explains why most children find certain flavors to be too ‘strong’ when adults do not(1). ...
... regenerate every two weeks. As with many of the senses, taste becomes altered as a function of the aging process, which explains why most children find certain flavors to be too ‘strong’ when adults do not(1). ...
NATURAL AND SYNTHETIC HYDROPHILIC MATRICES FOR DEVELOPMENT OF PREGABALIN Review Article
... Epilepsy is recognized as one of the most common neurological conditions in children and young people with a reported prevalence rate of 3.6–4.2 per 1000 for children in developed countries and a significantly higher rate for children in developing countries. It is one of the world’s most recognized ...
... Epilepsy is recognized as one of the most common neurological conditions in children and young people with a reported prevalence rate of 3.6–4.2 per 1000 for children in developed countries and a significantly higher rate for children in developing countries. It is one of the world’s most recognized ...
QUALITY BY DESIGN IN INHALATION PRODUCT DEVELOPMENT
... has been a response to regulatory requirements and industry concerns in the pharma and biotech industries. The US FDA is working to put it in place, through its pharmaceutical cGMP initiative, and through international collaboration as part of the International Conference on Harmonization (ICH) (see ...
... has been a response to regulatory requirements and industry concerns in the pharma and biotech industries. The US FDA is working to put it in place, through its pharmaceutical cGMP initiative, and through international collaboration as part of the International Conference on Harmonization (ICH) (see ...
Anticholinergic drugs
... Succinylcholine (SCh) and decamethonium have affinity as well as submaximal intrinsic activity at the NM-cholinoceptors. They depolarize muscle endplates by opening Na+ channels (just as ACh does) and initially produce twitching and fascilations. These drugs do not dissociate rapidly from the recept ...
... Succinylcholine (SCh) and decamethonium have affinity as well as submaximal intrinsic activity at the NM-cholinoceptors. They depolarize muscle endplates by opening Na+ channels (just as ACh does) and initially produce twitching and fascilations. These drugs do not dissociate rapidly from the recept ...
of > 1 )
... vities of its detailmen are essentially promotional in nature, rather than solicitational, since the detailmen do not engage in any direct solicitation of prescription drug sales, and such activities are therefore not within the scope of l'employee sales activity" as that phrase is used in regulatio ...
... vities of its detailmen are essentially promotional in nature, rather than solicitational, since the detailmen do not engage in any direct solicitation of prescription drug sales, and such activities are therefore not within the scope of l'employee sales activity" as that phrase is used in regulatio ...
Frog intestinal sac as an in vitro method
... green frogs, were used for the permeability experiments. Once the intestinal segment was filled with 300 l of the appropriate sample solution, the intestinal sac was immersed at 26 ± 0.1 ◦ C in a vial containing 1500 l of frog Ringer solution (FR) pH 8.2, with osmolality of 230 ± 10 mOsm/kg and re ...
... green frogs, were used for the permeability experiments. Once the intestinal segment was filled with 300 l of the appropriate sample solution, the intestinal sac was immersed at 26 ± 0.1 ◦ C in a vial containing 1500 l of frog Ringer solution (FR) pH 8.2, with osmolality of 230 ± 10 mOsm/kg and re ...
Author`s personal copy
... e.g. too slow or too fast absorption in the gastrointestinal tract. Osmotic technologies can be used to improve the pharmacokinetic properties of drugs by better adjustment of the release rate with respect to conventional tablets or pills. Therefore, in the past a lot of effort was dedicated to the ...
... e.g. too slow or too fast absorption in the gastrointestinal tract. Osmotic technologies can be used to improve the pharmacokinetic properties of drugs by better adjustment of the release rate with respect to conventional tablets or pills. Therefore, in the past a lot of effort was dedicated to the ...
MAXIPIME Rx only (Cefepime Hydrochloride, USP) for Injection DESCRIPTION
... effectiveness of MAXIPIME and other antibacterial drugs, MAXIPIME should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modify ...
... effectiveness of MAXIPIME and other antibacterial drugs, MAXIPIME should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modify ...
Slide 1
... History of any other concurrent serious illness ( e.g. Tuberculosis, HIV, malignancy) History of alcohol and/or drug abuse History of known allergy, sensitivity or intolerance to the study drugs and their formulation ingredients. Renal dysfunction demonstrated by abnormal serum creatinine levels (> ...
... History of any other concurrent serious illness ( e.g. Tuberculosis, HIV, malignancy) History of alcohol and/or drug abuse History of known allergy, sensitivity or intolerance to the study drugs and their formulation ingredients. Renal dysfunction demonstrated by abnormal serum creatinine levels (> ...
Bad Pharma
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Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.