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Antiretroviral-associated Hepatotoxicity
Antiretroviral-associated Hepatotoxicity

Formulation and evaluation of fluconazole and ichthammol ointment
Formulation and evaluation of fluconazole and ichthammol ointment

... Ointment was removed from each tube and each empty tube was washed with methanol. The empty tubes were dried and their weight was taken. The difference between two weights was calculated as net weight of the ointment of tube. The average of net weight of ointment of ten tubes was noted. ...
Evidence-based pharmacotherapy of Generalized Anxiety Disorder
Evidence-based pharmacotherapy of Generalized Anxiety Disorder

... GABA. The results of a recently published placebocontrolled study indicate that pregabalin was superior to placebo in reducing mean HAMA score from the first week of double-blind treatment (Feltner et al., 2003). In three randomized, double-blind, placebocontrolled ...
STATISTICAL OPTIMIZATION OF FIXED DOSE COMBINATION OF GLIMEPIRIDE AND  ATORVASTATIN CALCIUM IN IMMEDIATE RELEASE TABLET FORMULATION 
STATISTICAL OPTIMIZATION OF FIXED DOSE COMBINATION OF GLIMEPIRIDE AND  ATORVASTATIN CALCIUM IN IMMEDIATE RELEASE TABLET FORMULATION 

Drug-Induced Acute Renal Dysfunction Acute Renal Failure: PRE
Drug-Induced Acute Renal Dysfunction Acute Renal Failure: PRE

Side effects of glaucoma medications
Side effects of glaucoma medications

... are commonly used in both eyes once or twice a day, and that patients often squeeze more than one drop upon instillation, the systemic implications can be dangerous (65). Subjects lacking of the cytochrome P 450 enzyme CYP2D6 allowing betablockers to be metabolized could have greater risk to develop ...
pediatric dose/route
pediatric dose/route

...  Produces anesthesia in approximately 30 seconds. Effective only on mucous membranes.  Controls pain and gagging. INDICATIONS:  Used to assist as anesthesia during nasal intubation of patients CONTRAINDICATIONS:  Cetacaine is for intranasal use only, and is not to be used in the eyes.  Hypersen ...
Yohimbine in the treatment of orgasmic dysfunction
Yohimbine in the treatment of orgasmic dysfunction

... this parameter was unknown. This might suggest a positive correlation between the presence of NE and likelihood of success. Erectile disfunction was not a feature ...
Amphetamine-Type Stimulants in Latin America
Amphetamine-Type Stimulants in Latin America

... In Latin America, cannabis, cocaine and their derivatives continue to be the most significant drug problems both in terms of use and in terms of trafficking. However, although still low, especially when compared to other regions of the world like Asia, use of amphetamine-type stimulants seems to be ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... I – Awake and Alert.II – Awake and Drowsy.III - Eyes closed but Arousable to verbal commands. IV – Eyes closed but Arousable to Mild physical stimulation.V – Eyes closed and Unarousable After the completion of the study in all the patients, unblinding was done. As per the study drugs given to the pa ...
Drug Resistance
Drug Resistance

... Drug Resistance • an increasing problem – once resistance originates in a population it can be transmitted to other bacteria – a particular type of resistance mechanism is not confirmed to a single class of drugs ...
WHO Drug Dictionaries Best Practices v2
WHO Drug Dictionaries Best Practices v2

... Umbrella term to code to. Umbrella terms do not contain any ingredients, but do have ATC codes and can therefore still be used in analysis done on ATC codes. Umbrella terms can also be identified as having a Drug Code starting with 9. Example: After eliminating all possible entries for a non-unique ...
Oral Phosphate Binders in Patients with Kidney Failure
Oral Phosphate Binders in Patients with Kidney Failure

... stage IV or V kidney disease, the dietary intake of phosphate exceeds excretion, and without specific treatment, hyperphosphatemia occurs almost universally in those undergoing dialysis despite dietary phosphate restriction (Fig. 1). Large observational studies have shown a graded association betwee ...
Evaluation of the clinical efficacy and safety of “Anti-Dandruff
Evaluation of the clinical efficacy and safety of “Anti-Dandruff

... dermal inflammation and tissue damage. Currently available treatment options have various limitations, either due to poor clinical efficacy or due to the compliance issues. Also, these drugs are unable to prevent recurrence, which is the commonest problem. This study was planned to evaluate the clin ...
Tick-Borne Encephalitis vaccine
Tick-Borne Encephalitis vaccine

... Adverse reactions should be reported even if it is not certain that the vaccine caused it, if it is well recognised, or if other drugs were given at the same time. TBE vaccination is unlikely to affect a person's ability to drive and use machines. It should be taken into account, however, that impa ...
Evaluation of Normalization Methods To Predict CYP3A4 Induction
Evaluation of Normalization Methods To Predict CYP3A4 Induction

... The hepatocytes were then seeded onto collagen I–coated 48-well plates at 0.16  106 viable cells per well in 200 ml of medium. Plating efficiency was evaluated around 4 hours after seeding for the hepatocytes and then daily over the 2 additional days of culture in the presence of CYP inducers. Cell ...
CIPRODEX ® Suspension
CIPRODEX ® Suspension

... discontinued at the first appearance of a skin rash or any other sign of hypersensitivity. Serious and occasionally fatal hypersensitivity (anaphylactic) reactions, some following the first dose, have been reported in patients receiving systemic quinolones. Serious acute hypersensitivity reactions m ...
The efficacy and toxicity of Methotrexate (MTX) monotherapy vs
The efficacy and toxicity of Methotrexate (MTX) monotherapy vs

... CI -8.84 to -4.30), WMD -3.46 (95% CI-4.84 to -2.08), WMD -9.72 (95% CI-14.70 to 4.75), WMD -11.57 (95% CI-19.31 to -3.83), WMD -12.10 (95% CI-19.84 to -4.36) and WMD -0.28 (95% CI -0.36 to -0.21) respectively]. However, significant difference was not found for ESR[5-7] [WMD -0.53 (95% CI-11.47 to 1 ...
Ophthalmic Preparations - triphasepharmasolutions.com
Ophthalmic Preparations - triphasepharmasolutions.com

... substance and thus provide a more sustained action. Included in this dosage form category are those solid preparations that, when reconstituted according to the label instructions, result in a suspension. An ophthalmic suspension may be required when the active ingredient is insoluble in the desired ...
Staff Health Care Committee Power Point
Staff Health Care Committee Power Point

... evaluating patient progress to determine whether appropriate results were achieved. ...
national unit specification: general information
national unit specification: general information

... potential treatment methods is necessary in order to carry out foot care in an effective and safe manner. This Unit will also develop the candidate’s knowledge and skills of the drugs used to treat specific medical conditions and the medicaments commonly used in podiatry practice. The knowledge and ...
New antiarrhythmic agents for atrial fibrillation
New antiarrhythmic agents for atrial fibrillation

... is difficult, with most recurrences occurring within the first 5 days [11]. The increased vulnerability to recurrence is most likely secondary to AF-induced atrial electrophysiological remodeling, as described above. The above hypothesis was supported by animal experiments which suggested infusion o ...
Hyoscyamine Sulfate Extended-Release Tablets, USP 0.375 mg
Hyoscyamine Sulfate Extended-Release Tablets, USP 0.375 mg

... Reported clinical experience has not identified differences in safety between patients aged 65 and over and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepat ...
Alzheimer's Drugs Market, 2012 - 2017 Brochure
Alzheimer's Drugs Market, 2012 - 2017 Brochure

... chapter provides information on the two main segments (Acetylcholinesterase inhibitors and NMDA receptor antagonists), primary drugs, and leading companies. Chapter 4 focuses specifically on Acetylcholinesterase inhibitors market. The market size and forecasts are provided by sub-segments, drugs and ...
Psychotoxic or Psychedelic - Scholarly Commons
Psychotoxic or Psychedelic - Scholarly Commons

... these reasons, the psychotomimetics have been valuable in the study of the biochemical function of the nervous system. The foregoing brief discussion of the action of, psychotomimetic drugs has been presented so that a basis of comparison can be made with the effects from the inhalation of solvents ...
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Bad Pharma



Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. The book was published in September 2012 in the UK by the Fourth Estate imprint of HarperCollins, and in February 2013 in the United States by Faber and Faber.Goldacre argues in the book that ""the whole edifice of medicine is broken"" because the evidence on which it is based is systematically distorted by the pharmaceutical industry. He writes that the industry finances most of the clinical trials into its own products and much of doctors' continuing education, that clinical trials are often conducted on small groups of unrepresentative subjects and negative data is routinely withheld, and that apparently independent academic papers may be planned and even ghostwritten by pharmaceutical companies or their contractors, without disclosure. Goldacre calls the situation a ""murderous disaster,"" and makes suggestions for action by patients' groups, physicians, academics and the industry itself.Responding to the book's publication, the Association of the British Pharmaceutical Industry issued a statement arguing that the examples the book offers are historical, that the concerns have been addressed, that the industry is among the most regulated in the world, and that it discloses all data in accordance with international standards.In January 2013 Goldacre joined the Cochrane Collaboration, British Medical Journal and others in setting up AllTrials, a campaign calling for the results of all past and current clinical trials to be reported. The British House of Commons Public Accounts Committee expressed concern in January 2014 that drug companies were still only publishing around 50 percent of clinical-trial results.
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