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Human Ebola virus infection in West Africa: a
Human Ebola virus infection in West Africa: a

... a soluble non-virion form of GP1 and a scanty amount of GP1,2 are released into the circulation [9-12]. The virusassociated GP1,2 and not the other soluble glycoproteins released during the virus infection are responsible for primary target cell activation [13]. The highly glycosylated mucin-like re ...
Ebola - DevelopmentEducation.ie
Ebola - DevelopmentEducation.ie

... the blood, secretions, organs or other bodily fluids of infected people, and indirect contact with environments contaminated with such fluids. Burial ceremonies in which mourners have direct contact with the body of the deceased person can also play ...
President`s Report - Tulane University
President`s Report - Tulane University

... • In the occupational setting, multiple doses of Hepatitis B Immune Globulin initiated within 1 week following percutaneous exposure to hepatitis B surface antigen-positive blood provides an estimated 75% protection from HBV infection. • There is no cure available for acute HBV infection. There are ...
Biosafety Application
Biosafety Application

... Will there be deliberate transfer of drug resistance trait to microorganisms not known to acquire the trait naturally if such acquisition could compromise the use of the drug to control disease agents? Section III-A-1a Will there be transfer of rDNA into human or animal pathogens in Risk Groups 2 or ...
Infectious Diseases of Poverty
Infectious Diseases of Poverty

... cleaved by furin into two disulfide-linked subunits; a surface subunit, GP1; and a membranespanning subunit, GP2. GP1 contains the receptor-binding domain (RBD) for host cell attachment and a mucin-like domain to protect the RBD from humoral and cell-mediated immunity. The RBD responsible for recep ...
ndj10463_run-in_prn 2809..2831
ndj10463_run-in_prn 2809..2831

... and stable antiretroviral therapy for 3 months. The authors followed up 10 patients for 480 days, with a survival rate of 100%. Rejection occurred in 50% of the patients, and anti-thymocyte globulin (ATG) was used to treat episodes of rejection that were resistant to steroids. Infectious complicatio ...
Infectious bovine rhinotracheitis/infectious pustular vulvovaginitis
Infectious bovine rhinotracheitis/infectious pustular vulvovaginitis

... described, including DNA–DNA hybridisation and the PCR. The PCR is also increasingly used in routine diagnostic submissions (Moore et al., 2000). Compared with virus isolation, the PCR has the primary advantages of being more sensitive and more rapid: it can be performed in 1–2 days. It is also poss ...
File - Gulf Coast Maintenance
File - Gulf Coast Maintenance

... chance of developing severe liver diseases  50-100 times more infectious than HIV3, easily spread by sex or injection drug use  Very durable can survive in dried blood for at least seven days ...
Micr-22 Final Exam Study Guide Revised Spring 2017 Test
Micr-22 Final Exam Study Guide Revised Spring 2017 Test

... 45. discuss the implications of information from table 17.1: - how might their structures influence the effects of different classes of antibodies? (Note: not much is implied for IgA, IgD, or IgE) - half-life differences - placental transfer 46. explain the function of B cells. 47. explain how B cel ...
Assembly and budding of rabies virus
Assembly and budding of rabies virus

... wild type  ...
Review for Chap 7 Test
Review for Chap 7 Test

... broken-down chemicals. Nitrogen-converting bacteria make nitrogen compounds that plants need and can use. Both types of bacteria thus help plants survive and grow. DIF: L3 OBJ: A.2.2.4 28. ANS: An endospore is a thick-walled resting cell that may form inside a bacterium when the cell’s surrounding c ...
QuickTiter™ Hepatitis B Surface Antigen (HBsAg
QuickTiter™ Hepatitis B Surface Antigen (HBsAg

... Roughly one third of the world’s population have been infected with hepatitis B virus. 5-10% of adults and 90% of babies who have been infected will have the virus for the rest of their lives. The infection is preventable by vaccination. Diagnosis of chronic Hepatitis B Virus (HBV) infection has lon ...
Infectious Disease as Chronic Disease
Infectious Disease as Chronic Disease

... HIV prevalence in Canada is expected to follow US projections, where it is estimated that half of HIV-positive individuals will be 50 years or older by 2050 (14). This demographic shift will have important implications for disease management and the choice of care setting for these individuals. It i ...
2.2.4 Infectious Hematopoietic Necrosis
2.2.4 Infectious Hematopoietic Necrosis

... To aid in the diagnosis of IHN, certain key features such as life stage and species of fish, water temperature, clinical signs, and disease history of the facility and stock of fish are evaluated. To isolate IHNV, tissue and reproductive fluids are examined by standard cell culture techniques. Proce ...
T - Florida Department of Corrections
T - Florida Department of Corrections

... CDC standards must be reported to the Department of Health using the "Acquired Immunodeficiency Syndrome Adult Confidential Case Report" form (CDC 50.42A) or Acquired Immunodeficiency Syndrome case report form. A copy of the report form should be filed in the medical record behind “Communicable Dise ...
Anderson RM and May RM (1991). Infectious Diseases ofHumans
Anderson RM and May RM (1991). Infectious Diseases ofHumans

... Chaisson RE, Moss AR, Onishi R, et al (1987) . Human immunodeficiency virus in heterosexual drug users in San Francisco. AJPH 77 #2, 16 172 . Chu SY, Peterman TA, Doll LS, et al. (1992). AIDS in bisexual men in the United States : epidemiology and transmission to women . AJPH 82 #2, 220-224 . Coates ...
Populations and Infectious Diseases: Ecology or Epidemiology?
Populations and Infectious Diseases: Ecology or Epidemiology?

... subjects of research specialization, it is perhaps hardly surprising that I acquired an interest in parasite ecology as a young student. In the 1960s and 1970s, research in this area was more closely linked to the prevailing concepts and fashions in the discipline of parasitology, as opposed to thos ...
Nipah Virus: Effects of Urbanization and Climate Change
Nipah Virus: Effects of Urbanization and Climate Change

... 2007 from April 9th to 28th in the village Belechuapara in Nadia, West Bengal [12]. This time 5 cases were reported and all those who were diseased died. The one question that arises here is how did Nipah Virus originate and travel to India? It is known that this virus can spread through fomites but ...
The Role of Cell Differentiation as a Determinant
The Role of Cell Differentiation as a Determinant

... know t h a t the oncogenic viruses are not a homogeneous family of viruses with similar special attributes. On the contrary, they exhibit as much diversity as other animal viruses. Some propagate in the cell nucleus (1), others in the cytoplasm (18, 18, $6); some contain D N A (11, 19, 31), others R ...
Highly pathogenic H5N1 avian influenza outbreaks in poultry and in
Highly pathogenic H5N1 avian influenza outbreaks in poultry and in

... Highly pathogenic avian influenza virus can be found inside and on the surface of eggs laid by infected birds. Although sick birds will normally stop producing eggs, eggs laid in the early phase of the disease could contain viruses in the albumen and yolk as well as on the surface of the shell. In a ...
Genetic Strategy to Prevent Influenza Virus Infections in Animals
Genetic Strategy to Prevent Influenza Virus Infections in Animals

... The development and distribution of influenza-resistant poultry for the control of influenza in both poultry and human populations will be likely to face significant technical, logistical, and social challenges. First, technologies for producing influenza-resistant poultry have not been demonstrated ...
Evidence for emergence of an amphibian iridoviral disease because
Evidence for emergence of an amphibian iridoviral disease because

... © 2004 Blackwell Publishing Ltd, Molecular Ecology, 14, 213–224 ...
Blood and Body Fluid Exposure Follow-up
Blood and Body Fluid Exposure Follow-up

... There is essentially no risk of contracting HBV infection following exposure to blood, if the worker has been immunized with HBV vaccine and has developed an adequate antibody response to the HBsAg. If the worker is non-immune (HBsAb-negative), the risk of infection following exposure to HBV infecte ...
West Nile Virus and Greater Sage-Grouse
West Nile Virus and Greater Sage-Grouse

... requires that we estimate not only susceptibility and seroprevalence, but also disease-related mortality, which in turn allows estimation of actual infection rates. Knowing infection rate is also crucial for identifying potential strategies for mitigating disease impacts to susceptible species. If i ...
Chikungunya virus impacts the diversity of symbiotic bacteria in
Chikungunya virus impacts the diversity of symbiotic bacteria in

... mosquito species induce the expression of basal genes in the antimicrobial immune response, thus optimizing host immune signalling when pathogens attack. For instance, the microbiota of mosquito vector Aedes aegypti influence the infection by the dengue virus by modulating the gene expression of sev ...
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HIV



The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and acquired immunodeficiency syndrome (AIDS). AIDS is a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells.HIV infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells. HIV infection leads to low levels of CD4+ T cells through a number of mechanisms, including apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections.
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