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Slide 1
Slide 1

... Major pathway CYP3A4 ...
Mendel and the Gene Idea
Mendel and the Gene Idea

... May be caused by Polygenic Inheritance  More than 1 gene affects phenotype  Environmental factors also have effect ...
Shared Care Guidelines available. For the treatment
Shared Care Guidelines available. For the treatment

... Responsibilities of the specialist initiating treatment 1. Initiate and stabilise treatment with quetiapine (this phase is expected to last at least six months). To initiate therapy, arrange prescription and evaluate over the first 3 months. To establish baseline and after 3 months of treatment weig ...
Guidelines for the Chronic Use of Opioid Analgesics
Guidelines for the Chronic Use of Opioid Analgesics

... opiates or completely synthetic agents. Thus, drug tests that are “positive for opiates” have detected one of these compounds or a metabolite of heroin, 6-monoacetyl morphine (MAM). Drug tests that are “negative for opiates” have found no detectable levels of opiates in the sample, even though other ...
Cefdinir Use in Children - University of Virginia School of Medicine
Cefdinir Use in Children - University of Virginia School of Medicine

... colleagues described the effectiveness of their cefdinir noisome formulations to provide sustained drug release.15 In a study using goat intestinal membrane, the authors demonstrated 94% permeation across the membrane over 12 hours. These early studies suggest that it is possible to improve upon cur ...
the Note
the Note

... Dihybrid cross: Di = TWO, so when two pairs of contrasting traits are crossed to determine the possible inheritance of the offspring. There will be 16 possible combinations that result from the cross – 2 possibilities from the male and 4 possibilities from the female (4 x 4 = 16). Filial generation: ...
Bioprospecting of Genes and Allele Mining
Bioprospecting of Genes and Allele Mining

... • An allele from the Greek allelos, meaning each other • The word is a short form of allelomorph ('other form'), which is used to describe variant forms of a gene detected as different phenotypes. • For example, at the gene locus for ABO blood type proteins in human; eye colour in fruit fly. • Allel ...
A comparison of the efficacy and safety of once-daily fluticasone... twice-daily fluticasone propionate/salmeterol in moderate to very severe COPD
A comparison of the efficacy and safety of once-daily fluticasone... twice-daily fluticasone propionate/salmeterol in moderate to very severe COPD

... obtained with vilanterol (VI) in patients with COPD.2 The difference in wmFEV1 between the minimally effective dose of 3mcg (minimum dose demonstrating >= 100mL mean difference from placebo in trough FEV1) and the dose of 25mcg (plateau of the doseresponse curve) was 53mL. From this method, we estim ...
Biomedical Product Development
Biomedical Product Development

... Evaluation of Phase I data for safety Prepare Phase II Protocol Update Investigator’s Brochure Recruit Phase II clinical sites ...
View Full Text-PDF
View Full Text-PDF

... T cell/transmembrane immunoglobulin and mucin (TIM) molecules have a critical role in regulating immune responses.TIM-1 which is highly polymorphic in human has many nucleotide polymorphisms(SNPs) that have been studied for their role in allergic diseases, but the results were not consistent. The ai ...
8.5 - Allelic Frequencies & Population Genetics (AKA Hardy
8.5 - Allelic Frequencies & Population Genetics (AKA Hardy

...  What do you think the term would be for the number of times an allele occurs within a gene pool?  Allelic Frequency ...
Pharmacognosy-I
Pharmacognosy-I

... • The plant material can be dried either by the sun or by the use of artificial heat. But with some natural products, such as vanilla fermentation or sweating will occurs which will change the constituents, so such drugs require special drying processes, usually called curing. ...
Michigan Drug Fact Sheets - Rosecrance Health Network
Michigan Drug Fact Sheets - Rosecrance Health Network

... Given the drug’s extreme potency and narrow safety window, accurate measurement of doses is critical. Even a dose a few milligrams off can be life-threatening. Also, the slow onset of the high may lead some users to re-dose, which can result in death. Mislabeling of Bromo-Dragonfly as its far-less-p ...
Drugs for Depressive Disorders
Drugs for Depressive Disorders

... Therapeutic Uses of Antidepressants ➼ Most antidepressants are of equivalent efficacy in patients with major depressive disorder, when administered in comparable doses. ➼ Therefore many clinicians select an antidepressant by matching the patient’s presenting symptoms to the adverse effect profile o ...
macrotys. - David Winston`s Center for Herbal Studies
macrotys. - David Winston`s Center for Herbal Studies

... and following those named above authorities subsequent to King unite in saying that the Section of Cimicifuga Americana, most conspicuous product of Macrotys' disintegration is a compound resinous body, which was first discovered by Dr. John King in 1835. Subsequent studies have been largely devoted ...
the tyranny of knowledge
the tyranny of knowledge

... that world was left incomplete for man to complete it ...
Heredity Quiz 2016 Self-Testing Guide DUE day of quiz! ANSWERS
Heredity Quiz 2016 Self-Testing Guide DUE day of quiz! ANSWERS

... 14. Describe a heterozygous genotype. Since the word cell “hetero-“ means different, a heterozygous genotype will have one dominant allele and one recessive allele. For our hair texture example, the heterozygous genotype would be Hh. Describe 2 different homozygous genotypes. There are 2 homozygous ...
Treatments of Dysfunctional Behaviour
Treatments of Dysfunctional Behaviour

...  Conclusions:  The evidence is that there is no improved effect when given combined therapy as compared to only drug therapy.  Drug therapy is an effective way to treat depression. ...
Session A3
Session A3

... overdose. It is not intended to be a self-injector – therefore a family member or caregiver must administer the injection • It has an AWP of $862.50 for a kit containing two syringes • Evzio has been recommended by the myMatrixx P&T Committee to be a non-formulary drug for two reasons – one is price ...
MHRA Drug Safety Update - Royal College of Psychiatrists
MHRA Drug Safety Update - Royal College of Psychiatrists

... the likely time-to-onset of such events (the first few weeks of treatment for StevensJohnson syndrome and toxic epidermal necrolysis and usually within 3 – 6 weeks for drug rash with eosinophilia and systemic symptoms [DRESS]; see article A3). And finally, cases of keratitis and ulcerative keratitis ...
Genetics and Huntington disease - Huntington`s Disease Society of
Genetics and Huntington disease - Huntington`s Disease Society of

... Lessons from 15 years of predictive testing Uptake of predictive genetic testing– What percentage of the “at-risk” population chooses to have predictive genetic testing. • Prior to the availability of predictive testing, 60-85% of atrisk individuals said they would use a predictive test. •Large stu ...
Sex-Specific Genetic Control of Diabetic
Sex-Specific Genetic Control of Diabetic

... In EBioMedicine Meng et al. (2015a) reported the results from their second genome-wide association study on neuropathic pain that aimed to identify novel genetic factors contributing to neuropathic pain in diabetic patients. The first study (Meng et al., 2015b) published earlier this year in the Euro ...
`Drug-related Deaths – What You Should Know`:a 28
`Drug-related Deaths – What You Should Know`:a 28

... the lungs and air passages (organs) associated with breathing. ...
3-1General Properties of Drugs
3-1General Properties of Drugs

... Drugs do not perform any new functions on a tissue or organ in the body; they only modify existing functions. Drugs in general exert multiple actions rather than a single effect. Drug action results from a physiochemical interaction between the drug and a molecule in the body. ...
汤慧芳_抗阿米巴_滴虫
汤慧芳_抗阿米巴_滴虫

... effective to asymptomatic passers and the patients of evacuating amebic cyst. The therapeutic effect is not so good to acute amebic dysentery(急性阿米巴性痢疾), after controlling symptoms by metronidazole, treat it with diloxanide to kill the small trophozoite in intestinal tract, can radically cure amebic ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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