Accepted Manuscript
... for each topic by expert panels convened to develop critical questions (CQs), interpret the evidence and craft recommendations. In response to the 2011 report of the Institute of Medicine on the development of trustworthy clinical guidelines (1), the NHLBI Advisory Council (NHLBAC) recommended that ...
... for each topic by expert panels convened to develop critical questions (CQs), interpret the evidence and craft recommendations. In response to the 2011 report of the Institute of Medicine on the development of trustworthy clinical guidelines (1), the NHLBI Advisory Council (NHLBAC) recommended that ...
Extract from the Clinical Evaluation Report for macitentan
... defective prostacyclin synthase activity, and abnormalities of the nitric oxide pathway. Current pharmacological therapies for PAH are therefore targeted towards these three mediator pathways: endothelin receptor antagonists (ERA) which inhibit the effects of elevated ET-1 levels and thus reducing v ...
... defective prostacyclin synthase activity, and abnormalities of the nitric oxide pathway. Current pharmacological therapies for PAH are therefore targeted towards these three mediator pathways: endothelin receptor antagonists (ERA) which inhibit the effects of elevated ET-1 levels and thus reducing v ...
2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to
... for each topic by expert panels convened to develop critical questions (CQs), interpret the evidence and craft recommendations. In response to the 2011 report of the Institute of Medicine on the development of trustworthy clinical guidelines (1), the NHLBI Advisory Council (NHLBAC) recommended that ...
... for each topic by expert panels convened to develop critical questions (CQs), interpret the evidence and craft recommendations. In response to the 2011 report of the Institute of Medicine on the development of trustworthy clinical guidelines (1), the NHLBI Advisory Council (NHLBAC) recommended that ...
Pharmacokinetic and Pharmacodynamic Responses to
... Clopidogrel functions only when absorbed by the intestine after oral administration. Evidence has shown that clopidogrel absorption is limited by the intestinal efflux transporter P-glycoprotein (P-gp) encoded by ABCB1 gene. Taubert et al. firstly demonstrated that variable intestinal clopidogrel ab ...
... Clopidogrel functions only when absorbed by the intestine after oral administration. Evidence has shown that clopidogrel absorption is limited by the intestinal efflux transporter P-glycoprotein (P-gp) encoded by ABCB1 gene. Taubert et al. firstly demonstrated that variable intestinal clopidogrel ab ...
GMC Guidelines for Buprenorphine- Naloxone
... NOT a cure. This means that the patient will continue to need the stable dose of buprenorphine/naloxone, with regular monitoring by the doctor. This is similar to other chronic diseases, such as diabetes or asthma. These illnesses can be treated, but there is no permanent cure, so patients often sta ...
... NOT a cure. This means that the patient will continue to need the stable dose of buprenorphine/naloxone, with regular monitoring by the doctor. This is similar to other chronic diseases, such as diabetes or asthma. These illnesses can be treated, but there is no permanent cure, so patients often sta ...
Appendix 2: Underpinning Scientific Knowledge 2015
... Outlines the clinical pharmacology of analgesics and coanalgesics Discusses the use of drug combinations for pain management Describes different formulations and their use ...
... Outlines the clinical pharmacology of analgesics and coanalgesics Discusses the use of drug combinations for pain management Describes different formulations and their use ...
THE CONTRIBUTION OF FETAL METABOLISM TO THE
... morphine clearance in human infants. For morphine, fetal drug metabolism accounts for half the difference between fetal and maternal plasma concentrations. ...
... morphine clearance in human infants. For morphine, fetal drug metabolism accounts for half the difference between fetal and maternal plasma concentrations. ...
Lipid Modification (update): draft NICE guideline
... quality of the underpinning evidence. For some interventions, the Guideline Development Group is confident that, given the information it has looked at, most patients would choose the intervention. The wording used in the recommendations in this guideline denotes the certainty with which the recomme ...
... quality of the underpinning evidence. For some interventions, the Guideline Development Group is confident that, given the information it has looked at, most patients would choose the intervention. The wording used in the recommendations in this guideline denotes the certainty with which the recomme ...
PDF, 318KB - Queensland Courts
... It is a central nervous system depressant. Propoxyphene is available as 100 mg capsules on prescription only. The recommended dose is 100 mg or one capsule every four hours as necessary up to a maximum of 600 mg a day. It is intended to be used for the relief of mild to moderate pain in patients who ...
... It is a central nervous system depressant. Propoxyphene is available as 100 mg capsules on prescription only. The recommended dose is 100 mg or one capsule every four hours as necessary up to a maximum of 600 mg a day. It is intended to be used for the relief of mild to moderate pain in patients who ...
JAP Mar. 86/3 - Journal of Applied Physiology
... generators, and perturbations that alter cycle timing do so by directly affecting components of these generators. Although many studies have addressed various aspects of the action of commonly used antitussive drugs, a complete analysis of the effects of these drugs on the cough motor pattern has ne ...
... generators, and perturbations that alter cycle timing do so by directly affecting components of these generators. Although many studies have addressed various aspects of the action of commonly used antitussive drugs, a complete analysis of the effects of these drugs on the cough motor pattern has ne ...
John R. Hughes, M.D. January, 2014 June 7, 1949
... Contributor of questions, Core Content Review of Family Medicine, 1993 Training Committee, Society for Research on Nicotine and Tobacco, 2003 – 2006 Consultant for faculty development Canadian Addiction Research Foundation, 1995 - 1997 University of Kentucky Medical Center, 1995 - 1998 Contributor t ...
... Contributor of questions, Core Content Review of Family Medicine, 1993 Training Committee, Society for Research on Nicotine and Tobacco, 2003 – 2006 Consultant for faculty development Canadian Addiction Research Foundation, 1995 - 1997 University of Kentucky Medical Center, 1995 - 1998 Contributor t ...
AusPAR: Dapagliflozin - Therapeutic Goods Administration
... This work is copyright. You may reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction for any commercial purpose and reta ...
... This work is copyright. You may reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction for any commercial purpose and reta ...
BOTOX COSMETIC
... factors for neutralizing antibody formation have not been well characterized. The results from some studies suggest that BOTOX® injections at more frequent intervals or at higher doses may lead to greater incidence of antibody formation. When appropriate, the potential for antibody formation may be ...
... factors for neutralizing antibody formation have not been well characterized. The results from some studies suggest that BOTOX® injections at more frequent intervals or at higher doses may lead to greater incidence of antibody formation. When appropriate, the potential for antibody formation may be ...
The Background and Chemistry ofMDMA
... were also generated as contaminants, Two procedures exist for the synthesis of MDMA by the reductive amination ofpiperonyl acetone with methylamine. The reducing agents are either sodium cyanoborohydride in methanol (Braun, Shulgin & Braun 1980a) or amalgamated aluminum in aqueous isopropanol (see N ...
... were also generated as contaminants, Two procedures exist for the synthesis of MDMA by the reductive amination ofpiperonyl acetone with methylamine. The reducing agents are either sodium cyanoborohydride in methanol (Braun, Shulgin & Braun 1980a) or amalgamated aluminum in aqueous isopropanol (see N ...
DIABETES MELLITUS
... bran, tend to increase intestinal transit and may have beneficial effects on colonic function. In contrast, soluble fibers such as gums and pectins, as found in beans, oatmeal, or apple skin, tend to retard nutrient absorption rates so that glucose absorption is slower and hyperglycemia may be sligh ...
... bran, tend to increase intestinal transit and may have beneficial effects on colonic function. In contrast, soluble fibers such as gums and pectins, as found in beans, oatmeal, or apple skin, tend to retard nutrient absorption rates so that glucose absorption is slower and hyperglycemia may be sligh ...
3.1. INTRODUCTION TO SALT FORMATION
... issues are resolved by choosing the appropriate salt form while minor issues can be addressed using other development tools like formulation design. Salt selection is a critical step in the preformulation stage of drug development. As stated by Gould, the balance required in assessing the correct sa ...
... issues are resolved by choosing the appropriate salt form while minor issues can be addressed using other development tools like formulation design. Salt selection is a critical step in the preformulation stage of drug development. As stated by Gould, the balance required in assessing the correct sa ...
IPD Treatment Report
... bran, tend to increase intestinal transit and may have beneficial effects on colonic function. In contrast, soluble fibers such as gums and pectins, as found in beans, oatmeal, or apple skin, tend to retard nutrient absorption rates so that glucose absorption is slower and hyperglycemia may be sligh ...
... bran, tend to increase intestinal transit and may have beneficial effects on colonic function. In contrast, soluble fibers such as gums and pectins, as found in beans, oatmeal, or apple skin, tend to retard nutrient absorption rates so that glucose absorption is slower and hyperglycemia may be sligh ...
Studies and Comparisons with Placebo
... pindolol propranoloί metoprolol, nìtrendipine (in elderly patients), slow release nifedipine or captopril in patients with mild-to-moderate essential hypertension. Combined therapy with carvedilol 25mg and hydrochlorothiazide 25mg, nicardipine 60mg or slow release nifedipine 20mg has an additive ant ...
... pindolol propranoloί metoprolol, nìtrendipine (in elderly patients), slow release nifedipine or captopril in patients with mild-to-moderate essential hypertension. Combined therapy with carvedilol 25mg and hydrochlorothiazide 25mg, nicardipine 60mg or slow release nifedipine 20mg has an additive ant ...
Cytochrome P4502C9: an enzyme of major importance in human
... the CYP2C9 variants differ at only a few residues; the significance of the existence of allelic variants on CYP2C9 activity is discussed under ‘Pharmacogenetics’. The CYP2C9 cDNAs encode proteins of 490 amino acids which all have a calculated molecular mass of #55.6 KDa. Six substrate recognition si ...
... the CYP2C9 variants differ at only a few residues; the significance of the existence of allelic variants on CYP2C9 activity is discussed under ‘Pharmacogenetics’. The CYP2C9 cDNAs encode proteins of 490 amino acids which all have a calculated molecular mass of #55.6 KDa. Six substrate recognition si ...
Therapeutic Drug Monitoring of Lithium Carbonate
... aged between 18-80 years) in both inpatient and outpatient settings. All variables that might affect lithium clearance and/or lithium serum concentration were included and analyzed by stepwise multiple linear regression to produce equations describing lithium clearance and daily dosage requirements ...
... aged between 18-80 years) in both inpatient and outpatient settings. All variables that might affect lithium clearance and/or lithium serum concentration were included and analyzed by stepwise multiple linear regression to produce equations describing lithium clearance and daily dosage requirements ...
Dapagliflozin (as propanediol monohydrate) / Metformin hydrochloride
... Mechanism of Action XIGDUO XR combines two anti-hyperglycaemic agents with complementary mechanisms of action to improve both fasting plasma glucose (FPG) and postprandial plasma glucose (PPG) in patients with type 2 diabetes: dapagliflozin, a SGLT2 inhibitor, and metformin hydrochloride, a member o ...
... Mechanism of Action XIGDUO XR combines two anti-hyperglycaemic agents with complementary mechanisms of action to improve both fasting plasma glucose (FPG) and postprandial plasma glucose (PPG) in patients with type 2 diabetes: dapagliflozin, a SGLT2 inhibitor, and metformin hydrochloride, a member o ...
product monograph
... already receiving digitalis, the positive inotropic action of digitalis may appear to be reduced by propranolol hydrochloride's negative inotropic effect. Due to its negative effect on conduction time, caution must be exercised if it is given to patients with first degree heart block.The effects of ...
... already receiving digitalis, the positive inotropic action of digitalis may appear to be reduced by propranolol hydrochloride's negative inotropic effect. Due to its negative effect on conduction time, caution must be exercised if it is given to patients with first degree heart block.The effects of ...
modafinil - Awake Institute, LLC
... ability to sleep at night. In Europe, modafinil has been used since at least 1988 to treat narcolepsy and idiopathic hypersomnolence. Following two large, multicenter trials, Provigil was approved by the FDA in the U.S. in December 1998 for the treatment of narcolepsy. The use of the drug is rapidly ...
... ability to sleep at night. In Europe, modafinil has been used since at least 1988 to treat narcolepsy and idiopathic hypersomnolence. Following two large, multicenter trials, Provigil was approved by the FDA in the U.S. in December 1998 for the treatment of narcolepsy. The use of the drug is rapidly ...
Sedation for diagnostic and therapeutic procedures in children and
... administer sedation drugs safely, to monitor the effects of the drug and to use equipment to maintain a patent airway and adequate respiration. Prescribing drugs The guideline will assume that prescribers will use a drug’s summary of product characteristics to inform decisions made with individual p ...
... administer sedation drugs safely, to monitor the effects of the drug and to use equipment to maintain a patent airway and adequate respiration. Prescribing drugs The guideline will assume that prescribers will use a drug’s summary of product characteristics to inform decisions made with individual p ...
Bad Pharma
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Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.